LV12806B - Cc-1065 analogi ar divam cpi apaksvienibam - Google Patents

Cc-1065 analogi ar divam cpi apaksvienibam

Info

Publication number
LV12806B
LV12806B LV010180A LV010180A LV12806B LV 12806 B LV12806 B LV 12806B LV 010180 A LV010180 A LV 010180A LV 010180 A LV010180 A LV 010180A LV 12806 B LV12806 B LV 12806B
Authority
LV
Latvia
Prior art keywords
pct
formula
date mar
compounds
sec
Prior art date
Application number
LV010180A
Other languages
English (en)
Latvian (lv)
Other versions
LV12806A (en
Inventor
Robert C Kelly
Paul A Aristoff
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of LV12806A publication Critical patent/LV12806A/en
Publication of LV12806B publication Critical patent/LV12806B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Error Detection And Correction (AREA)
  • Solid State Image Pick-Up Elements (AREA)
  • Amplifiers (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Artificial Filaments (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Semiconductor Integrated Circuits (AREA)
  • Stereophonic System (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Television Receiver Circuits (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Television Systems (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
LV010180A 1988-09-12 2001-12-27 Cc-1065 analogi ar divam cpi apaksvienibam LV12806B (lv)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24335088A 1988-09-12 1988-09-12
PCT/US1989/003329 WO1990002746A1 (en) 1988-09-12 1989-08-07 Novel cc-1065 analogs having two cpi subunits

Publications (2)

Publication Number Publication Date
LV12806A LV12806A (en) 2002-03-20
LV12806B true LV12806B (lv) 2002-05-20

Family

ID=22918400

Family Applications (1)

Application Number Title Priority Date Filing Date
LV010180A LV12806B (lv) 1988-09-12 2001-12-27 Cc-1065 analogi ar divam cpi apaksvienibam

Country Status (14)

Country Link
US (1) US5541339A (cg-RX-API-DMAC10.html)
JP (1) JP3380237B2 (cg-RX-API-DMAC10.html)
KR (1) KR0137959B1 (cg-RX-API-DMAC10.html)
AT (1) ATE198335T1 (cg-RX-API-DMAC10.html)
AU (1) AU632288B2 (cg-RX-API-DMAC10.html)
CA (1) CA1340215C (cg-RX-API-DMAC10.html)
DE (1) DE68929275T2 (cg-RX-API-DMAC10.html)
DK (1) DK175458B1 (cg-RX-API-DMAC10.html)
FI (1) FI103668B1 (cg-RX-API-DMAC10.html)
GR (1) GR3035589T3 (cg-RX-API-DMAC10.html)
LV (1) LV12806B (cg-RX-API-DMAC10.html)
NO (1) NO303498B1 (cg-RX-API-DMAC10.html)
TW (1) TW217383B (cg-RX-API-DMAC10.html)
WO (1) WO1990002746A1 (cg-RX-API-DMAC10.html)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2149768T3 (es) * 1992-03-25 2000-11-16 Immunogen Inc Conjugados de agentes enlazantes de celulas derivados de cc-1065.
US5502068A (en) * 1995-01-31 1996-03-26 Synphar Laboratories, Inc. Cyclopropylpyrroloindole-oligopeptide anticancer agents
US20100056762A1 (en) 2001-05-11 2010-03-04 Old Lloyd J Specific binding proteins and uses thereof
CA2447139C (en) 2001-05-11 2013-11-19 Ludwig Institute For Cancer Research Specific binding proteins and uses thereof
JP2005509003A (ja) 2001-11-09 2005-04-07 ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド タンパク質キナーゼインヒビターとして有用なベンゾイミダゾール化合物
CA2494942A1 (en) * 2002-08-08 2004-02-19 Boehringer Ingelheim Pharmaceuticals, Inc. Substituted benzimidazole compounds
US20050215614A1 (en) * 2002-10-15 2005-09-29 Rigel Pharmaceuticals, Inc. Substituted indoles and their use as hcv inhibitors
CA2531485C (en) * 2003-07-07 2013-03-26 Merck Patent Gmbh Malonamide derivatives
US20050209284A1 (en) * 2004-02-12 2005-09-22 Boehringer Ingelheim Pharmaceuticals, Inc. Tec kinase inhibitors
MX2008002364A (es) * 2005-08-17 2008-03-18 Schering Corp Ligandos novedosos de cinasa basados en tiofeno y en furano de alta afinidad.
WO2008091701A2 (en) 2007-01-25 2008-07-31 Dana-Farber Cancer Institute Use of anti-egfr antibodies in treatment of egfr mutant mediated disease
MX2009009782A (es) 2007-03-15 2010-09-10 Ludwig Inst Cancer Res Metodo de tratamiento que utiliza anticuerpos egfr e inhibidores de src y formulaciones relacionadas.
US9901567B2 (en) 2007-08-01 2018-02-27 Syntarga B.V. Substituted CC-1065 analogs and their conjugates
CN108424454B (zh) 2007-08-14 2022-05-31 路德维格癌症研究所有限公司 靶向egf受体的单克隆抗体175及其衍生物和用途
MX2011004625A (es) 2008-11-03 2011-07-20 Syntarga Bv Analogos cc-1065 novedosos y sus conjugados.
EP3056203B1 (en) 2010-04-21 2017-12-13 Syntarga B.V. Conjugates of cc-1065 analogs and bifunctional linkers
EP2908809A2 (en) 2012-10-22 2015-08-26 Arnold Glazier Methods for the effective treatment of metastatic cancer
DE102013012622A1 (de) * 2013-07-30 2015-02-05 Clariant lnternational Ltd Neue sterisch gehinderte cyclische Amine
PT3092010T (pt) 2014-01-10 2018-09-28 Synthon Biopharmaceuticals Bv Método para purificação de conjugados anticorpo-fármaco ligados por cys
PL3099692T3 (pl) * 2014-01-27 2019-08-30 Pfizer Inc. Dwufunkcyjne środki cytotoksyczne
AU2015282627B2 (en) 2014-06-30 2020-04-02 Glykos Finland Oy Saccharide derivative of a toxic payload and antibody conjugates thereof
DE102015000124A1 (de) * 2015-01-07 2016-07-07 Clariant International Ltd. Verfahren zur Stabilisierung von Polyamiden
CA2923862C (en) * 2015-03-20 2024-02-13 Pfizer Inc. Bifunctional cytotoxic agents containing the cti pharmacophore

