LT2858985T - Kristalinės androgeno receptoriaus moduliatoriaus formos - Google Patents
Kristalinės androgeno receptoriaus moduliatoriaus formosInfo
- Publication number
- LT2858985T LT2858985T LTEP13800681.2T LT13800681T LT2858985T LT 2858985 T LT2858985 T LT 2858985T LT 13800681 T LT13800681 T LT 13800681T LT 2858985 T LT2858985 T LT 2858985T
- Authority
- LT
- Lithuania
- Prior art keywords
- androgen receptor
- crystalline forms
- receptor modulator
- modulator
- androgen
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/28—Antiandrogens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261656888P | 2012-06-07 | 2012-06-07 | |
| PCT/US2013/044116 WO2013184681A1 (en) | 2012-06-07 | 2013-06-04 | Crystalline forms of an androgen receptor modulator |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| LT2858985T true LT2858985T (lt) | 2018-09-25 |
Family
ID=49712550
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LTEP13800681.2T LT2858985T (lt) | 2012-06-07 | 2013-06-04 | Kristalinės androgeno receptoriaus moduliatoriaus formos |
| LTEP19169275.5T LT3533792T (lt) | 2012-06-07 | 2013-06-04 | Androgeno receptoriaus moduliatoriaus kristalinės formos |
| LTEP18157435.1T LT3348553T (lt) | 2012-06-07 | 2013-06-04 | Kristalinės androgeno receptoriaus moduliatoriaus formos |
| LTPA2021525C LTPA2021525I1 (lt) | 2012-06-07 | 2021-11-03 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LTEP19169275.5T LT3533792T (lt) | 2012-06-07 | 2013-06-04 | Androgeno receptoriaus moduliatoriaus kristalinės formos |
| LTEP18157435.1T LT3348553T (lt) | 2012-06-07 | 2013-06-04 | Kristalinės androgeno receptoriaus moduliatoriaus formos |
| LTPA2021525C LTPA2021525I1 (lt) | 2012-06-07 | 2021-11-03 |
Country Status (42)
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008119015A2 (en) | 2007-03-27 | 2008-10-02 | Sloan-Kettering Institute For Cancer Research | Synthesis of thiohydantoins |
| EP4282449A3 (en) | 2009-01-12 | 2024-02-28 | University Of Massachusetts Lowell | Polyisobutylene-based polyurethanes |
| AP2014007657A0 (en) | 2011-12-16 | 2014-05-31 | Olema Pharmaceuticals Inc | Novel benzopyran compounds, compositions and uses thereof |
| KR102195916B1 (ko) | 2012-06-07 | 2020-12-30 | 아라곤 파마슈티컬스, 인코포레이티드 | 안드로겐 수용체 조절제의 결정 형태 |
| TWI673051B (zh) | 2012-09-11 | 2019-10-01 | 美商梅維森前列腺療法有限責任公司 | 恩雜魯它脈（ｅｎｚａｌｕｔａｍｉｄｅ）之調和物 |
| NZ745682A (en) | 2012-09-26 | 2019-09-27 | Aragon Pharmaceuticals Inc | Anti-androgens for the treatment of non-metastatic castrate-resistant prostate cancer |
| JP2015535538A (ja) | 2012-11-21 | 2015-12-14 | ユニバーシティー オブ マサチューセッツＵｎｉｖｅｒｓｉｔｙ ｏｆ Ｍａｓｓａｃｈｕｓｅｔｔｓ | 高強度ポリイソブチレンポリウレタン |
| JOP20200097A1 (ar) * | 2013-01-15 | 2017-06-16 | Aragon Pharmaceuticals Inc | معدل مستقبل أندروجين واستخداماته |
| EP3186247B1 (en) * | 2014-08-26 | 2021-03-03 | Astar Biotech LLC | Protein kinase inhibitors |
| UA121123C2 (uk) | 2014-12-05 | 2020-04-10 | Араґон Фармасьютікалз, Інк. | Протиракові композиції |
| EP3925598A1 (en) | 2014-12-05 | 2021-12-22 | Aragon Pharmaceuticals, Inc. | Anticancer compositions |
| MA41107A (fr) * | 2014-12-05 | 2017-10-10 | Aragon Pharmaceuticals Inc | Compositions anti-cancéreuses |
| CN107113952B (zh) | 2014-12-19 | 2019-08-27 | 路创技术有限责任公司 | 具有多个发光二极管驱动器的多通道照明器具 |
| EP3463377A1 (en) | 2016-06-03 | 2019-04-10 | Aragon Pharmaceuticals, Inc. | Anticancer compositions |
| US11149017B2 (en) | 2016-12-13 | 2021-10-19 | Watson Laboratories Inc. | Solid state forms of apalutamide |
