LU81705A1 - Implant de delivrance de medicament pouvant etre enleve - Google Patents
Implant de delivrance de medicament pouvant etre enleve Download PDFInfo
- Publication number
- LU81705A1 LU81705A1 LU81705A LU81705A LU81705A1 LU 81705 A1 LU81705 A1 LU 81705A1 LU 81705 A LU81705 A LU 81705A LU 81705 A LU81705 A LU 81705A LU 81705 A1 LU81705 A1 LU 81705A1
- Authority
- LU
- Luxembourg
- Prior art keywords
- implant
- coating
- estradiol
- core
- inert
- Prior art date
Links
- 239000007943 implant Substances 0.000 title claims description 55
- 238000000576 coating method Methods 0.000 claims description 44
- 239000011248 coating agent Substances 0.000 claims description 43
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 claims description 38
- 229960005309 estradiol Drugs 0.000 claims description 38
- 229930182833 estradiol Natural products 0.000 claims description 38
- 229920001971 elastomer Polymers 0.000 claims description 15
- 229920002379 silicone rubber Polymers 0.000 claims description 15
- 239000005060 rubber Substances 0.000 claims description 13
- 239000004945 silicone rubber Substances 0.000 claims description 12
- 241000282849 Ruminantia Species 0.000 claims description 10
- 235000013870 dimethyl polysiloxane Nutrition 0.000 claims description 10
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 10
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 9
- 239000000203 mixture Substances 0.000 claims description 7
- 230000004584 weight gain Effects 0.000 claims description 7
- 235000019786 weight gain Nutrition 0.000 claims description 7
- 239000007787 solid Substances 0.000 claims description 6
- 238000007920 subcutaneous administration Methods 0.000 claims description 5
- 238000000034 method Methods 0.000 claims description 4
- 238000002513 implantation Methods 0.000 claims description 2
- 241001465754 Metazoa Species 0.000 description 23
- 239000011162 core material Substances 0.000 description 22
- 239000003814 drug Substances 0.000 description 15
- 229940079593 drug Drugs 0.000 description 12
- 230000002354 daily effect Effects 0.000 description 9
- 241000283725 Bos Species 0.000 description 5
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 5
- 239000003795 chemical substances by application Substances 0.000 description 5
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 5
- 239000000463 material Substances 0.000 description 4
- 238000011282 treatment Methods 0.000 description 4
- 230000003698 anagen phase Effects 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 244000309466 calf Species 0.000 description 3
- -1 for example Substances 0.000 description 3
- 230000012010 growth Effects 0.000 description 3
- 238000000338 in vitro Methods 0.000 description 3
- 241000283690 Bos taurus Species 0.000 description 2
- 238000002835 absorbance Methods 0.000 description 2
- 210000001124 body fluid Anatomy 0.000 description 2
- 239000010839 body fluid Substances 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 239000000806 elastomer Substances 0.000 description 2
- 230000000977 initiatory effect Effects 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000007937 lozenge Substances 0.000 description 2
- UYIFTLBWAOGQBI-BZDYCCQFSA-N Benzhormovarine Chemical compound C([C@@H]1[C@@H](C2=CC=3)CC[C@]4([C@H]1CC[C@@H]4O)C)CC2=CC=3OC(=O)C1=CC=CC=C1 UYIFTLBWAOGQBI-BZDYCCQFSA-N 0.000 description 1
