KR970701557A - 자기면역성 질환의 치료 수단 및 치료 방법(means for treating auto-immune diseases and method of treatment) - Google Patents
자기면역성 질환의 치료 수단 및 치료 방법(means for treating auto-immune diseases and method of treatment) Download PDFInfo
- Publication number
- KR970701557A KR970701557A KR1019960705237A KR19960705237A KR970701557A KR 970701557 A KR970701557 A KR 970701557A KR 1019960705237 A KR1019960705237 A KR 1019960705237A KR 19960705237 A KR19960705237 A KR 19960705237A KR 970701557 A KR970701557 A KR 970701557A
- Authority
- KR
- South Korea
- Prior art keywords
- glucoprotein
- trophoblast
- treatment
- treating
- immune diseases
- Prior art date
Links
- 208000023275 Autoimmune disease Diseases 0.000 title claims abstract 4
- 210000002993 trophoblast Anatomy 0.000 claims abstract 6
- 239000002955 immunomodulating agent Substances 0.000 claims 2
- 230000002584 immunomodulator Effects 0.000 claims 2
- 229940121354 immunomodulator Drugs 0.000 claims 2
- 230000001363 autoimmune Effects 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 230000001506 immunosuppresive effect Effects 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 210000005259 peripheral blood Anatomy 0.000 claims 1
- 239000011886 peripheral blood Substances 0.000 claims 1
- 210000005087 mononuclear cell Anatomy 0.000 abstract 2
- 206010061598 Immunodeficiency Diseases 0.000 abstract 1
- 208000029462 Immunodeficiency disease Diseases 0.000 abstract 1
- 239000002671 adjuvant Substances 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000007813 immunodeficiency Effects 0.000 abstract 1
- 230000035945 sensitivity Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/02—Peptides of undefined number of amino acids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
- A61K38/212—IFN-alpha
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Marine Sciences & Fisheries (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Transplantation (AREA)
- Rheumatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- External Artificial Organs (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
본 발명은 억제 면역결여를 보이는 자기번역성 질환을 치료하기 위한 수단으로서 사용되는 영양막 β-I-글루코프로테인에 관한다.
또한, 본 발명은, 단핵세포(MNC)의 TBG 민감성 시험과 관령되는 영양막 β-I-글루코프로테인(TBG)의 면역 보정제의 투여를 포함하는 자기면역성 질환의 치료방법에 관한 것이다.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (4)
- 자기면역성 질환을 치료하기 위한 수단으로서 사용되는 영양막 β-I-글루코프로테인(TBG).
- 면역상태를 사전연구하여, 억제자 결여가 발견되는 경우, 이어서 면역 보정제로서 영양막 β-I-글루코프로테인을 혈액 1ml당 3 내지 120㎍의 투여량으로 주입되는 것을 특징으로 하는, 면역 보정제를 주입시키는 것을 포함하는 자기면역성 질환의 치료방법.
- 제2항에 있어서, 영양막 β-I-글루코프로테인이 비경구적으로 주입되는 것을 특징으로 하는 방법.
- 제2항에 있어서, 60㎍/㎖ 농도의 영양막 β-I-글루코프로테인은 말초혈로부터 단리된 자기면역 세포와 배양되어, 정맥내로 주입되는 것을 특징으로 하는 방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
RU9494008169A RU2056852C1 (ru) | 1994-03-18 | 1994-03-18 | Средство для лечения аутоиммунных заболеваний с иммунодефицитом супрессоров и способ лечения аутоиммунных заболеваний |
RU94008169 | 1994-03-18 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR970701557A true KR970701557A (ko) | 1997-04-12 |
KR100382252B1 KR100382252B1 (ko) | 2003-07-07 |
Family
ID=20153349
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019960705237A KR100382252B1 (ko) | 1994-03-18 | 1995-03-16 | 자가면역성질환을치료하기위한약제조성물 |
Country Status (22)
Country | Link |
---|---|
US (1) | US6150326A (ko) |
EP (1) | EP0790059B1 (ko) |
JP (1) | JPH09510473A (ko) |
KR (1) | KR100382252B1 (ko) |
CN (1) | CN1146156A (ko) |
AT (1) | ATE260111T1 (ko) |
AU (1) | AU699896B2 (ko) |
BG (1) | BG62759B1 (ko) |
CA (1) | CA2185892A1 (ko) |
CZ (1) | CZ285856B6 (ko) |
DE (2) | DE790059T1 (ko) |
ES (1) | ES2107980T1 (ko) |
FI (1) | FI963671A (ko) |
GE (1) | GEP20012377B (ko) |
GR (1) | GR980300023T1 (ko) |
HU (1) | HUT75720A (ko) |
NO (1) | NO963911L (ko) |
PL (1) | PL179765B1 (ko) |
RU (1) | RU2056852C1 (ko) |
SK (1) | SK281948B6 (ko) |
UA (1) | UA26939C2 (ko) |
WO (1) | WO1995025531A1 (ko) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0030729D0 (en) * | 2000-12-16 | 2001-01-31 | Univ Nottingham | Substituted-4-Quinolones |
CA2501940A1 (en) * | 2002-10-09 | 2004-04-22 | Tolerrx, Inc. | Molecules preferentially associated with effector t cells or regulatory t cells and methods of their use |
RU2303995C1 (ru) * | 2006-04-28 | 2007-08-10 | Халлар Абдумуслимович Алиханов | Средство, обладающее иммунорегуляторным свойством и его применение для лечения аутоиммунных заболеваний |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5470384A (en) * | 1977-08-22 | 1979-06-06 | Inst Obu Kiyansaa Risaachi Roi | High molecular complex |
