LV10961B - Novel colon- or ileum-specific steroid derivatives - Google Patents

Novel colon- or ileum-specific steroid derivatives Download PDF

Info

Publication number
LV10961B
LV10961B LVP-95-207A LV950207A LV10961B LV 10961 B LV10961 B LV 10961B LV 950207 A LV950207 A LV 950207A LV 10961 B LV10961 B LV 10961B
Authority
LV
Latvia
Prior art keywords
compound according
epimer
gcs
sugar
formula
Prior art date
Application number
LVP-95-207A
Other languages
English (en)
Latvian (lv)
Other versions
LV10961A (lv
Inventor
Ralph Lennart Brattsand
Peter Edman
Thomas Hoegberg
Stinabritt Nilsson
Bror Arne Thalen
Jan Erik Ulmius
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE9300030A external-priority patent/SE9300030D0/xx
Priority claimed from SE9300082A external-priority patent/SE9300082D0/xx
Application filed by Astra Ab filed Critical Astra Ab
Publication of LV10961A publication Critical patent/LV10961A/xx
Publication of LV10961B publication Critical patent/LV10961B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/0026—Oxygen-containing hetero ring cyclic ketals
    • C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
LVP-95-207A 1993-01-08 1995-07-05 Novel colon- or ileum-specific steroid derivatives LV10961B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE9300030A SE9300030D0 (sv) 1993-01-08 1993-01-08 Novel colon- or ileum-specific steroid derivatives
SE9300082A SE9300082D0 (sv) 1993-01-14 1993-01-14 Novel colon- or ileum-specific steroid derivatives
PCT/SE1993/001081 WO1994015947A1 (en) 1993-01-08 1993-12-17 Novel colon- or ileum-specific steroid derivatives

Publications (2)

Publication Number Publication Date
LV10961A LV10961A (lv) 1995-12-20
LV10961B true LV10961B (en) 1996-08-20

Family

ID=26661623

Family Applications (1)

Application Number Title Priority Date Filing Date
LVP-95-207A LV10961B (en) 1993-01-08 1995-07-05 Novel colon- or ileum-specific steroid derivatives

Country Status (22)

Country Link
US (2) US5908833A (de)
EP (1) EP0678097B1 (de)
JP (1) JP3366640B2 (de)
KR (1) KR960700266A (de)
AT (1) ATE183192T1 (de)
BR (1) BR9307746A (de)
CA (1) CA2152374A1 (de)
CZ (1) CZ171095A3 (de)
DK (1) DK0678097T3 (de)
ES (1) ES2137353T3 (de)
FI (1) FI953358A (de)
GR (1) GR3031789T3 (de)
HU (1) HU221584B (de)
IS (1) IS4111A (de)
LV (1) LV10961B (de)
NO (1) NO305367B1 (de)
NZ (1) NZ259596A (de)
PL (1) PL178307B1 (de)
RU (1) RU95115547A (de)
SK (1) SK87295A3 (de)
TW (1) TW261615B (de)
WO (1) WO1994015947A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR960700266A (ko) * 1993-01-08 1996-01-19 클래스 빌헬름슨 신규 결장- 또는 회장-특이성 스테로이드 유도체(Novel Colon-or lleum-Specific Steroid Derivatives)
CA2172983A1 (en) * 1993-09-29 1995-04-06 Kei Sugai 21-substituted steroid compound
US6028190A (en) 1994-02-01 2000-02-22 The Regents Of The University Of California Probes labeled with energy transfer coupled dyes
US6166024A (en) 1995-03-30 2000-12-26 Mayo Foundation For Medical Education And Research Use of topical azathioprine and thioguanine to treat colorectal adenomas
JP4610734B2 (ja) * 1998-03-19 2011-01-12 三笠製薬株式会社 ２１−置換グリコシルステロイド化合物
US20030083231A1 (en) * 1998-11-24 2003-05-01 Ahlem Clarence N. Blood cell deficiency treatment method
CA2372720C (en) 1999-05-04 2007-09-11 John Antony Kanis Androgen glycosides and androgenic activity thereof
US8895064B2 (en) 1999-06-14 2014-11-25 Cosmo Technologies Limited Controlled release and taste masking oral pharmaceutical composition
CN1173695C (zh) 1999-06-14 2004-11-03 科斯默股份公司 控制释放与掩蔽味道的口服药物组合物
WO2001051057A2 (en) * 2000-01-14 2001-07-19 Strakan Limited Glycosides and orthoester glycosides of glucocorticoids and uses thereof
SE0101220D0 (sv) * 2001-04-04 2001-04-04 Astrazeneca Ab New use
EP1625854B1 (de) * 2004-08-09 2008-10-15 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Albuminkonjugate, die eine Glucuron-Verknüpfung enthalten
US20080200441A1 (en) * 2007-02-14 2008-08-21 University Of Southern California Estrogen receptor modulators associated pharmaceutical compositions and methods of use
US10154964B2 (en) 2011-09-07 2018-12-18 Cosmo Technologies Limited Controlled release and taste masking oral pharmaceutical composition
WO2018089373A2 (en) 2016-11-08 2018-05-17 Regeneron Pharmaceuticals, Inc. Steroids and protein-conjugates thereof
US11491232B2 (en) 2017-03-30 2022-11-08 Fruithy Holdings Limited Lactuloside compounds and preparation and use thereof
IL270594B2 (en) 2017-05-18 2024-06-01 Regeneron Pharma Protein conjugates - a drug of cyclodextrin
AU2019205542A1 (en) 2018-01-08 2020-07-16 Regeneron Pharmaceuticals, Inc. Steroids and antibody-conjugates thereof
CN112533951A (zh) 2018-05-09 2021-03-19 里珍纳龙药品有限公司 抗msr1抗体及其使用方法