- 239000004677 Nylon Substances 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 235000015278 beef Nutrition 0.000 description 1
- 239000000560 biocompatible material Substances 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 229920002301 cellulose acetate Polymers 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 238000010924 continuous production Methods 0.000 description 1
- 235000021316 daily nutritional intake Nutrition 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 238000001647 drug administration Methods 0.000 description 1
- 238000012377 drug delivery Methods 0.000 description 1
- 229950002007 estradiol benzoate Drugs 0.000 description 1
- 229940011871 estrogen Drugs 0.000 description 1
- 239000000262 estrogen Substances 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 239000010419 fine particle Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- 238000009304 pastoral farming Methods 0.000 description 1
- 239000000902 placebo Substances 0.000 description 1
- 229940068196 placebo Drugs 0.000 description 1
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 239000004926 polymethyl methacrylate Substances 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 229920000260 silastic Polymers 0.000 description 1
- 238000003307 slaughter Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/944,946 US4191741A (en) | 1978-09-22 | 1978-09-22 | Removable drug implant |
| US94494678 | 1978-09-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| LU81705A1 true LU81705A1 (fr) | 1980-01-24 |
Family
ID=25482344
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LU81705A LU81705A1 (fr) | 1978-09-22 | 1979-09-20 | Implant de delivrance de medicament pouvant etre enleve |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US4191741A (de) |
| EP (1) | EP0009410B1 (de) |
| JP (1) | JPS5545694A (de) |
| AU (1) | AU531797B2 (de) |
| BE (1) | BE878883A (de) |
| CA (1) | CA1128861A (de) |
| DE (1) | DE2965857D1 (de) |
| DK (1) | DK155865C (de) |
| FR (1) | FR2436601A1 (de) |
| GB (1) | GB2030044B (de) |
| HK (1) | HK42887A (de) |
| IE (1) | IE48555B1 (de) |
| IL (1) | IL58303A (de) |
| LU (1) | LU81705A1 (de) |
| MY (1) | MY8500567A (de) |
| NZ (1) | NZ191587A (de) |
| ZA (1) | ZA794968B (de) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4326523A (en) * | 1980-08-25 | 1982-04-27 | International Minerals & Chemical Corp. | Method of supplying micronutrients to animals |
| DK119884A (da) * | 1983-03-18 | 1984-09-19 | Lilly Co Eli | Fast, cylindrisk, subkutan implantation og dens anvendelse |
| US5385738A (en) * | 1983-10-14 | 1995-01-31 | Sumitomo Pharmaceuticals Company, Ltd. | Sustained-release injection |
| US4774091A (en) * | 1983-10-14 | 1988-09-27 | Sumitomo Pharmaceuticals Company, Ltd. | Long-term sustained-release preparation |
| NZ217844A (en) * | 1985-10-11 | 1989-10-27 | Sumitomo Pharma | A sustained release pharmaceutical composition containing silicone elastomer and an albumin |
| US4917685A (en) * | 1986-05-16 | 1990-04-17 | International Minerals & Chem. Corp. | Delivery device for the administration of stabilized growth promoting hormones |
| IE58536B1 (en) * | 1986-06-09 | 1993-10-06 | Chanelle Chemicals Ltd | Subcutaneous implant |
| FR2602423B1 (fr) * | 1986-08-08 | 1989-05-05 | Ethypharm Sa | Procede de preparation d'un medicament a base de fenofibrate, medicament obtenu par ce procede |
