LV10708B - New bronchospasmolytic compounds and a process for their preparation - Google Patents

New bronchospasmolytic compounds and a process for their preparation Download PDF

Info

Publication number
LV10708B
LV10708B LVP-93-866A LV930866A LV10708B LV 10708 B LV10708 B LV 10708B LV 930866 A LV930866 A LV 930866A LV 10708 B LV10708 B LV 10708B
Authority
LV
Latvia
Prior art keywords
compound
formula
hydrogen
compounds
hydroxy
Prior art date
Application number
LVP-93-866A
Other languages
English (en)
Latvian (lv)
Other versions
LV10708A (lv
Inventor
Svensson Leif-Ake
Olsson Otto-Agne Torsten
Pedaya Peter
Waldeck Carl Bertil
Wetterlin Kjell Ingvar Leopold
Original Assignee
Draco Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Draco Ab filed Critical Draco Ab
Publication of LV10708A publication Critical patent/LV10708A/xx
Publication of LV10708B publication Critical patent/LV10708B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
    • C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
    • C07C217/60—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms linked by carbon chains having two carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
    • C07C217/58—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms with amino groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/58—Radicals substituted by nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
LVP-93-866A 1989-03-28 1993-06-30 New bronchospasmolytic compounds and a process for their preparation LV10708B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE8901060A SE8901060D0 (sv) 1989-03-28 1989-03-28 New compounds

Publications (2)

Publication Number Publication Date
LV10708A LV10708A (lv) 1995-06-20
LV10708B true LV10708B (en) 1996-02-20

Family

ID=20375454

Family Applications (1)

Application Number Title Priority Date Filing Date
LVP-93-866A LV10708B (en) 1989-03-28 1993-06-30 New bronchospasmolytic compounds and a process for their preparation

Country Status (30)

Country Link
EP (1) EP0390762B1 (lt)
JP (1) JPH02286650A (lt)
KR (1) KR900014309A (lt)
CN (1) CN1045968A (lt)
AR (1) AR247197A1 (lt)
AT (1) ATE100437T1 (lt)
AU (1) AU618171B2 (lt)
CA (1) CA2013114A1 (lt)
CZ (1) CZ280747B6 (lt)
DD (1) DD297805A5 (lt)
DE (1) DE69006071T2 (lt)
DK (1) DK0390762T3 (lt)
EG (1) EG18954A (lt)
ES (1) ES2062495T3 (lt)
FI (1) FI901528A0 (lt)
HK (1) HK123396A (lt)
HR (1) HRP920765A2 (lt)
HU (1) HUT58043A (lt)
IE (1) IE64851B1 (lt)
IL (1) IL93799A (lt)
IS (1) IS1581B (lt)
LT (1) LT3979B (lt)
LV (1) LV10708B (lt)
NO (1) NO172115C (lt)
NZ (1) NZ232765A (lt)
PL (1) PL163566B1 (lt)
PT (1) PT93576B (lt)
SE (1) SE8901060D0 (lt)
YU (1) YU47508B (lt)
ZA (1) ZA901716B (lt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6040344A (en) * 1996-11-11 2000-03-21 Sepracor Inc. Formoterol process
ZA994264B (en) 1998-07-01 2000-01-25 Warner Lambert Co Stereoisomers with high affinity for adrenergic receptors.
US7232837B2 (en) 1999-06-29 2007-06-19 Mcneil-Ppc, Inc. Stereoisomers with high affinity for adrenergic receptors
US6472563B1 (en) 2001-11-09 2002-10-29 Sepracor Inc. Formoterol tartrate process and polymorph
US7169907B2 (en) * 2002-03-01 2007-01-30 Roche Diagnostics Operations, Inc. Derivatives, immunogens, and antibodies for detecting ecstasy-class drugs
EP2348013A1 (en) * 2010-01-25 2011-07-27 Inke, S.A. Process for preparation of intermediates of arformoterol

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4072720A (en) * 1971-01-19 1978-02-07 Mobil Oil Corporation Production of alcohol
US3700692A (en) * 1971-06-04 1972-10-24 Colgate Palmolive Co 1-(4{40 -hydroxy-3{40 -(hydroxy methyl)-phenyl)-1-hydroxy-2-aralkylaminoethanes
GB1531718A (en) * 1974-11-20 1978-11-08 Pharmacia As Phenylethanolamines

