LV11283B - Improved tangential filtration process and apparatus - Google Patents
Improved tangential filtration process and apparatus Download PDFInfo
- Publication number
- LV11283B LV11283B LVP-96-59A LV960059A LV11283B LV 11283 B LV11283 B LV 11283B LV 960059 A LV960059 A LV 960059A LV 11283 B LV11283 B LV 11283B
- Authority
- LV
- Latvia
- Prior art keywords
- filtration
- chamber
- filtering
- membrane
- filtered
- Prior art date
Links
- 238000001914 filtration Methods 0.000 title claims abstract description 322
- 230000001976 improved effect Effects 0.000 title description 5
- 239000012528 membrane Substances 0.000 claims abstract description 196
- 238000000034 method Methods 0.000 claims abstract description 110
- 230000008569 process Effects 0.000 claims abstract description 103
- 239000000203 mixture Substances 0.000 claims abstract description 60
- 239000011148 porous material Substances 0.000 claims abstract description 59
- 230000007704 transition Effects 0.000 claims abstract description 33
- 238000009295 crossflow filtration Methods 0.000 claims abstract description 14
- 239000000706 filtrate Substances 0.000 claims description 152
- 239000012530 fluid Substances 0.000 claims description 65
- 238000000108 ultra-filtration Methods 0.000 claims description 61
- 238000005086 pumping Methods 0.000 claims description 28
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- 230000004907 flux Effects 0.000 abstract description 69
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- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 6
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- CCTIOCVIZPCTGO-BYPYZUCNSA-N phosphoarginine Chemical compound OC(=O)[C@@H](N)CCCNC(=N)NP(O)(O)=O CCTIOCVIZPCTGO-BYPYZUCNSA-N 0.000 description 2
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- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
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- 238000005377 adsorption chromatography Methods 0.000 description 1
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- 229930182817 methionine Natural products 0.000 description 1
- 125000001360 methionine group Chemical group N[C@@H](CCSC)C(=O)* 0.000 description 1
- 230000010412 perfusion Effects 0.000 description 1
- 239000012466 permeate Substances 0.000 description 1
- 229920002492 poly(sulfone) Polymers 0.000 description 1
- 229920000447 polyanionic polymer Polymers 0.000 description 1
- 235000020004 porter Nutrition 0.000 description 1
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Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/14—Ultrafiltration; Microfiltration
- B01D61/145—Ultrafiltration
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/14—Ultrafiltration; Microfiltration
- B01D61/145—Ultrafiltration
- B01D61/146—Ultrafiltration comprising multiple ultrafiltration steps
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/14—Ultrafiltration; Microfiltration
- B01D61/147—Microfiltration
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/58—Reaction vessels connected in series or in parallel
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
- C12M47/02—Separating microorganisms from the culture medium; Concentration of biomass
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
- C12M47/10—Separation or concentration of fermentation products
Landscapes
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Water Supply & Treatment (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Sustainable Development (AREA)
- General Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Clinical Laboratory Science (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
- Cyclones (AREA)
- Combined Means For Separation Of Solids (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/583,886 US5256294A (en) | 1990-09-17 | 1990-09-17 | Tangential flow filtration process and apparatus |
PCT/US1991/006553 WO1992004970A1 (fr) | 1990-09-17 | 1991-09-11 | Procede et appareil ameliores de filtrage a flux tangentiel |
Publications (2)
Publication Number | Publication Date |
---|---|
LV11283A LV11283A (lv) | 1996-06-20 |
LV11283B true LV11283B (en) | 1996-12-20 |
Family
ID=24334996
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
LVP-96-59A LV11283B (en) | 1990-09-17 | 1996-02-28 | Improved tangential filtration process and apparatus |
Country Status (10)
Country | Link |
---|---|
US (2) | US5256294A (fr) |
EP (1) | EP0552192B1 (fr) |
JP (2) | JP3828143B2 (fr) |
AT (1) | ATE119063T1 (fr) |
CA (1) | CA2089663C (fr) |
DE (1) | DE69107855T2 (fr) |
DK (1) | DK0552192T3 (fr) |
