LU93162I2 - Peginterféron bêta-1a ou un dérivé pharmaceutiquement acceptable de celui-ci (PLEGRIDY) - Google Patents

Peginterféron bêta-1a ou un dérivé pharmaceutiquement acceptable de celui-ci (PLEGRIDY) Download PDF

Info

Publication number
LU93162I2
LU93162I2 LU93162C LU93162C LU93162I2 LU 93162 I2 LU93162 I2 LU 93162I2 LU 93162 C LU93162 C LU 93162C LU 93162 C LU93162 C LU 93162C LU 93162 I2 LU93162 I2 LU 93162I2
Authority
LU
Luxembourg
Prior art keywords
plegridy
pharmaceutically acceptable
acceptable derivative
interferon beta
peg interferon
Prior art date
Application number
LU93162C
Other languages
English (en)
French (fr)
Original Assignee
Biogen Ma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biogen Ma Inc filed Critical Biogen Ma Inc
Publication of LU93162I2 publication Critical patent/LU93162I2/fr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32Polymers modified by chemical after-treatment
    • C08G65/329Polymers modified by chemical after-treatment with organic compounds
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32Polymers modified by chemical after-treatment
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/31Somatostatins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/16Antivirals for RNA viruses for influenza or rhinoviruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
    • A61P31/22Antivirals for DNA viruses for herpes viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/34Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from hydroxy compounds or their metallic derivatives
    • C08G65/48Polymers modified by chemical after-treatment
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L71/00Compositions of polyethers obtained by reactions forming an ether link in the main chain; Compositions of derivatives of such polymers
    • C08L71/02Polyalkylene oxides
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2203/00Applications
    • C08L2203/02Applications for biomedical use

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Polymers & Plastics (AREA)
  • Molecular Biology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Zoology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pulmonology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Endocrinology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Polyethers (AREA)
LU93162C 2002-01-18 2016-08-03 Peginterféron bêta-1a ou un dérivé pharmaceutiquement acceptable de celui-ci (PLEGRIDY) LU93162I2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US34991702P 2002-01-18 2002-01-18
PCT/US2003/001559 WO2003061577A2 (en) 2002-01-18 2003-01-17 Polyalkylene glycol with moiety for conjugating biologically active compound

Publications (1)

Publication Number Publication Date
LU93162I2 true LU93162I2 (fr) 2016-10-03

Family

ID=27613339

Family Applications (1)

Application Number Title Priority Date Filing Date
LU93162C LU93162I2 (fr) 2002-01-18 2016-08-03 Peginterféron bêta-1a ou un dérivé pharmaceutiquement acceptable de celui-ci (PLEGRIDY)

Country Status (35)