JPS61186322A (ja) * | 1985-02-13 | 1986-08-20 | Nippon Univ | 免疾調節剤 |
IT1188646B (it) * | 1986-04-09 | 1988-01-20 | Ellem Ind Farmaceutica | Tripeptide ad attivita' immunostimolante |
US4803072A (en) * | 1986-09-10 | 1989-02-07 | Smithkline Beckman Corporation | Immunomodulation |
FR2609632B1 (fr) * | 1987-01-21 | 1991-03-29 | Shelly Marc | Nouvelle application therapeutique de la 17-(cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxymorphinon-6-one et les compositions pharmaceutiques destinees a cet usage |
US5169835A (en) * | 1989-01-18 | 1992-12-08 | Oklahoma Medical Research Foundation | Pregancy specific proteins applications |
FR2650183A1 (fr) * | 1989-07-25 | 1991-02-01 | Pasteur Institut | Proteines immunostimulantes, anticorps monoclonaux et polyclonaux correspondants, hybridomes correspondants et application de ces produits a des fins therapeutiques et de diagnostic |
US5118669A (en) * | 1989-09-20 | 1992-06-02 | Hitachi Chemical Co., Ltd. | Peptides and intermediates therefor useful as antiallergic agents, vasodilators and immunoregulators |
US5559097A (en) * | 1990-01-12 | 1996-09-24 | Idaho Research Foundation, Inc. | Use of a pregnancy specific protein as an immunosuppressive |
RU1836957C (ru) * | 1990-03-25 | 1993-08-30 | 2-й Московский государственный медицинский институт им.Н.И.Пирогова | Способ получени трофобластического бета @ -гликопротеина |
GB2251186A (en) * | 1990-12-04 | 1992-07-01 | Randall Neal Gatz | Polypeptide for use in treatment of autoimmune disease |
-
1994
- 1994-03-18 RU RU9494008169A patent/RU2056852C1/ru not_active IP Right Cessation
-
1995
- 1995-03-16 WO PCT/RU1995/000047 patent/WO1995025531A1/ru active IP Right Grant
- 1995-03-16 PL PL95316311A patent/PL179765B1/pl unknown
- 1995-03-16 ES ES95913445T patent/ES2107980T1/es active Pending
- 1995-03-16 GE GEAP19953411A patent/GEP20012377B/en unknown
- 1995-03-16 CN CN95192635A patent/CN1146156A/zh active Pending
- 1995-03-16 EP EP95913445A patent/EP0790059B1/en not_active Expired - Lifetime
- 1995-03-16 HU HU9602558A patent/HUT75720A/hu unknown
- 1995-03-16 SK SK1187-96A patent/SK281948B6/sk unknown
- 1995-03-16 UA UA96093436A patent/UA26939C2/uk unknown
- 1995-03-16 CA CA002185892A patent/CA2185892A1/en not_active Abandoned
- 1995-03-16 DE DE0790059T patent/DE790059T1/de active Pending
- 1995-03-16 US US08/716,139 patent/US6150326A/en not_active Expired - Fee Related
- 1995-03-16 KR KR1019960705237A patent/KR100382252B1/ko not_active IP Right Cessation
- 1995-03-16 AU AU20874/95A patent/AU699896B2/en not_active Ceased
- 1995-03-16 JP JP7524566A patent/JPH09510473A/ja not_active Ceased
- 1995-03-16 AT AT95913445T patent/ATE260111T1/de not_active IP Right Cessation
- 1995-03-16 CZ CZ962747A patent/CZ285856B6/cs not_active IP Right Cessation
- 1995-03-16 DE DE69532611T patent/DE69532611D1/de not_active Expired - Lifetime
-
1996
- 1996-09-17 FI FI963671A patent/FI963671A/fi not_active IP Right Cessation
- 1996-09-18 NO NO963911A patent/NO963911L/no not_active Application Discontinuation
- 1996-10-18 BG BG100921A patent/BG62759B1/bg unknown
-
1998
- 1998-04-30 GR GR980300023T patent/GR980300023T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
BG62759B1 (bg) | 2000-07-31 |
WO1995025531A1 (fr) | 1995-09-28 |
RU2056852C1 (ru) | 1996-03-27 |
KR100382252B1 (ko) | 2003-07-07 |
US6150326A (en) | 2000-11-21 |
SK118796A3 (en) | 1997-06-04 |
AU699896B2 (en) | 1998-12-17 |
CN1146156A (zh) | 1997-03-26 |
ATE260111T1 (de) | 2004-03-15 |
PL179765B1 (pl) | 2000-10-31 |
DE69532611D1 (de) | 2004-04-01 |
FI963671A0 (fi) | 1996-09-17 |
AU2087495A (en) | 1995-10-09 |
NO963911D0 (no) | 1996-09-18 |
BG100921A (en) | 1997-12-30 |
GEP20012377B (en) | 2001-03-25 |
PL316311A1 (en) | 1997-01-06 |
EP0790059A1 (en) | 1997-08-20 |
DE790059T1 (de) | 1998-03-12 |
JPH09510473A (ja) | 1997-10-21 |
CZ285856B6 (cs) | 1999-11-17 |
NO963911L (no) | 1996-11-08 |
HUT75720A (en) | 1997-05-28 |
GR980300023T1 (en) | 1998-04-30 |
UA26939C2 (uk) | 1999-12-29 |
ES2107980T1 (es) | 1997-12-16 |
EP0790059B1 (en) | 2004-02-25 |
CZ274796A3 (en) | 1997-06-11 |
HU9602558D0 (en) | 1996-11-28 |
SK281948B6 (sk) | 2001-09-11 |
EP0790059A4 (en) | 2000-11-02 |
FI963671A (fi) | 1996-11-14 |
CA2185892A1 (en) | 1995-09-28 |
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