LU92702I2 - Naloxegol ou un sel pharmaceutiquement acceptable de celui-ci (moventig) - Google Patents

Naloxegol ou un sel pharmaceutiquement acceptable de celui-ci (moventig) Download PDF

Info

Publication number
LU92702I2
LU92702I2 LU92702C LU92702C LU92702I2 LU 92702 I2 LU92702 I2 LU 92702I2 LU 92702 C LU92702 C LU 92702C LU 92702 C LU92702 C LU 92702C LU 92702 I2 LU92702 I2 LU 92702I2
Authority
LU
Luxembourg
Prior art keywords
moventig
naloxegol
pharmaceutically acceptable
acceptable salt
salt
Prior art date
Application number
LU92702C
Other languages
English (en)
Original Assignee
Nektar Therapeutics
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34700098&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=LU92702(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Nektar Therapeutics filed Critical Nektar Therapeutics
Publication of LU92702I2 publication Critical patent/LU92702I2/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • C08G65/337—Polymers modified by chemical after-treatment with organic compounds containing other elements
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/04—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers only
    • C08G65/06—Cyclic ethers having no atoms other than carbon and hydrogen outside the ring
    • C08G65/08—Saturated oxiranes
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • C08G65/331—Polymers modified by chemical after-treatment with organic compounds containing oxygen
    • C08G65/332—Polymers modified by chemical after-treatment with organic compounds containing oxygen containing carboxyl groups, or halides, or esters thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • C08G65/333—Polymers modified by chemical after-treatment with organic compounds containing nitrogen
    • C08G65/33303—Polymers modified by chemical after-treatment with organic compounds containing nitrogen containing amino group
    • C08G65/33317—Polymers modified by chemical after-treatment with organic compounds containing nitrogen containing amino group heterocyclic
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • C08G65/333—Polymers modified by chemical after-treatment with organic compounds containing nitrogen
    • C08G65/33396—Polymers modified by chemical after-treatment with organic compounds containing nitrogen having oxygen in addition to nitrogen
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2203/00—Applications
    • C08L2203/02—Applications for biomedical use

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Polymers & Plastics (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Addiction (AREA)
  • Biomedical Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Obesity (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Psychiatry (AREA)
  • Medicinal Preparation (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polyethers (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
LU92702C 2003-12-16 2015-04-29 Naloxegol ou un sel pharmaceutiquement acceptable de celui-ci (moventig) LU92702I2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US53012203P 2003-12-16 2003-12-16
PCT/US2004/042661 WO2005058367A2 (fr) 2003-12-16 2004-12-16 Petites molecules chimiquement modifiees

Publications (1)

Publication Number Publication Date
LU92702I2 true LU92702I2 (fr) 2016-07-29

Family

ID=34700098

Family Applications (1)

Application Number Title Priority Date Filing Date
LU92702C LU92702I2 (fr) 2003-12-16 2015-04-29 Naloxegol ou un sel pharmaceutiquement acceptable de celui-ci (moventig)

Country Status (26)

Country Link
US (2) US7786133B2 (fr)
EP (3) EP1694363B1 (fr)
JP (1) JP4991312B2 (fr)
KR (1) KR101168620B1 (fr)
CN (3) CN1925875A (fr)
AU (2) AU2004299138B2 (fr)
CA (2) CA2758460C (fr)
CY (2) CY1114992T1 (fr)
DK (1) DK1694363T3 (fr)
EA (2) EA018427B1 (fr)
ES (3) ES2733764T3 (fr)
FR (1) FR15C0037I2 (fr)
HK (2) HK1146645A1 (fr)
HR (1) HRP20140361T1 (fr)
HU (1) HUS1500026I1 (fr)
IL (2) IL176317A (fr)
LT (1) LTC1694363I2 (fr)
LU (1) LU92702I2 (fr)
NL (1) NL300737I2 (fr)
NZ (3) NZ583573A (fr)
PL (1) PL1694363T3 (fr)
PT (1) PT1694363E (fr)
RS (1) RS53279B (fr)
SI (1) SI1694363T1 (fr)
WO (1) WO2005058367A2 (fr)
ZA (1) ZA200605763B (fr)

