ES2010786A6 - Metodo para preparar nuecleosidos y nucleotidos mejoradores del sistema antiviral, antitumoral, antimetastatico e inmune. - Google Patents
Metodo para preparar nuecleosidos y nucleotidos mejoradores del sistema antiviral, antitumoral, antimetastatico e inmune.Info
- Publication number
- ES2010786A6 ES2010786A6 ES8802722A ES8802722A ES2010786A6 ES 2010786 A6 ES2010786 A6 ES 2010786A6 ES 8802722 A ES8802722 A ES 8802722A ES 8802722 A ES8802722 A ES 8802722A ES 2010786 A6 ES2010786 A6 ES 2010786A6
- Authority
- ES
- Spain
- Prior art keywords
- antimetastatic
- nucleotides
- immune system
- system enhancing
- enhancing nucleosides
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/24—Heterocyclic radicals containing oxygen or sulfur as ring hetero atom
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Saccharide Compounds (AREA)
Abstract
METODO PARA PREPARAR NUCLEOSIDOS Y NUCLEOTIDOS MEJORADORES DEL SISTEMA ANTIVIRAL, ANTITUMORAL, ANTIMETASTASICO E INMUNE QUE RESPONDEN A LA ESTRUCTURA: DONDE R4-R7 SON H, OH U O-ACILO C1-C18, R3 ES H, ACILO, C1-C18 U OP(OH2)2-, O R5 Y R7 SON H U OH, R6 ES H Y R3 Y R4 JUNTOS SON OPO(OH)-, X ES =O O =S, Y ES -OH, -SH, -NH2 O HALOGENO, Y Z ES H, -NH2, -OH O HALOGENO, SIENDO EL HALOGENO CL O BR. CONSISTE EN FORMAR UN DERIVADO SILILO DE UNA TIAZOLO[4,5-D]PIRIMIDINA 2,5,7-SUSTITUIDA, HACER REACCIONAR DICHO DERIVADO SILILO CON 1-SUSTITUIDO-BLOQUEADO-D-PENTOFURANOSA, EN PRESENCIA DE UN CATALIZADOR, FORMANDO UN NUCLEOSIDO BLOQUEADO, Y DESBLOQUEAR DICHO NUCLEOSIDO. LOS PRODUCTOS OBTENIDOS SON UTILES PARA TRATAR ENFERMEDADES VIRALES Y TUMORES EN MAMIFEROS.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/136,020 US4880784A (en) | 1987-12-21 | 1987-12-21 | Antiviral methods utilizing ribofuranosylthiazolo[4,5-d]pyrimdine derivatives |
US07/236,366 US5041426A (en) | 1987-12-21 | 1988-08-25 | Immune system enhancing 3-β-d-ribofuranosylthiazolo[4,5-d]pyridimine nucleosides and nucleotides |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2010786A6 true ES2010786A6 (es) | 1989-12-01 |
Family
ID=26833912
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES8802722A Expired ES2010786A6 (es) | 1987-12-21 | 1988-09-03 | Metodo para preparar nuecleosidos y nucleotidos mejoradores del sistema antiviral, antitumoral, antimetastatico e inmune. |
Country Status (11)
Country | Link |
---|---|
US (1) | US5041426A (es) |
EP (2) | EP0348446B1 (es) |
JP (1) | JP2590248B2 (es) |
KR (1) | KR970002611B1 (es) |
AR (1) | AR246104A1 (es) |
AT (2) | ATE173929T1 (es) |
CA (1) | CA1319931C (es) |
DE (2) | DE3856279T2 (es) |
DK (1) | DK406389A (es) |
ES (1) | ES2010786A6 (es) |
WO (1) | WO1989005649A1 (es) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5166141A (en) * | 1983-11-01 | 1992-11-24 | Scripps Clinic And Research Foundation | Immunostimulating 7-deaza-7-oxa- and 7-deaza-7-oxo-analogs of 8-substituted-guanine-9-(1'-beta-D-aldoglycosidyl) derivatives and methods of treating test animals |
AU3760489A (en) * | 1988-05-23 | 1989-12-12 | United States of America, as represented by the Secretary, U.S. Department of Commerce, The | Derivatives of cyclic amp as treatment for cancer |
