LT3348553T - Kristalinės androgeno receptoriaus moduliatoriaus formos - Google Patents

Kristalinės androgeno receptoriaus moduliatoriaus formos

Info

Publication number
LT3348553T
LT3348553T LTEP18157435.1T LT18157435T LT3348553T LT 3348553 T LT3348553 T LT 3348553T LT 18157435 T LT18157435 T LT 18157435T LT 3348553 T LT3348553 T LT 3348553T
Authority
LT
Lithuania
Prior art keywords
crystalline
androgen receptor
receptor modulator
modulator forms
forms
Prior art date
Application number
LTEP18157435.1T
Other languages
English (en)
Lithuanian (lt)
Inventor
Anna Dilhas
Ouathek Ouerfelli
Nicholas D. Smith
Mark R. Herbert
Original Assignee
Aragon Pharmaceuticals, Inc.
Sloan-Kettering Institute For Cancer Research
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49712550&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=LT3348553(T) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Aragon Pharmaceuticals, Inc., Sloan-Kettering Institute For Cancer Research filed Critical Aragon Pharmaceuticals, Inc.
Publication of LT3348553T publication Critical patent/LT3348553T/lt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • A61K31/41841,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/08Drugs for disorders of the urinary system of the prostate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/24Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/28Antiandrogens
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
LTEP18157435.1T 2012-06-07 2013-06-04 Kristalinės androgeno receptoriaus moduliatoriaus formos LT3348553T (lt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201261656888P 2012-06-07 2012-06-07

Publications (1)

Publication Number Publication Date
LT3348553T true LT3348553T (lt) 2020-09-25

Family

ID=49712550

Family Applications (4)

Application Number Title Priority Date Filing Date
LTEP18157435.1T LT3348553T (lt) 2012-06-07 2013-06-04 Kristalinės androgeno receptoriaus moduliatoriaus formos
LTEP13800681.2T LT2858985T (lt) 2012-06-07 2013-06-04 Kristalinės androgeno receptoriaus moduliatoriaus formos
LTEP19169275.5T LT3533792T (lt) 2012-06-07 2013-06-04 Androgeno receptoriaus moduliatoriaus kristalinės formos
LTPA2021525C LTC3533792I2 (enExample) 2012-06-07 2021-11-03

Family Applications After (3)

Application Number Title Priority Date Filing Date
LTEP13800681.2T LT2858985T (lt) 2012-06-07 2013-06-04 Kristalinės androgeno receptoriaus moduliatoriaus formos
LTEP19169275.5T LT3533792T (lt) 2012-06-07 2013-06-04 Androgeno receptoriaus moduliatoriaus kristalinės formos
LTPA2021525C LTC3533792I2 (enExample) 2012-06-07 2021-11-03

Country Status (45)

Country Link
US (9) US9481663B2 (enExample)
EP (4) EP3348553B1 (enExample)
JP (3) JP6182209B2 (enExample)
KR (2) KR102195916B1 (enExample)
CN (3) CN104619692A (enExample)
AU (3) AU2013271751B2 (enExample)
BR (1) BR112014030678A2 (enExample)
CA (4) CA3008345C (enExample)
CL (1) CL2014003331A1 (enExample)
CO (1) CO7240407A2 (enExample)
CR (2) CR20190331A (enExample)
CY (4) CY1120393T1 (enExample)
DK (3) DK3348553T3 (enExample)
EA (3) EA033956B1 (enExample)
EC (1) ECSP14030098A (enExample)
ES (3) ES2670683T3 (enExample)
FR (1) FR21C1050I2 (enExample)
GT (1) GT201400283A (enExample)
HK (2) HK1210175A1 (enExample)
HR (3) HRP20180902T1 (enExample)
HU (4) HUE050357T2 (enExample)
IL (5) IL267608B2 (enExample)
IN (1) IN2014DN10084A (enExample)
LT (4) LT3348553T (enExample)
LU (1) LUC00236I2 (enExample)
ME (2) ME03081B (enExample)
MX (1) MX356754B (enExample)
MY (1) MY187500A (enExample)
NI (1) NI201400142A (enExample)
NL (1) NL301144I2 (enExample)
NO (1) NO2021046I1 (enExample)
NZ (2) NZ717683A (enExample)
PE (3) PE20200725A1 (enExample)
PH (2) PH12014502714B1 (enExample)
PL (3) PL3533792T3 (enExample)
PT (3) PT2858985T (enExample)
RS (3) RS60617B1 (enExample)
SG (3) SG11201408140QA (enExample)
SI (3) SI3533792T1 (enExample)
SM (3) SMT202100355T1 (enExample)
TR (1) TR201808939T4 (enExample)
TW (1) TWI532732B (enExample)
UA (2) UA123142C2 (enExample)
WO (1) WO2013184681A1 (enExample)
ZA (1) ZA201500076B (enExample)

