LV12806B - Cc-1065 analogi ar divam cpi apaksvienibam - Google Patents

Cc-1065 analogi ar divam cpi apaksvienibam

Info

Publication number
LV12806B
LV12806B LV010180A LV010180A LV12806B LV 12806 B LV12806 B LV 12806B LV 010180 A LV010180 A LV 010180A LV 010180 A LV010180 A LV 010180A LV 12806 B LV12806 B LV 12806B
Authority
LV
Latvia
Prior art keywords
pct
formula
date mar
compounds
sec
Prior art date
Application number
LV010180A
Other languages
English (en)
Latvian (lv)
Other versions
LV12806A (en
Inventor
Robert C Kelly
Paul A Aristoff
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of LV12806A publication Critical patent/LV12806A/en
Publication of LV12806B publication Critical patent/LV12806B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Error Detection And Correction (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
  • Amplifiers (AREA)
  • Semiconductor Integrated Circuits (AREA)
  • Solid State Image Pick-Up Elements (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Television Systems (AREA)
  • Television Receiver Circuits (AREA)
  • Stereophonic System (AREA)
LV010180A 1988-09-12 2001-12-27 Cc-1065 analogi ar divam cpi apaksvienibam LV12806B (lv)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24335088A 1988-09-12 1988-09-12
PCT/US1989/003329 WO1990002746A1 (en) 1988-09-12 1989-08-07 Novel cc-1065 analogs having two cpi subunits

Publications (2)

Publication Number Publication Date
LV12806A LV12806A (en) 2002-03-20
LV12806B true LV12806B (lv) 2002-05-20

Family

ID=22918400

Family Applications (1)

Application Number Title Priority Date Filing Date
LV010180A LV12806B (lv) 1988-09-12 2001-12-27 Cc-1065 analogi ar divam cpi apaksvienibam

Country Status (14)

Country Link
US (1) US5541339A (zh)
JP (1) JP3380237B2 (zh)
KR (1) KR0137959B1 (zh)
AT (1) ATE198335T1 (zh)
AU (1) AU632288B2 (zh)
CA (1) CA1340215C (zh)
DE (1) DE68929275T2 (zh)
DK (1) DK175458B1 (zh)
FI (1) FI103668B1 (zh)
GR (1) GR3035589T3 (zh)
LV (1) LV12806B (zh)
NO (1) NO303498B1 (zh)
TW (1) TW217383B (zh)
WO (1) WO1990002746A1 (zh)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0563475B1 (en) * 1992-03-25 2000-05-31 Immunogen Inc Cell binding agent conjugates of derivatives of CC-1065
US5502068A (en) * 1995-01-31 1996-03-26 Synphar Laboratories, Inc. Cyclopropylpyrroloindole-oligopeptide anticancer agents
US20100056762A1 (en) 2001-05-11 2010-03-04 Old Lloyd J Specific binding proteins and uses thereof
JP4414142B2 (ja) 2001-05-11 2010-02-10 ルードヴィッヒ インスティテュート フォー キャンサー リサーチ 特異的結合タンパク質およびその使用
US6825219B2 (en) 2001-11-09 2004-11-30 Boehringer Ingelheim Pharmaceuticals, Inc. Substituted benzimidazole compounds
CA2494942A1 (en) * 2002-08-08 2004-02-19 Boehringer Ingelheim Pharmaceuticals, Inc. Substituted benzimidazole compounds
US20050215614A1 (en) * 2002-10-15 2005-09-29 Rigel Pharmaceuticals, Inc. Substituted indoles and their use as hcv inhibitors
WO2005005389A2 (en) * 2003-07-07 2005-01-20 Merck Patent Gmbh Malonamide derivatives
WO2005079791A1 (en) * 2004-02-12 2005-09-01 Boehringer Ingelheim Pharmaceuticals, Inc. Thiophene -2- carboxylic acid - (1h - benzimidazol - 2 yl) - amide derivatives and related compounds as inhibitors of the tec kinase itk (interleukin -2- inducible t cell kinase) for the treatment of inflammation, immunological and allergic disorders
JP2009504756A (ja) * 2005-08-17 2009-02-05 シェーリング コーポレイション 新規な高親和性のチオフェンベースおよびフランベースのキナーゼリガンド
CN101711284A (zh) 2007-01-25 2010-05-19 达娜-法勃肿瘤研究所 抗egfr抗体在治疗egfr突变体介导的疾病中的用途
MX2009009782A (es) 2007-03-15 2010-09-10 Ludwig Inst Cancer Res Metodo de tratamiento que utiliza anticuerpos egfr e inhibidores de src y formulaciones relacionadas.
US9901567B2 (en) 2007-08-01 2018-02-27 Syntarga B.V. Substituted CC-1065 analogs and their conjugates
CA2696360C (en) 2007-08-14 2018-11-20 Ludwig Institute For Cancer Research Monoclonal antibody targeting the egfr receptor and uses thereof
RU2562232C2 (ru) 2008-11-03 2015-09-10 Синтарга Б.В. Новые аналоги сс-1065 и их конъюгаты
CA2796712C (en) 2010-04-21 2017-02-28 Syntarga B.V. Novel conjugates of cc-1065 analogs and bifunctional linkers
EP3388060A1 (en) 2012-10-22 2018-10-17 Arnold Glazier Methods for the effective treatment of metastatic cancer
DE102013012622A1 (de) * 2013-07-30 2015-02-05 Clariant lnternational Ltd Neue sterisch gehinderte cyclische Amine
LT3092010T (lt) 2014-01-10 2018-10-25 Synthon Biopharmaceuticals B.V. Metodas, skirtas gryninimui cys-sujungtų antikūno-vaisto konjugatų
NZ722020A (en) * 2014-01-27 2018-05-25 Pfizer Bifunctional cytotoxic agents
US10973920B2 (en) 2014-06-30 2021-04-13 Glykos Finland Oy Saccharide derivative of a toxic payload and antibody conjugates thereof
DE102015000124A1 (de) * 2015-01-07 2016-07-07 Clariant International Ltd. Verfahren zur Stabilisierung von Polyamiden
AU2016238551B2 (en) * 2015-03-20 2020-01-02 Pfizer Inc. Bifunctional cytotoxic agents containing the CTI pharmacophore