ES (1) | ES2072017T3 (fr) |
LV (1) | LV11283B (fr) |
WO (1) | WO1992004970A1 (fr) |
Families Citing this family (121)
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DE4143639C2 (de) * | 1991-12-02 | 2002-10-24 | Qiagen Gmbh | Verfahren zur Isolierung und Reinigung von Nukleinsäuren |
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US6054051A (en) | 1996-01-17 | 2000-04-25 | Genentech, Inc. | Tangential-flow filtration system |
US6268487B1 (en) * | 1996-05-13 | 2001-07-31 | Genzyme Transgenics Corporation | Purification of biologically active peptides from milk |
US7026468B2 (en) * | 1996-07-19 | 2006-04-11 | Valentis, Inc. | Process and equipment for plasmid purification |
US7807822B2 (en) * | 1996-08-01 | 2010-10-05 | Robert Bridenbaugh | Methods for purifying nucleic acids |
US6022333A (en) * | 1997-05-01 | 2000-02-08 | S.L.I.M. Tech, Ltd. | Method and system for removing materials from lymphatic and other fluids |
US5919376A (en) * | 1997-06-10 | 1999-07-06 | Cae Ransohoff Inc. | Filtration apparatus and method |
US6265542B1 (en) | 1997-10-24 | 2001-07-24 | Genentech, Inc. | Purification of molecules |
US6077940A (en) * | 1997-12-24 | 2000-06-20 | Genentech, Inc. | Free solution ligand interaction molecular separation method |
JP2001000842A (ja) * | 1998-05-22 | 2001-01-09 | Daicel Chem Ind Ltd | 病原性原虫濃縮用モジュールおよび濃縮方法 |
DK1084136T3 (da) | 1998-06-01 | 2005-01-03 | Genentech Inc | Adskillelse af monomere af et antistof fra dets multimere ved anvendelse af ionbytterchromatografi |
BR9905868A (pt) * | 1998-11-06 | 2001-01-23 | Bio Sidus S A | Procedimento de cultivo massivo de células de mamìfero para a obtenção de eritropoetina humana, recombinante e a eritropoetina humana recombinante obtida com tal procedimento |
US7316780B1 (en) * | 1999-01-29 | 2008-01-08 | Pall Corporation | Range separation devices and processes |
CA2370694C (fr) * | 1999-06-25 | 2010-02-09 | American Cyanamid Company | Extraction de proteines membranaires entieres |
CA2378944A1 (fr) | 1999-07-23 | 2001-02-01 | Genentech, Inc. | Procede de purification d'adn de plasmide sans solvant organique ni rnase au moyen d'une filtration d'ecoulement tangentiel |
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US6296770B1 (en) | 1999-12-09 | 2001-10-02 | Eastman Kodak Company | Constant concentration at the UF membrane wall UF process control and apparatus |
DE10000196B4 (de) | 2000-01-05 | 2013-10-10 | Sartorius Stedim Biotech Gmbh | Verbesserte Crossflow-Filtrationseinheit |
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US20030171260A1 (en) * | 2002-03-11 | 2003-09-11 | Nelson Deanna Jean | Compositions and methods utilizing hydroxamates to scavenge oxidant toxins |
EP1501369B1 (fr) * | 2002-04-26 | 2015-06-24 | Genentech, Inc. | Purification de proteines basee sur la non affinite |
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-
1990
- 1990-09-17 US US07/583,886 patent/US5256294A/en not_active Expired - Lifetime
-
1991
- 1991-09-11 EP EP91917291A patent/EP0552192B1/fr not_active Expired - Lifetime
- 1991-09-11 DK DK91917291.6T patent/DK0552192T3/da active
- 1991-09-11 DE DE69107855T patent/DE69107855T2/de not_active Expired - Lifetime
- 1991-09-11 CA CA002089663A patent/CA2089663C/fr not_active Expired - Lifetime
- 1991-09-11 WO PCT/US1991/006553 patent/WO1992004970A1/fr active IP Right Grant
- 1991-09-11 AT AT91917291T patent/ATE119063T1/de not_active IP Right Cessation
- 1991-09-11 ES ES91917291T patent/ES2072017T3/es not_active Expired - Lifetime
- 1991-09-11 JP JP51568391A patent/JP3828143B2/ja not_active Expired - Lifetime
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1994
- 1994-07-06 US US08/271,223 patent/US5490937A/en not_active Expired - Lifetime
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1996
- 1996-02-28 LV LVP-96-59A patent/LV11283B/en unknown
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2003
- 2003-05-30 JP JP2003156060A patent/JP2003334425A/ja not_active Withdrawn
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EP0552192A1 (fr) | 1993-07-28 |
LV11283A (lv) | 1996-06-20 |
JP2003334425A (ja) | 2003-11-25 |
ATE119063T1 (de) | 1995-03-15 |
WO1992004970A1 (fr) | 1992-04-02 |
EP0552192B1 (fr) | 1995-03-01 |
DK0552192T3 (da) | 1995-07-17 |
US5256294A (en) | 1993-10-26 |
DE69107855T2 (de) | 1995-09-07 |
JP3828143B2 (ja) | 2006-10-04 |
ES2072017T3 (es) | 1995-07-01 |
CA2089663C (fr) | 2002-05-28 |
JPH06500730A (ja) | 1994-01-27 |
DE69107855D1 (de) | 1995-04-06 |
US5490937A (en) | 1996-02-13 |
CA2089663A1 (fr) | 1992-03-18 |
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