Country Link
US (2) US8017733B2 (US20030051240A1-20030313-M00001.png)
EP (3) EP3025726B1 (US20030051240A1-20030313-M00001.png)
JP (5) JP2005526151A (US20030051240A1-20030313-M00001.png)
KR (1) KR100964411B1 (US20030051240A1-20030313-M00001.png)
CN (2) CN101700401B (US20030051240A1-20030313-M00001.png)
AU (1) AU2003210564B2 (US20030051240A1-20030313-M00001.png)
BE (1) BE2016C040I2 (US20030051240A1-20030313-M00001.png)
BG (1) BG66525B1 (US20030051240A1-20030313-M00001.png)
BR (1) BRPI0306993B8 (US20030051240A1-20030313-M00001.png)
CA (4) CA2952488C (US20030051240A1-20030313-M00001.png)
CY (2) CY2016027I1 (US20030051240A1-20030313-M00001.png)
CZ (1) CZ2004877A3 (US20030051240A1-20030313-M00001.png)
DK (2) DK1476181T3 (US20030051240A1-20030313-M00001.png)
EA (2) EA011829B1 (US20030051240A1-20030313-M00001.png)
EE (1) EE05509B1 (US20030051240A1-20030313-M00001.png)
ES (2) ES2566797T3 (US20030051240A1-20030313-M00001.png)
GE (2) GEP20074024B (US20030051240A1-20030313-M00001.png)
HK (3) HK1072721A1 (US20030051240A1-20030313-M00001.png)
HU (4) HUE047557T2 (US20030051240A1-20030313-M00001.png)
IL (1) IL163006A (US20030051240A1-20030313-M00001.png)
IS (1) IS2989B (US20030051240A1-20030313-M00001.png)
LU (1) LU93162I2 (US20030051240A1-20030313-M00001.png)
ME (2) MEP35608A (US20030051240A1-20030313-M00001.png)
MX (1) MXPA04006855A (US20030051240A1-20030313-M00001.png)
NL (1) NL300826I2 (US20030051240A1-20030313-M00001.png)
NO (3) NO339857B1 (US20030051240A1-20030313-M00001.png)
NZ (1) NZ534708A (US20030051240A1-20030313-M00001.png)
PL (2) PL397261A1 (US20030051240A1-20030313-M00001.png)
PT (1) PT3025726T (US20030051240A1-20030313-M00001.png)
RS (1) RS55578B1 (US20030051240A1-20030313-M00001.png)
SI (2) SI1476181T1 (US20030051240A1-20030313-M00001.png)
SK (1) SK3102004A3 (US20030051240A1-20030313-M00001.png)
UA (1) UA82184C2 (US20030051240A1-20030313-M00001.png)
WO (1) WO2003061577A2 (US20030051240A1-20030313-M00001.png)
ZA (1) ZA200406555B (US20030051240A1-20030313-M00001.png)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2952488C (en) * 2002-01-18 2019-05-07 Biogen Ma Inc. Polyalkylene glycol with moiety for conjugating biologically active compounds
US20150246097A9 (en) * 2002-01-18 2015-09-03 Biogen Idec Ma Inc. Polyalkylene Polymer Compounds and Uses Thereof
KR20050093856A (ko) 2002-09-09 2005-09-23 넥타르 테라퓨틱스 에이엘, 코포레이션 수용성 중합체 알카날
US8129330B2 (en) 2002-09-30 2012-03-06 Mountain View Pharmaceuticals, Inc. Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof
RS20050501A (en) * 2002-12-26 2007-08-03 Mountain View Pharmaceuticals Inc., Polymer conjugates of cytokines,chemokines,growth factors, polypeptide hormones and antagonists thereof with preserved receptor-binding activity
CA2511814C (en) * 2002-12-26 2015-02-17 Mountain View Pharmaceuticals, Inc. Polymer conjugates of interferon-beta with enhanced biological potency
US7432331B2 (en) 2002-12-31 2008-10-07 Nektar Therapeutics Al, Corporation Hydrolytically stable maleimide-terminated polymers
SI1635875T1 (sl) 2003-06-26 2009-04-30 Psivida Inc Sistem za dajanje zdravila, ki se gelira in situ
JP5628467B2 (ja) 2003-06-26 2014-11-19 シヴィダ・ユーエス・インコーポレイテッドPsivida Us, Inc. 生体分解性徐放性ドラッグデリバリーシステム
