LUC00343I2 - - Google Patents

Info

Publication number
LUC00343I2
LUC00343I2 LU00343C LUC00343C LUC00343I2 LU C00343 I2 LUC00343 I2 LU C00343I2 LU 00343 C LU00343 C LU 00343C LU C00343 C LUC00343 C LU C00343C LU C00343 I2 LUC00343 I2 LU C00343I2
Authority
LU
Luxembourg
Application number
LU00343C
Original Assignee
Ucb Holdings Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=54834568&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=LUC00343(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ucb Holdings Inc filed Critical Ucb Holdings Inc
Publication of LUC00343I1 publication Critical patent/LUC00343I1/fr
Publication of LUC00343I2 publication Critical patent/LUC00343I2/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/472—Complement proteins, e.g. anaphylatoxin, C3a, C5a
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Transplantation (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
LU00343C 2014-06-12 2024-05-15 LUC00343I2 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462011368P 2014-06-12 2014-06-12
US201462077460P 2014-11-10 2014-11-10
US201562108772P 2015-01-28 2015-01-28

Publications (2)

Publication Number Publication Date
LUC00343I1 LUC00343I1 (fr) 2024-05-16
LUC00343I2 true LUC00343I2 (fr) 2026-05-05

Family

ID=54834568

Family Applications (1)

Application Number Title Priority Date Filing Date
LU00343C LUC00343I2 (fr) 2014-06-12 2024-05-15

Country Status (32)