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US8461343B2 (en) 2007-03-27 2013-06-11 Sloan-Kettering Institute For Cancer Research Synthesis of thiohydantoins
AP2014007657A0 (en) 2011-12-16 2014-05-31 Olema Pharmaceuticals Inc Novel benzopyran compounds, compositions and uses thereof
CA3008345C (en) 2012-06-07 2019-10-22 Aragon Pharmaceuticals, Inc. Crystalline forms of an androgen receptor modulator
CN105358535B (zh) 2012-09-11 2019-01-04 麦迪威森前列腺医疗有限责任公司 恩杂鲁胺制剂
EA030128B1 (ru) 2012-09-26 2018-06-29 Арагон Фармасьютикалз, Инк. Способ лечения неметастатического кастрационно-резистентного рака простаты
JOP20200097A1 (ar) 2013-01-15 2017-06-16 Aragon Pharmaceuticals Inc معدل مستقبل أندروجين واستخداماته
CN106795152B (zh) * 2014-08-26 2020-01-31 安斯达尔生物技术有限责任公司 蛋白激酶抑制剂
KR20200141533A (ko) 2014-12-05 2020-12-18 아라곤 파마슈티컬스, 인코포레이티드 항암 조성물
PT3226843T (pt) 2014-12-05 2021-07-07 Aragon Pharmaceuticals Inc Composições anticancro
ES3021508T3 (en) 2014-12-05 2025-05-27 Aragon Pharmaceuticals Inc Anticancer compositions
US9888543B2 (en) 2014-12-19 2018-02-06 Lutron Electronics Co, Inc. Multi-channel lighting fixture having multiple light-emitting diode drivers
MA45090A (fr) 2016-06-03 2021-04-28 Aragon Pharmaceuticals Inc Compositions anticancéreuses
EP3555061B1 (en) 2016-12-13 2023-06-07 Watson Laboratories Inc. Solid state forms of apalutamide
KR20240096623A (ko) 2017-10-16 2024-06-26 아라곤 파마슈티컬스, 인코포레이티드 비-전이성 거세-저항성 전립선암의 치료를 위한 항-안드로겐
WO2019135254A1 (en) * 2018-01-02 2019-07-11 Mylan Laboratories Limited Apalutamide polymorphs and their preparation thereof
EP3812378A4 (en) * 2018-06-20 2021-04-28 Crystal Pharmaceutical (Suzhou) Co., Ltd. CRYSTALLINE FORMS OF RNA-509, CORRESPONDING METHOD OF PREPARATION AND ASSOCIATED USE
WO2020049598A2 (en) 2018-09-08 2020-03-12 Cipla Limited Apalutamide polymorphs
IT201900003839A1 (it) 2019-03-15 2020-09-15 Olon Spa Sintesi di apalutamide amorfa stabile
WO2020234817A1 (en) * 2019-05-21 2020-11-26 Laurus Labs Limited Polymorphic forms of apalutamide and its preparation thereof
IT201900010593A1 (it) * 2019-07-01 2021-01-01 Dipharma Francis Srl Forma cristallina di un inibitore di recettori degli androgeni
EP4017848A1 (en) * 2019-08-22 2022-06-29 Dr. Reddy's Laboratories Ltd. Process for the preparation of apalutamide
IT201900015974A1 (it) 2019-09-10 2021-03-10 Olon Spa Apalutamide cristallina stabile in forma pura e processo per la sua preparazione
CN110590740A (zh) * 2019-09-20 2019-12-20 武汉大学 一种阿帕鲁胺化合物及其药物制剂
EP4208451A1 (en) 2020-09-04 2023-07-12 Synthon B.V. Improved process for preparation of apalutamide
CN112679468A (zh) * 2021-01-05 2021-04-20 四川科伦药物研究院有限公司 阿帕他胺的晶体形式、制备方法和用途
WO2023143090A1 (zh) * 2022-01-25 2023-08-03 成都苑东生物制药股份有限公司 一种阿帕他胺溶剂化物新晶型及其制备方法
CN115536634B (zh) * 2022-10-17 2024-06-11 上海博悦生物科技有限公司 一种阿帕他胺的合成方法
CN116332907A (zh) * 2023-03-16 2023-06-27 奥锐特药业股份有限公司 一种无定形阿帕他胺的制备方法
WO2025153768A1 (en) * 2024-01-18 2025-07-24 Nanoform Finland Oyj Composition comprising crystalline nanosized apalutamide

