LU81705A1 - Implant de delivrance de medicament pouvant etre enleve - Google Patents
Implant de delivrance de medicament pouvant etre enleve Download PDFInfo
- Publication number
- LU81705A1 LU81705A1 LU81705A LU81705A LU81705A1 LU 81705 A1 LU81705 A1 LU 81705A1 LU 81705 A LU81705 A LU 81705A LU 81705 A LU81705 A LU 81705A LU 81705 A1 LU81705 A1 LU 81705A1
- Authority
- LU
- Luxembourg
- Prior art keywords
- implant
- coating
- estradiol
- core
- inert
- Prior art date
Links
- 239000007943 implant Substances 0.000 title claims description 55
- 238000000576 coating method Methods 0.000 claims description 44
- 239000011248 coating agent Substances 0.000 claims description 43
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 claims description 38
- 229960005309 estradiol Drugs 0.000 claims description 38
- 229930182833 estradiol Natural products 0.000 claims description 38
- 229920001971 elastomer Polymers 0.000 claims description 15
- 229920002379 silicone rubber Polymers 0.000 claims description 15
- 239000005060 rubber Substances 0.000 claims description 13
- 239000004945 silicone rubber Substances 0.000 claims description 12
- 241000282849 Ruminantia Species 0.000 claims description 10
- 235000013870 dimethyl polysiloxane Nutrition 0.000 claims description 10
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 10
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 9
- 239000000203 mixture Substances 0.000 claims description 7
- 230000004584 weight gain Effects 0.000 claims description 7
- 235000019786 weight gain Nutrition 0.000 claims description 7
- 239000007787 solid Substances 0.000 claims description 6
- 238000007920 subcutaneous administration Methods 0.000 claims description 5
- 238000000034 method Methods 0.000 claims description 4
- 238000002513 implantation Methods 0.000 claims description 2
- 241001465754 Metazoa Species 0.000 description 23
- 239000011162 core material Substances 0.000 description 22
- 239000003814 drug Substances 0.000 description 15
- 229940079593 drug Drugs 0.000 description 12
- 230000002354 daily effect Effects 0.000 description 9
- 241000283725 Bos Species 0.000 description 5
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 5
- 239000003795 chemical substances by application Substances 0.000 description 5
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 5
- 239000000463 material Substances 0.000 description 4
- 238000011282 treatment Methods 0.000 description 4
- 230000003698 anagen phase Effects 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 244000309466 calf Species 0.000 description 3
- -1 for example Substances 0.000 description 3
- 230000012010 growth Effects 0.000 description 3
- 238000000338 in vitro Methods 0.000 description 3
- 241000283690 Bos taurus Species 0.000 description 2
- 238000002835 absorbance Methods 0.000 description 2
- 210000001124 body fluid Anatomy 0.000 description 2
- 239000010839 body fluid Substances 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 239000000806 elastomer Substances 0.000 description 2
- 230000000977 initiatory effect Effects 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000007937 lozenge Substances 0.000 description 2
- UYIFTLBWAOGQBI-BZDYCCQFSA-N Benzhormovarine Chemical compound C([C@@H]1[C@@H](C2=CC=3)CC[C@]4([C@H]1CC[C@@H]4O)C)CC2=CC=3OC(=O)C1=CC=CC=C1 UYIFTLBWAOGQBI-BZDYCCQFSA-N 0.000 description 1
- 239000004677 Nylon Substances 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 235000015278 beef Nutrition 0.000 description 1
- 239000000560 biocompatible material Substances 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 229920002301 cellulose acetate Polymers 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 238000010924 continuous production Methods 0.000 description 1
- 235000021316 daily nutritional intake Nutrition 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 238000001647 drug administration Methods 0.000 description 1
- 238000012377 drug delivery Methods 0.000 description 1
- 229950002007 estradiol benzoate Drugs 0.000 description 1
- 229940011871 estrogen Drugs 0.000 description 1
