IN2014DN10084A - - Google Patents
Info
- Publication number
- IN2014DN10084A IN2014DN10084A IN10084DEN2014A IN2014DN10084A IN 2014DN10084 A IN2014DN10084 A IN 2014DN10084A IN 10084DEN2014 A IN10084DEN2014 A IN 10084DEN2014A IN 2014DN10084 A IN2014DN10084 A IN 2014DN10084A
- Authority
- IN
- India
- Prior art keywords
- androgen receptor
- receptor modulator
- trifluoromethylpyridin
- diazaspiro
- methylbenzamide
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/28—Antiandrogens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Abstract
Described herein are amorphous and crystalline forms of the androgen receptor modulator 4 -[7- (6- cyano- 5- trifluoromethylpyridin 3- yl)- 8 oxo -6- thioxo- 5, 7 diazaspiro[3.4]oct- 5- yl]- 2- fluoro- N- methylbenzamide. Also described are pharmaceutical compositions suitable for administration to a mammal that include the androgen receptor modulator, and methods of using the androgen receptor modulator, alone and in combination with other compounds, for treating diseases or conditions that are associated with androgen receptor activity.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261656888P | 2012-06-07 | 2012-06-07 | |
| PCT/US2013/044116 WO2013184681A1 (en) | 2012-06-07 | 2013-06-04 | Crystalline forms of an androgen receptor modulator |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2014DN10084A true IN2014DN10084A (en) | 2015-08-21 |
Family
ID=49712550
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN10084DEN2014 IN2014DN10084A (en) | 2012-06-07 | 2013-06-04 |
Country Status (45)
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008119015A2 (en) | 2007-03-27 | 2008-10-02 | Sloan-Kettering Institute For Cancer Research | Synthesis of thiohydantoins |
| EP2791128A4 (en) | 2011-12-16 | 2015-04-22 | Olema Pharmaceuticals Inc | Novel benzopyran compounds, compositions and uses thereof |
| RS60617B1 (en) * | 2012-06-07 | 2020-09-30 | Aragon Pharmaceuticals Inc | Crystalline forms of an androgen receptor modulator |
| TWI673051B (en) | 2012-09-11 | 2019-10-01 | 美商梅維森前列腺療法有限責任公司 | Formulations of enzalutamide |
| CN115737643A (en) | 2012-09-26 | 2023-03-07 | 阿拉贡药品公司 | Antiandrogens for the treatment of non-metastatic castration resistant prostate cancer |
| DK2945628T3 (en) * | 2013-01-15 | 2020-05-04 | Aragon Pharmaceuticals Inc | ANDROGEN RECEPTOR MODULATOR IN COMBINATION WITH ABIRATERON ACETATE AND PREDNISON FOR TREATMENT OF PROSTATACANCES |
| CN106795152B (en) * | 2014-08-26 | 2020-01-31 | 安斯达尔生物技术有限责任公司 | protein kinase inhibitor |
| US10285948B2 (en) | 2014-12-05 | 2019-05-14 | Janssen Pharmaceutica Nv | Anticancer compositions |
| EA201791222A1 (en) * | 2014-12-05 | 2017-09-29 | Арагон Фармасьютикалз, Инк. | CONTRA-TRAY COMPOSITIONS |
| HUE051888T2 (en) | 2014-12-05 | 2021-03-29 | Aragon Pharmaceuticals Inc | Anticancer compositions |
| MX2017008050A (en) | 2014-12-19 | 2018-01-18 | Lutron Electronics Co | MULTICHANNEL LIGHTING ACCESSORY THAT HAS LIGHT ISSUING DIODE CONTROLLERS. |
| JP2019517497A (en) | 2016-06-03 | 2019-06-24 | アラゴン ファーマシューティカルズ，インコーポレイテッド | Anticancer composition |
| US11149017B2 (en) | 2016-12-13 | 2021-10-19 | Watson Laboratories Inc. | Solid state forms of apalutamide |
| MX2020003845A (en) | 2017-10-16 | 2020-11-06 | Aragon Pharmaceuticals Inc | ANTIANDROGENS FOR THE TREATMENT OF NON-METASTATIC PROSTATE CANCER RESISTANT TO CASTRATION. |
| WO2019135254A1 (en) | 2018-01-02 | 2019-07-11 | Mylan Laboratories Limited | Apalutamide polymorphs and their preparation thereof |
