LV12293B - Parathyroid hormone analogues for the treatment of osteoporosis - Google Patents

Parathyroid hormone analogues for the treatment of osteoporosis Download PDF

Info

Publication number
LV12293B
LV12293B LVP-99-15A LV990015A LV12293B LV 12293 B LV12293 B LV 12293B LV 990015 A LV990015 A LV 990015A LV 12293 B LV12293 B LV 12293B
Authority
LV
Latvia
Prior art keywords
lys
hpth
seq
leu
asp
Prior art date
Application number
LVP-99-15A
Other languages
English (en)
Latvian (lv)
Other versions
LV12293A (lv
Inventor
Jean-Rene Barbier
Paul Morley
Witold Neugebauer
Virginia Ross
James Whitfield
Gordon E Willick
Original Assignee
Ca Nat Research Council
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/691,647 external-priority patent/US5955425A/en
Application filed by Ca Nat Research Council filed Critical Ca Nat Research Council
Publication of LV12293A publication Critical patent/LV12293A/xx
Publication of LV12293B publication Critical patent/LV12293B/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/29Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/14Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/18Drugs for disorders of the endocrine system of the parathyroid hormones
    • A61P5/20Drugs for disorders of the endocrine system of the parathyroid hormones for decreasing, blocking or antagonising the activity of PTH
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/635Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Measurement Of Radiation (AREA)
  • Display Devices Of Pinball Game Machines (AREA)
LVP-99-15A 1996-08-02 1999-02-01 Parathyroid hormone analogues for the treatment of osteoporosis LV12293B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/691,647 US5955425A (en) 1996-08-02 1996-08-02 Parathyroid hormone analogues for the treatment of osteoporosis
US4056097P 1997-03-14 1997-03-14
PCT/CA1997/000547 WO1998005683A1 (en) 1996-08-02 1997-08-01 Parathyroid hormone analogues for the treatment of osteoporosis

Publications (2)

Publication Number Publication Date
LV12293A LV12293A (lv) 1999-06-20
LV12293B true LV12293B (en) 2000-11-20

Family

ID=26717175

Family Applications (1)

Application Number Title Priority Date Filing Date
LVP-99-15A LV12293B (en) 1996-08-02 1999-02-01 Parathyroid hormone analogues for the treatment of osteoporosis

Country Status (24)