Also Published As

Publication number Publication date
AU5067590A (en) 1990-10-04
HK123396A (en) 1996-07-19
PT93576A (pt) 1990-11-07
IS3567A7 (is) 1990-09-29
LT3979B (en) 1996-06-25
FI901528A0 (fi) 1990-03-27
IL93799A (en) 1994-12-29
NZ232765A (en) 1992-12-23
LV10708A (lv) 1995-06-20
NO172115C (no) 1993-06-09
LTIP1719A (en) 1995-07-25
DK0390762T3 (da) 1994-05-24
CZ151890A3 (en) 1995-12-13
ATE100437T1 (de) 1994-02-15
CA2013114A1 (en) 1990-09-28
CN1045968A (zh) 1990-10-10
EP0390762B1 (en) 1994-01-19
PL163566B1 (pl) 1994-04-29
AU618171B2 (en) 1991-12-12
PT93576B (pt) 1996-03-29
NO172115B (no) 1993-03-01
YU47508B (sh) 1995-10-03
DD297805A5 (de) 1992-01-23
YU46490A (en) 1992-05-28
CZ280747B6 (cs) 1996-04-17
EG18954A (en) 1994-03-30
DE69006071T2 (de) 1994-05-19
JPH02286650A (ja) 1990-11-26
DE69006071D1 (de) 1994-03-03
ZA901716B (en) 1990-12-28
KR900014309A (ko) 1990-10-23
IE64851B1 (en) 1995-09-06
AR247197A1 (es) 1994-11-30
IE901104L (en) 1990-09-28
NO900982D0 (no) 1990-03-01
NO900982L (no) 1990-10-01
HUT58043A (en) 1992-01-28
HU901854D0 (en) 1990-08-28
IS1581B (is) 1996-03-01
EP0390762A1 (en) 1990-10-03
ES2062495T3 (es) 1994-12-16
HRP920765A2 (en) 1995-02-28
SE8901060D0 (sv) 1989-03-28

Similar Documents

Publication Publication Date Title
US4183912A (en) Inhalation therapy for relieving bronchial spasm using quaternary salts of promethazine
BG60761B2 (bg) Арилоксифенилпропиламини
US4584404A (en) Substituted phenoxyphenylproply dimethylamines
JPS5919539B2 (ja) ３，４−ジヒドロカルボスチリル誘導体
US4391821A (en) 7-Substituted benzopyranes and process for the preparation thereof
US3966814A (en) 1-Phenyl-2-(Naphthylalkyl-amino)-ethanols and salts thereof
EP1093450B1 (en) Desformoterol and process for its preparation
US3408446A (en) Suppressing coughs and increasing secretions in warm-blooded animals with n-(amino-3,5-dihalobenzyl)-camphidines
EP0390762B1 (en) New bronchospasmolytic compounds and process for their preparation
EP2002831A1 (en) R-Bambuterol, its preparation and therapeutic uses
US4154761A (en) Pharmacologically active compounds
EP0143711B1 (fr) Dérivés de N-(méthoxyphénacyl)-amine, utilisation notamment en thérapeutique et procédé de préparation
US4000192A (en) Pharmacologically active compounds
CA1246083A (en) Ethanolamines
US4692465A (en) 2-phenylethylamine derivatives
EP0004835B1 (en) Ethanolamine compounds, processes for their preparation, pharmaceutical preparations containing them and their medicinal use
CA1331994C (en) (+)-1-¢(3,4,5-trimethoxy)-benzyloxymethyl!-1-phenyl-n,n- dimethyl-n-propylamine, process for preparing it and its therapeutical use
RU2051901C1 (ru) Производные 1-бензиламинофенил-2-(1-метил-2-фенилэтиламино)-этанола-1 в виде смеси изомеров или рацемата или их фармацевтически приемлемые соли, проявляющие бронхоспазмолитическую активность
US4701461A (en) Substituted cyclic amines
US4148908A (en) Indolyl cyanomethylphenethanolamines
FR2500823A1 (fr) 1-aminoalkyl-1, 2, 3, 4-tetrahydroanphtalenes mono- ou disubstitues utiles notamment comme adrenergiques et medicaments les contenant
KR790001909B1 (ko) 1-아릴옥시-2-하이드록시-3-알키닐아미노프로판의 제조방법
KR840001050B1 (ko) 페닐알킬아민 유도체의 제조방법
IE52015B1 (en) 1-(acylamino-aryloxy)-3-alkynylamino-propan-2-ols,processes for their preparation and pharmaceutical compositions containing them
NZ200858A (en) 3-phenoxypropan-2-olamines