LT4140297T - Pelės, turinčios genetiškai sukonstruotą imunoglobulino lambda lengvąją grandinę, ir jų panaudojimas - Google Patents

Pelės, turinčios genetiškai sukonstruotą imunoglobulino lambda lengvąją grandinę, ir jų panaudojimas

Info

Publication number
LT4140297T
LT4140297T LTEP22188627.8T LT22188627T LT4140297T LT 4140297 T LT4140297 T LT 4140297T LT 22188627 T LT22188627 T LT 22188627T LT 4140297 T LT4140297 T LT 4140297T
Authority
LT
Lithuania
Prior art keywords
mice
light chain
lambda light
engineered immunoglobulin
immunoglobulin lambda
Prior art date
Application number
LTEP22188627.8T
Other languages
English (en)
Lithuanian (lt)
Inventor
Andrew J. Murphy
Lynn Macdonald
Chunguang GUO
John Mcwhirter
Original Assignee
Regeneron Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharmaceuticals, Inc. filed Critical Regeneron Pharmaceuticals, Inc.
Publication of LT4140297T publication Critical patent/LT4140297T/lt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
    • C07K16/462—Igs containing a variable region (Fv) from one specie and a constant region (Fc) from another
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0603—Embryonic cells ; Embryoid bodies
    • C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1241—Nucleotidyltransferases (2.7.7)
    • C12N9/1264—DNA nucleotidylexotransferase (2.7.7.31), i.e. terminal nucleotidyl transferase
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A01K2217/052—Animals comprising random inserted nucleic acids (transgenic) inducing gain of function
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/15—Animals comprising multiple alterations of the genome, by transgenesis or homologous recombination, e.g. obtained by cross-breeding
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/01—Animal expressing industrially exogenous proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/515—Complete light chain, i.e. VL + CL

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Environmental Sciences (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Animal Husbandry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Developmental Biology & Embryology (AREA)
  • Reproductive Health (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
LTEP22188627.8T 2017-12-05 2018-12-04 Pelės, turinčios genetiškai sukonstruotą imunoglobulino lambda lengvąją grandinę, ir jų panaudojimas LT4140297T (lt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201762594946P 2017-12-05 2017-12-05
US201762594944P 2017-12-05 2017-12-05
US201762609251P 2017-12-21 2017-12-21
US201762609241P 2017-12-21 2017-12-21

Publications (1)

Publication Number Publication Date
LT4140297T true LT4140297T (lt) 2025-07-25

Family

ID=64734263

Family Applications (2)

Application Number Title Priority Date Filing Date
LTEP22188627.8T LT4140297T (lt) 2017-12-05 2018-12-04 Pelės, turinčios genetiškai sukonstruotą imunoglobulino lambda lengvąją grandinę, ir jų panaudojimas
LTEPPCT/US2018/063841T LT3720279T (lt) 2017-12-05 2018-12-04 Pelės, turinčios sukonstruotą imunoglobulino lambda lengvąją grandinę, ir jų panaudojimas

Family Applications After (1)

Application Number Title Priority Date Filing Date
LTEPPCT/US2018/063841T LT3720279T (lt) 2017-12-05 2018-12-04 Pelės, turinčios sukonstruotą imunoglobulino lambda lengvąją grandinę, ir jų panaudojimas

Country Status (24)

Country Link
US (4) US11051498B2 (https=)
EP (3) EP4140297B1 (https=)
JP (3) JP7430636B2 (https=)
KR (2) KR102760506B1 (https=)
CN (2) CN111432635B (https=)
AU (2) AU2018381316B2 (https=)
BR (1) BR112020011184A2 (https=)
CA (1) CA3084049A1 (https=)
DK (2) DK4140297T3 (https=)
ES (2) ES3035461T3 (https=)
FI (1) FI4140297T3 (https=)
HR (2) HRP20250920T1 (https=)
HU (2) HUE060608T2 (https=)
IL (2) IL318197A (https=)
LT (2) LT4140297T (https=)
MX (2) MX2020005830A (https=)
PL (2) PL4140297T3 (https=)
PT (2) PT4140297T (https=)
RS (2) RS63772B1 (https=)
SG (1) SG11202003044SA (https=)
SI (2) SI3720279T1 (https=)
SM (2) SMT202500277T1 (https=)
TW (2) TWI827567B (https=)
WO (1) WO2019113065A1 (https=)

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Also Published As

Publication number Publication date
LT3720279T (lt) 2022-10-25
RU2020118699A (ru) 2022-01-10
EP4596688A3 (en) 2025-11-12
ES2928995T3 (es) 2022-11-24
EP4140297A1 (en) 2023-03-01
US20210345591A1 (en) 2021-11-11
SMT202200448T1 (it) 2023-01-13
HRP20221459T1 (hr) 2023-01-20
JP2026016575A (ja) 2026-02-03
CA3084049A1 (en) 2019-06-13
IL318197A (en) 2025-03-01
KR20200093570A (ko) 2020-08-05
KR20250022220A (ko) 2025-02-14
IL274797B1 (en) 2025-02-01
FI4140297T3 (fi) 2025-07-10
SI3720279T1 (sl) 2022-11-30
TWI827567B (zh) 2024-01-01
SI4140297T1 (sl) 2025-08-29
JP2021505141A (ja) 2021-02-18
ES3035461T3 (en) 2025-09-03
EP3720279B1 (en) 2022-09-21
HUE071852T2 (hu) 2025-09-28
RS63772B1 (sr) 2022-12-30
KR102760506B1 (ko) 2025-02-04
US20260020545A1 (en) 2026-01-22
HRP20250920T1 (hr) 2025-09-26
JP7430636B2 (ja) 2024-02-13
BR112020011184A2 (pt) 2020-11-17
CN116058333A (zh) 2023-05-05
JP7765514B2 (ja) 2025-11-06
JP2024036440A (ja) 2024-03-15
TW201938019A (zh) 2019-10-01
EP4140297B1 (en) 2025-05-21
PL3720279T3 (pl) 2023-01-16
SG11202003044SA (en) 2020-04-29
SMT202500277T1 (it) 2025-09-12
IL274797B2 (en) 2025-06-01
IL274797A (en) 2020-07-30
MX2024004496A (es) 2024-05-08
CN111432635B (zh) 2022-10-21
US11051498B2 (en) 2021-07-06
CN111432635A (zh) 2020-07-17
EP4596688A2 (en) 2025-08-06
RU2020118699A3 (https=) 2022-04-07
DK3720279T3 (da) 2022-10-24
PT4140297T (pt) 2025-07-09
AU2018381316B2 (en) 2025-06-26
EP3720279A1 (en) 2020-10-14
MX2020005830A (es) 2020-08-20
WO2019113065A1 (en) 2019-06-13
DK4140297T3 (da) 2025-06-23
HUE060608T2 (hu) 2023-03-28
US20210292439A1 (en) 2021-09-23
TW202438676A (zh) 2024-10-01
PT3720279T (pt) 2022-10-06
US12356967B2 (en) 2025-07-15
PL4140297T3 (pl) 2025-08-25
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