LT3952B - Substituted benzimidazoles, process for their preparation and their pharmaceutical use - Google Patents

Substituted benzimidazoles, process for their preparation and their pharmaceutical use Download PDF

Info

Publication number
LT3952B
LT3952B LTIP1712A LTIP1712A LT3952B LT 3952 B LT3952 B LT 3952B LT IP1712 A LTIP1712 A LT IP1712A LT IP1712 A LTIP1712 A LT IP1712A LT 3952 B LT3952 B LT 3952B
Authority
LT
Lithuania
Prior art keywords
methyl
compound
formula
dimethoxy
pyridinyl
Prior art date
Application number
LTIP1712A
Other languages
English (en)
Lithuanian (lt)
Inventor
Arne Elof Braendstroem
Per Lennart Lindberg
Gunnel Elisabeth Sunden
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Ab filed Critical Astra Ab
Publication of LTIP1712A publication Critical patent/LTIP1712A/xx
Publication of LT3952B publication Critical patent/LT3952B/lt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
LTIP1712A 1990-06-20 1993-12-30 Substituted benzimidazoles, process for their preparation and their pharmaceutical use LT3952B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9002206A SE9002206D0 (sv) 1990-06-20 1990-06-20 New compounds

Publications (2)

Publication Number Publication Date
LTIP1712A LTIP1712A (en) 1995-08-25
LT3952B true LT3952B (en) 1996-05-27

Family

ID=20379831

Family Applications (2)

Application Number Title Priority Date Filing Date
LTIP1712A LT3952B (en) 1990-06-20 1993-12-30 Substituted benzimidazoles, process for their preparation and their pharmaceutical use
LTIP1713A LT3977B (en) 1990-06-20 1993-12-30 Dialkoxy-pyridinyl-benzimidazole derivatives, process for their preparation and their pharmaceutical use

Family Applications After (1)

Application Number Title Priority Date Filing Date
LTIP1713A LT3977B (en) 1990-06-20 1993-12-30 Dialkoxy-pyridinyl-benzimidazole derivatives, process for their preparation and their pharmaceutical use

Country Status (27)