Families Citing this family (100)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090143328A1 (en) * 2001-08-13 2009-06-04 Mcdonald George Method of Treating Cancer by Administration of Topical Active Corticosteroids
CA2463938C (fr) 2001-10-18 2011-08-09 Nektar Therapeutics Al, Corporation Conjugues polymeres d'antagonistes opioides
CA2758460C (fr) 2003-12-16 2014-09-23 Nektar Therapeutics Methodes de preparation de compositions de reactifs oligo (ethylene glycol) monodisperses
US20060182692A1 (en) 2003-12-16 2006-08-17 Fishburn C S Chemically modified small molecules
TWI515007B (zh) 2006-01-05 2016-01-01 美國猶他大學研究基金會 改善以神經系統為標的之藥劑之性質之方法及組合物
DK1988910T3 (en) 2006-02-28 2018-01-22 Kodiak Sciences Inc ACRYLOYLOXYETHYLPHOSPHORYLCHOLINE-CONTAINING POLYMER CONJUGATES AND PREPARATION thereof
NZ572252A (en) * 2006-04-21 2011-09-30 Nektar Therapeutics Stereoselective reduction of a morphinone
MX2009004965A (es) * 2006-11-07 2009-06-05 Nektar Therapeutics Al Corp Formas de dosificacion y co-administracion de un agonista de opioides y un antagonista de opioides.
KR100829890B1 (ko) 2007-02-08 2008-05-16 주식회사 바이오폴리메드 신규한 레티놀 유도체, 이의 제조방법 및 이를 포함하는주름 개선용 화장료 조성물
US8389759B2 (en) 2007-03-12 2013-03-05 Nektar Therapeutics Oligomer-anticholinergic agent conjugates
WO2008112289A2 (fr) * 2007-03-12 2008-09-18 Nektar Therapeutics Conjugués d'oligomère-inhibiteur de protéase
US20100184989A1 (en) * 2007-03-12 2010-07-22 Nektar Therapeutics De Novo Synthesis of Conjugates
AU2014200906B2 (en) * 2007-03-12 2016-07-07 Nektar Therapeutics Oligomer-protease inhibitor conjugates
EP2121031B1 (fr) * 2007-03-12 2013-10-16 Nektar Therapeutics Conjugués d'oligomère antihistaminique
KR101568428B1 (ko) 2007-03-12 2015-11-11 넥타르 테라퓨틱스 올리고머―오피오이드 효능제 컨주게이트
US10512644B2 (en) 2007-03-12 2019-12-24 Inheris Pharmaceuticals, Inc. Oligomer-opioid agonist conjugates
WO2008112287A1 (fr) * 2007-03-12 2008-09-18 Nektar Therapeutics Conjugués d'oligomère bêtabloquant
US8173666B2 (en) 2007-03-12 2012-05-08 Nektar Therapeutics Oligomer-opioid agonist conjugates
US8748648B2 (en) 2007-09-06 2014-06-10 Nektar Therapeutics Oligomer-calcium channel blocker conjugates
US8741858B2 (en) 2007-09-21 2014-06-03 Zhongxu Ren Oligomer-nucleoside phosphate conjugates
US8796248B2 (en) * 2007-10-05 2014-08-05 Nektar Therapeutics Oligomer-corticosteroid conjugates
WO2009054916A2 (fr) * 2007-10-19 2009-04-30 Nektar Therapeutics Al, Corporation Conjugués d'oligomère de lidocaïne et leurs dérivés
US8853247B2 (en) * 2007-11-02 2014-10-07 Nektar Therapeutics Oligomer-nitroimidazole anti-infective conjugates
WO2009067175A2 (fr) * 2007-11-16 2009-05-28 Nektar Therapeutics Al, Corporation Conjugués oligomère-dantrolène et composés associés
MX2010005813A (es) * 2007-11-28 2010-06-15 Nektar Therapeutics Conjugados oligomero-triciclicos.
US20110009446A1 (en) * 2008-01-11 2011-01-13 Nektar Therapeutics Oligomer-guanidine class conjugates
US8685979B2 (en) 2008-01-25 2014-04-01 Nektar Therapeutics Oligomer-diarylpiperazine conjugates
US8829043B2 (en) 2008-02-08 2014-09-09 Nektar Therapeutics Oligome-cannabinoid conjugates
WO2009105258A1 (fr) 2008-02-22 2009-08-27 Nektar Therapeutics Al, Corporation Conjugués oligomères de nucléosides hétéropentacycliques
US9006219B2 (en) 2008-03-12 2015-04-14 Nektar Therapeutics Oligomer-foscarnet conjugates
US9095620B2 (en) * 2008-03-12 2015-08-04 Nektar Therapeutics Reagents
US20110059921A1 (en) * 2008-03-27 2011-03-10 Ektar Therapeutics Oligomer-Nitrogenous Base Conjugates
CN101998866A (zh) * 2008-04-11 2011-03-30 尼克塔治疗公司 低聚物-芳氧基-取代的丙胺共轭物
US9095621B2 (en) * 2008-04-25 2015-08-04 Nektar Therapeutics Oligome-bis-chromonyl compound conjugates