ATE271063T1 (de) * | 1996-10-16 | 2004-07-15 | Icn Pharmaceuticals | Purin-l-nukleoside, deren analoga und verwendungen |
US6509320B1 (en) * | 1996-10-16 | 2003-01-21 | Icn Pharmaceuticals, Inc. | Purine L-nucleosides, analogs and uses thereof |
EP1103559A1 (en) * | 1997-01-17 | 2001-05-30 | ICN Pharmaceuticals, Inc. | Autoimmune nucleosides |
US7638496B2 (en) | 2000-02-15 | 2009-12-29 | Valeant Pharmaceuticals North America | Nucleoside analogs with carboxamidine modified monocyclic base |
US6645990B2 (en) * | 2000-08-15 | 2003-11-11 | Amgen Inc. | Thiazolyl urea compounds and methods of uses |
US7321033B2 (en) * | 2001-11-27 | 2008-01-22 | Anadys Pharmaceuticals, Inc. | 3-B-D-ribofuranosylthiazolo [4,5-d] pyrimidine nucleosides and uses thereof |
GEP20074099B (en) * | 2001-11-27 | 2007-05-10 | Anadys Pharmaceuticals Inc | 3-β-D-RIBOFURANO-SYLTHIAZOLO[4,5-d]PYRIDIMINE NUCLEOSIDES AND USES THEREOF |
KR20060096415A (ko) * | 2003-09-05 | 2006-09-11 | 애나디스 파마슈티칼스, 인코포레이티드 | C형 간염 바이러스에 의한 감염증을 치료하기 위해투여하는 tlr7 리간드 및 이의 전구약물 |
CN1845745B (zh) * | 2003-09-05 | 2011-11-02 | 安那迪斯药品股份有限公司 | Tlr7配体及其前药在制备用于治疗丙型肝炎病毒感染的药物中的用途 |
GB0500020D0 (en) | 2005-01-04 | 2005-02-09 | Novartis Ag | Organic compounds |
JP4856638B2 (ja) * | 2004-06-07 | 2012-01-18 | アナディス・ファーマシューティカルズ・インコーポレイテッド | 3−β−D−リボフラノシルチアゾロ[4,5−d]ピリミジンヌクレオシドおよびその使用 |
CN101212968B (zh) * | 2004-12-17 | 2011-11-16 | 安那迪斯药品股份有限公司 | 3,5-二取代的和3,5,7-三取代的-3H-噁唑并以及3H-噻唑并[4,5-d]嘧啶-2-酮化合物及其前药 |
MY176938A (en) * | 2004-12-17 | 2020-08-27 | Anadys Pharmaceuticals Inc | 3,5-disubstituted and 3,5,7-trisubstituted-3h-oxazolo and 3h-thiazolo[4,5-d] pyrimidin-2-one compounds and prodrugs thereof |
JP5117391B2 (ja) * | 2005-11-21 | 2013-01-16 | アナディス ファーマシューティカルズ インク | 5−アミノ−3H−チアゾロ[4,5−d]ピリミジン−2−オンを調製するための新規な方法 |
ES2543840T3 (es) | 2006-04-11 | 2015-08-24 | Novartis Ag | Inhibidores espirocíclicos del VHC/VIH y sus usos |
CN101516192B (zh) * | 2006-06-22 | 2012-09-19 | 安那迪斯药品股份有限公司 | 5-氨基-3-(3'-脱氧-β-D-呋喃核糖基)-噻唑并[4,5-d]嘧啶-2,7-二酮的前药 |
WO2008011406A2 (en) | 2006-07-18 | 2008-01-24 | Anadys Pharmaceuticals, Inc. | Carbonate and carbamate prodrugs of thiazolo [4,5-d] pyrimidines |
KR100880298B1 (ko) | 2006-12-06 | 2009-01-28 | 애나디스 파마슈티칼스, 인코포레이티드 | 3-β-D-리보푸라노실티아졸로[4,5-d]피리미딘뉴클레오시드 및 이의 용도 |
PE20120106A1 (es) | 2008-12-09 | 2012-02-20 | Gilead Sciences Inc | Moduladores de receptores tipo toll |
US20110182850A1 (en) | 2009-04-10 | 2011-07-28 | Trixi Brandl | Organic compounds and their uses |
US8512690B2 (en) | 2009-04-10 | 2013-08-20 | Novartis Ag | Derivatised proline containing peptide compounds as protease inhibitors |
PT2752422T (pt) | 2010-03-31 | 2017-11-07 | Gilead Pharmasset Llc | Síntese estereosseletiva de princípios ativos contendo fósforo |
AU2011311880B2 (en) | 2010-10-08 | 2014-07-24 | Novartis Ag | Vitamin E formulations of sulfamide NS3 inhibitors |
WO2012102366A1 (ja) * | 2011-01-28 | 2012-08-02 | 日本たばこ産業株式会社 | 新規ピペラジン化合物の製造方法 |
JP6522732B2 (ja) | 2014-07-11 | 2019-05-29 | ギリアード サイエンシーズ, インコーポレイテッド | Hivを治療するためのトール様受容体の調節因子 |
CA2960436C (en) | 2014-09-16 | 2021-01-05 | Gilead Sciences, Inc. | Solid forms of a toll-like receptor modulator |