Country Link
EP (1) EP0535081A1 (zh)
JP (1) JPH05507713A (zh)
CN (1) CN1058212A (zh)
AP (1) AP215A (zh)
AU (1) AU649453B2 (zh)
BG (1) BG97200A (zh)
CA (1) CA2083714A1 (zh)
CZ (1) CZ279772B6 (zh)
FI (1) FI925766A0 (zh)
HU (1) HUT62881A (zh)
IE (1) IE912025A1 (zh)
IL (1) IL98470A0 (zh)
IS (1) IS3721A7 (zh)
LT (2) LT3952B (zh)
LV (1) LV10953A (zh)
MA (1) MA22199A1 (zh)
NO (1) NO924775L (zh)
NZ (1) NZ238546A (zh)
OA (1) OA09682A (zh)
PT (1) PT98035A (zh)
RO (1) RO110493B1 (zh)
SE (1) SE9002206D0 (zh)
TN (1) TNSN91049A1 (zh)
TW (1) TW216418B (zh)
WO (1) WO1991019711A1 (zh)
YU (1) YU104191A (zh)
ZA (2) ZA914296B (zh)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9002043D0 (sv) * 1990-06-07 1990-06-07 Astra Ab Improved method for synthesis
SE9103776D0 (sv) * 1991-12-19 1991-12-19 Astra Ab New compounds
IS4232A (is) * 1993-12-06 1995-06-07 Astra Aktiebolag Súbstitúerað bensimidasól, aðferðir við framleiðslu þess og lyfjafræðileg notkun
SE9500422D0 (sv) * 1995-02-06 1995-02-06 Astra Ab New oral pharmaceutical dosage forms
SE9500478D0 (sv) * 1995-02-09 1995-02-09 Astra Ab New pharmaceutical formulation and process
SE9600070D0 (sv) 1996-01-08 1996-01-08 Astra Ab New oral pharmaceutical dosage forms
CA2400953A1 (en) 2000-02-24 2001-08-30 Kopran Research Laboratories Limited Orally administrable acid stable anti-ulcer benzimidazole derivatives
SE0101379D0 (sv) 2001-04-18 2001-04-18 Diabact Ab Komposition som hämmar utsöndring av magsyra
US8206741B2 (en) 2001-06-01 2012-06-26 Pozen Inc. Pharmaceutical compositions for the coordinated delivery of NSAIDs
MXPA04009968A (es) 2002-04-09 2004-12-13 Flamel Tech Sa Formulacion farmaceutica oral bajo forma de suspension acuosa de microcapsulas que permiten la liberacion modificada de principio (s) activo (s).
SE0203065D0 (sv) 2002-10-16 2002-10-16 Diabact Ab Gastric acid secretion inhibiting composition
WO2005072079A2 (en) 2003-09-26 2005-08-11 Alza Coporation Drug coating providing high drug loading and methods for providing the same
TW200606163A (en) 2004-04-22 2006-02-16 Eisai Co Ltd Imidazopyridine compound
US8541026B2 (en) 2004-09-24 2013-09-24 Abbvie Inc. Sustained release formulations of opioid and nonopioid analgesics
US20070015782A1 (en) 2005-04-15 2007-01-18 Eisai Co., Ltd. Benzimidazole compound
US9040564B2 (en) 2005-04-28 2015-05-26 Eisai R&D Management Co., Ltd. Stabilized composition
US7803817B2 (en) 2005-05-11 2010-09-28 Vecta, Ltd. Composition and methods for inhibiting gastric acid secretion
US7981908B2 (en) 2005-05-11 2011-07-19 Vecta, Ltd. Compositions and methods for inhibiting gastric acid secretion
WO2007122686A1 (ja) * 2006-04-14 2007-11-01 Eisai R & D Management Co., Ltd. ベンズイミダゾール化合物
PL2046334T3 (pl) 2006-07-25 2015-02-27 Vecta Ltd Kompozycje i sposoby hamowania wydzielania kwasów żołądkowych z wykorzystaniem pochodnych małych kwasów dikarboksylowych w połączeniu z PPI
WO2008047681A1 (fr) * 2006-10-13 2008-04-24 Eisai R & D Management Co., Ltd. Benzimidazole présentant une activité inhibitrice de la sécrétion d'acide gastrique
KR20110079641A (ko) 2008-09-09 2011-07-07 아스트라제네카 아베 제약 조성물을 이를 필요로 하는 환자에게 전달하는 방법
AU2010263304A1 (en) 2009-06-25 2012-02-02 Astrazeneca Ab Method for treating a patient at risk for developing an NSAID-associated ulcer
WO2011080500A2 (en) 2009-12-29 2011-07-07 Orexo Ab New pharmaceutical dosage form for the treatment of gastric acid-related disorders
US20120294937A1 (en) 2009-12-29 2012-11-22 Novartis Ag New pharmaceutical dosage form for the treatment of gastric acid-related disorders
WO2011080502A2 (en) 2009-12-29 2011-07-07 Orexo Ab New pharmaceutical dosage form for the treatment of gastric acid-related disorders
EP2601947A1 (en) 2011-12-05 2013-06-12 Abo Bakr Mohammed Ali Al-Mehdar Fixed-dose combination for treatment of helicobacter pylori associated diseases
EP2797600A4 (en) 2011-12-28 2015-09-16 Pozen Inc IMPROVED COMPOSITIONS AND METHODS OF DISTRIBUTING OMEPRAZOLE AND ACETYL SALICYLIC ACID
WO2018053161A1 (en) * 2016-09-14 2018-03-22 National Taiwan University Novel substituted benzimidazole derivatives as d-amino acid oxidase (daao) inhibitors

Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1500043A (en) 1974-02-18 1978-02-08 Haessle Ab Benzimidazole derivatives their preparation and their use in affecting gastric acid secretion
GB1525958A (en) 1974-05-16 1978-09-27 Haessle Ab 2-(heterocyclic substituted alkylsulphinyl)-benzimidazoles and their pharmaceutical compositions
US4182766A (en) 1977-09-19 1980-01-08 Hoffmann-La Roche Inc. Naphth[2,3-d]imidazoles
US4255431A (en) 1978-04-14 1981-03-10 Aktiebolaget Hassle Gastric acid secretion inhibiting substituted 2-(2-benzimidazolyl)-pyridines, pharmaceutical preparations containing same, and method for inhibiting gastric acid secretion
US4359465A (en) 1980-07-28 1982-11-16 The Upjohn Company Methods for treating gastrointestinal inflammation
BE898880A (fr) 1983-02-11 1984-08-10 Haessle Ab Nouveaux benzimidazoles, preparations pharmaceutiques qui les contiennent et leur preparation
EP0124495A2 (en) 1983-03-04 1984-11-07 Aktiebolaget Hässle Omeprazole salts
EP0176308A2 (en) 1984-09-24 1986-04-02 The Upjohn Company 2-(Pyridylalkylenesulfinyl) benzimidazoles
US4599347A (en) 1980-08-21 1986-07-08 Hoffmann-La Roche Inc. Tetrahydro-naphth (2.3-d) imidazole derivatives
EP0208452A2 (en) 1985-07-02 1987-01-14 Takeda Chemical Industries, Ltd. Pyridine derivatives, their production and use
EP0221041A2 (en) 1985-10-29 1987-05-06 Aktiebolaget Hässle Benzimidazole derivatives, process for their preparation and their pharmaceutical use
EP0279149A2 (en) 1986-11-21 1988-08-24 Aktiebolaget Hässle Benzimidazole derivatives, process for their production and a pharmaceutical composition containing the same

