LV12806B - Cc-1065 analogi ar divam cpi apaksvienibam - Google Patents
Cc-1065 analogi ar divam cpi apaksvienibamInfo
- Publication number
- LV12806B LV12806B LV010180A LV010180A LV12806B LV 12806 B LV12806 B LV 12806B LV 010180 A LV010180 A LV 010180A LV 010180 A LV010180 A LV 010180A LV 12806 B LV12806 B LV 12806B
- Authority
- LV
- Latvia
- Prior art keywords
- pct
- formula
- date mar
- compounds
- sec
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Error Detection And Correction (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Amplifiers (AREA)
- Solid State Image Pick-Up Elements (AREA)
- Semiconductor Integrated Circuits (AREA)
- Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
- Television Receiver Circuits (AREA)
- Stereophonic System (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Television Systems (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US24335088A | 1988-09-12 | 1988-09-12 | |
PCT/US1989/003329 WO1990002746A1 (en) | 1988-09-12 | 1989-08-07 | Novel cc-1065 analogs having two cpi subunits |
Publications (2)
Publication Number | Publication Date |
---|---|
LV12806A LV12806A (en) | 2002-03-20 |
LV12806B true LV12806B (lv) | 2002-05-20 |
Family
ID=22918400
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
LV010180A LV12806B (lv) | 1988-09-12 | 2001-12-27 | Cc-1065 analogi ar divam cpi apaksvienibam |
Country Status (14)
Country | Link |
---|---|
US (1) | US5541339A (da) |
JP (1) | JP3380237B2 (da) |
KR (1) | KR0137959B1 (da) |
AT (1) | ATE198335T1 (da) |
AU (1) | AU632288B2 (da) |
CA (1) | CA1340215C (da) |
DE (1) | DE68929275T2 (da) |
DK (1) | DK175458B1 (da) |
FI (1) | FI103668B1 (da) |
GR (1) | GR3035589T3 (da) |
LV (1) | LV12806B (da) |
NO (1) | NO303498B1 (da) |
TW (1) | TW217383B (da) |
WO (1) | WO1990002746A1 (da) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69231123T2 (de) * | 1992-03-25 | 2001-02-15 | Immunogen Inc | Konjugaten von Zell-bindender Mittel und Derivaten von CC-1065 |
US5502068A (en) * | 1995-01-31 | 1996-03-26 | Synphar Laboratories, Inc. | Cyclopropylpyrroloindole-oligopeptide anticancer agents |
EP2163256B1 (en) | 2001-05-11 | 2015-09-02 | Ludwig Institute for Cancer Research Ltd. | Specific binding proteins and uses thereof |
US20100056762A1 (en) | 2001-05-11 | 2010-03-04 | Old Lloyd J | Specific binding proteins and uses thereof |
YU37904A (sh) | 2001-11-09 | 2006-08-17 | Boehringer Ingelheim Pharmaceuticals Inc. | Benzimidazoli kao korisni inhibitori proteinske kinaze |
AU2003257094A1 (en) * | 2002-08-08 | 2004-02-25 | Boehringer Ingelheim Pharmaceuticals, Inc. | Substituted benzimidazole compounds |
US20050215614A1 (en) * | 2002-10-15 | 2005-09-29 | Rigel Pharmaceuticals, Inc. | Substituted indoles and their use as hcv inhibitors |
CA2531485C (en) * | 2003-07-07 | 2013-03-26 | Merck Patent Gmbh | Malonamide derivatives |
WO2005079791A1 (en) * | 2004-02-12 | 2005-09-01 | Boehringer Ingelheim Pharmaceuticals, Inc. | Thiophene -2- carboxylic acid - (1h - benzimidazol - 2 yl) - amide derivatives and related compounds as inhibitors of the tec kinase itk (interleukin -2- inducible t cell kinase) for the treatment of inflammation, immunological and allergic disorders |
JP2009504756A (ja) * | 2005-08-17 | 2009-02-05 | シェーリング コーポレイション | 新規な高親和性のチオフェンベースおよびフランベースのキナーゼリガンド |
CN101711284A (zh) | 2007-01-25 | 2010-05-19 | 达娜-法勃肿瘤研究所 | 抗egfr抗体在治疗egfr突变体介导的疾病中的用途 |
CN101688229B (zh) | 2007-03-15 | 2013-06-12 | 路德维格癌症研究所 | 包含egfr抗体和src抑制剂的组合物及其在制备用于治疗哺乳动物癌症的药物中的用途 |
US9901567B2 (en) | 2007-08-01 | 2018-02-27 | Syntarga B.V. | Substituted CC-1065 analogs and their conjugates |
CN108424454B (zh) | 2007-08-14 | 2022-05-31 | 路德维格癌症研究所有限公司 | 靶向egf受体的单克隆抗体175及其衍生物和用途 |
NO2344478T3 (da) | 2008-11-03 | 2018-02-24 | ||
