KR970002611B1 - Antiviral antitumor antimetastatic immune system enhancing nucleosides and nucleotides - Google Patents

Antiviral antitumor antimetastatic immune system enhancing nucleosides and nucleotides Download PDF

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Publication number
KR970002611B1
KR970002611B1 KR89701557A KR890701557A KR970002611B1 KR 970002611 B1 KR970002611 B1 KR 970002611B1 KR 89701557 A KR89701557 A KR 89701557A KR 890701557 A KR890701557 A KR 890701557A KR 970002611 B1 KR970002611 B1 KR 970002611B1
Authority
KR
South Korea
Prior art keywords
antimetastatic
nucleotides
immune system
system enhancing
enhancing nucleosides
Prior art date
Application number
KR89701557A
Other languages
English (en)
Other versions
KR900700106A (ko
Inventor
Roland Kenith Robins
Howard Brinkerhoff Cttam
Original Assignee
Univ Brigham Young
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/136,020 external-priority patent/US4880784A/en
Application filed by Univ Brigham Young filed Critical Univ Brigham Young
Publication of KR900700106A publication Critical patent/KR900700106A/ko
Application granted granted Critical
Publication of KR970002611B1 publication Critical patent/KR970002611B1/ko

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/24—Heterocyclic radicals containing oxygen or sulfur as ring hetero atom

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)
KR89701557A 1987-12-21 1989-08-21 Antiviral antitumor antimetastatic immune system enhancing nucleosides and nucleotides KR970002611B1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US136.020 1987-12-21
US07/136,020 US4880784A (en) 1987-12-21 1987-12-21 Antiviral methods utilizing ribofuranosylthiazolo[4,5-d]pyrimdine derivatives
US236.366 1988-08-25
US07/236,366 US5041426A (en) 1987-12-21 1988-08-25 Immune system enhancing 3-β-d-ribofuranosylthiazolo[4,5-d]pyridimine nucleosides and nucleotides
PCT/US1988/002982 WO1989005649A1 (en) 1987-12-21 1988-09-02 Antiviral antitumor antimetastatic immune system enhancing nucleosides and nucleotides

Publications (2)

Publication Number Publication Date
KR900700106A KR900700106A (ko) 1990-08-11
KR970002611B1 true KR970002611B1 (en) 1997-03-06

Family

ID=26833912

Family Applications (1)

Application Number Title Priority Date Filing Date
KR89701557A KR970002611B1 (en) 1987-12-21 1989-08-21 Antiviral antitumor antimetastatic immune system enhancing nucleosides and nucleotides

Country Status (11)

Country Link
US (1) US5041426A (ko)
EP (2) EP0348446B1 (ko)
JP (1) JP2590248B2 (ko)
KR (1) KR970002611B1 (ko)
AR (1) AR246104A1 (ko)
AT (2) ATE173929T1 (ko)
CA (1) CA1319931C (ko)
DE (2) DE3854297T2 (ko)
DK (1) DK406389A (ko)
ES (1) ES2010786A6 (ko)
WO (1) WO1989005649A1 (ko)