| US10526429B2 (en) | 2017-03-07 | 2020-01-07 | Cardiac Pacemakers, Inc. | Hydroboration/oxidation of allyl-terminated polyisobutylene |
| EP3668912B1 (en) | 2017-08-17 | 2021-06-30 | Cardiac Pacemakers, Inc. | Photocrosslinked polymers for enhanced durability |
| WO2019078920A1 (en) | 2017-10-16 | 2019-04-25 | Aragon Pharmaceuticals, Inc. | ANTI-ANDROGENS FOR THE TREATMENT OF NON-METASTATIC RESISTANT PROSTATE CANCER |
| WO2019135254A1 (en) | 2018-01-02 | 2019-07-11 | Mylan Laboratories Limited | Apalutamide polymorphs and their preparation thereof |
| US11472911B2 (en) | 2018-01-17 | 2022-10-18 | Cardiac Pacemakers, Inc. | End-capped polyisobutylene polyurethane |
| WO2019242439A1 (zh) | 2018-06-20 | 2019-12-26 | 苏州科睿思制药有限公司 | Arn-509的晶型及其制备方法和用途 |
| WO2020049598A2 (en) | 2018-09-08 | 2020-03-12 | Cipla Limited | Apalutamide polymorphs |
| IT201900003839A1 (it) | 2019-03-15 | 2020-09-15 | Olon Spa | Sintesi di apalutamide amorfa stabile |
| WO2020234817A1 (en) * | 2019-05-21 | 2020-11-26 | Laurus Labs Limited | Polymorphic forms of apalutamide and its preparation thereof |
| IT201900010593A1 (it) | 2019-07-01 | 2021-01-01 | Dipharma Francis Srl | Forma cristallina di un inibitore di recettori degli androgeni |
| US20220281836A1 (en) * | 2019-08-22 | 2022-09-08 | Dr. Reddy's Laboratories Limited | Process for the preparation of apalutamide |
| IT201900015974A1 (it) | 2019-09-10 | 2021-03-10 | Olon Spa | Apalutamide cristallina stabile in forma pura e processo per la sua preparazione |
| CN110590740A (zh) * | 2019-09-20 | 2019-12-20 | 武汉大学 | 一种阿帕鲁胺化合物及其药物制剂 |
| US20230312507A1 (en) | 2020-09-04 | 2023-10-05 | Synthon B.V. | Improved process for preparation of apalutamide |
| WO2023143090A1 (zh) * | 2022-01-25 | 2023-08-03 | 成都苑东生物制药股份有限公司 | 一种阿帕他胺溶剂化物新晶型及其制备方法 |
| CN115536634A (zh) * | 2022-10-17 | 2022-12-30 | 上海博悦生物科技有限公司 | 一种阿帕他胺的合成方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5323907A (en) | 1992-06-23 | 1994-06-28 | Multi-Comp, Inc. | Child resistant package assembly for dispensing pharmaceutical medications |
| US7709517B2 (en) | 2005-05-13 | 2010-05-04 | The Regents Of The University Of California | Diarylhydantoin compounds |
| AU2007245022A1 (en) | 2006-03-29 | 2007-11-08 | The Regents Of The University Of California | Diarylthiohydantoin compounds |
| CN101032483B (zh) * | 2006-03-09 | 2011-05-04 | 陈德桂 | 调节雄激素受体活性的乙内酰脲衍生物及其应用 |
| PT2656842T (pt) | 2006-03-27 | 2016-10-04 | Univ California | Modulador do recetor de androgénios para o tratamento de cancro da próstata e doenças associadas ao recetor de androgénios |
| WO2008119015A2 (en) * | 2007-03-27 | 2008-10-02 | Sloan-Kettering Institute For Cancer Research | Synthesis of thiohydantoins |
| CA2787083C (en) * | 2010-02-16 | 2018-05-22 | Aragon Pharmaceuticals, Inc. | Androgen receptor modulators and uses thereof |
| KR102195916B1 (ko) | 2012-06-07 | 2020-12-30 | 아라곤 파마슈티컬스, 인코포레이티드 | 안드로겐 수용체 조절제의 결정 형태 |
| WO2019242439A1 (zh) | 2018-06-20 | 2019-12-26 | 苏州科睿思制药有限公司 | Arn-509的晶型及其制备方法和用途 |
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2013
- 2013-06-04 KR KR1020197033592A patent/KR102195916B1/ko active IP Right Grant
- 2013-06-04 EP EP19169275.5A patent/EP3533792B1/en active Active
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- 2013-06-04 MX MX2014015005A patent/MX356754B/es active IP Right Grant
- 2013-06-04 CN CN201380041652.3A patent/CN104619692A/zh active Pending
- 2013-06-04 UA UAA201702779A patent/UA123142C2/uk unknown