US20090312344A1 (en) * 2004-05-31 2009-12-17 Mohammad Salman Arylpiperazine derivatives as adrenergic receptor antagonists
EP1827501B2 (en) 2004-12-21 2013-11-20 Nektar Therapeutics Stabilized polymeric thiol reagents
US20070004635A1 (en) * 2005-06-02 2007-01-04 Schering Corporation Method of treating interferon non-responders using HCV protease inhibitor
AU2006269382B2 (en) 2005-07-08 2014-01-16 Biogen Idec Ma Inc. Preparation of polymer conjugates of therapeutic, agricultural, and food additive compounds
TW200817369A (en) * 2006-05-22 2008-04-16 Elan Pharm Inc Preparation of polymer conjugates of therapeutic, agricultural and food additive compounds
US20100222546A1 (en) * 2006-11-28 2010-09-02 David Crich Methods for the preparation of functionalized peptides, proteins and carbohydrates and their conjugates
WO2009009712A1 (en) * 2007-07-11 2009-01-15 Enzon Pharmaceuticals, Inc. Polymeric drug delivery system containing a multi-substituted aromatic moiety
WO2009009716A1 (en) * 2007-07-11 2009-01-15 Enzon Pharmaceuticals, Inc. Polymeric drug delivery systems containing an aromatic allylic acid
CL2008002399A1 (es) * 2007-08-16 2009-01-02 Pharmaessentia Corp Conjugado sustancialmente puro que posee una porcion polimerica, una porcion proteica (interferon alfa 2b) y un ligante alifatico de 1 a 10 atomos de carbono, util en el tratamiento de las hepatitis b o c.
AU2009255994B2 (en) * 2008-06-05 2014-07-17 Bristol-Myers Squibb Company Use of pegylated Type III Interferons for the treatment of hepatitis C
UA104146C2 (ru) * 2008-07-31 2014-01-10 Фармаиссеншиа Корп. ПОЛИМЕРНЫЕ КОНЪЮГАТЫ ФРАГМЕНТОВ ИНТЕРФЕРОНА-β, ЭРИТРОПОЭТИНА И ГОРМОНА РОСТА
GB0823309D0 (en) * 2008-12-19 2009-01-28 Univ Bath Functionalising reagents and their uses
JPWO2010140350A1 (ja) 2009-06-02 2012-11-15 パナソニック株式会社 ダウンミックス装置、符号化装置、及びこれらの方法
UA109646C2 (uk) * 2009-12-10 2015-09-25 Терапевтичне застосування кон'югатів білка з полімером
US20130225789A1 (en) * 2012-02-29 2013-08-29 Yi Sun Polyethylene Glycol Having Hetero Multiple Functional Groups
US8993614B2 (en) 2012-03-15 2015-03-31 F. Hoffmann-La Roche Ag Substituted pyrrolidine-2-carboxamides
KR101475630B1 (ko) * 2013-05-31 2014-12-22 동국대학교 산학협력단 포도근 추출물 또는 이의 분획물을 유효성분으로 포함하는 c형 간염의 예방 또는 치료용 조성물
US11759500B2 (en) * 2014-07-24 2023-09-19 Abion Inc. PEGylated interferon-beta variant
ES2824028T3 (es) 2014-08-19 2021-05-11 Biogen Ma Inc Método de PEGilación
GB201419108D0 (en) 2014-10-27 2014-12-10 Glythera Ltd Materials and methods relating to linkers for use in antibody drug conjugates
RS65015B1 (sr) 2014-11-06 2024-01-31 Pharmaessentia Corp Režim doziranja pegiliranog interferona
ES2831079T3 (es) * 2017-06-28 2021-06-07 Construction Research & Technology Gmbh Dispersante para partículas inorgánicas
US11472894B2 (en) 2018-07-23 2022-10-18 Carnegie Mellon University Enzyme-assisted ATRP procedures
WO2020028715A1 (en) 2018-08-01 2020-02-06 Russell Alan J Amino-reactive positively charged atrp initiators that maintain their positive charge during synthesis of biomacro-initiators
CN109232898A (zh) * 2018-08-02 2019-01-18 张玲 一种具有抗凝血功能的聚酰亚胺新材料的制备方法
CN111534458B (zh) * 2020-04-13 2022-01-14 浙江工业大学 无色杆菌tbc-1及其在降解1,3,6,8-四溴咔唑中的应用
CN113716982B (zh) * 2021-08-24 2022-05-06 重庆云瑞肥业有限公司 一种食品垃圾回收用发酵制肥装置