| WO2019242439A1 (en) * | 2018-06-20 | 2019-12-26 | 苏州科睿思制药有限公司 | Crystal form of arn-509, preparation method therefor and use thereof |
| WO2020049598A2 (en) | 2018-09-08 | 2020-03-12 | Cipla Limited | Apalutamide polymorphs |
| IT201900003839A1 (en) | 2019-03-15 | 2020-09-15 | Olon Spa | STABLE AMORPHOUS APALUTAMIDE SYNTHESIS |
| WO2020234817A1 (en) * | 2019-05-21 | 2020-11-26 | Laurus Labs Limited | Polymorphic forms of apalutamide and its preparation thereof |
| IT201900010593A1 (en) | 2019-07-01 | 2021-01-01 | Dipharma Francis Srl | CRYSTALLINE FORM OF AN ANDROGEN RECEPTOR INHIBITOR |
| US20220281836A1 (en) * | 2019-08-22 | 2022-09-08 | Dr. Reddy's Laboratories Limited | Process for the preparation of apalutamide |
| IT201900015974A1 (en) | 2019-09-10 | 2021-03-10 | Olon Spa | STABLE CRYSTALLINE APALUTAMIDE IN PURE FORM AND PROCESS FOR ITS PREPARATION |
| CN110590740A (en) * | 2019-09-20 | 2019-12-20 | 武汉大学 | A kind of apalutamide compound and its pharmaceutical preparation |
| EP4541786A3 (en) | 2020-09-04 | 2025-08-06 | Synthon B.V. | Improved process for preparation of apalutamide |
| CN112679468A (en) * | 2021-01-05 | 2021-04-20 | 四川科伦药物研究院有限公司 | Crystal form of apatamide, preparation method and application |
| WO2023143090A1 (en) * | 2022-01-25 | 2023-08-03 | 成都苑东生物制药股份有限公司 | Novel crystalline form of apalutamide solvate and preparation method therefor |
| CN115536634B (en) * | 2022-10-17 | 2024-06-11 | 上海博悦生物科技有限公司 | A kind of synthetic method of apalutamide |
| CN116332907A (en) * | 2023-03-16 | 2023-06-27 | 奥锐特药业股份有限公司 | A kind of preparation method of amorphous apalutamide |
| WO2025153768A1 (en) * | 2024-01-18 | 2025-07-24 | Nanoform Finland Oyj | Composition comprising crystalline nanosized apalutamide |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5323907A (en) | 1992-06-23 | 1994-06-28 | Multi-Comp, Inc. | Child resistant package assembly for dispensing pharmaceutical medications |
| US7709517B2 (en) | 2005-05-13 | 2010-05-04 | The Regents Of The University Of California | Diarylhydantoin compounds |
| CN101032483B (en) * | 2006-03-09 | 2011-05-04 | 陈德桂 | Hydantoin derivative for adjusting estrogen receptor activity and application thereof |
| ES2689292T3 (en) | 2006-03-27 | 2018-11-13 | The Regents Of The University Of California | Androgen receptor modulator for the treatment of prostate cancer and diseases associated with the androgen receptor |
| NZ572374A (en) | 2006-03-29 | 2011-12-22 | Univ California | Diarylthiohydantoin compounds |
| WO2008119015A2 (en) * | 2007-03-27 | 2008-10-02 | Sloan-Kettering Institute For Cancer Research | Synthesis of thiohydantoins |
| SG10201907588XA (en) | 2010-02-16 | 2019-09-27 | Aragon Pharmaceuticals Inc | Androgen Receptor Modulators And Uses Thereof |
| RS60617B1 (en) * | 2012-06-07 | 2020-09-30 | Aragon Pharmaceuticals Inc | Crystalline forms of an androgen receptor modulator |
| WO2019242439A1 (en) | 2018-06-20 | 2019-12-26 | 苏州科睿思制药有限公司 | Crystal form of arn-509, preparation method therefor and use thereof |
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2013
- 2013-06-04 RS RS20200913A patent/RS60617B1/en unknown
- 2013-06-04 PT PT138006812T patent/PT2858985T/en unknown
- 2013-06-04 DK DK18157435.1T patent/DK3348553T3/en active
- 2013-06-04 LT LTEP13800681.2T patent/LT2858985T/en unknown
- 2013-06-04 NZ NZ702203A patent/NZ702203A/en unknown
- 2013-06-04 PE PE2020000234A patent/PE20200795A1/en unknown