CN104524590B (zh) 2008-04-30 2019-06-21 伊缪诺金公司 交联剂和它们的用途
BRPI0912219A2 (pt) * 2008-05-07 2015-10-06 Nektar Therapeutics método, forma de dose unitária, e, antagonista de opióide oralmente administrável que atua perifericamente.
WO2009151590A2 (fr) * 2008-06-09 2009-12-17 Nektar Therapeutics Procédés de traitement de métaboliseurs alternatifs de cyp2d6
US20110237614A1 (en) * 2008-09-16 2011-09-29 Nektar Therapeutics Pegylated Opioids with Low Potential for Abuse
JP2012502906A (ja) * 2008-09-17 2012-02-02 ネクター セラピューティックス オリゴマー−プロテアーゼ阻害剤コンジュゲート
WO2010033219A2 (fr) 2008-09-17 2010-03-25 Nektar Therapeutics Inhibiteurs de protéases ayant des propriétés améliorées
CA2749126C (fr) * 2009-01-28 2017-08-22 Nektar Therapeutics Conjugues oligomere-phenothiazine
WO2010099200A1 (fr) 2009-02-24 2010-09-02 Nektar Therapeutics Conjugués oligomère-acides aminés
US8530492B2 (en) 2009-04-17 2013-09-10 Nektar Therapeutics Oligomer-protein tyrosine kinase inhibitor conjugates
US8816077B2 (en) 2009-04-17 2014-08-26 Nektar Therapeutics Oligomer-protein tyrosine kinase inhibitor conjugates
WO2010132693A2 (fr) 2009-05-13 2010-11-18 Nektar Therapeutics Composés pyrrolidine contenant un oligomère
EP2430003B1 (fr) * 2009-05-13 2019-02-27 Nektar Therapeutics Composés triazine aromatiques substitués contenant un oligomère
SI2437790T1 (sl) 2009-06-03 2019-07-31 Immunogen, Inc. Konjugacijske metode
JP2012530069A (ja) 2009-06-12 2012-11-29 ネクター セラピューティックス プロテアーゼ阻害剤、水溶性非ペプチドオリゴマーおよび親油性部分を含む共有結合体
CA2768392C (fr) 2009-07-21 2018-04-17 Nektar Therapeutics Conjugues oligomeres-agonistes opioides
CN105503889B (zh) * 2009-07-21 2019-12-24 尼克塔治疗公司 低聚物-阿片样激动剂轭合物
AU2010315805B2 (en) * 2009-09-29 2015-09-17 Nektar Therapeutics Oligomer-calcimimetic conjugates and related compounds
US8722732B2 (en) 2009-09-29 2014-05-13 Nektar Therapeutics Oligomer-calcimimetic conjugates and related compounds
US8765432B2 (en) 2009-12-18 2014-07-01 Oligasis, Llc Targeted drug phosphorylcholine polymer conjugates
US20130023553A1 (en) 2010-01-12 2013-01-24 Nektar Therapeutics Pegylated opioids with low potential for abuse and side effects
WO2011091050A1 (fr) 2010-01-19 2011-07-28 Nektar Therapeutics Conjugués oligomères-tricycliques
WO2011103559A1 (fr) * 2010-02-22 2011-08-25 Nektar Therapeutics Composés diaromatiques substitués modifiés par un oligomère
US20160015656A2 (en) * 2010-08-05 2016-01-21 Nitto Denko Corporation Composition for regenerating normal tissue from fibrotic tissue
US9012469B2 (en) * 2010-09-30 2015-04-21 Astrazeneca Ab Crystalline naloxol-peg conjugate
US9226971B2 (en) 2010-10-15 2016-01-05 Nektar Therapeutics N-optionally substituted aryl-2-oligomer-3-alkoxypropionamides
US9090535B2 (en) 2010-12-10 2015-07-28 Nektar Therapeutics Hydroxylated tricyclic compounds
WO2012082995A1 (fr) 2010-12-15 2012-06-21 Nektar Therapeutics Composés d'hydantoïne contenant un oligomère
AU2011343822B2 (en) * 2010-12-15 2017-06-29 Neuroadjuvants, Inc. Neuropeptide analogs, compositions, and methods for treating pain
WO2012083153A1 (fr) 2010-12-16 2012-06-21 Nektar Therapeutics Composés comprenant une fraction apremilast et contenant un oligomère
US9943605B2 (en) 2010-12-23 2018-04-17 Nektar Therapeutics Polymer-semaxanib moiety conjugates
US10525054B2 (en) 2011-11-07 2020-01-07 Inheris Biopharma, Inc. Compositions, dosage forms, and co-administration of an opioid agonist compound and an analgesic compound
CN103906522B (zh) 2011-11-07 2017-04-12 尼克塔治疗公司 阿片激动剂化合物和止痛化合物的组合物、剂型以及共给药
CN103289075B (zh) * 2012-02-22 2016-01-20 天津键凯科技有限公司 聚乙二醇与纳洛酮的结合物及其药物组合物和应用
JP6265998B2 (ja) 2012-09-17 2018-01-24 ネクター セラピューティクス オリゴマー含有ベンズアミド系化合物
