LTIP1687A - Novel antiarrhythmic agents, process for the preparation thereof and pharmaceutical compositions - Google Patents

Novel antiarrhythmic agents, process for the preparation thereof and pharmaceutical compositions

Info

Publication number
LTIP1687A
LTIP1687A LTIP1687A LTIP1687A LTIP1687A LT IP1687 A LTIP1687 A LT IP1687A LT IP1687 A LTIP1687 A LT IP1687A LT IP1687 A LTIP1687 A LT IP1687A LT IP1687 A LTIP1687 A LT IP1687A
Authority
LT
Lithuania
Prior art keywords
preparation
pharmaceutical compositions
antiarrhythmic agents
novel antiarrhythmic
novel
Prior art date
Application number
LTIP1687A
Other languages
English (en)
Inventor
Olle Almgren
Bert Goeran Duke Duker
Gert Strandlund
Original Assignee
Haessle Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Haessle Ab filed Critical Haessle Ab
Publication of LTIP1687A publication Critical patent/LTIP1687A/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00Carboxylic acid nitriles
    • C07C255/49Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/54Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and etherified hydroxy groups bound to the carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/24Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/25Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/06Antiarrhythmics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00Sulfones; Sulfoxides
    • C07C317/26Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C317/32Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/31Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C07C323/32Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton having at least one of the nitrogen atoms bound to an acyclic carbon atom of the carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/39Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C07C323/40Y being a hydrogen or a carbon atom
    • C07C323/41Y being a hydrogen or an acyclic carbon atom

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Pyridine Compounds (AREA)
LTIP1687A 1987-12-23 1993-12-28 Novel antiarrhythmic agents, process for the preparation thereof and pharmaceutical compositions LTIP1687A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE8705150A SE8705150D0 (sv) 1987-12-23 1987-12-23 Novel antiarrhythmic agents

Publications (1)

Publication Number Publication Date
LTIP1687A true LTIP1687A (en) 1995-07-25

Family

ID=20370706

Family Applications (4)

Application Number Title Priority Date Filing Date
LTIP1688A LTIP1688A (en) 1987-12-23 1993-12-28 Process for the preparation of antiarrhythmic agents
LTIP1687A LTIP1687A (en) 1987-12-23 1993-12-28 Novel antiarrhythmic agents, process for the preparation thereof and pharmaceutical compositions
LTIP1720A LTIP1720A (en) 1987-12-23 1993-12-30 Novel antiarrhythmic agents, process for the preparation and use thereof
LTIP1752A LTIP1752A (en) 1987-12-23 1993-12-31 Benzonitrile derivatives

Family Applications Before (1)

Application Number Title Priority Date Filing Date
LTIP1688A LTIP1688A (en) 1987-12-23 1993-12-28 Process for the preparation of antiarrhythmic agents

Family Applications After (2)

Application Number Title Priority Date Filing Date
LTIP1720A LTIP1720A (en) 1987-12-23 1993-12-30 Novel antiarrhythmic agents, process for the preparation and use thereof
LTIP1752A LTIP1752A (en) 1987-12-23 1993-12-31 Benzonitrile derivatives

Country Status (33)