Country Link
US (7) US10106579B2 (fr)
EP (4) EP3154561B1 (fr)
JP (4) JP6432954B2 (fr)
KR (3) KR101981532B1 (fr)
CN (3) CN119236050A (fr)
AP (1) AP2016009612A0 (fr)
AU (3) AU2015274482B2 (fr)
BR (3) BR122021025449B1 (fr)
CA (3) CA3174909A1 (fr)
CY (3) CY1122227T1 (fr)
DK (2) DK3154561T3 (fr)
ES (2) ES2750556T3 (fr)
FI (1) FIC20240015I1 (fr)
FR (1) FR24C1022I2 (fr)
HR (2) HRP20191763T1 (fr)
HU (3) HUE045646T2 (fr)
IL (3) IL249093B (fr)
LT (3) LT3628680T (fr)
LU (1) LUC00343I2 (fr)
MX (2) MX2016016449A (fr)
NL (1) NL301275I2 (fr)
NO (1) NO2024023I1 (fr)
NZ (1) NZ727420A (fr)
PL (2) PL3628680T3 (fr)
PT (2) PT3154561T (fr)
RS (2) RS62428B1 (fr)
RU (1) RU2670988C2 (fr)
SG (1) SG11201610222UA (fr)
SI (2) SI3154561T1 (fr)
SM (2) SMT201900568T1 (fr)
WO (1) WO2015191951A2 (fr)
ZA (3) ZA201706379B (fr)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE045646T2 (hu) 2014-06-12 2020-01-28 Ra Pharmaceuticals Inc Komplement aktivitás modulálása
WO2016123371A1 (fr) 2015-01-28 2016-08-04 Ra Pharmaceuticals, Inc. Modulateurs d'activité du complément
EP4218790B1 (fr) * 2015-12-16 2026-02-18 UCB Holdings, Inc. Modulateurs de l'activité du complément
US11026945B2 (en) 2016-04-29 2021-06-08 The Trustees Of The University Of Pennsylvania Protein kinase RNA-like endoplasmic reticulum kinase (PERK) inhibitors for prevention and/or treatment of lung injury and/or inflammation
CA3045114A1 (fr) 2016-12-07 2018-06-14 Ra Pharmaceuticals, Inc. Modulateurs de l'activite du complement
EP3810177B1 (fr) * 2018-06-21 2024-12-04 Ra Pharmaceuticals, Inc. Peptides cycliques pour l'inhibition de la pcsk9
IL321719A (en) 2018-06-21 2025-08-01 Merck Sharp ַ& Dohme Llc Pcsk9 antagonist compounds
US11530244B2 (en) 2018-06-21 2022-12-20 Merck Sharp & Dohme Llc Cyclic polypeptides for PCSK9 inhibition
WO2019246386A1 (fr) 2018-06-21 2019-12-26 Ra Pharmaceuticals Inc. Polypeptides cycliques pour l'inhibition de la pcsk9
US20220133841A1 (en) 2018-10-22 2022-05-05 Ra Pharmaceuticals, Inc. Neurological disease treatment with zilucoplan
EP3934675A2 (fr) 2019-03-08 2022-01-12 RA Pharmaceuticals, Inc. Modulateurs d'activité du complément
CA3137895A1 (fr) * 2019-04-24 2020-10-29 Ra Pharmaceuticals, Inc. Compositions et methodes de modulation de l'activite du complement
US12558398B2 (en) 2019-06-04 2026-02-24 Ucb Holdings, Inc. Inflammatory disease treatment with complement inhibitors
US20220370548A1 (en) 2019-09-12 2022-11-24 Ra Pharmaceuticals, Inc. Neurological disease treatment with complement inhibitors
US12577259B2 (en) 2019-12-20 2026-03-17 Merck Sharp & Dohme Llc PCSK9 antagonist compounds
WO2021132462A1 (fr) 2019-12-26 2021-07-01 エーザイ・アール・アンド・ディー・マネジメント株式会社 Composition pharmaceutique contenant de l'acide ribonucléique double brin inhibant l'expression du complément c5
US11932705B2 (en) 2020-12-18 2024-03-19 Merck Sharp & Dohme Llc Cyclic polypeptides for PCSK9 inhibition
WO2022159395A1 (fr) 2021-01-20 2022-07-28 Viking Therapeutics, Inc. Compositions et procédés pour le traitement de troubles métaboliques et hépatiques
WO2022177635A2 (fr) * 2021-02-22 2022-08-25 Ra Pharmaceuticals, Inc. Compositions et méthodes pour le traitement de maladies microbiennes
IL311411A (en) 2021-09-15 2024-05-01 Viking Therapeutics Inc Preparations and methods for the treatment of metabolic and liver disorders
WO2023215294A1 (fr) * 2022-05-02 2023-11-09 The Board Of Trustees Of The Leland Stanford Junior University Inhibition de la voie du complément à des fins de cicatrisation
US20260048028A1 (en) * 2022-08-16 2026-02-19 Ps Therapy, Inc. Methods of Use for Disulfiram and Metabolites Thereof
TW202506645A (zh) * 2023-03-31 2025-02-16 美商弗列克斯美國公司 雜芳基抗降解劑