- 2013-06-04 EA EA201992010A patent/EA201992010A1/ru unknown
- 2013-06-04 BR BR112014030678A patent/BR112014030678A2/pt not_active Application Discontinuation
- 2013-06-04 RS RS20200913A patent/RS60617B1/sr unknown
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- 2013-06-04 CN CN201610202980.2A patent/CN105693692A/zh active Pending
- 2013-06-04 WO PCT/US2013/044116 patent/WO2013184681A1/en active Application Filing
- 2013-06-04 HU HUE13800681A patent/HUE038082T2/hu unknown
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- 2013-06-04 LT LTEP13800681.2T patent/LT2858985T/lt unknown
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- 2013-06-04 TW TW102119817A patent/TWI532732B/zh active
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- 2013-06-04 DK DK13800681.2T patent/DK2858985T3/en active
- 2013-06-04 ES ES13800681.2T patent/ES2670683T3/es active Active
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- 2013-06-04 EP EP21171579.2A patent/EP3922629A1/en active Pending
- 2013-06-04 DK DK19169275.5T patent/DK3533792T3/da active
- 2013-06-04 IN IN10084DEN2014 patent/IN2014DN10084A/en unknown
- 2013-06-04 PT PT138006812T patent/PT2858985T/pt unknown
- 2013-06-04 ME MEP-2018-158A patent/ME03081B/me unknown
- 2013-06-04 KR KR1020157000266A patent/KR102062024B1/ko active IP Right Grant
- 2013-06-04 LT LTEP19169275.5T patent/LT3533792T/lt unknown
- 2013-06-04 EP EP13800681.2A patent/EP2858985B1/en active Active
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- 2013-06-04 CA CA3008345A patent/CA3008345C/en active Active
- 2013-06-04 TR TR2018/08939T patent/TR201808939T4/tr unknown
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- 2013-06-04 LT LTEP18157435.1T patent/LT3348553T/lt unknown
- 2013-06-04 PT PT181574351T patent/PT3348553T/pt unknown
- 2013-06-04 EA EA201492272A patent/EA028791B1/ru unknown
- 2013-06-04 ES ES18157435T patent/ES2809738T3/es active Active
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- 2013-06-04 CA CA3114726A patent/CA3114726A1/en active Pending
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- 2013-06-04 CN CN202110417935.XA patent/CN113135892A/zh active Pending
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- 2013-06-04 CA CA3055660A patent/CA3055660A1/en not_active Abandoned
- 2013-06-04 CA CA2875767A patent/CA2875767C/en active Active
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2014
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2015
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2016
- 2016-07-26 PH PH12016501470A patent/PH12016501470A1/en unknown
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2017
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2018
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- 2018-06-11 HR HRP20180902TT patent/HRP20180902T1/hr unknown
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2019
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2020
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2021
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- 2021-06-08 HR HRP20210909TT patent/HRP20210909T1/hr unknown
- 2021-07-02 CY CY20211100595T patent/CY1124831T1/el unknown
- 2021-11-02 NO NO2021046C patent/NO2021046I1/no unknown
- 2021-11-03 LT LTPA2021525C patent/LTPA2021525I1/lt unknown
- 2021-11-03 FR FR21C1050C patent/FR21C1050I1/fr active Active
- 2021-11-04 HU HUS2100047C patent/HUS2100047I1/hu unknown
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