Country Link
US (2) US5034411A (fi)
EP (2) EP0322389B1 (fi)
JP (2) JPH0637458B2 (fi)
KR (2) KR900700441A (fi)
CN (3) CN1033804A (fi)
AR (1) AR247729A1 (fi)
AT (2) ATE82257T1 (fi)
AU (4) AU2824489A (fi)
DD (2) DD277274A5 (fi)
DE (2) DE3875934T2 (fi)
DK (2) DK404789A (fi)
EG (1) EG18681A (fi)
ES (2) ES2045189T3 (fi)
FI (2) FI92192C (fi)
GR (2) GR3006241T3 (fi)
HU (3) HU205895B (fi)
IE (2) IE883860L (fi)
IL (2) IL88749A (fi)
IS (1) IS1558B (fi)
LT (4) LTIP1688A (fi)
LV (1) LV10250A (fi)
MX (1) MX174084B (fi)
MY (1) MY103945A (fi)
NO (2) NO171724C (fi)
NZ (1) NZ227381A (fi)
PH (2) PH25526A (fi)
PL (2) PL159551B1 (fi)
PT (2) PT89311B (fi)
RU (3) RU1836342C (fi)
SE (1) SE8705150D0 (fi)
WO (3) WO1989005795A1 (fi)
YU (2) YU47580B (fi)
ZA (2) ZA889424B (fi)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8705150D0 (sv) * 1987-12-23 1987-12-23 Haessle Ab Novel antiarrhythmic agents
SE8902236D0 (sv) * 1989-06-20 1989-06-20 Haessle Ab Novel polystyrenesulfonate
SE8902237D0 (sv) * 1989-06-20 1989-06-20 Haessle Ab Novel stereoisomers
SE9003902D0 (sv) * 1990-12-07 1990-12-07 Astra Ab Solid dosage forms of a drug
SE8902235D0 (sv) * 1989-06-20 1989-06-20 Haessle Ab Novel cyclodextrin inclusion complexes
US5084463A (en) * 1989-12-11 1992-01-28 American Home Products Corporation N-quinolinyl alkyl-substituted 1-aryloxy-2-propanolamine and propylamine derivatives possessing class III antiarrhythmic activity
US5619274A (en) * 1990-09-10 1997-04-08 Starsight Telecast, Inc. Television schedule information transmission and utilization system and process
UA26190C2 (uk) * 1992-07-28 1999-07-19 Сейфтек Ай Лімітед Шприц
US5679706A (en) * 1994-09-30 1997-10-21 Bristol-Myers Squibb Company Combination of a potassium channel activator and an antiarrhythmic agent
US6143569A (en) * 1998-08-31 2000-11-07 The United States Of America As Represented By The Secretary Of The Navy Chelators exhibiting triple fluorescence
GB0123961D0 (en) * 2001-10-05 2001-11-28 Astrazeneca Ab Process and intermediates
WO2004113305A2 (en) 2003-06-16 2004-12-29 Vertex Pharmaceuticals Incorporated Diamino substituted quinazoline derivatives as promoters of smn2
US7356365B2 (en) * 2003-07-09 2008-04-08 Glucolight Corporation Method and apparatus for tissue oximetry
RU2631231C1 (ru) * 2016-12-01 2017-09-19 Научно-производственная ассоциация "Технопарк Авиационных Технологий" Способ получения заготовки лопатки газотурбинного двигателя для линейной сварки трением
CN115417973B (zh) * 2022-11-03 2023-03-24 广东粤港澳大湾区黄埔材料研究院 抗菌聚氨酯材料及其制备方法和应用

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3149147A (en) * 1961-03-16 1964-09-15 Smith Kline French Lab Novel substituted phenylalkylamines
FR152F (fi) * 1962-01-24
GB1069345A (en) * 1963-07-19 1967-05-17 Ici Ltd New alkanolamine derivatives
DE1593771A1 (de) * 1967-04-06 1970-04-30 Boehringer Sohn Ingelheim Verfahren zur Herstellung von 1-Phenoxy-2-amino-alkanen
BE757005A (fr) * 1969-10-02 1971-04-02 Bristol Myers Co Phenethanolamines substituees et procede pour leur preparation
GB1457876A (en) * 1972-12-15 1976-12-08 Ici Ltd Alkanolamine derivatives device for use in
SE404793B (sv) * 1973-05-25 1978-10-30 Boehringer Sohn Ingelheim Forfarande for framstellning av vissa angivna nitrilsubstituerade 1-fenoxi-2-hydroxi-3-lagalkylaminopropaner
GB1433920A (en) * 1973-10-01 1976-04-28 Ici Ltd Alkanolamine derivatives
FR2280376A1 (fr) * 1974-08-02 1976-02-27 Sogeras Nouveaux derives du piperidine-4 ethanol
DE2503222A1 (de) * 1975-01-27 1976-07-29 Boehringer Sohn Ingelheim Verfahren zur herstellung von 1-aryl- oxy-3-n-substituierten aminopropanderivaten
SE421123B (sv) * 1976-08-25 1981-11-30 Boehringer Sohn Ingelheim Forfarande for framstellning av vissa angivna nitrilsubstituerade 1-fenoxi-2-hydroxi-3-alkylaminopropaner
US4283534A (en) * 1979-04-11 1981-08-11 Basf Aktiengesellschaft Reductive alkylation of nitrogen heterocycles
US4544654A (en) * 1984-03-20 1985-10-01 Schering A.G. Substituted sulfonamidobenzamides, antiarrhythmic agents and compositions thereof
US4614746A (en) * 1985-03-21 1986-09-30 American Cyanamid Company 5-fluorobenzonitrile derivatives for increasing the lean meat to fat ratio and/or enhancing the growth rate of warm-blooded animals
CA1267416A (en) * 1985-06-17 1990-04-03 Ila Sircar 1,4-dihydropyridine derivatives useful for the treatment of cardiovascular disorders
EG18188A (en) * 1986-05-01 1992-09-30 Pfizer Ltd Process for preparation anti-arhythmia agents
SE8705150D0 (sv) * 1987-12-23 1987-12-23 Haessle Ab Novel antiarrhythmic agents
SE8902237D0 (sv) * 1989-06-20 1989-06-20 Haessle Ab Novel stereoisomers
SE8902236D0 (sv) * 1989-06-20 1989-06-20 Haessle Ab Novel polystyrenesulfonate