Family Cites Families (116)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4271068A (en) 1968-05-10 1981-06-02 Ciba-Geigy Corporation Process for the manufacture of cystine-containing peptides
US4179337A (en) 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
US4033940A (en) 1975-11-12 1977-07-05 Armour Pharmaceutical Company Cyclization of peptides
US4216141A (en) 1978-07-19 1980-08-05 The Salk Institute For Biological Studies Method for cyclization of peptides
JPS6023084B2 (ja) 1979-07-11 1985-06-05 味の素株式会社 代用血液
NZ199722A (en) 1981-02-25 1985-12-13 Genentech Inc Dna transfer vector for expression of exogenous polypeptide in yeast;transformed yeast strain
US4640835A (en) 1981-10-30 1987-02-03 Nippon Chemiphar Company, Ltd. Plasminogen activator derivatives
US4496689A (en) 1983-12-27 1985-01-29 Miles Laboratories, Inc. Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer
US6309669B1 (en) 1984-03-16 2001-10-30 The United States Of America As Represented By The Secretary Of The Army Therapeutic treatment and prevention of infections with a bioactive materials encapsulated within a biodegradable-biocompatible polymeric matrix
DE3675588D1 (de) 1985-06-19 1990-12-20 Ajinomoto Kk Haemoglobin, das an ein poly(alkenylenoxid) gebunden ist.
US4791192A (en) 1986-06-26 1988-12-13 Takeda Chemical Industries, Ltd. Chemically modified protein with polyethyleneglycol
US5371109A (en) 1986-07-01 1994-12-06 Drilletten Ab Controlled release composition for a biologically active material dissolved or dispersed in an L2-phase
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
FR2641081A1 (fr) * 1988-12-23 1990-06-29 Medgenix Group
DE3920358A1 (de) 1989-06-22 1991-01-17 Behringwerke Ag Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
ES2118066T3 (es) 1989-10-05 1998-09-16 Optein Inc Sintesis y aislamiento, exentos de celulas, de nuevos genes y polipeptidos.
US5585353A (en) 1990-02-02 1996-12-17 The Rockefeller University Antibiotic peptides containing D-amino acids
US5427908A (en) 1990-05-01 1995-06-27 Affymax Technologies N.V. Recombinant library screening methods
US5766897A (en) 1990-06-21 1998-06-16 Incyte Pharmaceuticals, Inc. Cysteine-pegylated proteins
US5843701A (en) 1990-08-02 1998-12-01 Nexstar Pharmaceticals, Inc. Systematic polypeptide evolution by reverse translation
US5270170A (en) 1991-10-16 1993-12-14 Affymax Technologies N.V. Peptide library and screening method
DE69233528T2 (de) 1991-11-25 2006-03-16 Enzon, Inc. Verfahren zur Herstellung von multivalenten antigenbindenden Proteinen
CA2163620A1 (fr) 1993-05-28 1994-12-08 Michael V. Doyle Methode pour la selection de sequences peptidiques biologiquement actives
WO1995001368A1 (fr) 1993-06-29 1995-01-12 Ferring B.V. Synthese amelioree de peptides cycliques
US6074642A (en) 1994-05-02 2000-06-13 Alexion Pharmaceuticals, Inc. Use of antibodies specific to human complement component C5 for the treatment of glomerulonephritis