Country Link
EP (1) EP0915911B1 (ja)
JP (3) JP4122061B2 (ja)
KR (1) KR100500859B1 (ja)
CN (1) CN1176947C (ja)
AT (1) ATE253078T1 (ja)
AU (1) AU723728B2 (ja)
BG (1) BG103128A (ja)
BR (1) BR9711002B1 (ja)
CA (1) CA2261564C (ja)
CZ (1) CZ34799A3 (ja)
DE (1) DE69725850T2 (ja)
DK (1) DK0915911T3 (ja)
EE (1) EE9900039A (ja)
ES (1) ES2207740T3 (ja)
FI (1) FI990126A (ja)
GE (1) GEP20033095B (ja)
IS (1) IS4962A (ja)
LV (1) LV12293B (ja)
NZ (1) NZ333809A (ja)
PT (1) PT915911E (ja)
RU (1) RU2203286C2 (ja)
SI (1) SI9720057A (ja)
SK (1) SK287397B6 (ja)
WO (1) WO1998005683A1 (ja)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA002819B1 (ru) * 1997-05-14 2002-10-31 Авентис Фармасьютикалз Продактс Инк. Циклическое пептидное соединение и его применение, бициклопептидное соединение, пептидное соединение и его применение, фармацевтическая композиция
EP1123401A1 (en) 1998-10-22 2001-08-16 The General Hospital Corporation BIOACTIVE PEPTIDES AND PEPTIDE DERIVATIVES OF PARATHYROID HORMONE (PTH) AND PARATHYROID HORMONE-RELATED PEPTIDE (PTHrP)
JP4486258B2 (ja) 1998-11-25 2010-06-23 ザ・ジェネラル・ホスピタル・コーポレイション ヒト副甲状腺ホルモンの改変、調製および使用
DK1141237T3 (da) 1998-12-31 2006-02-13 Gen Hospital Corp PTH-receptor og screeningsassay der anvender denne
AU777634B2 (en) * 1999-07-28 2004-10-28 Kazuhiro Aoki Methods of inhibiting osteoclastogenesis
US6316410B1 (en) * 1999-09-22 2001-11-13 National Research Council Of Canada Parathyroid hormone analogues for the treatment of osteoporosis
CA2454275C (en) 2001-07-23 2012-10-23 The General Hospital Corporation Conformationally constrained parathyroid hormone (pth) analogs
MXPA04006728A (es) 2002-01-10 2005-08-19 Osteotrophin Llc Tratamiento de desordenes oseos con medicamentos anabolicos esqueleticos.
AU2002359391A1 (en) * 2002-11-01 2004-07-29 Amgen, Inc. Modulators of receptors for parathyrois hormone and parathyroid hormone-related protein
US8088734B2 (en) * 2003-01-21 2012-01-03 Unigene Laboratories Inc. Oral delivery of peptides
CA2621264A1 (en) * 2005-09-06 2007-11-15 Zelos Therapeutics, Inc. Parathyroid hormone analogues and methods of use
WO2008016404A2 (en) * 2006-07-31 2008-02-07 Zelos Therapeutics, Inc. Parathyroid hormone analogues and uses thereof
DK2084183T3 (da) 2006-10-13 2010-08-16 Lilly Co Eli Pegyleret PTH som PTH-receptormodulatorer og anvendelser deraf
KR101661730B1 (ko) 2007-08-01 2016-10-04 더 제너럴 하스피탈 코포레이션 G―단백질 결합 수용체를 이용한 스크리닝 방법 및 관련 조성물
WO2011143406A2 (en) 2010-05-13 2011-11-17 The General Hospital Corporation Parathyroid hormone analogs and uses thereof
CN105440126B (zh) * 2015-12-31 2019-10-25 南京工业大学 治疗骨质疏松的α-螺旋多肽及其制备方法与应用
US11219697B2 (en) 2017-07-15 2022-01-11 The Regents Of The University Of California Osteoadsorptive fluorogenic substrate of cathepsin k for imaging osteoclast activity and migration
BR112021003442A2 (pt) 2018-09-26 2021-05-18 Borealis Ag composição de copolímero de propileno com excelentes propriedades mecânicas e ópticas
JP7342310B2 (ja) 2019-05-28 2023-09-12 国立大学法人東北大学 電源装置、超伝導装置、超伝導デバイス、及び超伝導デバイスの製造方法
CN113549144A (zh) * 2021-06-30 2021-10-26 华南理工大学 一种特立帕肽hPTH(1-34)的生产和纯化方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5317010A (en) * 1991-10-10 1994-05-31 Peter K. T. Pang Parathyroid hormone analogues substituted at AA 25, 26, 27, and use in osteoporosis treatment
US5814603A (en) * 1992-06-12 1998-09-29 Affymax Technologies N.V. Compounds with PTH activity
AU672790B2 (en) * 1992-07-15 1996-10-17 Novartis Ag Variants of parathyroid hormone and its fragments
US5556940A (en) * 1994-06-20 1996-09-17 National Research Council Of Canada Parathyroid hormone analogues for the treatment of osteoporosis

Also Published As

Publication number Publication date
JP2001500845A (ja) 2001-01-23
KR20000029783A (ko) 2000-05-25
ATE253078T1 (de) 2003-11-15
SI9720057A (sl) 1999-12-31
BG103128A (en) 2000-05-31
DK0915911T3 (da) 2004-03-08
CN1231676A (zh) 1999-10-13
FI990126A (fi) 1999-03-31
RU2203286C2 (ru) 2003-04-27
CN1176947C (zh) 2004-11-24
KR100500859B1 (ko) 2005-07-14
CZ34799A3 (cs) 1999-07-14
DE69725850T2 (de) 2004-08-19
BR9711002B1 (pt) 2011-09-06
CA2261564C (en) 2007-10-30
EP0915911B1 (en) 2003-10-29
BR9711002A (pt) 2002-01-15
ES2207740T3 (es) 2004-06-01
EE9900039A (et) 1999-08-16
EP0915911A1 (en) 1999-05-19
SK287397B6 (sk) 2010-08-09
AU3690597A (en) 1998-02-25
JP4122061B2 (ja) 2008-07-23
JP2007254480A (ja) 2007-10-04
SK13299A3 (en) 1999-10-08
WO1998005683A1 (en) 1998-02-12
PT915911E (pt) 2004-03-31
JP2009057386A (ja) 2009-03-19
AU723728B2 (en) 2000-09-07
CA2261564A1 (en) 1998-02-12
NZ333809A (en) 2000-07-28
IS4962A (is) 1999-01-29
GEP20033095B (en) 2003-10-27
JP4224111B2 (ja) 2009-02-12
LV12293A (lv) 1999-06-20
FI990126A0 (fi) 1999-01-22
DE69725850D1 (de) 2003-12-04

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