LT3952B - Substituted benzimidazoles, process for their preparation and their pharmaceutical use - Google Patents

Substituted benzimidazoles, process for their preparation and their pharmaceutical use Download PDF

Info

Publication number
LT3952B
LT3952B LTIP1712A LTIP1712A LT3952B LT 3952 B LT3952 B LT 3952B LT IP1712 A LTIP1712 A LT IP1712A LT IP1712 A LTIP1712 A LT IP1712A LT 3952 B LT3952 B LT 3952B
Authority
LT
Lithuania
Prior art keywords
methyl
compound
formula
dimethoxy
pyridinyl
Prior art date
Application number
LTIP1712A
Other languages
English (en)
Lithuanian (lt)
Inventor
Arne Elof Braendstroem
Per Lennart Lindberg
Gunnel Elisabeth Sunden
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Ab filed Critical Astra Ab
Publication of LTIP1712A publication Critical patent/LTIP1712A/xx
Publication of LT3952B publication Critical patent/LT3952B/lt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
LTIP1712A 1990-06-20 1993-12-30 Substituted benzimidazoles, process for their preparation and their pharmaceutical use LT3952B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9002206A SE9002206D0 (sv) 1990-06-20 1990-06-20 New compounds

Publications (2)

Publication Number Publication Date
LTIP1712A LTIP1712A (en) 1995-08-25
LT3952B true LT3952B (en) 1996-05-27

Family

ID=20379831

Family Applications (2)

Application Number Title Priority Date Filing Date
LTIP1712A LT3952B (en) 1990-06-20 1993-12-30 Substituted benzimidazoles, process for their preparation and their pharmaceutical use
LTIP1713A LT3977B (en) 1990-06-20 1993-12-30 Dialkoxy-pyridinyl-benzimidazole derivatives, process for their preparation and their pharmaceutical use

Family Applications After (1)

Application Number Title Priority Date Filing Date
LTIP1713A LT3977B (en) 1990-06-20 1993-12-30 Dialkoxy-pyridinyl-benzimidazole derivatives, process for their preparation and their pharmaceutical use

Country Status (27)

Country Link
EP (1) EP0535081A1 (de)
JP (1) JPH05507713A (de)
CN (1) CN1058212A (de)
AP (1) AP215A (de)
AU (1) AU649453B2 (de)
BG (1) BG97200A (de)
CA (1) CA2083714A1 (de)
CZ (1) CZ279772B6 (de)
FI (1) FI925766A (de)
HU (1) HUT62881A (de)
IE (1) IE912025A1 (de)
IL (1) IL98470A0 (de)
IS (1) IS3721A7 (de)
LT (2) LT3952B (de)
LV (1) LV10953A (de)
MA (1) MA22199A1 (de)
NO (1) NO924775L (de)
NZ (1) NZ238546A (de)
OA (1) OA09682A (de)
PT (1) PT98035A (de)
RO (1) RO110493B1 (de)
SE (1) SE9002206D0 (de)
TN (1) TNSN91049A1 (de)
TW (1) TW216418B (de)
WO (1) WO1991019711A1 (de)
YU (1) YU104191A (de)
ZA (2) ZA914296B (de)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9002043D0 (sv) * 1990-06-07 1990-06-07 Astra Ab Improved method for synthesis
SE9103776D0 (sv) * 1991-12-19 1991-12-19 Astra Ab New compounds
IS4232A (is) * 1993-12-06 1995-06-07 Astra Aktiebolag Súbstitúerað bensimidasól, aðferðir við framleiðslu þess og lyfjafræðileg notkun
SE9500422D0 (sv) * 1995-02-06 1995-02-06 Astra Ab New oral pharmaceutical dosage forms
SE9500478D0 (sv) * 1995-02-09 1995-02-09 Astra Ab New pharmaceutical formulation and process
SE9600070D0 (sv) 1996-01-08 1996-01-08 Astra Ab New oral pharmaceutical dosage forms
ATE281164T1 (de) 2000-02-24 2004-11-15 Kopran Res Lab Ltd Oral verabreichbare säurebeständige geschwürbehandelnde benzimidazolderivate
SE0101379D0 (sv) 2001-04-18 2001-04-18 Diabact Ab Komposition som hämmar utsöndring av magsyra
US8206741B2 (en) 2001-06-01 2012-06-26 Pozen Inc. Pharmaceutical compositions for the coordinated delivery of NSAIDs
DE60325709D1 (de) 2002-04-09 2009-02-26 Flamel Tech Sa Orale wässrige suspension, mikrokapseln enthaltend, zur kontrollierten freisetzung von wirkstoffen
SE0203065D0 (sv) 2002-10-16 2002-10-16 Diabact Ab Gastric acid secretion inhibiting composition
KR20060092255A (ko) 2003-09-26 2006-08-22 알자 코포레이션 고도의 약물적재를 제공하는 약물코팅제 및 그의 제조방법
TW200606163A (en) 2004-04-22 2006-02-16 Eisai Co Ltd Imidazopyridine compound
US8541026B2 (en) 2004-09-24 2013-09-24 Abbvie Inc. Sustained release formulations of opioid and nonopioid analgesics
US20070015782A1 (en) * 2005-04-15 2007-01-18 Eisai Co., Ltd. Benzimidazole compound
US9040564B2 (en) 2005-04-28 2015-05-26 Eisai R&D Management Co., Ltd. Stabilized composition
US7981908B2 (en) 2005-05-11 2011-07-19 Vecta, Ltd. Compositions and methods for inhibiting gastric acid secretion
US7803817B2 (en) 2005-05-11 2010-09-28 Vecta, Ltd. Composition and methods for inhibiting gastric acid secretion
WO2007122686A1 (ja) * 2006-04-14 2007-11-01 Eisai R & D Management Co., Ltd. ベンズイミダゾール化合物
PL2046334T3 (pl) 2006-07-25 2015-02-27 Vecta Ltd Kompozycje i sposoby hamowania wydzielania kwasów żołądkowych z wykorzystaniem pochodnych małych kwasów dikarboksylowych w połączeniu z PPI
US20110009624A9 (en) * 2006-10-13 2011-01-13 Masato Ueda Benzimidazole compounds having gastric acid secretion inhibitory action
AU2009290712A1 (en) 2008-09-09 2010-03-18 Astrazeneca Ab Method for delivering a pharmaceutical composition to patient in need thereof
WO2010151216A1 (en) 2009-06-25 2010-12-29 Astrazeneca Ab Method for treating a patient at risk for developing an nsaid-associated ulcer
EP2519229A2 (de) 2009-12-29 2012-11-07 Novartis AG Neue pharmazeutische darreichungsform zur behandlung von magensäurebedingten erkrankungen
WO2011080500A2 (en) 2009-12-29 2011-07-07 Orexo Ab New pharmaceutical dosage form for the treatment of gastric acid-related disorders
WO2011080502A2 (en) 2009-12-29 2011-07-07 Orexo Ab New pharmaceutical dosage form for the treatment of gastric acid-related disorders
EP2601947A1 (de) 2011-12-05 2013-06-12 Abo Bakr Mohammed Ali Al-Mehdar Kombinationspräparat mit fester Dosierung zur Behandlung von Erkrankungen einhergehend mit Helicobacter pylori
CA2860231A1 (en) 2011-12-28 2013-07-04 Pozen Inc. Improved compositions and methods for delivery of omeprazole plus acetylsalicylic acid
MX2019002726A (es) * 2016-09-14 2019-09-23 Jane Tseng Yufeng Novedosos derivados sustituidos como inhibidores de la d-aminoacido oxidasa (daao).

Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1500043A (en) 1974-02-18 1978-02-08 Haessle Ab Benzimidazole derivatives their preparation and their use in affecting gastric acid secretion
GB1525958A (en) 1974-05-16 1978-09-27 Haessle Ab 2-(heterocyclic substituted alkylsulphinyl)-benzimidazoles and their pharmaceutical compositions
US4182766A (en) 1977-09-19 1980-01-08 Hoffmann-La Roche Inc. Naphth[2,3-d]imidazoles
US4255431A (en) 1978-04-14 1981-03-10 Aktiebolaget Hassle Gastric acid secretion inhibiting substituted 2-(2-benzimidazolyl)-pyridines, pharmaceutical preparations containing same, and method for inhibiting gastric acid secretion
US4359465A (en) 1980-07-28 1982-11-16 The Upjohn Company Methods for treating gastrointestinal inflammation
BE898880A (fr) 1983-02-11 1984-08-10 Haessle Ab Nouveaux benzimidazoles, preparations pharmaceutiques qui les contiennent et leur preparation
EP0124495A2 (de) 1983-03-04 1984-11-07 Aktiebolaget Hässle Omeprazol-Salze
EP0176308A2 (de) 1984-09-24 1986-04-02 The Upjohn Company 2-(Pyridylalkenylsulfinyl)benzimidazole
US4599347A (en) 1980-08-21 1986-07-08 Hoffmann-La Roche Inc. Tetrahydro-naphth (2.3-d) imidazole derivatives
EP0208452A2 (de) 1985-07-02 1987-01-14 Takeda Chemical Industries, Ltd. Pyridinderivate, deren Herstellung und Anwendung
EP0221041A2 (de) 1985-10-29 1987-05-06 Aktiebolaget Hässle Benzimidazolderivate, Verfahren zu deren Herstellung und ihre pharmazeutische Verwendung
EP0279149A2 (de) 1986-11-21 1988-08-24 Aktiebolaget Hässle Benzimidazolderivate, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Präparate

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL75400A (en) * 1984-06-16 1988-10-31 Byk Gulden Lomberg Chem Fab Dialkoxypyridine methyl(sulfinyl or sulfonyl)benzimidazoles,processes for the preparation thereof and pharmaceutical compositions containing the same
IL76839A (en) * 1984-10-31 1988-08-31 Byk Gulden Lomberg Chem Fab Picoline derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
DE3722810A1 (de) * 1987-07-10 1989-01-19 Hoechst Ag Substituierte benzimidazole, verfahren zu deren herstellung, diese enthaltende pharmazeutische zubereitungen und deren verwendung
WO1989003830A1 (en) * 1987-10-30 1989-05-05 Aktiebolaget Hässle 2-pyridinylmethyl (sulfinyl or thio)benzimidazoles for treatment of diseases related to bone loss
EP0390842A1 (de) * 1987-12-11 1990-10-10 Byk Gulden Lomberg Chemische Fabrik GmbH Neue benzimidazolderivate
EP0415990A1 (de) * 1988-05-25 1991-03-13 Byk Gulden Lomberg Chemische Fabrik GmbH Neue fluoralkoxyverbindungen