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US5323907A (en) 1992-06-23 1994-06-28 Multi-Comp, Inc. Child resistant package assembly for dispensing pharmaceutical medications
US7709517B2 (en) * 2005-05-13 2010-05-04 The Regents Of The University Of California Diarylhydantoin compounds
CN101032483B (zh) * 2006-03-09 2011-05-04 陈德桂 调节雄激素受体活性的乙内酰脲衍生物及其应用
LT2656842T (lt) * 2006-03-27 2016-09-26 The Regents Of The University Of California Androgeno receptoriaus moduliatorius, skirtas prostatos vėžio ir su androgeno receptoriumi susijusių ligų gydymui
CN102755318B (zh) * 2006-03-29 2014-09-10 加利福尼亚大学董事会 二芳基硫代乙内酰脲化合物
US8461343B2 (en) 2007-03-27 2013-06-11 Sloan-Kettering Institute For Cancer Research Synthesis of thiohydantoins
KR101819199B1 (ko) * 2010-02-16 2018-01-16 아라곤 파마슈티컬스, 인코포레이티드 안드로겐 수용체 조절제 및 이의 용도
CA3008345C (en) 2012-06-07 2019-10-22 Aragon Pharmaceuticals, Inc. Crystalline forms of an androgen receptor modulator
EP3812378A4 (en) 2018-06-20 2021-04-28 Crystal Pharmaceutical (Suzhou) Co., Ltd. CRYSTALLINE FORMS OF RNA-509, CORRESPONDING METHOD OF PREPARATION AND ASSOCIATED USE