| US4758435A (en) * | 1986-08-11 | 1988-07-19 | American Cyanamid Company | Estradiol implant composition and method for preparation |
| GB8704755D0 (en) * | 1987-02-28 | 1987-04-01 | Dow Corning Ltd | Pharmaceutical delivery device |
| HU197519B (en) * | 1987-06-22 | 1989-04-28 | Biogal Gyogyszergyar | Process for producing medicine form capable for penetrating through epidermis and suitable for intaking the agent through epidermis by kinetics of zero-grade |
| US4846844A (en) * | 1987-08-31 | 1989-07-11 | Eli Lilly And Company | Antimicrobial coated implants |
| US5141748A (en) * | 1989-02-17 | 1992-08-25 | Hoffmann-La Roche, Inc. | Implant drug delivery device |
| JP3720386B2 (ja) * | 1993-12-27 | 2005-11-24 | 住友製薬株式会社 | 薬物放出制御製剤 |
| US5759577A (en) * | 1995-01-17 | 1998-06-02 | American Home Products Corporation | Controlled release of steroids from sugar coatings |
| US6197815B1 (en) | 1998-03-18 | 2001-03-06 | J.H. Biotech, Inc. | Amino acid chelates to reduce still births and increase birth weight in non-human animals |
| TW586944B (en) * | 1998-05-29 | 2004-05-11 | Sumitomo Pharma | Controlled release agent having a multi-layer structure |
| US6117441A (en) * | 1998-07-02 | 2000-09-12 | The Population Council, Inc. | Silicone core long term androgen delivery implant |
| CA2342587C (en) | 1998-09-10 | 2008-11-18 | Sumitomo Pharmaceuticals Co., Ltd. | Long term drug-sustained release preparation |
| US7767708B2 (en) * | 1998-11-04 | 2010-08-03 | Schering-Plough Animal Health Corp. | Growth stimulant compositions |
| US6361780B1 (en) | 1998-11-12 | 2002-03-26 | Cardiac Pacemakers, Inc. | Microporous drug delivery system |
| TW524696B (en) | 1999-11-10 | 2003-03-21 | Sumitomo Pharma | Sustained-release drug formulations |
| US7187980B2 (en) * | 2001-11-09 | 2007-03-06 | Oscor Inc. | Cardiac lead with steroid eluting ring |
| US20050025797A1 (en) * | 2003-04-08 | 2005-02-03 | Xingwu Wang | Medical device with low magnetic susceptibility |
| US20050079132A1 (en) * | 2003-04-08 | 2005-04-14 | Xingwu Wang | Medical device with low magnetic susceptibility |
| US20060034943A1 (en) * | 2003-10-31 | 2006-02-16 | Technology Innovations Llc | Process for treating a biological organism |
| BRPI0907598A2 (pt) * | 2008-03-28 | 2015-07-21 | Boehringer Ingelheim Int | Processo para o preparo de formulações de dabigatrana administradas por via oral |
| US20110123635A1 (en) | 2008-07-14 | 2011-05-26 | Boehringer Ingelheim International Gmbh | Method for manufacturing medicinal compounds containing dabigatran |
| US8419793B2 (en) * | 2008-09-19 | 2013-04-16 | Mentor Worldwide Llc | Coating with antimicrobial agents |
| US8420153B2 (en) * | 2008-09-19 | 2013-04-16 | Mentor Worldwide Llc | Coating with antimicrobial agents |
| CN103356614A (zh) | 2008-11-11 | 2013-10-23 | 贝林格尔.英格海姆国际有限公司 | 使用达比加群酯或其盐治疗或预防血栓形成且与常规华法林疗法相比具有改良安全性的方法 |
| JP5869551B2 (ja) * | 2010-03-16 | 2016-02-24 | タイタン ファーマシューティカルズ インコーポレイテッド | 薬物送達のための不均一な埋め込み型デバイス |
| CA2807225A1 (en) | 2010-08-06 | 2012-02-09 | Miho Maeda | Pharmaceutical preparation for controlling water-soluble drug release |
| CA2807224A1 (en) | 2010-08-06 | 2012-02-09 | Dainippon Sumitomo Pharma Co., Ltd. | Preparation for treatment of spinal cord injury |
| US20130236524A1 (en) * | 2011-09-09 | 2013-09-12 | Axxia Pharmaceuticals, Llc | Silicone coated implant |
