LT3348556T - Heteroarilo amidai kaip baltymų agregacijos inhibitoriai - Google Patents

Heteroarilo amidai kaip baltymų agregacijos inhibitoriai

Info

Publication number
LT3348556T
LT3348556T LTEP18156929.4T LT18156929T LT3348556T LT 3348556 T LT3348556 T LT 3348556T LT 18156929 T LT18156929 T LT 18156929T LT 3348556 T LT3348556 T LT 3348556T
Authority
LT
Lithuania
Prior art keywords
amids
heteroaryl
protein aggregation
aggregation inhibitors
inhibitors
Prior art date
Application number
LTEP18156929.4T
Other languages
English (en)
Lithuanian (lt)
Inventor
Emily M. Stocking
Wolfgang Wrasidlo
Original Assignee
UCB Biopharma SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=52484559&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=LT3348556(T) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by UCB Biopharma SRL filed Critical UCB Biopharma SRL
Publication of LT3348556T publication Critical patent/LT3348556T/lt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
LTEP18156929.4T 2014-01-29 2015-01-28 Heteroarilo amidai kaip baltymų agregacijos inhibitoriai LT3348556T (lt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461933246P 2014-01-29 2014-01-29
US201462078895P 2014-11-12 2014-11-12

Publications (1)

Publication Number Publication Date
LT3348556T true LT3348556T (lt) 2020-08-10

Family

ID=52484559

Family Applications (2)

Application Number Title Priority Date Filing Date
LTEP18156929.4T LT3348556T (lt) 2014-01-29 2015-01-28 Heteroarilo amidai kaip baltymų agregacijos inhibitoriai
LTEP15705417.2T LT3099684T (lt) 2014-01-29 2015-01-28 Heteroarilamidai, kaip baltymų agregacijos inhibitoriai

Family Applications After (1)

Application Number Title Priority Date Filing Date
LTEP15705417.2T LT3099684T (lt) 2014-01-29 2015-01-28 Heteroarilamidai, kaip baltymų agregacijos inhibitoriai

Country Status (38)

Country Link
US (3) US9738635B2 (enExample)
EP (2) EP3348556B1 (enExample)
JP (2) JP6619741B2 (enExample)
KR (1) KR102383038B1 (enExample)
CN (2) CN111039939B (enExample)
AP (1) AP2016009347A0 (enExample)
AU (1) AU2015211119B2 (enExample)
BR (2) BR112016017344B1 (enExample)
CA (1) CA2937967C (enExample)
CL (1) CL2016001918A1 (enExample)
CR (1) CR20160394A (enExample)
CY (2) CY1120348T1 (enExample)
DK (2) DK3348556T3 (enExample)
EA (1) EA032374B1 (enExample)
EC (1) ECSP16070327A (enExample)
ES (2) ES2675301T3 (enExample)
HK (1) HK1231470A1 (enExample)
HR (2) HRP20180813T1 (enExample)
HU (2) HUE040274T2 (enExample)
IL (1) IL246987B (enExample)
LT (2) LT3348556T (enExample)
ME (1) ME03800B (enExample)
MX (1) MX2016009896A (enExample)
MY (1) MY187450A (enExample)
NZ (1) NZ722487A (enExample)
PE (1) PE20161393A1 (enExample)
PH (1) PH12016501493B1 (enExample)
PL (2) PL3348556T3 (enExample)
PT (2) PT3099684T (enExample)
RS (2) RS60547B1 (enExample)
SA (1) SA516371579B1 (enExample)
SG (1) SG11201606108RA (enExample)
SI (2) SI3099684T1 (enExample)
SM (2) SMT202000376T1 (enExample)
TR (1) TR201809440T4 (enExample)
UA (1) UA118209C2 (enExample)
WO (1) WO2015116663A1 (enExample)
ZA (1) ZA201605246B (enExample)