Also Published As

Publication number Publication date
DK404889D0 (da) 1989-08-17
FI893936A0 (fi) 1989-08-22
DK404789A (da) 1989-10-19
DK404789D0 (da) 1989-08-17
ZA889424B (en) 1989-08-30
MX14310A (es) 1993-10-01
HUT54346A (en) 1991-02-28
DE3875600D1 (de) 1992-12-03
NO893375D0 (no) 1989-08-22
LTIP1688A (en) 1995-07-25
EP0322389A2 (en) 1989-06-28
YU234088A (en) 1990-06-30
IL88749A (en) 1994-04-12
HUT54345A (en) 1991-02-28
JPH02502725A (ja) 1990-08-30
SE8705150D0 (sv) 1987-12-23
AU2824189A (en) 1989-07-19
CN1033804A (zh) 1989-07-12
HU913679D0 (en) 1992-02-28
YU19690A (en) 1992-05-28
KR900700441A (ko) 1990-08-13
FI893936A (fi) 1989-08-22
FI893937A0 (fi) 1989-08-22
LV10250A (lv) 1994-10-20
DD295353A5 (de) 1991-10-31
MX174084B (es) 1994-04-20
FI893937A (fi) 1989-08-22
IS3425A7 (is) 1989-06-24
ATE82257T1 (de) 1992-11-15
MY103945A (en) 1993-10-30
IE883860L (en) 1989-06-23
WO1989005794A1 (en) 1989-06-29
ES2043891T3 (es) 1994-01-01
GR3006912T3 (fi) 1993-06-30
JPH02502726A (ja) 1990-08-30
PH25526A (en) 1991-07-24
DE3875934D1 (de) 1992-12-17
PT89311A (pt) 1989-12-29
DD277274A5 (de) 1990-03-28
PT89312B (pt) 1993-08-31
PT89311B (pt) 1993-08-31
DE3875934T2 (de) 1993-03-25
AU2824489A (en) 1989-07-19
NO893375L (no) 1989-08-22
AU2910389A (en) 1989-07-19
EP0322389B1 (en) 1992-10-28
IL103741A (en) 1994-04-12
IE883859L (en) 1989-06-23
GR3006241T3 (fi) 1993-06-21
NO171784B (no) 1993-01-25
EP0322390A2 (en) 1989-06-28
AU625872B2 (en) 1992-07-16
WO1989005806A1 (en) 1989-06-29
NO171784C (no) 1993-05-05
PL276698A1 (en) 1989-08-07
ATE81848T1 (de) 1992-11-15
EP0322390A3 (en) 1989-09-06
PL157747B1 (pl) 1992-06-30
FI92192B (fi) 1994-06-30
US5034411A (en) 1991-07-23
DK404889A (da) 1989-10-19
HU205895B (en) 1992-07-28
YU47580B (sh) 1995-10-24
LTIP1752A (en) 1995-07-25
CN1048214A (zh) 1991-01-02
AU625774B2 (en) 1992-07-16
RU1836343C (ru) 1993-08-23
ES2045189T3 (es) 1994-01-16
NO171724C (no) 1993-04-28
WO1989005795A1 (en) 1989-06-29
KR900700442A (ko) 1990-08-13
US5155133A (en) 1992-10-13
PH26828A (en) 1992-11-05
DE3875600T2 (de) 1993-03-11
PL159551B1 (pl) 1992-12-31
EP0322390B1 (en) 1992-11-11
RU1836342C (ru) 1993-08-23
CN1097736A (zh) 1995-01-25
EG18681A (en) 1993-10-30
RU2024503C1 (ru) 1994-12-15
LTIP1720A (en) 1995-07-25
NO171724B (no) 1993-01-18
FI92192C (fi) 1994-10-10
JPH0637458B2 (ja) 1994-05-18
AR247729A1 (es) 1995-03-31
NZ227381A (en) 1992-07-28
NO893376D0 (no) 1989-08-22
ZA894441B (en) 1990-02-28
PT89312A (pt) 1989-12-29
NO893376L (no) 1989-08-22
EP0322389A3 (en) 1989-09-06
IS1558B (is) 1994-10-05