Also Published As

Publication number Publication date
LT3533792T (lt) 2021-07-26
ES2670683T3 (es) 2018-05-31
HUE050357T2 (hu) 2020-11-30
CA2875767A1 (en) 2013-12-12
LTPA2021525I1 (enExample) 2021-11-25
JP2015518890A (ja) 2015-07-06
US9994545B2 (en) 2018-06-12
US10526310B2 (en) 2020-01-07
IN2014DN10084A (enExample) 2015-08-21
TWI532732B (zh) 2016-05-11
DK3348553T3 (da) 2020-07-27
CA3008345C (en) 2019-10-22
CN105693692A (zh) 2016-06-22
EA201791592A1 (ru) 2018-01-31
AU2017279807B2 (en) 2018-11-08
IL275413A (en) 2020-07-30
CL2014003331A1 (es) 2016-03-04
MY187500A (en) 2021-09-24
NI201400142A (es) 2016-12-02
US10934271B2 (en) 2021-03-02
CY1123427T1 (el) 2021-12-31
PL2858985T3 (pl) 2018-09-28
BR112014030678A2 (pt) 2017-06-27
LUC00236I2 (enExample) 2025-02-03
US10556882B2 (en) 2020-02-11
EP3533792B1 (en) 2021-05-05
EP3348553A1 (en) 2018-07-18
IL267608A (en) 2019-08-29
IL320522A (en) 2025-06-01
FR21C1050I1 (fr) 2021-12-10
EP2858985A4 (en) 2016-05-25
HUE054595T2 (hu) 2021-09-28
KR20190132543A (ko) 2019-11-27
DK2858985T3 (en) 2018-05-28
ES2875932T3 (es) 2021-11-11
JP2018141009A (ja) 2018-09-13
UA115665C2 (uk) 2017-12-11
EP2858985A1 (en) 2015-04-15
CY1120393T1 (el) 2019-07-10
CA3008345A1 (en) 2013-12-12
SI3533792T1 (sl) 2021-11-30
CR20140549A (es) 2015-04-06
RS57370B1 (sr) 2018-08-31
CO7240407A2 (es) 2015-04-17
EA201992010A1 (ru) 2020-01-24
US20170001977A1 (en) 2017-01-05
IL259738A (en) 2018-07-31
IL236055A0 (en) 2015-02-01
RS60617B1 (sr) 2020-09-30
CA3055660A1 (en) 2013-12-12
EP3348553B1 (en) 2020-07-08
ZA201500076B (en) 2016-10-26
SI2858985T1 (sl) 2018-12-31
KR102062024B1 (ko) 2020-01-03
SMT202000496T1 (it) 2020-11-10
PL3533792T3 (pl) 2021-11-29
MX2014015005A (es) 2015-09-04
JP6182209B2 (ja) 2017-08-16
US12018008B2 (en) 2024-06-25
US20180258067A1 (en) 2018-09-13
KR20150021993A (ko) 2015-03-03
CY2021032I1 (enExample) 2022-03-24
NZ702203A (en) 2016-09-30
EA028791B1 (ru) 2017-12-29
US20190241539A1 (en) 2019-08-08
DK3533792T3 (da) 2021-06-28
SMT201800311T1 (it) 2018-07-17
PT3533792T (pt) 2021-06-07
PE20150631A1 (es) 2015-05-11
NL301144I2 (nl) 2025-03-20
PH12014502714A1 (en) 2015-02-02
KR102195916B1 (ko) 2020-12-30
PL3348553T3 (pl) 2021-02-08
FR21C1050I2 (fr) 2024-05-24
HRP20210909T1 (hr) 2021-09-03
LT2858985T (lt) 2018-09-25
IL259738B (en) 2021-06-30
EA033956B1 (ru) 2019-12-13
CY1124831T1 (el) 2022-03-24
AU2013271751A1 (en) 2014-12-18
AU2013271751B2 (en) 2017-02-23
PE20200795A1 (es) 2020-08-10
WO2013184681A1 (en) 2013-12-12
EP3533792A1 (en) 2019-09-04
CY2021032I2 (el) 2022-03-24
HRP20201387T1 (hr) 2020-11-27
US20150133481A1 (en) 2015-05-14
CA2875767C (en) 2018-08-14
HUE038082T2 (hu) 2018-09-28
EP2858985B1 (en) 2018-04-18
CA3114726A1 (en) 2013-12-12
SG10201610249TA (en) 2017-02-27
PH12014502714B1 (en) 2015-02-02
AU2017279807A1 (en) 2018-01-25
US20190330182A1 (en) 2019-10-31
PH12016501470A1 (en) 2017-07-10
US10766875B2 (en) 2020-09-08
TW201402561A (zh) 2014-01-16
ES2809738T3 (es) 2021-03-05
ECSP14030098A (es) 2016-01-29
JP6345821B2 (ja) 2018-06-20
PT2858985T (pt) 2018-07-10
ME03815B (me) 2021-04-20
IL267608B2 (en) 2025-10-01
AU2017200298B2 (en) 2017-09-28
MX356754B (es) 2018-06-11
US20200115361A1 (en) 2020-04-16
UA123142C2 (uk) 2021-02-24
HUS2100047I1 (hu) 2021-11-29
CR20190331A (es) 2019-11-12
NO2021046I1 (no) 2021-11-02
US9481663B2 (en) 2016-11-01
LTC3533792I2 (enExample) 2024-07-10
US10308630B2 (en) 2019-06-04
IL267608B1 (en) 2025-06-01
SG11201408140QA (en) 2015-01-29
TR201808939T4 (tr) 2018-07-23
CN113135892A (zh) 2021-07-20
EA201492272A1 (ru) 2015-05-29
PT3348553T (pt) 2020-09-28
ME03081B (me) 2019-01-20
RS61988B1 (sr) 2021-07-30
SG10201610248SA (en) 2017-02-27
US20210163441A1 (en) 2021-06-03
HK1210175A1 (en) 2016-04-15
SMT202100355T1 (it) 2021-07-12
AU2017200298A1 (en) 2017-02-02
SI3348553T1 (sl) 2020-11-30
US20200354335A1 (en) 2020-11-12
JP2017178923A (ja) 2017-10-05
PH12016501470B1 (en) 2021-12-10
HK1226066A1 (zh) 2017-09-22
GT201400283A (es) 2017-07-03
EP3922629A1 (en) 2021-12-15
NZ717683A (en) 2018-04-27
PE20200725A1 (es) 2020-07-21
CN104619692A (zh) 2015-05-13
HRP20180902T1 (hr) 2018-08-24
US20250092011A1 (en) 2025-03-20

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