- 239000000262 estrogen Substances 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 239000010419 fine particle Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- 238000009304 pastoral farming Methods 0.000 description 1
- 239000000902 placebo Substances 0.000 description 1
- 229940068196 placebo Drugs 0.000 description 1
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 239000004926 polymethyl methacrylate Substances 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 229920000260 silastic Polymers 0.000 description 1
- 238000003307 slaughter Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/944,946 US4191741A (en) | 1978-09-22 | 1978-09-22 | Removable drug implant |
| US94494678 | 1978-09-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| LU81705A1 true LU81705A1 (fr) | 1980-01-24 |
Family
ID=25482344
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LU81705A LU81705A1 (fr) | 1978-09-22 | 1979-09-20 | Implant de delivrance de medicament pouvant etre enleve |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US4191741A (ja) |
| EP (1) | EP0009410B1 (ja) |
| JP (1) | JPS5545694A (ja) |
| AU (1) | AU531797B2 (ja) |
| BE (1) | BE878883A (ja) |
| CA (1) | CA1128861A (ja) |
| DE (1) | DE2965857D1 (ja) |
| DK (1) | DK155865C (ja) |
| FR (1) | FR2436601A1 (ja) |
| GB (1) | GB2030044B (ja) |
| HK (1) | HK42887A (ja) |
| IE (1) | IE48555B1 (ja) |
| IL (1) | IL58303A (ja) |
| LU (1) | LU81705A1 (ja) |
| MY (1) | MY8500567A (ja) |
| NZ (1) | NZ191587A (ja) |
| ZA (1) | ZA794968B (ja) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4326523A (en) * | 1980-08-25 | 1982-04-27 | International Minerals & Chemical Corp. | Method of supplying micronutrients to animals |
| DK119884A (da) * | 1983-03-18 | 1984-09-19 | Lilly Co Eli | Fast, cylindrisk, subkutan implantation og dens anvendelse |
| US5385738A (en) * | 1983-10-14 | 1995-01-31 | Sumitomo Pharmaceuticals Company, Ltd. | Sustained-release injection |
| US4774091A (en) * | 1983-10-14 | 1988-09-27 | Sumitomo Pharmaceuticals Company, Ltd. | Long-term sustained-release preparation |
| NZ217844A (en) * | 1985-10-11 | 1989-10-27 | Sumitomo Pharma | A sustained release pharmaceutical composition containing silicone elastomer and an albumin |
| US4917685A (en) * | 1986-05-16 | 1990-04-17 | International Minerals & Chem. Corp. | Delivery device for the administration of stabilized growth promoting hormones |
| IE58536B1 (en) * | 1986-06-09 | 1993-10-06 | Chanelle Chemicals Ltd | Subcutaneous implant |
| FR2602423B1 (fr) * | 1986-08-08 | 1989-05-05 | Ethypharm Sa | Procede de preparation d'un medicament a base de fenofibrate, medicament obtenu par ce procede |
| US4758435A (en) * | 1986-08-11 | 1988-07-19 | American Cyanamid Company | Estradiol implant composition and method for preparation |
| GB8704755D0 (en) * | 1987-02-28 | 1987-04-01 | Dow Corning Ltd | Pharmaceutical delivery device |
| HU197519B (en) * | 1987-06-22 | 1989-04-28 | Biogal Gyogyszergyar | Process for producing medicine form capable for penetrating through epidermis and suitable for intaking the agent through epidermis by kinetics of zero-grade |
| US4846844A (en) * | 1987-08-31 | 1989-07-11 | Eli Lilly And Company | Antimicrobial coated implants |
| US5141748A (en) * | 1989-02-17 | 1992-08-25 | Hoffmann-La Roche, Inc. | Implant drug delivery device |
| JP3720386B2 (ja) * | 1993-12-27 | 2005-11-24 | 住友製薬株式会社 | 薬物放出制御製剤 |
| US5759577A (en) * | 1995-01-17 | 1998-06-02 | American Home Products Corporation | Controlled release of steroids from sugar coatings |
| US6197815B1 (en) | 1998-03-18 | 2001-03-06 | J.H. Biotech, Inc. | Amino acid chelates to reduce still births and increase birth weight in non-human animals |
| TW586944B (en) | 1998-05-29 | 2004-05-11 | Sumitomo Pharma | Controlled release agent having a multi-layer structure |
| US6117441A (en) * | 1998-07-02 | 2000-09-12 | The Population Council, Inc. | Silicone core long term androgen delivery implant |
| US6756048B1 (en) | 1998-09-10 | 2004-06-29 | Sumitomo Pharmaceuticals Company, Limited | Long time drug-sustained release preparation |