Family Cites Families (81)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3710795A (en) 1970-09-29 1973-01-16 Alza Corp Drug-delivery device with stretched, rate-controlling membrane
US4179337A (en) 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
US4002531A (en) 1976-01-22 1977-01-11 Pierce Chemical Company Modifying enzymes with polyethylene glycol and product produced thereby
EP0082481B2 (en) 1981-12-23 1990-09-12 Schering Corporation Stabilised alpha-interferon formulations and their preparation
WO1985003934A1 (en) * 1984-03-06 1985-09-12 Takeda Chemical Industries, Ltd. Chemically modified protein and process for its preparation
GB8334102D0 (en) 1983-12-21 1984-02-01 Searle & Co Interferons with cysteine pattern
EP0154316B1 (en) 1984-03-06 1989-09-13 Takeda Chemical Industries, Ltd. Chemically modified lymphokine and production thereof
EP0206448B1 (en) 1985-06-19 1990-11-14 Ajinomoto Co., Inc. Hemoglobin combined with a poly(alkylene oxide)
JP2524586B2 (ja) 1985-06-26 1996-08-14 シタス コーポレイション ポリマ−接合を利用する医薬組成物用蛋白質の可溶化
US4917888A (en) 1985-06-26 1990-04-17 Cetus Corporation Solubilization of immunotoxins for pharmaceutical compositions using polymer conjugation
US4766106A (en) 1985-06-26 1988-08-23 Cetus Corporation Solubilization of proteins for pharmaceutical compositions using polymer conjugation
JP2514950B2 (ja) 1986-03-10 1996-07-10 エフ・ホフマン―ラ ロシユ アーゲー 化学修飾蛋白質,その製造法および中間体
US4894226A (en) 1986-11-14 1990-01-16 Cetus Corporation Solubilization of proteins for pharmaceutical compositions using polyproline conjugation
US5080891A (en) 1987-08-03 1992-01-14 Ddi Pharmaceuticals, Inc. Conjugates of superoxide dismutase coupled to high molecular weight polyalkylene glycols
US5135919A (en) 1988-01-19 1992-08-04 Children's Medical Center Corporation Method and a pharmaceutical composition for the inhibition of angiogenesis
US5116964A (en) 1989-02-23 1992-05-26 Genentech, Inc. Hybrid immunoglobulins
US5286637A (en) * 1989-08-07 1994-02-15 Debiopharm, S.A. Biologically active drug polymer derivatives and method for preparing same
US5252714A (en) * 1990-11-28 1993-10-12 The University Of Alabama In Huntsville Preparation and use of polyethylene glycol propionaldehyde
US5595732A (en) 1991-03-25 1997-01-21 Hoffmann-La Roche Inc. Polyethylene-protein conjugates
US5281698A (en) 1991-07-23 1994-01-25 Cetus Oncology Corporation Preparation of an activated polymer ester for protein conjugation
AU3423293A (en) 1991-12-19 1993-07-19 Baylor College Of Medicine Pva or peg conjugates of peptides for epitope-specific immunosuppression
ZA933926B (en) 1992-06-17 1994-01-03 Amgen Inc Polyoxymethylene-oxyethylene copolymers in conjuction with blomolecules
US5382657A (en) * 1992-08-26 1995-01-17 Hoffmann-La Roche Inc. Peg-interferon conjugates
US5262564A (en) 1992-10-30 1993-11-16 Octamer, Inc. Sulfinic acid adducts of organo nitroso compounds useful as retroviral inactivating agents anti-retroviral agents and anti-tumor agents
US5298410A (en) 1993-02-25 1994-03-29 Sterling Winthrop Inc. Lyophilized formulation of polyethylene oxide modified proteins with increased shelf-life
US5359030A (en) 1993-05-10 1994-10-25 Protein Delivery, Inc. Conjugation-stabilized polypeptide compositions, therapeutic delivery and diagnostic formulations comprising same, and method of making and using the same