- 2013-06-04 LT LTEP19169275.5T patent/LT3533792T/en unknown
- 2013-06-04 US US14/406,520 patent/US9481663B2/en active Active
- 2013-06-04 RS RS20180680A patent/RS57370B1/en unknown
- 2013-06-04 IN IN10084DEN2014 patent/IN2014DN10084A/en unknown
- 2013-06-04 PL PL13800681T patent/PL2858985T3/en unknown
- 2013-06-04 MY MYPI2014703627A patent/MY187500A/en unknown
- 2013-06-04 SG SG10201610248SA patent/SG10201610248SA/en unknown
- 2013-06-04 HU HUE18157435A patent/HUE050357T2/en unknown
- 2013-06-04 HU HUE19169275A patent/HUE054595T2/en unknown
- 2013-06-04 ES ES13800681.2T patent/ES2670683T3/en active Active
- 2013-06-04 CN CN201610202980.2A patent/CN105693692A/en active Pending
- 2013-06-04 EP EP19169275.5A patent/EP3533792B1/en active Active
- 2013-06-04 PT PT191692755T patent/PT3533792T/en unknown
- 2013-06-04 WO PCT/US2013/044116 patent/WO2013184681A1/en not_active Ceased
- 2013-06-04 CN CN201380041652.3A patent/CN104619692A/en active Pending
- 2013-06-04 SI SI201331788T patent/SI3348553T1/en unknown
- 2013-06-04 SI SI201331894T patent/SI3533792T1/en unknown
- 2013-06-04 UA UAA201500086A patent/UA115665C2/en unknown
- 2013-06-04 CN CN202110417935.XA patent/CN113135892A/en active Pending
- 2013-06-04 UA UAA201702779A patent/UA123142C2/en unknown
- 2013-06-04 SI SI201331010T patent/SI2858985T1/en unknown
- 2013-06-04 PL PL18157435T patent/PL3348553T3/en unknown
- 2013-06-04 EP EP13800681.2A patent/EP2858985B1/en active Active
- 2013-06-04 CA CA2875767A patent/CA2875767C/en active Active
- 2013-06-04 EP EP18157435.1A patent/EP3348553B1/en not_active Revoked
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- 2013-06-04 ME MEP-2020-163A patent/ME03815B/en unknown
- 2013-06-04 TR TR2018/08939T patent/TR201808939T4/en unknown
- 2013-06-04 BR BR112014030678A patent/BR112014030678A2/en not_active Application Discontinuation
- 2013-06-04 ES ES19169275T patent/ES2875932T3/en active Active
- 2013-06-04 EP EP21171579.2A patent/EP3922629A1/en active Pending
- 2013-06-04 SG SG10201610249TA patent/SG10201610249TA/en unknown
- 2013-06-04 SM SM20180311T patent/SMT201800311T1/en unknown
- 2013-06-04 ME MEP-2018-158A patent/ME03081B/en unknown
- 2013-06-04 DK DK19169275.5T patent/DK3533792T3/en active
- 2013-06-04 CA CA3055660A patent/CA3055660A1/en not_active Abandoned
- 2013-06-04 DK DK13800681.2T patent/DK2858985T3/en active
- 2013-06-04 SM SM20210355T patent/SMT202100355T1/en unknown
- 2013-06-04 PT PT181574351T patent/PT3348553T/en unknown
- 2013-06-04 ES ES18157435T patent/ES2809738T3/en active Active
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- 2013-06-04 NZ NZ717683A patent/NZ717683A/en unknown
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- 2013-06-04 CA CA3008345A patent/CA3008345C/en active Active
- 2013-06-04 RS RS20210739A patent/RS61988B1/en unknown
- 2013-06-04 SM SM20200496T patent/SMT202000496T1/en unknown
- 2013-06-04 JP JP2015516121A patent/JP6182209B2/en active Active
- 2013-06-04 MX MX2014015005A patent/MX356754B/en active IP Right Grant
- 2013-06-04 IL IL267608A patent/IL267608B2/en unknown
- 2013-06-04 EA EA201492272A patent/EA028791B1/en unknown
- 2013-06-04 KR KR1020197033592A patent/KR102195916B1/en active Active
- 2013-06-04 HR HRP20180902TT patent/HRP20180902T1/en unknown
- 2013-06-04 CR CR20190331A patent/CR20190331A/en unknown
- 2013-06-04 EA EA201791592A patent/EA033956B1/en unknown
- 2013-06-04 HU HUE13800681A patent/HUE038082T2/en unknown
- 2013-06-04 KR KR1020157000266A patent/KR102062024B1/en active Active