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4169888A (en) * 1977-10-17 1979-10-02 The Upjohn Company Composition of matter and process
US4301248A (en) * 1979-12-21 1981-11-17 Bristol-Myers Company Fermentation process for making rachelmycin
US4413132A (en) * 1980-11-18 1983-11-01 The Upjohn Company Antibiotic CC-1065 indoline intermediates
CA1238907A (en) * 1984-02-21 1988-07-05 Robert C. Kelly 1,2,8,8a-tetrahydrocyclopropa¬c|pyrrolo(3,2-e)- indol-4(5h)-ones and related compounds
US4912227A (en) * 1984-02-21 1990-03-27 The Upjohn Company 1,2,8,8A-tetrahydrocyclopropa(c)pyrrolo(3,2-e)-indol-4-(5H)-ones and related compounds
GB8528848D0 (en) * 1985-11-22 1985-12-24 Davy Mckee Poole Rolling mills
DE3750612T2 (de) * 1986-12-19 1995-03-02 Upjohn Co Cc-1065 analoge.

Also Published As

Publication number Publication date
FI103668B (fi) 1999-08-13
TW217383B (cg-RX-API-DMAC10.html) 1993-12-11
NO303498B1 (no) 1998-07-20
FI103668B1 (fi) 1999-08-13
DE68929275D1 (de) 2001-02-01
AU632288B2 (en) 1992-12-24
JP3380237B2 (ja) 2003-02-24
KR900701801A (ko) 1990-12-04
WO1990002746A1 (en) 1990-03-22
ATE198335T1 (de) 2001-01-15
AU4192289A (en) 1990-04-02
KR0137959B1 (ko) 1998-05-15
JPH04500664A (ja) 1992-02-06
DK41791A (da) 1991-03-08
LV12806A (en) 2002-03-20
GR3035589T3 (en) 2001-06-29
US5541339A (en) 1996-07-30
CA1340215C (en) 1998-12-15
DE68929275T2 (de) 2001-05-23
DK41791D0 (da) 1991-03-08
NO910958L (no) 1991-05-10
FI911193A0 (fi) 1991-03-11
DK175458B1 (da) 2004-11-01
NO910958D0 (no) 1991-03-11

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