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US5166141A (en) * 1983-11-01 1992-11-24 Scripps Clinic And Research Foundation Immunostimulating 7-deaza-7-oxa- and 7-deaza-7-oxo-analogs of 8-substituted-guanine-9-(1'-beta-D-aldoglycosidyl) derivatives and methods of treating test animals
WO1989011487A1 (en) * 1988-05-23 1989-11-30 United States Of America, Represented By The Secre Derivatives of cyclic amp as treatment for cancer
US6509320B1 (en) * 1996-10-16 2003-01-21 Icn Pharmaceuticals, Inc. Purine L-nucleosides, analogs and uses thereof
CN1233254A (zh) * 1996-10-16 1999-10-27 Icn药品公司 嘌呤l－核苷、其类似物及其用途
EP1103559A1 (en) * 1997-01-17 2001-05-30 ICN Pharmaceuticals, Inc. Autoimmune nucleosides
US7638496B2 (en) 2000-02-15 2009-12-29 Valeant Pharmaceuticals North America Nucleoside analogs with carboxamidine modified monocyclic base
US6645990B2 (en) * 2000-08-15 2003-11-11 Amgen Inc. Thiazolyl urea compounds and methods of uses
US7321033B2 (en) * 2001-11-27 2008-01-22 Anadys Pharmaceuticals, Inc. 3-B-D-ribofuranosylthiazolo [4,5-d] pyrimidine nucleosides and uses thereof
KR100718371B1 (ko) * 2001-11-27 2007-05-14 애나디스 파마슈티칼스, 인코포레이티드 ３-β-Ｄ-리보푸라노실티아졸로[４,５-ｄ]피리디민누클레오시드 및 이의 용도
US7576068B2 (en) 2003-09-05 2009-08-18 Anadys Pharmaceuticals, Inc. Administration of TLR7 ligands and prodrugs thereof for treatment of infection by hepatitis C virus
CN1845745B (zh) * 2003-09-05 2011-11-02 安那迪斯药品股份有限公司 Tlr7配体及其前药在制备用于治疗丙型肝炎病毒感染的药物中的用途
GB0500020D0 (en) 2005-01-04 2005-02-09 Novartis Ag Organic compounds
EP1758916B1 (en) * 2004-06-07 2012-11-21 Anadys Pharmaceuticals, Inc. 3-BETA-D-RIBOFURANOSYLTHIAZOLO[4,5-d]PYRIDIMINE NUCLEOSIDES AND USES THEREOF
WO2006066080A1 (en) * 2004-12-17 2006-06-22 Anadys Pharmaceuticals, Inc. 3, 5-DISUBSTITUTED AND 3,5,7-TRISUBSTITUTED-3H-OXAZOLO AND 3H-THIAZOLO [4,5-d]PYRIMIDIN-2-ONE COMPOUNDS AND PRODRUGS THEREOF
CN101212968B (zh) * 2004-12-17 2011-11-16 安那迪斯药品股份有限公司 3,5-二取代的和3,5,7-三取代的-3H-噁唑并以及3H-噻唑并[4,5-d]嘧啶-2-酮化合物及其前药
KR20080090400A (ko) * 2005-11-21 2008-10-08 애나디스 파마슈티칼스, 인코포레이티드 5-아미노-3Ｈ-티아졸로[4,5-ｄ]피리미딘-2-온의 제조 방법
BRPI0710878A2 (pt) 2006-04-11 2015-03-31 Novartis Ag Compostos orgânicos e seus usos
CA2655904C (en) * 2006-06-22 2014-11-18 Anadys Pharmaceuticals, Inc. Prodrugs of 5-amino-3-(3'-deoxy-.beta.-d-ribofuranosyl)-thiazolo[4,5-d]pyrimidin-2,7-dione
ATE499940T1 (de) * 2006-07-18 2011-03-15 Anadys Pharmaceuticals Inc Carbonat- und carbamat-prodrugs von thiazolo ä4,5-dü-pyrimidinen
KR100880298B1 (ko) 2006-12-06 2009-01-28 애나디스 파마슈티칼스, 인코포레이티드 ３-β-Ｄ-리보푸라노실티아졸로[４,５-ｄ]피리미딘뉴클레오시드 및 이의 용도
UY32306A (es) 2008-12-09 2010-07-30 Gilead Sciences Inc Derivados de pteridinona y pirimidinodiazepinona y composiciones farmacéuticas que modulan en forma selectiva los receptores tipo toll, métodos y usos
US20110182850A1 (en) 2009-04-10 2011-07-28 Trixi Brandl Organic compounds and their uses
US8512690B2 (en) 2009-04-10 2013-08-20 Novartis Ag Derivatised proline containing peptide compounds as protease inhibitors
CA2794671C (en) 2010-03-31 2018-05-01 Gilead Pharmasset Llc Stereoselective synthesis of phosphorus containing actives
BR112013008510A2 (pt) 2010-10-08 2016-07-05 Novartis Ag vitamina e formulações de inibidores de sulfamida ns3
JPWO2012102366A1 (ja) * 2011-01-28 2014-06-30 日本たばこ産業株式会社 新規ピペラジン化合物の製造方法
TWI806081B (zh) 2014-07-11 2023-06-21 美商基利科學股份有限公司 用於治療HIV之toll樣受體調節劑
PT3194401T (pt) 2014-09-16 2020-12-23 Gilead Sciences Inc Formas sólidas de modulador de recetor tipo toll
WO2016091698A1 (en) * 2014-12-08 2016-06-16 F. Hoffmann-La Roche Ag 3-substituted 5-amino-6h-thiazolo[4,5-d]pyrimidine-2,7-dione compounds for the treatment and prophylaxis of virus infection
KR102139708B1 (ko) 2015-03-16 2020-07-31 에프. 호프만-라 로슈 아게 Tlr7 작용제 및 hbv 캡시드 조립 억제제를 사용하는 병용 치료
CN107743491B (zh) 2015-05-08 2020-08-21 豪夫迈·罗氏有限公司 用于治疗和预防病毒感染的新的氧硫杂环戊烷甲酸及其衍生物
JP6806709B2 (ja) 2015-05-12 2021-01-06 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ ウイルス感染症の治療と予防のための新規置換アミノチアゾロピリミジンジオン
EP3317289B1 (en) 2015-06-30 2021-10-27 F. Hoffmann-La Roche AG Novel substituted aminothiazolopyrimidinedione for the treatment and prophylaxis of virus infection
BR112019013884A2 (pt) 2017-01-06 2020-03-03 F. Hoffmann-La Roche Ag Processo para a preparação de compostos de 5 -amino -6h´ -tiazolo [4,5 -d] pirimidina -2,7 -diona 3 -substituídos

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4746651A (en) * 1983-11-01 1988-05-24 Scripps Clinic And Research Foundation Antimicrobial chemotherapeutic potentiation using substituted nucleoside derivatives
US5166141A (en) * 1983-11-01 1992-11-24 Scripps Clinic And Research Foundation Immunostimulating 7-deaza-7-oxa- and 7-deaza-7-oxo-analogs of 8-substituted-guanine-9-(1'-beta-D-aldoglycosidyl) derivatives and methods of treating test animals

Also Published As

Publication number Publication date
JP2590248B2 (ja) 1997-03-12
DK406389A (da) 1989-10-04
EP0348446B1 (en) 1995-08-09
WO1989005649A1 (en) 1989-06-29
ATE126060T1 (de) 1995-08-15
US5041426A (en) 1991-08-20
ES2010786A6 (es) 1989-12-01
AR246104A1 (es) 1994-03-30
DE3856279T2 (de) 1999-05-20
DE3856279D1 (de) 1999-01-14
EP0348446A4 (en) 1991-09-25
JPH03504122A (ja) 1991-09-12
DK406389D0 (da) 1989-08-18
EP0636372A1 (en) 1995-02-01
ATE173929T1 (de) 1998-12-15
CA1319931C (en) 1993-07-06
DE3854297T2 (de) 1996-03-28
DE3854297D1 (de) 1995-09-14
EP0348446A1 (en) 1990-01-03
EP0636372B1 (en) 1998-12-02
KR900700106A (ko) 1990-08-11

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