US5824784A (en) 1994-10-12 1998-10-20 Amgen Inc. N-terminally chemically modified protein compositions and methods
US6037453A (en) * 1995-03-15 2000-03-14 Genentech, Inc. Immunoglobulin variants
US5834318A (en) 1995-05-10 1998-11-10 Bayer Corporation Screening of combinatorial peptide libraries for selection of peptide ligand useful in affinity purification of target proteins
US5912014A (en) 1996-03-15 1999-06-15 Unigene Laboratories, Inc. Oral salmon calcitonin pharmaceutical products
US6720472B2 (en) 1996-07-12 2004-04-13 University Of Medicine And Dentistry Of New Jersey HMGI proteins in cancer and obesity
US6268343B1 (en) 1996-08-30 2001-07-31 Novo Nordisk A/S Derivatives of GLP-1 analogs
US6348584B1 (en) 1996-10-17 2002-02-19 John Edward Hodgson Fibronectin binding protein compounds
EP0962527B1 (fr) 1996-10-17 2004-08-04 Mitsubishi Chemical Corporation Molecule permettant d'homologuer un genotype et un phenotype, et utilisation de celle-ci
US5922680A (en) 1996-10-23 1999-07-13 Ferring, B.V. Stabilized composition for oral administration of peptides
DK0971946T3 (da) 1997-01-21 2006-10-30 Gen Hospital Corp Selektion af proteiner ved anvendelse af RNA-protein-fusioner
US6261804B1 (en) 1997-01-21 2001-07-17 The General Hospital Corporation Selection of proteins using RNA-protein fusions
US5990237A (en) 1997-05-21 1999-11-23 Shearwater Polymers, Inc. Poly(ethylene glycol) aldehyde hydrates and related polymers and applications in modifying amines
JP3614866B2 (ja) 1997-06-12 2005-01-26 リサーチ コーポレイション テクノロジーズ，インコーポレイティド 人工抗体ポリペプチド
EP0896001A1 (fr) 1997-08-08 1999-02-10 Daicel Chemical Industries, Ltd. Procédé pour la préparation de dérivés d'antagonistes de l'oxytocin, produits intérmédiares pour la préparation de dérivés d'antagonistes de l'oxytocin et procédé pour la préparation de produits intermédiares
US6429301B1 (en) 1998-04-17 2002-08-06 Whitehead Institute For Biomedical Research Use of a ribozyme to join nucleic acids and peptides
IL140930A0 (en) 1998-08-07 2002-02-10 Emisphere Tech Inc Compounds and compositions for delivering active agents
JP2002525382A (ja) * 1998-09-25 2002-08-13 ザ チルドレンズ メディカル センター コーポレイション プロテインキナーゼの活性を選択的に調節するショートペプチド
WO2000021559A2 (fr) 1998-10-09 2000-04-20 Musc Foundation For Research Development Facteur de blocage b destine a traiter une maladie d'origine immunitaire induite par complement
US6962781B1 (en) 2000-05-19 2005-11-08 Proteonova, Inc. In vitro evolution of nucleic acids and encoded polypeptide
US7244701B2 (en) 2000-06-16 2007-07-17 Zealand Phama A/S Diuretic peptide conjugate
US20030232014A1 (en) * 2002-03-01 2003-12-18 Mds Proteomics Inc. Phosphorylated proteins and uses related thereto
WO2004035624A2 (fr) * 2002-10-14 2004-04-29 Novo Nordisk A/S Composes glp-2, leurs formulations et leurs utilisations
CN100594037C (zh) * 2002-11-15 2010-03-17 Musc研究发展基金会 通过补体受体2定向的补体调节剂
NZ568459A (en) * 2003-05-05 2009-06-26 Probiodrug Ag Use of effectors of glutaminyl and glutamate cyclases
WO2004103294A2 (fr) 2003-05-15 2004-12-02 Tanox, Inc. Procedes et compositions pour la prevention et le traitement de la sepsie