| US7767708B2 (en) * | 1998-11-04 | 2010-08-03 | Schering-Plough Animal Health Corp. | Growth stimulant compositions |
| US6361780B1 (en) | 1998-11-12 | 2002-03-26 | Cardiac Pacemakers, Inc. | Microporous drug delivery system |
| TW524696B (en) | 1999-11-10 | 2003-03-21 | Sumitomo Pharma | Sustained-release drug formulations |
| US6671562B2 (en) | 2001-11-09 | 2003-12-30 | Oscor Inc. | High impedance drug eluting cardiac lead |
| US20050025797A1 (en) * | 2003-04-08 | 2005-02-03 | Xingwu Wang | Medical device with low magnetic susceptibility |
| US20050079132A1 (en) * | 2003-04-08 | 2005-04-14 | Xingwu Wang | Medical device with low magnetic susceptibility |
| US20060034943A1 (en) * | 2003-10-31 | 2006-02-16 | Technology Innovations Llc | Process for treating a biological organism |
| NZ586868A (en) * | 2008-03-28 | 2012-02-24 | Boehringer Ingelheim Int | Process for preparing orally administered dabigatran formulations |
| AU2009272796A1 (en) * | 2008-07-14 | 2010-01-21 | Boehringer Ingelheim International Gmbh | Method for manufacturing medicinal compounds containing dabigatran |
| US8420153B2 (en) * | 2008-09-19 | 2013-04-16 | Mentor Worldwide Llc | Coating with antimicrobial agents |
| US8419793B2 (en) * | 2008-09-19 | 2013-04-16 | Mentor Worldwide Llc | Coating with antimicrobial agents |
| NZ592616A (en) | 2008-11-11 | 2013-04-26 | Boehringer Ingelheim Int | Method for treating or preventing thrombosis using dabigatran etexilate or a salt thereof with improved safety profile over conventional warfarin therapy |
| ES2699200T3 (es) * | 2010-03-16 | 2019-02-07 | Titan Pharmaceuticals Inc | Dispositivos implantables heterogéneos de administración de fármacos |
| US9040062B2 (en) | 2010-08-06 | 2015-05-26 | Sumitomo Dainippon Pharma Co., Ltd. | Preparation for treatment of spinal cord injury |
| US20130137781A1 (en) | 2010-08-06 | 2013-05-30 | Miho Maeda | Pharmaceutical preparation for controlling water-soluble drug release |
| WO2013036775A1 (en) * | 2011-09-09 | 2013-03-14 | Axxia Pharmaceuticals, Llc | Silicone coated implants |
| EP4037666B1 (en) | 2020-12-08 | 2024-05-01 | Ruminant Biotech Corp Limited | Improvements to devices and methods for delivery of substances to animals |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3279996A (en) * | 1962-08-28 | 1966-10-18 | Jr David M Long | Polysiloxane carrier for controlled release of drugs and other agents |
| USRE28536E (en) | 1966-08-16 | 1975-09-02 | Animal husbandry | |
| US3499445A (en) * | 1966-08-16 | 1970-03-10 | Phytogen Prod Inc | Animal husbandry |
| US3545439A (en) * | 1968-01-04 | 1970-12-08 | Upjohn Co | Medicated devices and methods |
| BE792502A (fr) * | 1971-12-09 | 1973-06-08 | Upjohn Co | Nouvelles formes pharmaceutiques et leur procede de preparation |
| US3920805A (en) * | 1971-12-09 | 1975-11-18 | Upjohn Co | Pharmaceutical devices and method |
| DE2445971A1 (de) * | 1974-09-24 | 1976-04-08 | Schering Ag | Arzneimittelwirkstofftraeger ii |
| IL48277A (en) * | 1974-10-18 | 1978-03-10 | Schering Ag | Vaginal ring |
| US3946106A (en) * | 1974-10-24 | 1976-03-23 | G. D. Searle & Co. | Microsealed pharmaceutical delivery device |
| US3992518A (en) * | 1974-10-24 | 1976-11-16 | G. D. Searle & Co. | Method for making a microsealed delivery device |
| US4053580A (en) * | 1975-01-01 | 1977-10-11 | G. D. Searle & Co. | Microsealed pharmaceutical delivery device |
| CA1076480A (en) * | 1975-04-28 | 1980-04-29 | John S. Kent | Inert core implant pellet |
-
1978
- 1978-09-22 US US05/944,946 patent/US4191741A/en not_active Expired - Lifetime
-
1979
- 1979-09-17 NZ NZ191587A patent/NZ191587A/xx unknown
- 1979-09-17 AU AU50898/79A patent/AU531797B2/en not_active Expired
- 1979-09-17 CA CA335,737A patent/CA1128861A/en not_active Expired
- 1979-09-19 ZA ZA00794968A patent/ZA794968B/xx unknown
- 1979-09-19 FR FR7923357A patent/FR2436601A1/fr active Granted
- 1979-09-20 LU LU81705A patent/LU81705A1/fr unknown
- 1979-09-20 BE BE1/9533A patent/BE878883A/fr not_active IP Right Cessation