US10131682B2 (en) 2012-11-24 2018-11-20 Hangzhou Dac Biotech Co., Ltd. Hydrophilic linkers and their uses for conjugation of drugs to a cell binding molecules
US9789198B2 (en) * 2013-05-31 2017-10-17 Jenkem Technology Co., Ltd. (Tianjin) Low molecular weight polyethylene glycol drug conjugates having improved drug biological activity
CN104208715B (zh) 2013-05-31 2016-12-28 天津键凯科技有限公司 具有提高的药物生物活性的低分子量聚乙二醇药物结合物
JP6577943B2 (ja) 2013-06-28 2019-09-18 ネクター セラピューティクス κオピオイド作動薬及びその使用
SI3041513T1 (sl) 2013-09-08 2020-11-30 Kodiak Sciences Inc. Zwitterionski polimerni konjugati faktorja VIII
EP3074379B1 (fr) 2013-11-27 2019-06-26 Nektar Therapeutics (India) Pvt. Ltd. Agonistes opioïdes et leurs utilisations
CA2875384A1 (fr) 2013-12-20 2015-06-20 AntiOP, Inc. Compositions de naxlone intranasales et procedes de fabrication et d'utilisation de celles-ci
CN114262344A (zh) 2014-02-28 2022-04-01 杭州多禧生物科技有限公司 带电荷链接体及其在共轭反应上的应用
US9840553B2 (en) 2014-06-28 2017-12-12 Kodiak Sciences Inc. Dual PDGF/VEGF antagonists
WO2016004321A1 (fr) * 2014-07-03 2016-01-07 Board Of Regents, The University Of Texas System Composés pour traiter une infection à biofilm
JP6849590B2 (ja) 2014-10-17 2021-03-24 コディアック サイエンシーズ インコーポレイテッドＫｏｄｉａｋ Ｓｃｉｅｎｃｅｓ Ｉｎｃ． ブチリルコリンエステラーゼ両性イオン性ポリマーコンジュゲート
GB2545368B (en) * 2014-10-20 2021-04-21 Elysium Therapeutics Inc Diversion-resistant opioid formulations
CN104473927A (zh) * 2014-12-05 2015-04-01 北京键凯科技有限公司 一种聚乙二醇与药物分子结合物及其制备方法
US10322107B2 (en) 2014-12-23 2019-06-18 Nektar Therapeutics N-methyl-N-(1-phenyl-2-(1-pyrrolidinyl)ethyl)-2-aminophenylacetamide derivatives agonists for the kappa opioid receptor
US10766864B2 (en) 2015-05-08 2020-09-08 Nektar Therapeutics Morphinan derivatives for the treatment of neuropathic pain
CA2991973C (fr) 2015-07-12 2021-12-07 Suzhou M-Conj Biotech Co., Ltd. Lieurs de pontage pour la conjugaison d'une molecule de liaison cellulaire
US9839687B2 (en) 2015-07-15 2017-12-12 Suzhou M-Conj Biotech Co., Ltd. Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule
CN108712911A (zh) 2015-12-30 2018-10-26 科达制药股份有限公司 抗体及其缀合物
CN107033154B (zh) * 2016-02-02 2020-02-04 上海瀚迈生物医药科技有限公司 阿片受体拮抗剂缀合物及其应用
CN107033155B (zh) * 2016-02-04 2019-04-26 国药集团国瑞药业有限公司 一种吗啡酮类化合物的立体选择性还原方法
EP3228307A1 (fr) 2016-04-05 2017-10-11 Sandoz Ag Solid dispersion contenant des antagonistes opioides
KR20220150408A (ko) 2016-11-14 2022-11-10 항저우 디에이씨 바이오테크 씨오, 엘티디 결합 링커, 그러한 결합 링커를 함유하는 세포 결합 분자-약물 결합체, 링커를 갖는 그러한 결합체의 제조 및 사용
US11077103B2 (en) 2016-11-23 2021-08-03 Aurobindo Pharma Ltd. Naloxegol oxalate and solid dispersion thereof
US11419946B2 (en) 2017-03-30 2022-08-23 Nof Corporation Heterobifunctional monodispersed polyethylene glycol and conjugate using same
EP3604384B1 (fr) 2017-03-30 2021-09-08 NOF Corporation Dérivé de polymère hydrophile comportant un coupleur acétal auto-immolable et composite l'utilisant
CN109134479A (zh) * 2017-06-27 2019-01-04 石家庄蒎格医药科技有限公司 结晶聚乙二醇纳洛酮草酸盐及制备方法
WO2019058387A1 (fr) * 2017-09-19 2019-03-28 Msn Laboratories Private Limited, R&D Center Procédé amélioré de préparation de (5α,6α)-17-allyl-6-(2,5,8,11,14,17,20-heptaoxadocosan-22-yloxy) -4,5-époxymorphinane-3,14-diol et de ses sels pharmaceutiquement acceptables
JP7204078B2 (ja) 2018-03-13 2023-01-16 日油株式会社 主鎖および側鎖に単分散ポリエチレングリコールを有するヘテロ二官能性化合物
WO2021060439A1 (fr) 2019-09-26 2021-04-01 日油株式会社 Polyéthylène glycol monodispersé hétérobifonctionnel ayant un lieur peptidique
JP2022553640A (ja) 2019-10-10 2022-12-26 コディアック サイエンシーズ インコーポレイテッド 眼障害を処置する方法
CN113827576B (zh) * 2021-11-17 2023-08-01 北京尚修堂医药科技有限公司 一种活性成分为草酸纳洛解的药物组合物及制备方法
WO2024134619A1 (fr) 2022-12-23 2024-06-27 Sintalica S.R.L. Composés de tryptamine non hallucinogènes, préparation, compositions pharmaceutiques et leurs utilisations