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE378110B (de) * 1972-05-19 1975-08-18 Bofors Ab
US3992534A (en) * 1972-05-19 1976-11-16 Ab Bofors Compositions and method of treating with component B of stereoisomeric mixtures of 2'-unsymmetrical 16,17-methylenedioxy steriods
SE378109B (de) * 1972-05-19 1975-08-18 Bofors Ab
US3996359A (en) * 1972-05-19 1976-12-07 Ab Bofors Novel stereoisomeric component A of stereoisomeric mixtures of 2'-unsymmetrical 16,17-methylenedioxy steroid 21-acylates, compositions thereof, and method of treating therewith
US3938233A (en) * 1974-08-12 1976-02-17 Cannon Robert B Heat transfer apparatus
DE2803660A1 (de) * 1978-01-25 1979-07-26 Schering Ag Neue in 17-position substituierte steroide der pregnanreihe, ihre herstellung und verwendung
BG33737A3 (en) * 1978-01-25 1983-04-15 Schering Aktiengesellschaft Method for obtaining of substituated in 17- th position steroids from pregnan row
US4221787A (en) * 1978-03-28 1980-09-09 Interx Research Corporation Esteramide prodrugs of anti-inflammatory corticosteroids
SE8008524L (sv) * 1980-12-04 1982-06-05 Draco Ab 4-pregnen-derivat, ett forfarande for deras framstellning, beredning och metod for behandling av inflammatoriska tillstand
US4456602A (en) * 1982-08-23 1984-06-26 The Upjohn Company Amine containing ester prodrugs of corticosteroids
US4443440A (en) * 1982-08-30 1984-04-17 The Upjohn Company Amine containing ester prodrugs of corticosteroids
US4472392A (en) * 1983-01-21 1984-09-18 The Upjohn Company Sulfonate containing ester prodrugs of corticosteroids
US4469689A (en) * 1983-03-30 1984-09-04 The Upjohn Company Sulfonate containing ester prodrugs of corticosteroids
WO1984004041A1 (en) * 1983-04-14 1984-10-25 Univ California Colon-specific drug delivery system
US4548922A (en) * 1983-06-06 1985-10-22 Beth Israel Hospital Drug administration
US4959358A (en) * 1983-06-06 1990-09-25 Beth Israel Hospital Assn. Drug administration
SE8306370D0 (sv) * 1983-11-18 1983-11-18 Draco Ab Novel androstane-17beta-carboxylic acid esters, a process and intermediates for their preparation, compositions and method for the treatment of inflammatory conditions
US4588718A (en) * 1984-03-28 1986-05-13 The Upjohn Company Carboxy containing ester prodrugs of corticosteroids
SE8403905D0 (sv) * 1984-07-30 1984-07-30 Draco Ab Liposomes and steroid esters
US5215979A (en) * 1985-12-19 1993-06-01 Aktiebolaget Draco 16,17-acetalsubstituted pregnane 21-oic acid derivatives
GB8600490D0 (en) * 1986-01-09 1986-02-12 Erba Farmitalia Aminoglycoside norcholanic acid lactams
GB8600491D0 (en) * 1986-01-09 1986-02-12 Erba Farmitalia Aminoglycoside norcholanic acid derivatives
GB8600489D0 (en) * 1986-01-09 1986-02-12 Erba Farmitalia Aminoglycoside steroids
CA1324603C (en) * 1986-05-12 1993-11-23 Haruo Ogura Sialosyl cholesterol, process for producing the same, and neuropathy remedy comprising the same
CA1299653C (en) * 1988-07-07 1992-04-28 Markwell Medical Institute, Inc. Biological fluid measuring device
US5643602A (en) * 1989-11-22 1997-07-01 Astra Aktiebolag Oral composition for the treatment of inflammatory bowel disease
SE8903914D0 (sv) * 1989-11-22 1989-11-22 Draco Ab Oral composition for the treatment of inflammatory bowel diseases
SE9100342D0 (sv) * 1991-02-04 1991-02-04 Astra Ab Novel steroid esters
US5888995A (en) * 1991-02-04 1999-03-30 Astra Aktiebolag Steroid esters
SE9100341D0 (sv) * 1991-02-04 1991-02-04 Astra Ab Novel steroids
WO1993022334A1 (en) * 1992-05-04 1993-11-11 Sri International Pharmaceutical compositions and methods for colonic delivery of corticosteroids
KR960700266A (ko) * 1993-01-08 1996-01-19 클래스 빌헬름슨 신규 결장- 또는 회장-특이성 스테로이드 유도체(Novel Colon-or lleum-Specific Steroid Derivatives)