US7348401B2 (en) 2003-09-10 2008-03-25 Innate Biotech, Inc. Peptides that inhibit complement activation
US20050191343A1 (en) 2003-11-26 2005-09-01 Shire Laboratories, Inc. Micellar systems useful for delivery of lipophilic or hydrophobic compounds
US7803931B2 (en) 2004-02-12 2010-09-28 Archemix Corp. Aptamer therapeutics useful in the treatment of complement-related disorders
US20060027059A1 (en) 2004-08-09 2006-02-09 Chih-Ching Hsien Extendable handle device
WO2006066258A2 (fr) * 2004-12-17 2006-06-22 Neose Technologies, Inc. Lipoconjugaison de peptides
PT1844337E (pt) 2005-01-24 2014-04-03 Pepscan Systems Bv Compostos ligantes, compostos imunogénicos e peptidomiméticos
EP1874289A2 (fr) 2005-03-29 2008-01-09 Cardax Pharmaceuticals, Inc. Reduction de l'activation du complement et de l'inflammation dans une lesion tissulaire a l'aide de carotenoides, d'analogues de carotenoides ou de derives de carotenoides
US8911733B2 (en) 2005-05-26 2014-12-16 Musc Foundation For Research Development Inhibition of the alternative complement pathway for treatment of traumatic brain injury, spinal cord injury and related conditions
CN101217940B (zh) 2005-06-06 2013-03-27 卡穆鲁斯公司 Glp-1类似物制剂
PT2500030E (pt) 2005-11-04 2015-09-24 Genentech Inc Uso de inibidores da via do complemento para tratar doenças oculares
ES2965283T3 (es) 2006-03-15 2024-05-28 Alexion Pharma Inc Tratamiento de pacientes con hemoglobinuria paroxística nocturna mediante un inhibidor del complemento
EP1876183A1 (fr) * 2006-07-04 2008-01-09 Technische Universität München Peptides d'une longueur minimalisée ayant une haute affinité pour protéines de facteur VIII et des protéines analogue à facteur VIII
SI3028716T1 (sl) 2006-10-10 2021-01-29 Regenesance B.V. Komplementarna inhibicija za izboljšano regeneracijo živcev
US7736860B2 (en) 2006-11-09 2010-06-15 Univeristy Of Massachusetts Methods of identifying compounds for the treatment of sterile inflammation
EP2121016A1 (fr) * 2007-03-06 2009-11-25 Novo Nordisk A/S Modulation d'activation de systeme du complement pour traitement d'inflammation liee a un saignement
MX2009010181A (es) * 2007-03-22 2009-12-04 Novartis Ag Antigenos c5 y usos de los mismos.
US20100015139A1 (en) 2008-07-10 2010-01-21 Rekha Bansal METHOD OF INHIBITING COMPLEMENT ACTIVATION WITH FACTOR Ba SPECIFIC ANTIBODIES AND USE THEREOF
RU2009144142A (ru) 2007-04-30 2011-06-10 Алькон Рисерч, Лтд. (Us) Лечение возрастной дегенерации желтого пятна с применением ингибиторов фактора d комплемента
KR101572700B1 (ko) 2007-06-07 2015-11-30 제넨테크, 인크. 보체-관련 장애의 예방 및 치료를 위한 Ｃ３ｂ 항체 및 방법
WO2009014633A1 (fr) 2007-07-20 2009-01-29 Trustees Of The University Of Pennsylvania Procédé de traitement du syndrome de détresse respiratoire aiguë
WO2009046198A2 (fr) 2007-10-02 2009-04-09 Potentia Pharmaceuticals, Inc. Distribution soutenue d'analogues de compstatine à partir de gels