- 1979-09-21 DK DK396279A patent/DK155865C/da not_active IP Right Cessation
- 1979-09-21 JP JP12250779A patent/JPS5545694A/ja active Pending
- 1979-09-21 DE DE7979301970T patent/DE2965857D1/de not_active Expired
- 1979-09-21 EP EP79301970A patent/EP0009410B1/en not_active Expired
- 1979-09-21 GB GB7932888A patent/GB2030044B/en not_active Expired
- 1979-09-21 IL IL58303A patent/IL58303A/xx unknown
- 1979-09-21 IE IE1791/79A patent/IE48555B1/en unknown
-
1985
- 1985-12-30 MY MY567/85A patent/MY8500567A/xx unknown
-
1987
- 1987-05-28 HK HK428/87A patent/HK42887A/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| IL58303A0 (en) | 1979-12-30 |
| US4191741A (en) | 1980-03-04 |
| NZ191587A (en) | 1981-10-19 |
| AU531797B2 (en) | 1983-09-08 |
| DE2965857D1 (en) | 1983-08-18 |
| EP0009410A2 (en) | 1980-04-02 |
| DK155865B (da) | 1989-05-29 |
| DK155865C (da) | 1989-11-13 |
| JPS5545694A (en) | 1980-03-31 |
| IE791791L (en) | 1980-03-22 |
| EP0009410B1 (en) | 1983-07-13 |
| MY8500567A (en) | 1985-12-31 |
| FR2436601A1 (fr) | 1980-04-18 |
| DK396279A (da) | 1980-03-23 |
| AU5089879A (en) | 1980-03-27 |
| GB2030044B (en) | 1983-08-24 |
| CA1128861A (en) | 1982-08-03 |
| FR2436601B1 (ja) | 1984-06-08 |
| BE878883A (fr) | 1980-03-20 |
| IL58303A (en) | 1982-03-31 |
| HK42887A (en) | 1987-06-05 |
| GB2030044A (en) | 1980-04-02 |
| ZA794968B (en) | 1981-05-27 |
| IE48555B1 (en) | 1985-03-06 |
| EP0009410A3 (en) | 1980-04-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| LU81705A1 (fr) | Implant de delivrance de medicament pouvant etre enleve | |
| EP0639069B1 (fr) | Forme galenique pour administration oculaire et procede de preparation | |
| CH654482A5 (fr) | Composition therapeutique de dimethylsulfoxyde. | |
| FR2718018A1 (fr) | Composition cosmétique et/ou dermatologique à support hydrophile et vitamine C mélangeables extemporanément. | |
| DE68909409T2 (de) | Heilmitteldosierung zur verabreichung an fische. | |
| CA2391162A1 (fr) | Nouvelles compositions estro-progestatives topiques a effet systemique | |
| AU697144B2 (en) | Device for administration of beneficial materials to ruminants | |
| WO1998055101A1 (fr) | Implants pour la liberation controlee de principes pharmaceutiquement actifs et procede pour leur fabrication | |
| EP0664120B1 (fr) | Dispositif pour l'administration vaginale du tamoxifème et de ses analogues | |
| DE602004009552T2 (de) | Orales abgabesystem mit einem antibakteriellen und einem entzündungshemmenden mittel | |
| NL8503227A (nl) | Inrichtingen met anaboliserende inplantaten met een langdurige afgifte. | |
| NZ211320A (en) | Delayed release device: matrix support based on isoluble polymers or copolymers | |
| CH646055A5 (fr) | Composition anti-parasites a base de fenbendazole permettant la liberation maitrisee de cet agent. | |
| GB2154138A (en) | Subcutaneous silicone implant | |
| EP0549441B1 (fr) | Agents systémiques d'hormones juvéniles contre les ectoparasites | |
| FR2464713A1 (fr) | Compositions biodegradables a liberation maitrisee d'agents d'amelioration de la croissance et leur utilisation chez les ruminants | |
| Ganesha et al. | Expression of FGF-2 and fibronectin in citrus limon fruit peel malang essential oil gel treated traumatic ulcer in diabetic wistar rats (Rattus novergicus) | |
| CN112870154B (zh) | 兽用复方塞来昔布纳米脂质体凝胶及其制备方法 | |
| CH635748A5 (fr) | Procede d'obtention de cellules placentaires de brebis. | |
| BE1000189A3 (fr) | Preparation pharmaceutique a usage veterinaire. | |
| NL192818C (nl) | Samenstelsel voor een geprogrammeerde vrijmaking. | |
| RU2390333C1 (ru) | Ветеринарное имплантируемое средство пролонгированного действия для повышения продуктивности сельскохозяйственных животных (варианты) | |
| Malvisi et al. | Tissue distribution and residue depletion of thiamphenicol after multiple oral dosing in seabass (Dicentrarchus labrax L.) and seabream (Sparus aurata L.) | |
| Mamurova et al. | Brain morphological changes in the experimental hypothyroidism correction | |
| FR2685998A1 (fr) | Methode pour augmenter chez les agneaux la production de laine, sa qualite et le poids des animaux. |