LU90408I2 - Regranex-becaplermin - Google Patents

Regranex-becaplermin

Info

Publication number
LU90408I2
LU90408I2 LU90408C LU90408C LU90408I2 LU 90408 I2 LU90408 I2 LU 90408I2 LU 90408 C LU90408 C LU 90408C LU 90408 C LU90408 C LU 90408C LU 90408 I2 LU90408 I2 LU 90408I2
Authority
LU
Luxembourg
Prior art keywords
pdgf
chain
factor
secretion
gene
Prior art date
Application number
LU90408C
Other languages
English (en)
Original Assignee
Zymogenetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45478613&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=LU90408(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US06/660,496 external-priority patent/US4769328A/en
Application filed by Zymogenetics Inc filed Critical Zymogenetics Inc
Publication of LU90408I2 publication Critical patent/LU90408I2/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/49—Platelet-derived growth factor [PDGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/036—Fusion polypeptide containing a localisation/targetting motif targeting to the medium outside of the cell, e.g. type III secretion
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/11011—Alpharetrovirus, e.g. avian leucosis virus
    • C12N2740/11022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/12—Growth hormone, growth factor other than t-cell or b-cell growth factor, and growth hormone releasing factor; related peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/22—Viral peptide or viral protein
    • Y10S930/221—Retrovirus related, or human immunodeficiency virus related, or simian immunodeficiency virus related

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Mycology (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Virology (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Diaphragms For Electromechanical Transducers (AREA)
  • Dry Formation Of Fiberboard And The Like (AREA)
LU90408C 1984-10-12 1999-06-25 Regranex-becaplermin LU90408I2 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US06/660,496 US4769328A (en) 1984-10-12 1984-10-12 Expression of biologically active PDGF analogs in yeast
US06/705,175 US4801542A (en) 1984-10-12 1985-02-25 Expression of biologically active PDGF analogs in eucaryotic cells
CA000492370A CA1340212C (fr) 1984-10-12 1985-10-07 Expression, dans des cellules eucaryotes, d'analogues de facteurs de croissance derives de plaquettes biologiquement actives
CA 617115 CA1340846E (fr) 1984-10-12 1999-06-11 Expression, dans des cellules eucaryotes, d'analogues de facteurs de croissance derives de plaquettes biologiquement actives

Publications (1)

Publication Number Publication Date
LU90408I2 true LU90408I2 (fr) 1999-08-25

Family

ID=45478613

Family Applications (1)

Application Number Title Priority Date Filing Date
LU90408C LU90408I2 (fr) 1984-10-12 1999-06-25 Regranex-becaplermin

Country Status (9)