Family Cites Families (91)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4223163A (en) * 1976-12-10 1980-09-16 The Procter & Gamble Company Process for making ethoxylated fatty alcohols with narrow polyethoxy chain distribution
US4366159A (en) * 1981-09-08 1982-12-28 Michael Richard Magruder Nalbuphine-narcotic analgesic composition and method of producing analgesia
FR2514644A1 (fr) 1981-10-19 1983-04-22 Sanofi Sa Composition pharmaceutique a action antagoniste peripherique des opiaces
US4587046A (en) * 1982-05-18 1986-05-06 The Regents Of The University Of California Drug-carrier conjugates
DE3675588D1 (de) * 1985-06-19 1990-12-20 Ajinomoto Kk Haemoglobin, das an ein poly(alkenylenoxid) gebunden ist.
US4806556A (en) * 1985-12-12 1989-02-21 Regents Of The University Of Minnesota Gut-selective opiates
US4730048A (en) * 1985-12-12 1988-03-08 Regents Of The University Of Minnesota Gut-selective opiates
US4719215A (en) * 1986-03-07 1988-01-12 University Of Chicago Quaternary derivatives of noroxymorphone which relieve nausea and emesis
US4861781A (en) * 1986-03-07 1989-08-29 The University Of Chicago Quaternary derivatives of noroxymorphone which relieve nausea and emesis
US4801575A (en) * 1986-07-30 1989-01-31 The Regents Of The University Of California Chimeric peptides for neuropeptide delivery through the blood-brain barrier
US5080891A (en) * 1987-08-03 1992-01-14 Ddi Pharmaceuticals, Inc. Conjugates of superoxide dismutase coupled to high molecular weight polyalkylene glycols
JPH01207320A (ja) 1988-02-15 1989-08-21 Daicel Chem Ind Ltd 芳香族ポリエーテルの製造方法
IT1216687B (it) * 1988-04-01 1990-03-08 Boehringer Biochemia Srl Complessi di platino (ii), loro preparazione e impiego come antitumorali.
US5102887A (en) * 1989-02-17 1992-04-07 Arch Development Corporation Method for reducing emesis and nausea induced by the administration of an emesis causing agent
ES2104566T3 (es) * 1989-03-10 1997-10-16 Hoffmann La Roche Reactivos para la determinacion de drogas.
US5324844A (en) * 1989-04-19 1994-06-28 Enzon, Inc. Active carbonates of polyalkylene oxides for modification of polypeptides
US5122614A (en) * 1989-04-19 1992-06-16 Enzon, Inc. Active carbonates of polyalkylene oxides for modification of polypeptides
JPH0383914A (ja) * 1989-08-18 1991-04-09 W R Grace & Co ドラッグキャリアー
DE3937797A1 (de) * 1989-11-14 1991-05-16 Basf Ag Verfahren zur herstellung von polyetherglykolen
US5130126A (en) * 1990-07-09 1992-07-14 Nippon Oil & Fats Co., Ltd. Polymer-drug conjugate and a method of producing it
IE912365A1 (en) * 1990-07-23 1992-01-29 Zeneca Ltd Continuous release pharmaceutical compositions
JP2829794B2 (ja) * 1991-02-08 1998-12-02 エスエス製薬 株式会社 徐放性経口投与型プラノプロフェン製剤
US5159081A (en) 1991-03-29 1992-10-27 Eli Lilly And Company Intermediates of peripherally selective n-carbonyl-3,4,4-trisubstituted piperidine opioid antagonists
US5270328A (en) 1991-03-29 1993-12-14 Eli Lilly And Company Peripherally selective piperidine opioid antagonists
US5250542A (en) * 1991-03-29 1993-10-05 Eli Lilly And Company Peripherally selective piperidine carboxylate opioid antagonists
WO1993024476A1 (fr) 1992-06-04 1993-12-09 Clover Consolidated, Limited Vehicules polymeres solubles dans l'eau servant a la liberation de medicaments
GB9316895D0 (en) * 1993-08-13 1993-09-29 Guy S And St Thomas Hospitals Hepatoselective insulin analogues
EP0599303A3 (fr) * 1992-11-27 1998-07-29 Takeda Chemical Industries, Ltd. Conjugués peptidiques
US5298643A (en) * 1992-12-22 1994-03-29 Enzon, Inc. Aryl imidate activated polyalkylene oxides
US5321095A (en) * 1993-02-02 1994-06-14 Enzon, Inc. Azlactone activated polyalkylene oxides
US5298410A (en) * 1993-02-25 1994-03-29 Sterling Winthrop Inc. Lyophilized formulation of polyethylene oxide modified proteins with increased shelf-life