Also Published As

Publication number Publication date
PL178307B1 (pl) 2000-04-28
US5908833A (en) 1999-06-01
HUT73227A (en) 1996-07-29
ES2137353T3 (es) 1999-12-16
HU9502087D0 (en) 1995-09-28
KR960700266A (ko) 1996-01-19
JP3366640B2 (ja) 2003-01-14
SK87295A3 (en) 1996-04-03
TW261615B (de) 1995-11-01
JPH08505616A (ja) 1996-06-18
US6140308A (en) 2000-10-31
RU95115547A (ru) 1997-06-10
DK0678097T3 (da) 2000-02-07
AU5844794A (en) 1994-08-15
FI953358A0 (fi) 1995-07-07
ATE183192T1 (de) 1999-08-15
EP0678097A1 (de) 1995-10-25
CZ171095A3 (en) 1996-01-17
CA2152374A1 (en) 1994-07-21
BR9307746A (pt) 1995-11-14
AU678803B2 (en) 1997-06-12
IS4111A (is) 1994-07-09
FI953358A (fi) 1995-07-07
GR3031789T3 (en) 2000-02-29
NO952683D0 (no) 1995-07-06
LV10961A (lv) 1995-12-20
PL309777A1 (en) 1995-11-13
WO1994015947A1 (en) 1994-07-21
NO305367B1 (no) 1999-05-18
EP0678097B1 (de) 1999-08-11
NO952683L (no) 1995-07-06
NZ259596A (en) 1997-04-24
HU221584B (hu) 2002-11-28

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