Country Link
US (1) US4801542A (fr)
EP (1) EP0177957B2 (fr)
JP (2) JP2837407B2 (fr)
AT (2) ATE188255T1 (fr)
AU (2) AU4845485A (fr)
CA (2) CA1340212C (fr)
DE (4) DE3588218T2 (fr)
LU (1) LU90408I2 (fr)
NL (1) NL990016I2 (fr)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0259632B1 (fr) * 1986-08-13 1995-12-13 Zymogenetics, Inc. Expression d'analogues de PDGF biologiquement actifs dans des cellules eucaryotiques
US5474982A (en) * 1986-08-13 1995-12-12 Zymogenetics, Inc. PDGF analogs and methods of use
US5019559A (en) * 1986-11-14 1991-05-28 President And Fellows Of Harvard College Wound healing using PDGF and IGF-II
JPH01502669A (ja) 1987-03-13 1989-09-14 アムジエン・インコーポレーテツド 精製された血小板由来の成長因子及びその精製方法
DE3855504T2 (de) * 1987-04-22 1997-01-23 Chiron Corp Rekombinante Herstellung von A-Ketten-Polypeptiden von PDGF
US5219759A (en) * 1987-04-22 1993-06-15 Chiron Corporation Recombinant DNA encoding PDGF A-chain polypeptide and expression vectors
US6939849B1 (en) 1987-04-22 2005-09-06 Chiron Corporation Recombinant PDGF A-chain homodimers and methods of use
US5094941A (en) * 1987-12-31 1992-03-10 Zymogenetics, Inc. Monoclonal antibodies to PDGF
US5759815A (en) * 1988-02-11 1998-06-02 Creative Biomolecules, Inc. Production of platelet derived growth factor (PDGF) an muteins thereof
JP2892726B2 (ja) * 1988-06-30 1999-05-17 コア セラピューティクス，インコーポレイティド 血小板阻止ペプチド
US5037743A (en) * 1988-08-05 1991-08-06 Zymogenetics, Inc. BAR1 secretion signal
DE3900770A1 (de) * 1989-01-12 1990-07-26 Juergen Prof Dr Hoppe Verfahren zur herstellung von pdgf-a und pdgf-aa
US6899882B1 (en) 1989-03-24 2005-05-31 The Regents Of The University Of California Endothelial cell growth factor methods of isolation and expression
US5686410A (en) * 1989-07-20 1997-11-11 Novartis Ag Polypeptide derivatives
US5219739A (en) * 1989-07-27 1993-06-15 Scios Nova Inc. DNA sequences encoding bVEGF120 and hVEGF121 and methods for the production of bovine and human vascular endothelial cell growth factors, bVEGF120 and hVEGF121
US5272064A (en) * 1989-12-19 1993-12-21 Amgen Inc. DNA molecules encoding platelet-derived growth factor B chain analogs and method for expression thereof
US6172039B1 (en) 1990-04-16 2001-01-09 Apex Bioscience, Inc. Expression of recombinant hemoglobin and hemoglobin variants in yeast
ATE107665T1 (de) * 1990-07-23 1994-07-15 Zymogenetics Inc Proteaseresistenter pdgf und dessen verwendungen.
US5886141A (en) * 1990-10-26 1999-03-23 Takeda Chemical Industries, Ltd. Smooth muscle mitogen peptides and DNA coding therefor
GB9101645D0 (en) * 1991-01-25 1991-03-06 British Bio Technology Compounds
ATE145939T1 (de) * 1992-02-10 1996-12-15 Takeda Chemical Industries Ltd Mitogen für die glatte muskulatur und dessen kodierende dns
EP1486565B1 (fr) * 1995-10-11 2007-11-21 Novartis Vaccines and Diagnostics, Inc. Combinaison de PDGF, de KGF, d'IGF et d'IGFBP pour guérir les blessures
US6017731A (en) * 1996-12-13 2000-01-25 Chiron Corporation Method for expression of heterologous proteins in yeast
ATE374247T1 (de) 1997-10-14 2007-10-15 Darwin Molecular Corp Thymidinkinase mutanten und fusionproteine mit thymidinkinase und guanylatekinase aktivitäten
US6194169B1 (en) * 1998-06-04 2001-02-27 The University Of Kentucky Research Foundation Enhanced expression of human platelet-derived growth factor in Pichia pastoris
US20040009535A1 (en) 1998-11-27 2004-01-15 Celltech R&D, Inc. Compositions and methods for increasing bone mineralization
EP1133558B2 (fr) 1998-11-27 2016-04-13 UCB Pharma S.A. Compositions et methodes d'augmentation de la mineralisation de la substance osseuse
US7063850B1 (en) * 1998-12-22 2006-06-20 University Of Tennessee Research Foundation Protective antigen of group A Streptococci
US6358733B1 (en) 2000-05-19 2002-03-19 Apolife, Inc. Expression of heterologous multi-domain proteins in yeast
JP4353701B2 (ja) 2001-05-08 2009-10-28 ダーウィン モレキュラー コーポレイション Ｆｏｘｐ３蛋白質を用いた霊長類における免疫機能の調節方法
JP2005523000A (ja) * 2001-10-26 2005-08-04 アイディー バイオメディカル コーポレイション オブ ワシントン 多価連鎖球菌性ワクチン組成物および使用方法
US20050158296A1 (en) 2002-01-11 2005-07-21 Starr Christopher M. Use of p97 as an enzyme delivery system for the delivery of therapeutic lysosomal enzymes
US20030139333A1 (en) * 2002-01-18 2003-07-24 Genetix Pharmaceuticals, Inc. Methods and compositions for promoting angiogenesis
US20050048041A1 (en) * 2003-01-13 2005-03-03 Rao Mahendra S. Persistent expression of candidate molecule in proliferating stem and progenitor cells for delivery of therapeutic products
WO2008005533A2 (fr) * 2006-07-06 2008-01-10 Aaron Thomas Tabor Compositions et procédés de modification génétique de cellules ayant une fonction cosmétique pour l'amélioration de l'aspect cosmétique
EP2094301A4 (fr) * 2006-11-30 2012-02-01 Taplmmune Inc Traitement des poxviridae comportant tap-1 et/ou tap-2 en tant qu'adjuvant moléculaire
WO2011008904A1 (fr) 2009-07-17 2011-01-20 Tabor Aaron T Compositions et procédés pour la modification génétique de cellules ayant une fonction cosmétique afin d'améliorer l'aspect cosmétique
HUE029855T2 (en) 2011-07-05 2017-04-28 Bioasis Technologies Inc p97 antibody conjugates
PT2739649T (pt) 2011-08-05 2018-01-03 Bioasis Technologies Inc Fragmentos de p97 com atividade de transferência
CA2880162C (fr) 2012-07-31 2023-04-04 Bioasis Technologies, Inc. Proteines de maladie de stockage lysosomal dephosphorylees et leurs procedes d'utilisation
WO2014160438A1 (fr) 2013-03-13 2014-10-02 Bioasis Technologies Inc. Fragments de p97 et leurs utilisations
ES2703341T3 (es) 2013-03-14 2019-03-08 Genvivo Inc Ensayo diagnóstico de timidina quinasa para aplicaciones de terapia génica
AU2015210612B2 (en) 2014-02-03 2020-04-09 Bioasis Technologies Inc. P97 fusion proteins
DK3107562T3 (da) 2014-02-19 2019-12-16 Bioasis Technologies Inc P97-ids-fusionsproteiner
CN106413757B (zh) 2014-05-01 2022-01-14 比奥阿赛斯技术有限公司 p97-多核苷酸结合物
CN107106492B (zh) 2014-10-14 2022-07-05 塞缪尔·林奇 用于治疗伤口的组合物

