SG10201610248SA - Crystalline forms of an androgen receptor modulator - Google Patents
Crystalline forms of an androgen receptor modulatorInfo
- Publication number
- SG10201610248SA SG10201610248SA SG10201610248SA SG10201610248SA SG10201610248SA SG 10201610248S A SG10201610248S A SG 10201610248SA SG 10201610248S A SG10201610248S A SG 10201610248SA SG 10201610248S A SG10201610248S A SG 10201610248SA SG 10201610248S A SG10201610248S A SG 10201610248SA
- Authority
- SG
- Singapore
- Prior art keywords
- androgen receptor
- crystalline forms
- receptor modulator
- modulator
- androgen
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/28—Antiandrogens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261656888P | 2012-06-07 | 2012-06-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG10201610248SA true SG10201610248SA (en) | 2017-02-27 |
Family
ID=49712550
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG10201610249TA SG10201610249TA (en) | 2012-06-07 | 2013-06-04 | Crystalline forms of an androgen receptor modulator |
| SG10201610248SA SG10201610248SA (en) | 2012-06-07 | 2013-06-04 | Crystalline forms of an androgen receptor modulator |
| SG11201408140QA SG11201408140QA (en) | 2012-06-07 | 2013-06-04 | Crystalline forms of an androgen receptor modulator |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG10201610249TA SG10201610249TA (en) | 2012-06-07 | 2013-06-04 | Crystalline forms of an androgen receptor modulator |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201408140QA SG11201408140QA (en) | 2012-06-07 | 2013-06-04 | Crystalline forms of an androgen receptor modulator |
Country Status (42)
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8461343B2 (en) | 2007-03-27 | 2013-06-11 | Sloan-Kettering Institute For Cancer Research | Synthesis of thiohydantoins |
| EP2385960B1 (en) | 2009-01-12 | 2020-03-11 | University Of Massachusetts Lowell | Polyisobutylene-based polyurethanes |
| MX2014007198A (en) | 2011-12-16 | 2014-10-13 | Olema Pharmaceuticals Inc | Novel benzopyran compounds, compositions and uses thereof. |
| PL3533792T3 (en) | 2012-06-07 | 2021-11-29 | Aragon Pharmaceuticals, Inc. | Crystalline forms of an androgen receptor modulator |
| CN109897004A (en) | 2012-09-11 | 2019-06-18 | 麦迪威森前列腺医疗有限责任公司 | The miscellaneous Shandong amine preparation of grace |
| ES2836424T3 (en) | 2012-09-26 | 2021-06-25 | Aragon Pharmaceuticals Inc | Antiandrogens to treat castration-resistant and non-metastatic prostate cancer |
| EP2922888B1 (en) | 2012-11-21 | 2021-08-18 | The University of Massachusetts | High strength polyisobutylene polyurethanes |
| JOP20200097A1 (en) * | 2013-01-15 | 2017-06-16 | Aragon Pharmaceuticals Inc | Androgen receptor modulator and uses thereof |
| CN106795152B (en) * | 2014-08-26 | 2020-01-31 | 安斯达尔生物技术有限责任公司 | Protein kinase inhibitors |
| US10285948B2 (en) | 2014-12-05 | 2019-05-14 | Janssen Pharmaceutica Nv | Anticancer compositions |
| MA41107A (en) * | 2014-12-05 | 2017-10-10 | Aragon Pharmaceuticals Inc | ANTI-CANCER COMPOSITIONS |
| ES2839128T3 (en) | 2014-12-05 | 2021-07-05 | Aragon Pharmaceuticals Inc | Anticancer compositions |
| WO2016100905A1 (en) | 2014-12-19 | 2016-06-23 | Lutron Electronics Co., Inc. | Multi-channel lighting fixture having multiple light-emitting diode drivers |
| AU2017275396A1 (en) | 2016-06-03 | 2018-11-22 | Aragon Pharmaceuticals, Inc. | Anticancer compositions |
| EP3555061B1 (en) | 2016-12-13 | 2023-06-07 | Watson Laboratories Inc. | Solid state forms of apalutamide |
| EP3592786B1 (en) | 2017-03-07 | 2023-05-10 | Cardiac Pacemakers, Inc. | Hydroboration/oxidation of allyl-terminated polyisobutylene |
| US10835638B2 (en) | 2017-08-17 | 2020-11-17 | Cardiac Pacemakers, Inc. | Photocrosslinked polymers for enhanced durability |