| AU2021396978A1 (en) | 2020-12-08 | 2023-02-23 | Ruminant Biotech Corp Limited | Improvements to devices and methods for delivery of substances to animals |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3279996A (en) * | 1962-08-28 | 1966-10-18 | Jr David M Long | Polysiloxane carrier for controlled release of drugs and other agents |
| USRE28536E (en) | 1966-08-16 | 1975-09-02 | Animal husbandry | |
| US3499445A (en) * | 1966-08-16 | 1970-03-10 | Phytogen Prod Inc | Animal husbandry |
| US3545439A (en) * | 1968-01-04 | 1970-12-08 | Upjohn Co | Medicated devices and methods |
| BE792502A (fr) * | 1971-12-09 | 1973-06-08 | Upjohn Co | Nouvelles formes pharmaceutiques et leur procede de preparation |
| US3920805A (en) * | 1971-12-09 | 1975-11-18 | Upjohn Co | Pharmaceutical devices and method |
| DE2445971A1 (de) * | 1974-09-24 | 1976-04-08 | Schering Ag | Arzneimittelwirkstofftraeger ii |
| IL48277A (en) * | 1974-10-18 | 1978-03-10 | Schering Ag | Vaginal ring |
| US3992518A (en) * | 1974-10-24 | 1976-11-16 | G. D. Searle & Co. | Method for making a microsealed delivery device |
| US3946106A (en) * | 1974-10-24 | 1976-03-23 | G. D. Searle & Co. | Microsealed pharmaceutical delivery device |
| US4053580A (en) * | 1975-01-01 | 1977-10-11 | G. D. Searle & Co. | Microsealed pharmaceutical delivery device |
| CA1076480A (en) * | 1975-04-28 | 1980-04-29 | John S. Kent | Inert core implant pellet |
-
1978
- 1978-09-22 US US05/944,946 patent/US4191741A/en not_active Expired - Lifetime
-
1979
- 1979-09-17 CA CA335,737A patent/CA1128861A/en not_active Expired
- 1979-09-17 NZ NZ191587A patent/NZ191587A/xx unknown
- 1979-09-17 AU AU50898/79A patent/AU531797B2/en not_active Expired
- 1979-09-19 FR FR7923357A patent/FR2436601A1/fr active Granted
- 1979-09-19 ZA ZA00794968A patent/ZA794968B/xx unknown
- 1979-09-20 BE BE1/9533A patent/BE878883A/fr not_active IP Right Cessation
- 1979-09-20 LU LU81705A patent/LU81705A1/fr unknown
- 1979-09-21 GB GB7932888A patent/GB2030044B/en not_active Expired
- 1979-09-21 IE IE1791/79A patent/IE48555B1/en unknown
- 1979-09-21 IL IL58303A patent/IL58303A/xx unknown
- 1979-09-21 DK DK396279A patent/DK155865C/da not_active IP Right Cessation
- 1979-09-21 JP JP12250779A patent/JPS5545694A/ja active Pending
- 1979-09-21 EP EP79301970A patent/EP0009410B1/de not_active Expired
- 1979-09-21 DE DE7979301970T patent/DE2965857D1/de not_active Expired
-
1985
- 1985-12-30 MY MY567/85A patent/MY8500567A/xx unknown
-
1987
- 1987-05-28 HK HK428/87A patent/HK42887A/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CA1128861A (en) | 1982-08-03 |
| AU5089879A (en) | 1980-03-27 |
| IL58303A (en) | 1982-03-31 |
| FR2436601A1 (fr) | 1980-04-18 |
| EP0009410A3 (en) | 1980-04-16 |
| BE878883A (fr) | 1980-03-20 |
| EP0009410A2 (de) | 1980-04-02 |
| DE2965857D1 (en) | 1983-08-18 |
| FR2436601B1 (de) | 1984-06-08 |
| IE48555B1 (en) | 1985-03-06 |
| ZA794968B (en) | 1981-05-27 |
| AU531797B2 (en) | 1983-09-08 |
| US4191741A (en) | 1980-03-04 |
| DK155865B (da) | 1989-05-29 |
| DK396279A (da) | 1980-03-23 |
| GB2030044B (en) | 1983-08-24 |
| HK42887A (en) | 1987-06-05 |
| IE791791L (en) | 1980-03-22 |
| NZ191587A (en) | 1981-10-19 |
| EP0009410B1 (de) | 1983-07-13 |
| DK155865C (da) | 1989-11-13 |
| GB2030044A (en) | 1980-04-02 |
| JPS5545694A (en) | 1980-03-31 |
| IL58303A0 (en) | 1979-12-30 |
| MY8500567A (en) | 1985-12-31 |
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