US5681811A (en) 1993-05-10 1997-10-28 Protein Delivery, Inc. Conjugation-stabilized therapeutic agent compositions, delivery and diagnostic formulations comprising same, and method of making and using the same
US5874075A (en) 1993-10-06 1999-02-23 Amgen Inc. Stable protein: phospholipid compositions and methods
ATE214940T1 (de) 1993-11-10 2002-04-15 Enzon Inc Verbesserte interferon-polymerkonjugate
US5951974A (en) 1993-11-10 1999-09-14 Enzon, Inc. Interferon polymer conjugates
US5446090A (en) 1993-11-12 1995-08-29 Shearwater Polymers, Inc. Isolatable, water soluble, and hydrolytically stable active sulfones of poly(ethylene glycol) and related polymers for modification of surfaces and molecules
US5639725A (en) 1994-04-26 1997-06-17 Children's Hospital Medical Center Corp. Angiostatin protein
US5730990A (en) * 1994-06-24 1998-03-24 Enzon, Inc. Non-antigenic amine derived polymers and polymer conjugates
US5650234A (en) 1994-09-09 1997-07-22 Surface Engineering Technologies, Division Of Innerdyne, Inc. Electrophilic polyethylene oxides for the modification of polysaccharides, polypeptides (proteins) and surfaces
US5824784A (en) 1994-10-12 1998-10-20 Amgen Inc. N-terminally chemically modified protein compositions and methods
US5738846A (en) 1994-11-10 1998-04-14 Enzon, Inc. Interferon polymer conjugates and process for preparing the same
AU697440B2 (en) 1994-12-07 1998-10-08 Novozymes A/S Polypeptide with reduced allergenicity
US5932462A (en) 1995-01-10 1999-08-03 Shearwater Polymers, Inc. Multiarmed, monofunctional, polymer for coupling to molecules and surfaces
US5672662A (en) 1995-07-07 1997-09-30 Shearwater Polymers, Inc. Poly(ethylene glycol) and related polymers monosubstituted with propionic or butanoic acids and functional derivatives thereof for biotechnical applications
SE9503380D0 (sv) * 1995-09-29 1995-09-29 Pharmacia Ab Protein derivatives
NZ322686A (en) * 1995-10-19 2000-01-28 Univ Washington Discrete-length polyethene glycols
US5702717A (en) 1995-10-25 1997-12-30 Macromed, Inc. Thermosensitive biodegradable polymers based on poly(ether-ester)block copolymers
US5908621A (en) * 1995-11-02 1999-06-01 Schering Corporation Polyethylene glycol modified interferon therapy
US5747639A (en) 1996-03-06 1998-05-05 Amgen Boulder Inc. Use of hydrophobic interaction chromatography to purify polyethylene glycols
EP0921817B1 (en) 1997-01-29 2001-03-28 PolyMASC Pharmaceuticals plc Pegylation process
CN1268980A (zh) 1997-03-05 2000-10-04 华盛顿州大学 用于鉴定选择性抑制丙型肝炎病毒复制的试剂的新筛选方法
US5990237A (en) * 1997-05-21 1999-11-23 Shearwater Polymers, Inc. Poly(ethylene glycol) aldehyde hydrates and related polymers and applications in modifying amines
US6448369B1 (en) 1997-11-06 2002-09-10 Shearwater Corporation Heterobifunctional poly(ethylene glycol) derivatives and methods for their preparation
US7642323B2 (en) 1997-11-06 2010-01-05 Nektar Therapeutics Heterobifunctional poly(ethylene glycol) derivatives and methods for their preparation
US6180095B1 (en) 1997-12-17 2001-01-30 Enzon, Inc. Polymeric prodrugs of amino- and hydroxyl-containing bioactive agents
AU1825299A (en) * 1997-12-17 1999-07-05 Enzon, Inc. Polymeric prodrugs of amino- and hydroxyl-containing bioactive agents
US5981709A (en) 1997-12-19 1999-11-09 Enzon, Inc. α-interferon-polymer-conjugates having enhanced biological activity and methods of preparing the same
US5985263A (en) 1997-12-19 1999-11-16 Enzon, Inc. Substantially pure histidine-linked protein polymer conjugates