Similar Documents

Publication Publication Date Title
ZA859756B (en) Peptide-aldehydes,process for the preparation thereof and pharmaceutical compositions containing the same
IL84863A (en) 3-aryloxy-3-substituted propanamines,process for their preparation and pharmaceutical compositions comprising them
PT84964A (en) Process for the preparation of 1,5-diaryl-3-substituted-pyrazoles and of pharmaceutical compositions containing them
IL75400A0 (en) Dialkoxypyridines,processes for the preparation thereof and pharmaceutical compositions containing the same
IL75120A0 (en) New pyrrolobenzimidazoles,processes for the preparation thereof and pharmaceutical compositions containing them
HK18194A (en) Substituted benzamide derivatives,processes for the preparation thereof,and pharmaceutical compositions containing the same
IL82231A (en) 1-hydroxy-2-pyridones,process for their preparation and pharmaceutical compositions which contain them
IL83760A (en) 3-pyrazoliomethyl-3- cephem-4-carboxylate derivatives, process for the preparation thereof, and pharmacetuical compositions containing the same
IL84589A0 (en) Pyrrolobenzimidazoles,processes for the preparation thereof and pharmaceutical compositions containing them
ZA89958B (en) Pharmaceutical compositions containing lactams,new substituted lactams and processes for the preparation thereof
HUT48624A (en) Process for producing 6-benzoxazinyl- and 6-benzothiazinyl-2,3,4,5-tetrahydropyridazin-3-ones and pharmaceutical compositions comprising such compounds
IL92425A0 (en) Alpha-d-glucofuranose derivatives,pharmaceutical compositions containing the same and processes for the preparation thereof
LTIP1687A (en) Novel antiarrhythmic agents, process for the preparation thereof and pharmaceutical compositions
OA08608A (en) Pestical compositions and process for preparation thereof.
IL85290A0 (en) Substituted 3,4-dihydro-2h-benzopyrans,processes for their preparation and pharmaceutical compositions containing same
AR243499A1 (es) Un procedimiento para la preparacion de derivados de sulfonanilida.
EP0251453A3 (en) Substituted amino-dihydrooxazoles, -thiazoles and -imidazoles, process for their preparation and pharmaceutical compositions containing them
IL86027A (en) 2-acylpyrrolidine derivatives,a process for the preparation thereof,compositions containing them,and their use
HUT46303A (en) Process for producing 3-/omega-/3,5-di-/tetrabutil/-4-hydroxy-phenyl/-alkanoyl/-pyrroles andtheyr deoxy-analogues and pharmaceutical compositions containing them
IL87563A (en) Isoxazole-b-carboline derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same
IL84955A0 (en) Novel carbamoyloxylabdanes,process for the preparation thereof and pharmaceutical compositions containing them
IL95210A0 (en) 14,17alpha-etheno-and-ethanoestratrienes,process for the preparation thereof and pharmaceutical compositions containing the same
IL86173A0 (en) Pyrrolidine derivatives,processes for the preparation thereof and pharmaceutical compositions containing them
IL84791A0 (en) Substituted aminopropionamides,process for their preparation and pharmaceutical compositions containing them
EP0418020A3 (en) Cephalosporinderivatives, process for their preparation and pharmaceutical compositions

Legal Events

Date Code Title Description
FD9A Withdrawn applications

Free format text: 951221