WO2009067191A2 (fr) 2007-11-16 2009-05-28 The General Hospital Corporation Procédés et compositions pour le traitement d'une infection par le virus de l'hépatite c (vhc)
WO2009121065A2 (fr) 2008-03-28 2009-10-01 Apellis Ag Modulation et réplétion/amélioration du système complémentaire dans le traitement des traumatismes
WO2010014830A2 (fr) 2008-07-30 2010-02-04 Cosmix Therapeutics Llc Produits thérapeutiques peptidiques qui se lient à vegf et leurs procédés d'utilisation
PY09026846A (es) * 2008-08-05 2015-09-01 Novartis Ag Composiciones y métodos para anticuerpos que se dirigen a la proteína de complemento c5
WO2010025510A1 (fr) 2008-09-03 2010-03-11 Xenome Ltd Bibliothèques de conjugués peptidiques et leurs méthodes de fabrication
US9447176B2 (en) 2008-11-10 2016-09-20 Alexion Pharmaceuticals, Inc. Methods and compositions for treating complement-associated disorders
AU2009230735B1 (en) 2009-01-08 2010-01-21 Shane Ramodien Electronic equipment housing
AU2010306581B2 (en) 2009-10-16 2015-03-19 Omeros Corporation Methods for treating disseminated intravascular coagulation by inhibiting MASP-2 dependent complement activation
EP2496259B1 (fr) 2009-11-05 2017-02-22 Alexion Pharmaceuticals, Inc. Traitement de l'hémoglobinurie paroxystique nocturne
CA2784757A1 (fr) 2009-12-16 2011-07-07 Novo Nordisk A/S Derives a double acylation de glp-1
US9172511B2 (en) 2009-12-24 2015-10-27 Samsung Electronics Co., Ltd. Apparatus and method of communicating automatic repeat request (ARQ) feedback in a wireless communication network
US9358266B2 (en) 2010-02-25 2016-06-07 The Trustees Of The University Of Pennsylvania Treatment of sepsis using complement inhibitors
ES2659409T3 (es) * 2010-03-12 2018-03-15 The Regents Of The University Of California Conjugados de lípido-péptido-polímero y nanopartículas de los mismos
WO2011139343A2 (fr) * 2010-04-28 2011-11-10 Wu Nian Conjugués peg-lipide reliés à un acide aminé
WO2011137363A1 (fr) 2010-04-30 2011-11-03 Allergan, Inc. Nouveau traitement pour la dégénérescence maculaire liée à l'âge et la maladie ischémique oculaire associée à l'activation du complément par le ciblage de la 5-lipoxygénase
TW201241008A (en) 2010-10-01 2012-10-16 Alexion Pharma Inc Polypeptides that bind to human complement component C5
US9340590B2 (en) * 2011-03-16 2016-05-17 Amgen Inc. Potent and selective inhibitors of NaV1.3 and NaV1.7
CN107638565B (zh) 2011-04-08 2021-12-21 莱斯特大学 用于治疗与masp-2依赖性补体活化相关的状况的方法
WO2012162215A1 (fr) 2011-05-20 2012-11-29 The Trustees Of The University Of Pennsylvania Promotion de la cicatrisation de fracture à l'aide d'inhibiteurs du complément
WO2012174055A1 (fr) 2011-06-13 2012-12-20 The Trustees Of The University Of Pennsylvania Cicatrisation d'une plaie à l'aide d'inhibiteurs du complément
CN102321170B (zh) * 2011-09-14 2013-11-13 深圳翰宇药业股份有限公司 利拉鲁肽变构体及其缀合物
WO2013052736A2 (fr) * 2011-10-06 2013-04-11 The Medicines Company Procédés de traitement ou de prévention de la perte de sang pendant une chirurgie à l'aide de l'inhibiteur de la sérine protéase mdco-2010