ES2815678T3 (es) | 2010-04-21 | 2021-03-30 | Syntarga Bv | Conjugados de análogos de CC-1065 y conectores bifuncionales |
EP2908809A2 (en) | 2012-10-22 | 2015-08-26 | Arnold Glazier | Methods for the effective treatment of metastatic cancer |
DE102013012622A1 (de) * | 2013-07-30 | 2015-02-05 | Clariant lnternational Ltd | Neue sterisch gehinderte cyclische Amine |
CA2935456C (en) | 2014-01-10 | 2018-09-18 | Synthon Biopharmaceuticals B.V. | Method for purifying cys-linked antibody-drug conjugates |
SG11201605437YA (en) * | 2014-01-27 | 2016-08-30 | Pfizer | Bifunctional cytotoxic agents |
EP3160513B1 (en) | 2014-06-30 | 2020-02-12 | Glykos Finland Oy | Saccharide derivative of a toxic payload and antibody conjugates thereof |
DE102015000124A1 (de) * | 2015-01-07 | 2016-07-07 | Clariant International Ltd. | Verfahren zur Stabilisierung von Polyamiden |
CA2923862C (en) * | 2015-03-20 | 2024-02-13 | Pfizer Inc. | Bifunctional cytotoxic agents containing the cti pharmacophore |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4169888A (en) * | 1977-10-17 | 1979-10-02 | The Upjohn Company | Composition of matter and process |
US4301248A (en) * | 1979-12-21 | 1981-11-17 | Bristol-Myers Company | Fermentation process for making rachelmycin |
US4413132A (en) * | 1980-11-18 | 1983-11-01 | The Upjohn Company | Antibiotic CC-1065 indoline intermediates |
US4912227A (en) * | 1984-02-21 | 1990-03-27 | The Upjohn Company | 1,2,8,8A-tetrahydrocyclopropa(c)pyrrolo(3,2-e)-indol-4-(5H)-ones and related compounds |
CA1238907A (en) * | 1984-02-21 | 1988-07-05 | Robert C. Kelly | 1,2,8,8a-tetrahydrocyclopropa¬c|pyrrolo(3,2-e)- indol-4(5h)-ones and related compounds |
GB8528848D0 (en) * | 1985-11-22 | 1985-12-24 | Davy Mckee Poole | Rolling mills |
AU617304B2 (en) * | 1986-12-19 | 1991-11-28 | Pharmacia & Upjohn Company | Novel cc-1065 analogs |
-
1989
- 1989-08-07 US US07/659,415 patent/US5541339A/en not_active Expired - Fee Related
- 1989-08-07 JP JP50923689A patent/JP3380237B2/ja not_active Expired - Fee Related
- 1989-08-07 AU AU41922/89A patent/AU632288B2/en not_active Ceased
- 1989-08-07 WO PCT/US1989/003329 patent/WO1990002746A1/en active IP Right Grant
- 1989-08-07 KR KR1019900700977A patent/KR0137959B1/ko not_active IP Right Cessation
- 1989-08-21 CA CA000608908A patent/CA1340215C/en not_active Expired - Fee Related
- 1989-08-23 TW TW078106510A patent/TW217383B/zh active
- 1989-09-04 AT AT89308920T patent/ATE198335T1/de not_active IP Right Cessation
- 1989-09-04 DE DE68929275T patent/DE68929275T2/de not_active Expired - Fee Related
-
1991
- 1991-03-08 DK DK41791A patent/DK175458B1/da not_active IP Right Cessation
- 1991-03-11 NO NO910958A patent/NO303498B1/no unknown
- 1991-03-11 FI FI911193A patent/FI103668B1/fi not_active IP Right Cessation
-
2001
- 2001-03-15 GR GR20010400433T patent/GR3035589T3/el not_active IP Right Cessation
- 2001-12-27 LV LV010180A patent/LV12806B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
FI103668B (fi) | 1999-08-13 |
AU632288B2 (en) | 1992-12-24 |
LV12806A (en) | 2002-03-20 |
CA1340215C (en) | 1998-12-15 |
DK41791A (da) | 1991-03-08 |
ATE198335T1 (de) | 2001-01-15 |
JP3380237B2 (ja) | 2003-02-24 |
NO303498B1 (no) | 1998-07-20 |
NO910958L (no) | 1991-05-10 |
US5541339A (en) | 1996-07-30 |
AU4192289A (en) | 1990-04-02 |
FI103668B1 (fi) | 1999-08-13 |
DE68929275T2 (de) | 2001-05-23 |
TW217383B (da) | 1993-12-11 |
KR900701801A (ko) | 1990-12-04 |
DE68929275D1 (de) | 2001-02-01 |
DK41791D0 (da) | 1991-03-08 |
GR3035589T3 (en) | 2001-06-29 |
WO1990002746A1 (en) | 1990-03-22 |
FI911193A0 (fi) | 1991-03-11 |
NO910958D0 (no) | 1991-03-11 |
JPH04500664A (ja) | 1992-02-06 |
KR0137959B1 (ko) | 1998-05-15 |
DK175458B1 (da) | 2004-11-01 |
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