| EP3697398A1 (en) | 2017-10-16 | 2020-08-26 | Aragon Pharmaceuticals, Inc. | Anti-androgens for the treatment of non-metastatic castration-resistant prostate cancer |
| WO2019135254A1 (en) * | 2018-01-02 | 2019-07-11 | Mylan Laboratories Limited | Apalutamide polymorphs and their preparation thereof |
| CN111479596B (en) | 2018-01-17 | 2023-04-07 | 心脏起搏器股份公司 | Blocked polyisobutylene polyurethanes |
| EP3812378A1 (en) * | 2018-06-20 | 2021-04-28 | Crystal Pharmaceutical (Suzhou) Co., Ltd. | Crystal form of arn-509, preparation method therefor and use thereof |
| WO2020049598A2 (en) | 2018-09-08 | 2020-03-12 | Cipla Limited | Apalutamide polymorphs |
| IT201900003839A1 (en) | 2019-03-15 | 2020-09-15 | Olon Spa | STABLE AMORPHOUS APALUTAMIDE SYNTHESIS |
| WO2020234817A1 (en) * | 2019-05-21 | 2020-11-26 | Laurus Labs Limited | Polymorphic forms of apalutamide and its preparation thereof |
| IT201900010593A1 (en) * | 2019-07-01 | 2021-01-01 | Dipharma Francis Srl | CRYSTALLINE FORM OF AN ANDROGEN RECEPTOR INHIBITOR |
| EP4017848A1 (en) * | 2019-08-22 | 2022-06-29 | Dr. Reddy's Laboratories Ltd. | Process for the preparation of apalutamide |
| IT201900015974A1 (en) | 2019-09-10 | 2021-03-10 | Olon Spa | STABLE CRYSTALLINE APALUTAMIDE IN PURE FORM AND PROCESS FOR ITS PREPARATION |
| CN110590740A (en) * | 2019-09-20 | 2019-12-20 | 武汉大学 | Apaglus amine compound and pharmaceutical preparation thereof |
| US20230312507A1 (en) | 2020-09-04 | 2023-10-05 | Synthon B.V. | Improved process for preparation of apalutamide |
| WO2023143090A1 (en) * | 2022-01-25 | 2023-08-03 | 成都苑东生物制药股份有限公司 | Novel crystalline form of apalutamide solvate and preparation method therefor |
| CN115536634A (en) * | 2022-10-17 | 2022-12-30 | 上海博悦生物科技有限公司 | Synthetic method of apatamide |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5323907A (en) | 1992-06-23 | 1994-06-28 | Multi-Comp, Inc. | Child resistant package assembly for dispensing pharmaceutical medications |
| US7709517B2 (en) | 2005-05-13 | 2010-05-04 | The Regents Of The University Of California | Diarylhydantoin compounds |
| CN101032483B (en) * | 2006-03-09 | 2011-05-04 | 陈德桂 | Hydantoin derivative for adjusting estrogen receptor activity and application thereof |
| DK2368550T3 (en) | 2006-03-27 | 2013-09-30 | Univ California | Androgen receptor modulator for the treatment of prostate cancer and androgen receptor-associated diseases |
| EP2439196A1 (en) * | 2006-03-29 | 2012-04-11 | The Regents of The University of California | Diarylthiohydantoin compounds for use in a method for the treatment of a hyperproliferative disorder |
| US8461343B2 (en) | 2007-03-27 | 2013-06-11 | Sloan-Kettering Institute For Cancer Research | Synthesis of thiohydantoins |
| SG10201501202TA (en) * | 2010-02-16 | 2015-04-29 | Aragon Pharmaceuticals Inc | Androgen Receptor Modulators And Uses Thereof |
| PL3533792T3 (en) | 2012-06-07 | 2021-11-29 | Aragon Pharmaceuticals, Inc. | Crystalline forms of an androgen receptor modulator |
| EP3812378A1 (en) | 2018-06-20 | 2021-04-28 | Crystal Pharmaceutical (Suzhou) Co., Ltd. | Crystal form of arn-509, preparation method therefor and use thereof |
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2013
- 2013-06-04 PL PL19169275T patent/PL3533792T3/en unknown
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- 2013-06-04 WO PCT/US2013/044116 patent/WO2013184681A1/en active Application Filing
- 2013-06-04 PT PT181574351T patent/PT3348553T/en unknown
- 2013-06-04 SG SG10201610249TA patent/SG10201610249TA/en unknown
- 2013-06-04 ES ES18157435T patent/ES2809738T3/en active Active
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2016
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2019
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