ES2122261T3 (es) * 1993-03-17 1998-12-16 Minnesota Mining & Mfg Formulacion de aerosol que contiene un adyuvante de dispersion derivado de un ester, una amida o un mercaptoester.
AU7113594A (en) * 1993-06-21 1995-01-17 Enzon, Inc. Site specific synthesis of conjugated peptides
US5643575A (en) * 1993-10-27 1997-07-01 Enzon, Inc. Non-antigenic branched polymer conjugates
US5434171A (en) 1993-12-08 1995-07-18 Eli Lilly And Company Preparation of 3,4,4-trisubstituted-piperidinyl-N-alkylcarboxylates and intermediates
US5693609A (en) 1994-11-17 1997-12-02 Eli Lilly And Company Acylated insulin analogs
US5932462A (en) 1995-01-10 1999-08-03 Shearwater Polymers, Inc. Multiarmed, monofunctional, polymer for coupling to molecules and surfaces
US5670477A (en) * 1995-04-20 1997-09-23 Joseph F. Poduslo Method to enhance permeability of the blood/brain blood/nerve bariers to therapeutic agents
AU712713B2 (en) 1995-06-07 1999-11-11 Affymax Technologies N.V. Compounds and peptides that bind to the erythropoietin receptor
US5672662A (en) 1995-07-07 1997-09-30 Shearwater Polymers, Inc. Poly(ethylene glycol) and related polymers monosubstituted with propionic or butanoic acids and functional derivatives thereof for biotechnical applications
AU730969B2 (en) 1995-10-19 2001-03-22 University Of Washington Discrete-length polyethylene glycols
US5639705A (en) * 1996-01-19 1997-06-17 Arco Chemical Technology, L.P. Double metal cyanide catalysts and methods for making them
PT914097E (pt) * 1996-03-12 2002-06-28 Alza Corp Composicao e forma de dosagem compreendendo antagonista de opioide
US5856369A (en) 1996-07-30 1999-01-05 Osi Specialties, Inc. Polyethers and polysiloxane copolymers manufactured with double metal cyanide catalysts
DE19632440A1 (de) 1996-08-12 1998-02-19 Basf Ag Verfahren zur Herstellung von aus Polykationen aufgebauten, geformten Mischhydroxiden
US6214966B1 (en) * 1996-09-26 2001-04-10 Shearwater Corporation Soluble, degradable poly(ethylene glycol) derivatives for controllable release of bound molecules into solution
DE19651551C2 (de) * 1996-12-11 2000-02-03 Klinge Co Chem Pharm Fab Opioidantagonisthaltige galenische Formulierung
US6011008A (en) * 1997-01-08 2000-01-04 Yissum Research Developement Company Of The Hebrew University Of Jerusalem Conjugates of biologically active substances
GB9703044D0 (en) * 1997-02-14 1997-04-02 Glaxo Group Ltd Phenyl xanthine esters and amides
US6565885B1 (en) * 1997-09-29 2003-05-20 Inhale Therapeutic Systems, Inc. Methods of spray drying pharmaceutical compositions
US5972954A (en) * 1997-11-03 1999-10-26 Arch Development Corporation Use of methylnaltrexone and related compounds
EP1037649B1 (fr) * 1997-12-17 2009-09-30 Enzon, Inc. Prodrogues polymeriques d'agents bioactifs contenant amine ou hydroxy
US6624142B2 (en) 1997-12-30 2003-09-23 Enzon, Inc. Trimethyl lock based tetrapartate prodrugs
WO1999045964A1 (fr) 1998-03-12 1999-09-16 Shearwater Polymers, Incorporated Derives de poly(ethylene glycol) avec groupes reactifs proximaux
WO1999050240A1 (fr) * 1998-03-30 1999-10-07 Lg Chemical Ltd. Derives de retinamide polyethoxyles et leur procede de preparation
US6703381B1 (en) * 1998-08-14 2004-03-09 Nobex Corporation Methods for delivery therapeutic compounds across the blood-brain barrier
EP0995757A3 (fr) * 1998-08-26 2002-05-22 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Inhibiteurs bivalentes de la proteasome
US7060708B2 (en) 1999-03-10 2006-06-13 New River Pharmaceuticals Inc. Active agent delivery systems and methods for protecting and administering active agents
KR100345214B1 (ko) 1999-08-17 2002-07-25 이강춘 생체적합성 고분자가 수식된 펩타이드의 비점막 전달