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JP7100042B2 (ja) * 2017-01-26 2022-07-12 ユーシービー バイオファルマ エスアールエル タンパク質凝集のモジュレーターとしてのアルコキシビス－ヘテロアリール誘導体
JP7100043B2 (ja) * 2017-01-26 2022-07-12 ユーシービー バイオファルマ エスアールエル タンパク質凝集のモジュレーターとしてのビス－ヘテロアリール誘導体
ES3035044T3 (en) * 2017-05-12 2025-08-27 Max Planck Gesellschaft Phenyl-heterocycle-phenyl derivatives for use in the treatment or prevention of melanoma
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DK3348556T3 (da) 2014-01-29 2020-08-03 UCB Biopharma SRL Heteroarylamider som hæmmere af proteinaggregering
US10975066B2 (en) 2015-07-29 2021-04-13 UCB Biopharma SRL Bis-heteroaryl derivatives as modulators of protein aggregation
BR112019011924A2 (pt) 2017-01-26 2019-10-29 Ucb Biopharma Sprl derivados de bis-heteroarila bicíclicos como moduladores de agregação de proteína
JP7100043B2 (ja) 2017-01-26 2022-07-12 ユーシービー バイオファルマ エスアールエル タンパク質凝集のモジュレーターとしてのビス－ヘテロアリール誘導体

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CA2937967A1 (en) 2015-08-06
JP6619741B2 (ja) 2019-12-11
US9738635B2 (en) 2017-08-22
PL3348556T3 (pl) 2020-11-02
EP3099684B8 (en) 2018-07-04
EA201691529A1 (ru) 2017-01-30
SMT201800318T1 (it) 2018-07-17
US10358443B2 (en) 2019-07-23
US20190308965A1 (en) 2019-10-10
EP3099684B1 (en) 2018-04-04
SMT202000376T1 (it) 2020-09-10
CN111039939B (zh) 2023-09-19
RS57533B1 (sr) 2018-10-31
EP3099684A1 (en) 2016-12-07
PT3099684T (pt) 2018-10-22
JP6783900B2 (ja) 2020-11-11
SI3099684T1 (en) 2018-08-31
TR201809440T4 (tr) 2018-07-23
MX2016009896A (es) 2017-01-11
CN106132960B (zh) 2019-12-17
AU2015211119A8 (en) 2016-12-15
US20160207912A1 (en) 2016-07-21
CY1120348T1 (el) 2019-07-10
SI3348556T1 (sl) 2020-10-30
DK3099684T3 (en) 2018-07-16
ME03800B (me) 2021-04-20
PH12016501493A1 (en) 2017-02-06
HUE050964T2 (hu) 2021-01-28
BR122018001892B1 (pt) 2023-05-02
PE20161393A1 (es) 2017-01-08
ES2808978T8 (es) 2021-03-22
ES2808978T3 (es) 2021-03-02
US20180093979A1 (en) 2018-04-05
SG11201606108RA (en) 2016-08-30
EP3348556B1 (en) 2020-04-29
AP2016009347A0 (en) 2016-07-31
CR20160394A (es) 2016-11-01
AU2015211119A1 (en) 2016-08-11
CA2937967C (en) 2022-07-26
ES2675301T3 (es) 2018-07-10
HRP20201107T8 (hr) 2020-12-11
HUE040274T2 (hu) 2019-03-28
ECSP16070327A (es) 2018-05-31
MY187450A (en) 2021-09-22
WO2015116663A8 (en) 2016-09-15
CY1123374T1 (el) 2021-12-31
PL3099684T3 (pl) 2018-09-28
IL246987A0 (en) 2016-09-29
CN111039939A (zh) 2020-04-21
KR20160113287A (ko) 2016-09-28
US11078196B2 (en) 2021-08-03
ZA201605246B (en) 2022-05-25
HK1231470A1 (zh) 2017-12-22
BR112016017344A2 (pt) 2017-10-03
BR112016017344B1 (pt) 2023-05-16
NZ722487A (en) 2022-04-29
SA516371579B1 (ar) 2019-07-16
EA032374B1 (ru) 2019-05-31
JP2019163321A (ja) 2019-09-26
AU2015211119B2 (en) 2019-05-30
KR102383038B1 (ko) 2022-04-05
JP2017505779A (ja) 2017-02-23
CL2016001918A1 (es) 2017-01-13
RS60547B1 (sr) 2020-08-31
PH12016501493B1 (en) 2017-02-06
HRP20180813T1 (hr) 2018-07-27
CN106132960A (zh) 2016-11-16
HRP20201107T1 (hr) 2020-10-30
LT3099684T (lt) 2018-06-25
DK3348556T3 (da) 2020-08-03
EP3348556A1 (en) 2018-07-18
PT3348556T (pt) 2020-07-27
IL246987B (en) 2021-12-01
UA118209C2 (uk) 2018-12-10
WO2015116663A1 (en) 2015-08-06

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