RS58503B1 (sr) 2012-02-20 2019-04-30 Swedish Orphan Biovitrum Ab Publ Polipeptidi koji se vezuju za humani komplement c5
US20130246083A1 (en) 2012-03-16 2013-09-19 Alexion Pharmaceuticals, Inc. Methods of distributing complement-inhibiting drugs to patients receiving a complement inhibitor
EP2850095B1 (fr) 2012-05-17 2019-10-09 RA Pharmaceuticals, Inc. Inhibiteurs peptidiques et peptidomimétiques
US9579360B2 (en) 2012-06-20 2017-02-28 The Trustees Of The University Of Pennsylvania Methods of treating or preventing periodontitis and diseases associated with periodontitis
WO2014004733A1 (fr) 2012-06-26 2014-01-03 The Regents Of The University Of California Composition pour la néphropathie lupique et ses méthodes de fabrication et d'utilisation
WO2014078622A1 (fr) 2012-11-15 2014-05-22 The Brigham And Women's Hospital, Inc. Procédé et système pour diagnostiquer et traiter la prééclampsie
US9700633B2 (en) * 2013-01-28 2017-07-11 Jenkem Technology Co., Ltd., Tianjin Branch Conjugates of water soluble polymer-amino acid oligopeptide-drug, preparation method and use thereof
GB201301632D0 (en) * 2013-01-30 2013-03-13 Imp Innovations Complement System
US20140234275A1 (en) 2013-02-15 2014-08-21 Jason Williams Method for treating als via the increased production of factor h
WO2015025312A1 (fr) 2013-08-21 2015-02-26 Cannabics Pharmaceuticals Inc Compositions combinant une libération immédiate et une libération prolongée de cannabinoïdes, leurs méthodes de fabrication et d'utilisation
JP6718379B2 (ja) 2014-03-20 2020-07-08 インフラルクス ゲーエムベーハー ウイルス性肺炎治療のためのＣ５ａの阻害剤
HUE045646T2 (hu) * 2014-06-12 2020-01-28 Ra Pharmaceuticals Inc Komplement aktivitás modulálása
US20160168237A1 (en) 2014-12-12 2016-06-16 Alexion Pharmaceuticals, Inc. Method for treating a complement mediated disorder caused by an infectious agent in a patient
CN107427482A (zh) 2015-01-21 2017-12-01 帕西拉制药有限公司 凝血酸的多囊脂质体制剂
WO2016123371A1 (fr) 2015-01-28 2016-08-04 Ra Pharmaceuticals, Inc. Modulateurs d'activité du complément
WO2017035362A1 (fr) 2015-08-26 2017-03-02 Achillion Pharmaceuticals, Inc. Utilisation de composés inhibiteurs de la voie du complément pour atténuer des réponses immunitaires indésirables associées à une thérapie adoptive par lymphocytes t
EP4218790B1 (fr) 2015-12-16 2026-02-18 UCB Holdings, Inc. Modulateurs de l'activité du complément
CA3045114A1 (fr) 2016-12-07 2018-06-14 Ra Pharmaceuticals, Inc. Modulateurs de l'activite du complement
EP3978523A1 (fr) 2017-04-03 2022-04-06 InflaRx GmbH Traitement de maladies inflammatoires au moyen d'inhibiteurs de l'activité c5a
EP3682016A4 (fr) 2017-09-11 2021-06-02 RA Pharmaceuticals, Inc. Formulations pour l'administration de composés
KR20200095485A (ko) 2017-12-04 2020-08-10 라 파마슈티컬스 인코포레이티드 보체 활성의 조절인자
EP3934675A2 (fr) 2019-03-08 2022-01-12 RA Pharmaceuticals, Inc. Modulateurs d'activité du complément
CA3137895A1 (fr) 2019-04-24 2020-10-29 Ra Pharmaceuticals, Inc. Compositions et methodes de modulation de l'activite du complement