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4169888A (en) * 1977-10-17 1979-10-02 The Upjohn Company Composition of matter and process
US4301248A (en) * 1979-12-21 1981-11-17 Bristol-Myers Company Fermentation process for making rachelmycin
US4413132A (en) * 1980-11-18 1983-11-01 The Upjohn Company Antibiotic CC-1065 indoline intermediates
US4912227A (en) * 1984-02-21 1990-03-27 The Upjohn Company 1,2,8,8A-tetrahydrocyclopropa(c)pyrrolo(3,2-e)-indol-4-(5H)-ones and related compounds
CA1238907A (en) * 1984-02-21 1988-07-05 Robert C. Kelly 1,2,8,8a-tetrahydrocyclopropa¬c|pyrrolo(3,2-e)- indol-4(5h)-ones and related compounds
GB8528848D0 (en) * 1985-11-22 1985-12-24 Davy Mckee Poole Rolling mills
JP2598819B2 (ja) * 1986-12-19 1997-04-09 ジ・アップジョン・カンパニー 新規なｃｃ‐１０６５同族体

Also Published As

Publication number Publication date
NO910958D0 (no) 1991-03-11
ATE198335T1 (de) 2001-01-15
DK175458B1 (da) 2004-11-01
DE68929275T2 (de) 2001-05-23
FI911193A0 (fi) 1991-03-11
DK41791D0 (da) 1991-03-08
JP3380237B2 (ja) 2003-02-24
NO303498B1 (no) 1998-07-20
AU4192289A (en) 1990-04-02
GR3035589T3 (en) 2001-06-29
DE68929275D1 (de) 2001-02-01
KR0137959B1 (ko) 1998-05-15
US5541339A (en) 1996-07-30
LV12806A (en) 2002-03-20
KR900701801A (ko) 1990-12-04
JPH04500664A (ja) 1992-02-06
CA1340215C (en) 1998-12-15
AU632288B2 (en) 1992-12-24
WO1990002746A1 (en) 1990-03-22
FI103668B (fi) 1999-08-13
FI103668B1 (fi) 1999-08-13
NO910958L (no) 1991-05-10
DK41791A (da) 1991-03-08
TW217383B (zh) 1993-12-11

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