US6380405B1 (en) * 1999-09-13 2002-04-30 Nobex Corporation Taxane prodrugs
US6541508B2 (en) * 1999-09-13 2003-04-01 Nobex Corporation Taxane prodrugs
US6713454B1 (en) * 1999-09-13 2004-03-30 Nobex Corporation Prodrugs of etoposide and etoposide analogs
US6451806B2 (en) * 1999-09-29 2002-09-17 Adolor Corporation Methods and compositions involving opioids and antagonists thereof
KR100702878B1 (ko) * 1999-10-29 2007-04-04 넥타르 테라퓨틱스 개선된 분산성을 갖는 건조 분말 조성물
JP4861586B2 (ja) * 1999-12-22 2012-01-25 ネクター セラピューティックス 水溶性ポリマーの立体的に妨害される誘導体
US6413507B1 (en) * 1999-12-23 2002-07-02 Shearwater Corporation Hydrolytically degradable carbamate derivatives of poly (ethylene glycol)
WO2001062299A2 (fr) 2000-02-28 2001-08-30 Shearwater Corporation Conjugues polymeres hydrosolubles d'acide artelinique
CA2403252A1 (fr) 2000-03-15 2001-09-20 Wolfgang Sadee Antagonistes neutres et utilisation de ces derniers dans le traitement de l'abus des drogues
IL154536A0 (en) * 2000-08-29 2003-09-17 Nobex Corp Immunoregulatory compounds and derivatives and methods of treating diseases therewith
US7829074B2 (en) * 2001-10-18 2010-11-09 Nektar Therapeutics Hydroxypatite-targeting poly(ethylene glycol) and related polymers
JP2004514701A (ja) 2000-11-30 2004-05-20 ネクター　セラピューティクス　エーエル，コーポレイション トリアジン誘導体の水溶性ポリマー複合体
PT1349855E (pt) * 2000-12-22 2006-12-29 Smithkline Beecham Plc Sal misilato de 5-{4-[2-(n-metil-n-(2-piridil)amino)etoxi]benzil}tiazolidino-2, 4-diona
CA2437989A1 (fr) * 2001-02-20 2002-08-29 Enzon, Inc. Lieurs polymeres a terminaisons ramifiees, et conjugues polymeres en contenant
US20020169125A1 (en) * 2001-03-21 2002-11-14 Cell Therapeutics, Inc. Recombinant production of polyanionic polymers and uses thereof
US6858580B2 (en) * 2001-06-04 2005-02-22 Nobex Corporation Mixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6828305B2 (en) * 2001-06-04 2004-12-07 Nobex Corporation Mixtures of growth hormone drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6835802B2 (en) 2001-06-04 2004-12-28 Nobex Corporation Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties
US6713452B2 (en) * 2001-06-04 2004-03-30 Nobex Corporation Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6756354B2 (en) * 2001-09-05 2004-06-29 Deanna Jean Nelson Therapeutic compositions containing oligo (ethylene glycol)-terminated 1,2-dithiolanes and their conjugates
CA2463938C (fr) * 2001-10-18 2011-08-09 Nektar Therapeutics Al, Corporation Conjugues polymeres d'antagonistes opioides
EP1441772A2 (fr) 2001-10-29 2004-08-04 Nektar Therapeutics Al, Corporation Conjugues polymeres d'inhibiteurs de proteine kinease c
ATE359829T1 (de) * 2001-10-30 2007-05-15 Nektar Therapeutics Al Corp Wasserlösliche polymerkonjugate von retinoesäure
EP1501352B1 (fr) 2001-12-14 2015-02-18 The University Of Wyoming Liberation controlee de l'oxycodone
EP2316468A1 (fr) 2002-02-22 2011-05-04 Shire LLC Système de distribution et méthodes de protection et d'administration de dextroamphetamine
WO2004043396A2 (fr) 2002-11-09 2004-05-27 Nobex Corporation Promedicaments contenant du carbamate modifie et methodes de synthese de ces derniers
JP2006520392A (ja) * 2003-03-13 2006-09-07 コントロールド・ケミカルズ・インコーポレーテッド 薬物の乱用可能性を低下させ且つ作用持続時間を延長する化合物および方法
GB0317815D0 (en) * 2003-07-30 2003-09-03 Amersham Health As Imaging agents
US7335751B2 (en) 2003-08-01 2008-02-26 Biocon Limited Aryl carbamate oligomers for hydrolyzable prodrugs and prodrugs comprising same
CA2547140A1 (fr) * 2003-11-24 2005-06-09 Neose Technologies, Inc. Erythropoietine glycopegylee
CA2758460C (fr) 2003-12-16 2014-09-23 Nektar Therapeutics Methodes de preparation de compositions de reactifs oligo (ethylene glycol) monodisperses
NZ572252A (en) * 2006-04-21 2011-09-30 Nektar Therapeutics Stereoselective reduction of a morphinone