- 2013-06-04 PE PE2019002096A patent/PE20200725A1/en unknown
- 2013-06-04 PE PE2014002383A patent/PE20150631A1/en active IP Right Grant
- 2013-06-04 SG SG11201408140QA patent/SG11201408140QA/en unknown
- 2013-06-04 EA EA201992010A patent/EA201992010A1/en unknown
- 2013-06-04 LT LTEP18157435.1T patent/LT3348553T/en unknown
- 2013-06-04 TW TW102119817A patent/TWI532732B/en active
- 2013-06-04 AU AU2013271751A patent/AU2013271751B2/en active Active
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2014
- 2014-12-01 CR CR20140549A patent/CR20140549A/en unknown
- 2014-12-04 NI NI201400142A patent/NI201400142A/en unknown
- 2014-12-04 IL IL236055A patent/IL236055A0/en unknown
- 2014-12-04 PH PH12014502714A patent/PH12014502714B1/en unknown
- 2014-12-05 CL CL2014003331A patent/CL2014003331A1/en unknown
- 2014-12-05 EC ECIEPI201430098A patent/ECSP14030098A/en unknown
- 2014-12-05 GT GT201400283A patent/GT201400283A/en unknown
- 2014-12-09 CO CO14270612A patent/CO7240407A2/en unknown
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2015
- 2015-01-06 ZA ZA2015/00076A patent/ZA201500076B/en unknown
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2016
- 2016-07-26 PH PH12016501470A patent/PH12016501470B1/en unknown
- 2016-09-12 US US15/262,522 patent/US9994545B2/en active Active
- 2016-12-19 HK HK16114389.2A patent/HK1226066A1/en unknown
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2017
- 2017-01-17 AU AU2017200298A patent/AU2017200298B2/en active Active
- 2017-02-15 JP JP2017025746A patent/JP6345821B2/en active Active
- 2017-12-22 AU AU2017279807A patent/AU2017279807B2/en active Active
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2018
- 2018-05-09 US US15/975,449 patent/US10308630B2/en active Active
- 2018-05-23 JP JP2018098638A patent/JP2018141009A/en active Pending
- 2018-05-31 IL IL259738A patent/IL259738B/en active IP Right Grant
- 2018-07-06 CY CY20181100712T patent/CY1120393T1/en unknown
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2019
- 2019-04-15 US US16/384,002 patent/US10526310B2/en active Active
- 2019-07-10 US US16/507,780 patent/US10556882B2/en active Active
- 2019-12-11 US US16/710,785 patent/US10766875B2/en active Active
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2020
- 2020-06-15 IL IL275413A patent/IL275413A/en unknown
- 2020-07-29 US US16/942,069 patent/US10934271B2/en active Active
- 2020-08-31 HR HRP20201387TT patent/HRP20201387T1/en unknown
- 2020-09-23 CY CY20201100901T patent/CY1123427T1/en unknown
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2021
- 2021-01-26 US US17/158,806 patent/US12018008B2/en active Active
- 2021-06-08 HR HRP20210909TT patent/HRP20210909T1/en unknown
- 2021-07-02 CY CY20211100595T patent/CY1124831T1/en unknown
- 2021-11-02 LU LU00236C patent/LUC00236I2/fr unknown
- 2021-11-02 NO NO2021046C patent/NO2021046I1/en unknown
- 2021-11-03 LT LTPA2021525C patent/LTC3533792I2/lt unknown
- 2021-11-03 NL NL301144C patent/NL301144I2/en unknown
- 2021-11-03 FR FR21C1050C patent/FR21C1050I2/en active Active
- 2021-11-04 HU HUS2100047C patent/HUS2100047I1/en unknown
- 2021-11-04 CY CY2021032C patent/CY2021032I2/en unknown
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2024
- 2024-05-13 US US18/662,345 patent/US20250092011A1/en not_active Abandoned
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2025
- 2025-04-18 US US19/183,276 patent/US20260109683A1/en active Pending
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