US5965119A (en) 1997-12-30 1999-10-12 Enzon, Inc. Trialkyl-lock-facilitated polymeric prodrugs of amino-containing bioactive agents
ES2222689T3 (es) 1998-03-12 2005-02-01 Nektar Therapeutics Al, Corporation Derivados del polietilenglicol con grupos reactivos proximales.
EE05214B1 (et) 1998-04-28 2009-10-15 Applied Research Systems Ars Holding N.V. Polool-IFN- β konjugaat, selle valmistamismeetod ja farmatseutiline kompositsioon
US6703381B1 (en) 1998-08-14 2004-03-09 Nobex Corporation Methods for delivery therapeutic compounds across the blood-brain barrier
PL206536B1 (pl) 1998-10-16 2010-08-31 Biogen Idec Inc Kompozycja, kompozycja farmaceutyczna glikozylowanego interferonu-beta-1a, zastosowanie kompozycji glikozylowanego interferonu-beta-1a, sposób in vitro przedłużania aktywności glikozylowanego interferonu-beta-1a
AU1249001A (en) * 1999-06-11 2001-01-31 Nektar Therapeutics Al, Corporation Hydrogels derived from chitosan and poly(ethylene glycol) or related polymers
US7144574B2 (en) 1999-08-27 2006-12-05 Maxygen Aps Interferon β variants and conjugates
US6531122B1 (en) * 1999-08-27 2003-03-11 Maxygen Aps Interferon-β variants and conjugates
JP2003527090A (ja) 1999-08-27 2003-09-16 マキシゲン・エイピーエス 新規なインターフェロンベータ様分子
ATE317868T1 (de) 1999-12-22 2006-03-15 Nektar Therapeutics Al Corp Sterisch gehinderte derivate von wasserlöslichen polymeren
US6413507B1 (en) * 1999-12-23 2002-07-02 Shearwater Corporation Hydrolytically degradable carbamate derivatives of poly (ethylene glycol)
WO2002026265A2 (en) * 2000-09-29 2002-04-04 Schering Corporation Pegylated interleukin-10
US7053150B2 (en) 2000-12-18 2006-05-30 Nektar Therapeutics Al, Corporation Segmented polymers and their conjugates
TW593427B (en) * 2000-12-18 2004-06-21 Nektar Therapeutics Al Corp Synthesis of high molecular weight non-peptidic polymer derivatives
MXPA03006805A (es) * 2001-02-01 2003-11-13 Biogen Inc Conjugados de polimero de neublastina y metodos de uso de los mismos.
RU2003128955A (ru) 2001-02-27 2005-04-10 Максиген Апс (Dk) Новые интерферон бета-подобные молекулы
US7009033B2 (en) 2001-07-02 2006-03-07 Polymer Source Inc. Heterofunctional polyethylene glycol and polyethylene oxide, process for their manufacture
DK2939696T3 (en) * 2001-10-18 2016-05-23 Nektar Therapeutics Polymer Conjugates of Opioid Antagonists
KR20050044858A (ko) * 2001-11-20 2005-05-13 파마시아 코포레이션 화학적으로 개질된 인간 성장 호르몬 콘쥬게이트
KR100488351B1 (ko) 2001-12-11 2005-05-11 선바이오(주) 신규한 폴리에틸렌글리콜-프로피온알데히드 유도체
US7041855B2 (en) 2001-12-11 2006-05-09 Sun Bio, Inc. Monofunctional polyethylene glycol aldehydes
WO2003049699A2 (en) * 2001-12-11 2003-06-19 Sun Bio, Inc. Novel monofunctional polyethylene glycol aldehydes
US6956135B2 (en) 2001-12-11 2005-10-18 Sun Bio, Inc. Monofunctional polyethylene glycol aldehydes
US6916962B2 (en) 2001-12-11 2005-07-12 Sun Bio, Inc. Monofunctional polyethylene glycol aldehydes
CA2952488C (en) * 2002-01-18 2019-05-07 Biogen Ma Inc. Polyalkylene glycol with moiety for conjugating biologically active compounds
KR20050093856A (ko) 2002-09-09 2005-09-23 넥타르 테라퓨틱스 에이엘, 코포레이션 수용성 중합체 알카날
CA2511814C (en) 2002-12-26 2015-02-17 Mountain View Pharmaceuticals, Inc. Polymer conjugates of interferon-beta with enhanced biological potency
US20110165122A1 (en) * 2009-11-10 2011-07-07 The Regents Of The University Of California Method for targeted and sustained antiviral therapy