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4350687A (en) * 1980-02-10 1982-09-21 Research Corporation Platelet derived cell growth factor
AU600885B2 (en) * 1984-05-25 1990-08-30 Zymogenetics Inc. Stable DNA constructs

Also Published As

Publication number Publication date
DE3586960D1 (fr) 1993-02-18
EP0177957B1 (fr) 1993-01-07
NL990016I1 (nl) 1999-08-02
EP0177957A2 (fr) 1986-04-16
JPH10117790A (ja) 1998-05-12
EP0177957A3 (en) 1988-02-03
CA1340846E (fr) 1999-12-07
EP0177957B2 (fr) 2004-08-25
DE3586960T2 (de) 1993-05-13
DE3588218T2 (de) 2000-05-18
AU638010B2 (en) 1993-06-17
JPS62278A (ja) 1987-01-06
JP2837407B2 (ja) 1998-12-16
AU4845485A (en) 1986-04-17
ATE84312T1 (de) 1993-01-15
DE3586960T3 (de) 2005-01-20
US4801542A (en) 1989-01-31
ATE188255T1 (de) 2000-01-15
DE487116T1 (de) 1992-10-15
NL990016I2 (nl) 1999-11-01
JP3145968B2 (ja) 2001-03-12
DE3588218D1 (de) 2000-02-03
CA1340212C (fr) 1998-12-15
AU5488590A (en) 1991-01-31
DE19975042I2 (de) 2004-01-29

Similar Documents

Publication Publication Date Title
LU90408I2 (fr) Regranex-becaplermin
KR910015309A (ko) 종양괴사인자(tnf) 억제제 및 그 제조방법
DK521888A (da) Vaekstfaktor og fremgangsmaade til fremstilling deraf
IL88223A0 (en) Polypeptides,process,nucleotide sequences,expression vectors and host organisms for their production and pharmaceutical compositions comprising them
DE69020335T2 (de) B-ketten-analoge des von blutplättchen abstammenden wachstumsfaktors und verfahren zu deren homogener herstellung.
FI98829B (fi) Menetelmä rekombinoidun proteiinikompleksin valmistamiseksi, jolla on humaanitekijä VIII:C-aktiivisuutta
DE3669175D1 (de) Fusionsproteine, verfahren zu ihrer herstellung und ihre verwendung.
AU7681687A (en) Expression of platelet-derived growth factor and analogues
DE3688900T2 (de) Expression von Protein C.
EP0111814A3 (fr) Clonage et expression de séquences de nucléotides codant pour l'hormone de croissance bovine
DK237985A (da) Genteknologisk fremgangsmaade til fremstilling af human-interleukin-2 og middel til gennemfoerelse af fremgangsmaaden
EP0287075A3 (en) Process for the construction of an animal cell line for the production of human beta-interferon
PT82860B (pt) Metodo para a producao da hormona de crescimento suina
EP0072541A3 (fr) Interferons de leucocytes humains, procédé pour leur production microbiologique, intermédiaires et compositions les contenant
DE3650477D1 (de) Produktion von Cystinreste enthaltenden aktiven Proteinen
HUP9800520A2 (hu) Génexpresszió emlős sejtekben
JPS54110384A (en) Culturing medium for humanized lymphocyte
Clark et al. 4868119 Hematopoietic growth factors