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL75400A (en) * 1984-06-16 1988-10-31 Byk Gulden Lomberg Chem Fab Dialkoxypyridine methyl(sulfinyl or sulfonyl)benzimidazoles,processes for the preparation thereof and pharmaceutical compositions containing the same
IL76839A (en) * 1984-10-31 1988-08-31 Byk Gulden Lomberg Chem Fab Picoline derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
DE3722810A1 (de) * 1987-07-10 1989-01-19 Hoechst Ag Substituierte benzimidazole, verfahren zu deren herstellung, diese enthaltende pharmazeutische zubereitungen und deren verwendung
MY103790A (en) * 1987-10-30 1993-09-30 Ab Hassle Novel compound for the treatment of several bone affecting diseases
AU2817989A (en) * 1987-12-11 1989-07-05 Byk Gulden Lomberg Chemische Fabrik Gmbh Novel benzimidazole derivatives
AU3690289A (en) * 1988-05-25 1989-12-12 Byk Gulden Lomberg Chemische Fabrik Gmbh New fluoralkoxy compounds

Patent Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1500043A (en) 1974-02-18 1978-02-08 Haessle Ab Benzimidazole derivatives their preparation and their use in affecting gastric acid secretion
GB1525958A (en) 1974-05-16 1978-09-27 Haessle Ab 2-(heterocyclic substituted alkylsulphinyl)-benzimidazoles and their pharmaceutical compositions
US4182766A (en) 1977-09-19 1980-01-08 Hoffmann-La Roche Inc. Naphth[2,3-d]imidazoles
US4255431A (en) 1978-04-14 1981-03-10 Aktiebolaget Hassle Gastric acid secretion inhibiting substituted 2-(2-benzimidazolyl)-pyridines, pharmaceutical preparations containing same, and method for inhibiting gastric acid secretion
US4359465A (en) 1980-07-28 1982-11-16 The Upjohn Company Methods for treating gastrointestinal inflammation
US4599347A (en) 1980-08-21 1986-07-08 Hoffmann-La Roche Inc. Tetrahydro-naphth (2.3-d) imidazole derivatives
BE898880A (fr) 1983-02-11 1984-08-10 Haessle Ab Nouveaux benzimidazoles, preparations pharmaceutiques qui les contiennent et leur preparation
EP0124495A2 (en) 1983-03-04 1984-11-07 Aktiebolaget Hässle Omeprazole salts
EP0176308A2 (en) 1984-09-24 1986-04-02 The Upjohn Company 2-(Pyridylalkylenesulfinyl) benzimidazoles
EP0208452A2 (en) 1985-07-02 1987-01-14 Takeda Chemical Industries, Ltd. Pyridine derivatives, their production and use
EP0221041A2 (en) 1985-10-29 1987-05-06 Aktiebolaget Hässle Benzimidazole derivatives, process for their preparation and their pharmaceutical use
EP0279149A2 (en) 1986-11-21 1988-08-24 Aktiebolaget Hässle Benzimidazole derivatives, process for their production and a pharmaceutical composition containing the same

Also Published As

Publication number Publication date
FI925766A (fi) 1992-12-18
TW216418B (zh) 1993-11-21
YU104191A (sh) 1994-01-20
AP9100285A0 (en) 1991-07-31
ZA914296B (en) 1992-03-25
CS189491A3 (en) 1992-04-15
MA22199A1 (fr) 1992-04-01
OA09682A (en) 1993-05-15
LTIP1713A (en) 1995-08-25
FI925766A0 (fi) 1992-12-18
NO924775D0 (no) 1992-12-10
NZ238546A (en) 1994-03-25
BG97200A (bg) 1993-12-24
AU649453B2 (en) 1994-05-26
CZ279772B6 (cs) 1995-06-14
PT98035A (pt) 1992-03-31
AU8009791A (en) 1992-01-07
LV10953A (lv) 1995-12-20
AP215A (en) 1992-09-02
NO924775L (no) 1992-12-10
CA2083714A1 (en) 1991-12-21
JPH05507713A (ja) 1993-11-04
HU9204033D0 (en) 1993-03-29
WO1991019711A1 (en) 1991-12-26
LTIP1712A (en) 1995-08-25
EP0535081A1 (en) 1993-04-07
CN1058212A (zh) 1992-01-29
TNSN91049A1 (fr) 1992-10-25
IS3721A7 (is) 1991-12-21
LT3977B (en) 1996-06-25
IL98470A0 (en) 1992-07-15
RO110493B1 (ro) 1996-01-30
HUT62881A (en) 1993-06-28
SE9002206D0 (sv) 1990-06-20
IE912025A1 (en) 1992-01-01
ZA914297B (en) 1992-03-25

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Effective date: 19961230