Patent Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1500043A (en) 1974-02-18 1978-02-08 Haessle Ab Benzimidazole derivatives their preparation and their use in affecting gastric acid secretion
GB1525958A (en) 1974-05-16 1978-09-27 Haessle Ab 2-(heterocyclic substituted alkylsulphinyl)-benzimidazoles and their pharmaceutical compositions
US4182766A (en) 1977-09-19 1980-01-08 Hoffmann-La Roche Inc. Naphth[2,3-d]imidazoles
US4255431A (en) 1978-04-14 1981-03-10 Aktiebolaget Hassle Gastric acid secretion inhibiting substituted 2-(2-benzimidazolyl)-pyridines, pharmaceutical preparations containing same, and method for inhibiting gastric acid secretion
US4359465A (en) 1980-07-28 1982-11-16 The Upjohn Company Methods for treating gastrointestinal inflammation
US4599347A (en) 1980-08-21 1986-07-08 Hoffmann-La Roche Inc. Tetrahydro-naphth (2.3-d) imidazole derivatives
BE898880A (fr) 1983-02-11 1984-08-10 Haessle Ab Nouveaux benzimidazoles, preparations pharmaceutiques qui les contiennent et leur preparation
EP0124495A2 (de) 1983-03-04 1984-11-07 Aktiebolaget Hässle Omeprazol-Salze
EP0176308A2 (de) 1984-09-24 1986-04-02 The Upjohn Company 2-(Pyridylalkenylsulfinyl)benzimidazole
EP0208452A2 (de) 1985-07-02 1987-01-14 Takeda Chemical Industries, Ltd. Pyridinderivate, deren Herstellung und Anwendung
EP0221041A2 (de) 1985-10-29 1987-05-06 Aktiebolaget Hässle Benzimidazolderivate, Verfahren zu deren Herstellung und ihre pharmazeutische Verwendung
EP0279149A2 (de) 1986-11-21 1988-08-24 Aktiebolaget Hässle Benzimidazolderivate, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Präparate

Also Published As

Publication number Publication date
LTIP1712A (en) 1995-08-25
IS3721A7 (is) 1991-12-21
CZ279772B6 (cs) 1995-06-14
LTIP1713A (en) 1995-08-25
HU9204033D0 (en) 1993-03-29
TW216418B (de) 1993-11-21
MA22199A1 (fr) 1992-04-01
FI925766A0 (fi) 1992-12-18
JPH05507713A (ja) 1993-11-04
LV10953A (lv) 1995-12-20
IE912025A1 (en) 1992-01-01
NO924775D0 (no) 1992-12-10
SE9002206D0 (sv) 1990-06-20
CA2083714A1 (en) 1991-12-21
YU104191A (sh) 1994-01-20
AU649453B2 (en) 1994-05-26
AP9100285A0 (en) 1991-07-31
CN1058212A (zh) 1992-01-29
NO924775L (no) 1992-12-10
ZA914297B (en) 1992-03-25
AP215A (en) 1992-09-02
OA09682A (en) 1993-05-15
CS189491A3 (en) 1992-04-15
HUT62881A (en) 1993-06-28
WO1991019711A1 (en) 1991-12-26
TNSN91049A1 (fr) 1992-10-25
LT3977B (en) 1996-06-25
NZ238546A (en) 1994-03-25
AU8009791A (en) 1992-01-07
IL98470A0 (en) 1992-07-15
RO110493B1 (ro) 1996-01-30
BG97200A (bg) 1993-12-24
PT98035A (pt) 1992-03-31
FI925766A (fi) 1992-12-18
ZA914296B (en) 1992-03-25
EP0535081A1 (de) 1993-04-07

Similar Documents

Publication Publication Date Title
LT3952B (en) Substituted benzimidazoles, process for their preparation and their pharmaceutical use
EP0593463B1 (de) Dialkoxypyridinylbenzimidazolderivate, verfahren zur herstellung und ihre pharmazeutische verwendung
EP0449940B1 (de) Therapeutisch aktive verbindung und verfahren zu deren herstellung
US4965269A (en) Therapeutically active chloro substituted benzimidazoles
EP0451188B1 (de) Therapeutisch aktive substituierte Benzimidazole und Verfahren zu ihrer Herstellung
EP0449935B1 (de) Verbindungen mit magensäureinhibitorwirkung und verfahren zur herstellung
US5049674A (en) Therapeutically active fluoro substituted benzimidazoles
US5441968A (en) Therapeutically active fluoro substituted benzimidazoles

Legal Events

Date Code Title Description
MM9A Lapsed patents

Effective date: 19961230