Also Published As

Publication number Publication date
RU2018136750A (ru) 2018-11-06
BR112016029076A8 (pt) 2022-02-08
IL273746A (en) 2020-05-31
FIC20240015I1 (fi) 2024-05-28
CA2949985C (fr) 2023-10-17
NL301275I2 (nl) 2024-06-20
RS62428B1 (sr) 2021-11-30
RU2018136750A3 (fr) 2021-10-19
JP2017523232A (ja) 2017-08-17
SI3628680T1 (sl) 2021-12-31
CN106456701B (zh) 2020-01-07
ZA201706379B (en) 2018-12-19
PT3154561T (pt) 2019-10-25
KR20170003993A (ko) 2017-01-10
AU2015274482B2 (en) 2018-11-08
US20200002380A1 (en) 2020-01-02
HRP20211561T1 (hr) 2021-12-24
US20180371019A1 (en) 2018-12-27
HUS2400015I1 (hu) 2024-06-28
EP3628680B1 (fr) 2021-09-08
DK3154561T3 (da) 2019-10-07
NZ736573A (en) 2024-03-22
LT3628680T (lt) 2021-11-25
MX2016016449A (es) 2017-08-24
CY2024015I2 (el) 2024-12-13
EP3154561A2 (fr) 2017-04-19
IL281264A (en) 2021-04-29
CY1122227T1 (el) 2020-11-25
JP2019048834A (ja) 2019-03-28
US11535650B1 (en) 2022-12-27
US10106579B2 (en) 2018-10-23
SI3154561T1 (sl) 2019-11-29
SMT202100588T1 (it) 2021-11-12
FR24C1022I1 (fr) 2024-07-19
NZ761610A (en) 2024-03-22
LT3154561T (lt) 2019-11-25
ZA202001859B (en) 2021-04-28
HRP20211561T8 (hr) 2022-03-04
CY1124595T1 (el) 2022-07-22
IL273746B (en) 2021-03-25
JP7002597B2 (ja) 2022-02-04
AP2016009612A0 (en) 2016-12-31
SG11201610222UA (en) 2017-01-27
US20170137468A1 (en) 2017-05-18
AU2021204313A1 (en) 2021-07-22
PT3628680T (pt) 2021-10-07
LTPA2024514I1 (fr) 2024-06-10
CN111187338B (zh) 2024-08-02
RU2016147080A3 (fr) 2018-06-01
JP2020128417A (ja) 2020-08-27
NZ727420A (en) 2018-06-29
BR112016029076B1 (pt) 2024-02-15
RS59353B1 (sr) 2019-10-31
KR102346228B1 (ko) 2022-01-04
CN106456701A (zh) 2017-02-22
CN111187338A (zh) 2020-05-22
EP3973994A1 (fr) 2022-03-30
CA3174909A1 (fr) 2015-12-17
RU2670988C2 (ru) 2018-10-29
CA3241273A1 (fr) 2015-12-17
ZA201900497B (en) 2019-10-30
US10208089B2 (en) 2019-02-19
JP2022034057A (ja) 2022-03-02
KR102503319B1 (ko) 2023-02-28
US20210246167A1 (en) 2021-08-12
EP4223317A2 (fr) 2023-08-09
WO2015191951A3 (fr) 2016-03-03
PL3154561T3 (pl) 2019-12-31
LTC3154561I2 (fr) 2025-11-10
CN119236050A (zh) 2025-01-03
NO2024023I1 (no) 2024-05-24
US11965040B2 (en) 2024-04-23
IL249093B (en) 2020-05-31
FR24C1022I2 (fr) 2025-05-23
US10435438B2 (en) 2019-10-08
ES2895029T3 (es) 2022-02-17
EP4223317A3 (fr) 2023-09-27
JP6770043B2 (ja) 2020-10-14
KR101981532B1 (ko) 2019-09-02
EP3154561A4 (fr) 2018-04-18
US10562934B2 (en) 2020-02-18
AU2019200828A1 (en) 2019-02-28
SMT201900568T1 (it) 2019-11-13
AU2019200828B2 (en) 2021-04-08
KR20220002727A (ko) 2022-01-06
US20200123202A1 (en) 2020-04-23
BR112016029076A2 (pt) 2018-06-05
AU2021204313B2 (en) 2024-01-04
WO2015191951A2 (fr) 2015-12-17
EP3154561B1 (fr) 2019-09-04
JP7454545B2 (ja) 2024-03-22
PL3628680T3 (pl) 2022-01-10
BR122021025449B1 (pt) 2024-02-15
MX2021009309A (es) 2021-10-26
CY2024015I1 (el) 2024-12-13
CA2949985A1 (fr) 2015-12-17
EP3628680A1 (fr) 2020-04-01
ES2750556T3 (es) 2020-03-26
AU2015274482A1 (en) 2017-01-12
HUE045646T2 (hu) 2020-01-28
DK3628680T3 (da) 2021-10-11
JP6432954B2 (ja) 2018-12-05
US20190119328A1 (en) 2019-04-25
LUC00343I1 (fr) 2024-05-16
US11014965B2 (en) 2021-05-25
BR122023024819A2 (pt) 2023-12-26
KR20190057420A (ko) 2019-05-28
HUE055931T2 (hu) 2022-01-28
IL249093A0 (en) 2017-01-31
RU2016147080A (ru) 2018-06-01
HRP20191763T1 (hr) 2019-12-27
IL281264B (en) 2022-05-01

Similar Documents

Publication Publication Date Title
BR112016016761A2 (fr)
BR112016015519A2 (fr)
BR112016016602A2 (fr)
BR112016003131A2 (fr)
BR112016016546A2 (fr)
BR112016017103A2 (fr)
BR112016014949A2 (fr)
BR112016015503A2 (fr)
BR112016017031A2 (fr)
BR112016016924A2 (fr)
BR112016017226A2 (fr)
BR112016016421A2 (fr)
BR112016016558A2 (fr)
BR112016026089A2 (fr)
BR112016015798A2 (fr)
BR112016017356A2 (fr)
BR112016016468A2 (fr)
BR112016015915A2 (fr)
BR112016016657A2 (fr)
BR112016003522A2 (fr)
BR112016016459A2 (fr)
BR112016014482A2 (fr)
BR112016017130A2 (fr)
BR112016017135A2 (fr)
BR112016017675A2 (fr)