Also Published As

Publication number Publication date
HUE028163T2 (en) 2016-11-28
US8524660B2 (en) 2013-09-03
EA009783B1 (ru) 2008-04-28
SI3025726T1 (sl) 2020-03-31
PL372728A1 (en) 2005-08-08
EE200400105A (et) 2004-12-15
WO2003061577A8 (en) 2008-11-20
EP1476181A4 (en) 2008-11-19
MEP35608A (en) 2011-02-10
NO2017013I2 (no) 2018-08-20
CN101700401B (zh) 2013-08-14
JP5275125B2 (ja) 2013-08-28
HU230473B1 (hu) 2016-07-28
IS7353A (is) 2004-07-15
ES2566797T3 (es) 2016-04-15
US8017733B2 (en) 2011-09-13
CA2753899A1 (en) 2003-07-31
CA2952488C (en) 2019-05-07
EP3669887A1 (en) 2020-06-24
WO2003061577A3 (en) 2003-10-02
CY2016027I2 (el) 2017-06-28
EE05509B1 (et) 2012-02-15
DK1476181T3 (en) 2016-05-23
HK1072721A1 (zh) 2005-09-09
NZ534708A (en) 2007-05-31
RS63504A (en) 2007-02-05
PT3025726T (pt) 2020-01-09
CA2952488A1 (en) 2003-07-31
MXPA04006855A (es) 2005-04-19
BRPI0306993B8 (pt) 2021-05-25
CA2473526C (en) 2013-10-22
WO2003061577A2 (en) 2003-07-31
NO20043422L (no) 2004-10-11
EP3025726B1 (en) 2019-11-20
CY1122841T1 (el) 2021-10-29
CZ2004877A3 (cs) 2004-12-15
NO2017013I1 (no) 2017-04-10
IL163006A (en) 2011-01-31
EA200400962A1 (ru) 2005-06-30
BG108839A (bg) 2005-04-30
BRPI0306993B1 (pt) 2020-03-10
US20120014916A1 (en) 2012-01-19
ES2774801T3 (es) 2020-07-22
CN101700401A (zh) 2010-05-05
CA2840490A1 (en) 2003-07-31
PL213322B1 (pl) 2013-02-28
BR0306993A (pt) 2005-09-06
JP2016014022A (ja) 2016-01-28
CA2840490C (en) 2017-02-28
JP2013136756A (ja) 2013-07-11
CY2016027I1 (el) 2017-06-28
DK3025726T3 (da) 2019-12-09
EP3025726A1 (en) 2016-06-01
JP2005526151A (ja) 2005-09-02
PL397261A1 (pl) 2012-03-26
GEP20064024B (en) 2007-01-10
EA011829B1 (ru) 2009-06-30
NL300826I2 (US20030051240A1-20030313-M00001.png) 2017-03-16
EA200701386A1 (ru) 2007-10-26
IS2989B (is) 2017-11-15
CA2753899C (en) 2014-03-25
KR20040081463A (ko) 2004-09-21
CN1630530A (zh) 2005-06-22
KR100964411B1 (ko) 2010-06-15
ME00239B (me) 2011-05-10
CA2473526A1 (en) 2003-07-31
HK1143553A1 (en) 2011-01-07
EP1476181A2 (en) 2004-11-17
HUP0500457A2 (hu) 2005-08-29
JP6030717B2 (ja) 2016-11-24
HK1224185A1 (zh) 2017-08-18
ZA200406555B (en) 2005-11-30
RS55578B1 (sr) 2017-06-30
SI1476181T1 (sl) 2016-10-28
NO339857B1 (no) 2017-02-06
HUS1600035I1 (hu) 2016-10-28
JP2009235409A (ja) 2009-10-15
SK3102004A3 (sk) 2005-01-03
JP2012255156A (ja) 2012-12-27
NO20151082A1 (no) 2015-08-26
BE2016C040I2 (US20030051240A1-20030313-M00001.png) 2022-05-17
UA82184C2 (uk) 2008-03-25
NO344612B1 (no) 2020-02-10
US20050107277A1 (en) 2005-05-19
EP1476181B1 (en) 2016-03-23
BG66525B1 (bg) 2016-04-28
HUP0500457A3 (en) 2012-09-28
AU2003210564B2 (en) 2008-10-23
GEP20074024B (en) 2007-01-10
HUE047557T2 (hu) 2020-04-28

Similar Documents

Publication Publication Date Title
LU93162I2 (fr) Peginterféron bêta-1a ou un dérivé pharmaceutiquement acceptable de celui-ci (PLEGRIDY)
NO2015016I1 (no) Vorapaxar, eller et farmasøytisk akseptabelt salt eller solvat derav
DK1467789T3 (da) Lægemiddeldispenser
NO2009013I2 (no) Laropiprant eller et farmasøytisk akseptabelt saltderav
DE60029796D1 (de) Nichtklebrige latexgegenstände
DE60220542D1 (de) Fördereinrichtung
NO20033556D0 (no) Farmasöytiske preparater
DE60302699D1 (de) Fördergerät
EE200300416A (et) Ravimvorm
GB2388309B (en) Suction nozzle configuration
ATE424414T1 (de) Chimere somatostatin-dopamin-analoga
NO20035315D0 (no) Farmasöytiske kombinasjoner
DE50301246D1 (de) Fördereinrichtung
FR2801349B1 (fr) Compresseur a vis unique
ITVA20020024A0 (it) Prodotti per l'edilizia a base di idrossialchilguaro idrofobizzato purificato
ATE455748T1 (de) Vitamin-d-analoga
NO20020555L (no) Mikropartikler for lungeadministrering
DE60309784D1 (de) Vakuumschalter
DE50309273D1 (de) Fördervorrichtung
NO20032963D0 (no) Peptidforbindelser
IS7581A (is) Lyfjasamsetning
DE50207908D1 (de) Fördersystem
DE50005970D1 (de) Absaugvorrichtung
ITBO20000668A0 (it) Compressore a vite
NO20050436D0 (no) Beta-lagnedbrytende peptider