Also Published As

Publication number Publication date
LTC1694363I2 (lt) 2017-05-10
CA2758460A1 (fr) 2005-06-30
EP2905033A1 (fr) 2015-08-12
CN101805343B (zh) 2014-04-16
ZA200605763B (en) 2007-04-25
AU2004299138A1 (en) 2005-06-30
US7786133B2 (en) 2010-08-31
JP2007514761A (ja) 2007-06-07
IL176317A (en) 2014-01-30
HRP20140361T1 (hr) 2014-05-23
EP2905033B1 (fr) 2020-09-02
US20050136031A1 (en) 2005-06-23
RS53279B (en) 2014-08-29
IL229509A0 (en) 2013-12-31
CN1925875A (zh) 2007-03-07
FR15C0037I1 (fr) 2015-06-26
US8034825B2 (en) 2011-10-11
EP2604282B1 (fr) 2019-06-19
ES2445585T3 (es) 2014-03-04
CA2758460C (fr) 2014-09-23
IL176317A0 (en) 2006-10-05
AU2010202277A1 (en) 2010-06-24
CN102895666A (zh) 2013-01-30
ES2817799T3 (es) 2021-04-08
DK1694363T3 (en) 2014-03-24
CN102895666B (zh) 2015-08-19
JP4991312B2 (ja) 2012-08-01
CA2549730A1 (fr) 2005-06-30
ES2733764T3 (es) 2019-12-02
CY1114992T1 (el) 2016-12-14
EA200601167A1 (ru) 2006-12-29
HUS1500026I1 (hu) 2017-10-30
FR15C0037I2 (fr) 2016-09-30
HK1210418A1 (en) 2016-04-22
EP1694363B1 (fr) 2014-01-22
CY2015019I1 (el) 2016-12-14
KR101168620B1 (ko) 2012-08-03
PT1694363E (pt) 2014-02-20
PL1694363T3 (pl) 2014-07-31
US20100305147A1 (en) 2010-12-02
CY2015019I2 (el) 2016-12-14
WO2005058367A3 (fr) 2006-03-30
EA201000994A3 (ru) 2011-10-31
NZ594834A (en) 2013-03-28
EA015333B1 (ru) 2011-06-30
AU2010202277B2 (en) 2013-03-21
EA018427B1 (ru) 2013-07-30
CN101805343A (zh) 2010-08-18
NZ583573A (en) 2011-12-22
SI1694363T1 (sl) 2014-03-31
WO2005058367A2 (fr) 2005-06-30
HK1146645A1 (en) 2011-06-24
EP1694363A2 (fr) 2006-08-30
NL300737I2 (fr) 2017-01-31
KR20060126714A (ko) 2006-12-08
EA201000994A2 (ru) 2011-08-30
IL229509A (en) 2016-05-31
NZ548529A (en) 2010-08-27
EP2604282A1 (fr) 2013-06-19
AU2004299138B2 (en) 2010-03-25
CA2549730C (fr) 2012-02-14

Similar Documents

Publication Publication Date Title
LU92702I2 (fr) Naloxegol ou un sel pharmaceutiquement acceptable de celui-ci (moventig)
LU93320I2 (fr) Everolimus ou un sel pharmaceutiquement acceptable de celui-ci
LU93327I2 (fr) Opicapone ou un sel pharmaceutiquement acceptable de celui-ci
LU92890I2 (fr) Panobinstat ou un sel pharmaceutiquement acceptable, ou un dérivé de celui-ci (farydak)
LU92684I2 (fr) Fidaxomicine ou son sel pharmaceutiquement acceptable
LU93266I2 (fr) Sélexipag ou un sel de celui-ci
LU92439I2 (fr) Vilanterol ou un sel ou un solvate de celui-ci
LU92446I2 (fr) Dolutégravir ou un sel ou solvate pharmaceutiquement acceptable de celui-ci, y compris de dolutégravir de sodium
NO2015016I1 (no) Vorapaxar, eller et farmasøytisk akseptabelt salt eller solvat derav
LU92701I2 (fr) Pasiréotide ou un sel pharmaceutiquement acceptable qui en dérive ou un hydrate qui en dérive
EG23424A (en) Fungicidal azo-carboxamide derivatives.
LU92512I2 (fr) Afoxolaner, ou un oxyde nitrique de celui-ci, ou un sel pharmaceutiquement acceptable de celui-ci
ATE406162T1 (de) Pramipexol-tablette mit verzögerter wirkstoffabgabe
EP1663113A4 (fr) Sulfonamides substitues
DE60317391D1 (de) Verbinder
ATE325420T1 (de) Übertrager
DE60301239D1 (de) Verbinder
DE60315937D1 (de) Verbinder
DE60208885D1 (de) Verbinder
DE60223352D1 (de) Verbinder
FI5838U1 (fi) Kuori
FR2856663B1 (fr) Capsule de bouchage a vis amelioree
DE50304722D1 (de) Fungizide Wirkstoffkombinationen
DE10301279B8 (de) Verbinder
DE60218623D1 (de) Verbinder