ES2864223T3 (es) | 2014-12-08 | 2021-10-13 | Hoffmann La Roche | Compuestos de 5-amino-6H-tiazolo[4,5-d]pirimidin-2,7-diona 3-sustituida para el tratamiento y profilaxis de infección vírica |
PE20171648A1 (es) | 2015-03-16 | 2017-11-13 | Hoffmann La Roche | Tratamiento combinado con un agonista de tlr7 y un inhibidor del ensamblaje de la capsida del vhb |
CN107743491B (zh) | 2015-05-08 | 2020-08-21 | 豪夫迈·罗氏有限公司 | 用于治疗和预防病毒感染的新的氧硫杂环戊烷甲酸及其衍生物 |
EP4001283A1 (en) | 2015-05-12 | 2022-05-25 | F. Hoffmann-La Roche AG | Substituted aminothiazolopyrimidinedione derivatives for the treatment and prophylaxis of virus infection |
EP3317289B1 (en) | 2015-06-30 | 2021-10-27 | F. Hoffmann-La Roche AG | Novel substituted aminothiazolopyrimidinedione for the treatment and prophylaxis of virus infection |
BR112019013884A2 (pt) | 2017-01-06 | 2020-03-03 | F. Hoffmann-La Roche Ag | Processo para a preparação de compostos de 5 -amino -6h´ -tiazolo [4,5 -d] pirimidina -2,7 -diona 3 -substituídos |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4746651A (en) * | 1983-11-01 | 1988-05-24 | Scripps Clinic And Research Foundation | Antimicrobial chemotherapeutic potentiation using substituted nucleoside derivatives |
US5166141A (en) * | 1983-11-01 | 1992-11-24 | Scripps Clinic And Research Foundation | Immunostimulating 7-deaza-7-oxa- and 7-deaza-7-oxo-analogs of 8-substituted-guanine-9-(1'-beta-D-aldoglycosidyl) derivatives and methods of treating test animals |
-
1988
- 1988-08-25 US US07/236,366 patent/US5041426A/en not_active Expired - Lifetime
- 1988-09-02 AT AT94112331T patent/ATE173929T1/de not_active IP Right Cessation
- 1988-09-02 JP JP63507805A patent/JP2590248B2/ja not_active Expired - Lifetime
- 1988-09-02 AT AT88908566T patent/ATE126060T1/de not_active IP Right Cessation
- 1988-09-02 DE DE3856279T patent/DE3856279T2/de not_active Expired - Lifetime
- 1988-09-02 EP EP88908566A patent/EP0348446B1/en not_active Expired - Lifetime
- 1988-09-02 EP EP94112331A patent/EP0636372B1/en not_active Expired - Lifetime
- 1988-09-02 AR AR88311844A patent/AR246104A1/es active
- 1988-09-02 CA CA000576416A patent/CA1319931C/en not_active Expired - Lifetime
- 1988-09-02 DE DE3854297T patent/DE3854297T2/de not_active Expired - Lifetime
- 1988-09-02 WO PCT/US1988/002982 patent/WO1989005649A1/en active IP Right Grant
- 1988-09-03 ES ES8802722A patent/ES2010786A6/es not_active Expired
-
1989
- 1989-08-18 DK DK406389A patent/DK406389A/da unknown
- 1989-08-21 KR KR89701557A patent/KR970002611B1/ko not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
CA1319931C (en) | 1993-07-06 |
DK406389A (da) | 1989-10-04 |
AR246104A1 (es) | 1994-03-30 |
DE3856279D1 (de) | 1999-01-14 |
EP0348446A4 (en) | 1991-09-25 |
JPH03504122A (ja) | 1991-09-12 |
JP2590248B2 (ja) | 1997-03-12 |
DE3856279T2 (de) | 1999-05-20 |
EP0348446B1 (en) | 1995-08-09 |
EP0636372A1 (en) | 1995-02-01 |
US5041426A (en) | 1991-08-20 |
ATE173929T1 (de) | 1998-12-15 |
ATE126060T1 (de) | 1995-08-15 |
DK406389D0 (da) | 1989-08-18 |
DE3854297T2 (de) | 1996-03-28 |
DE3854297D1 (de) | 1995-09-14 |
KR970002611B1 (en) | 1997-03-06 |
KR900700106A (ko) | 1990-08-11 |
EP0636372B1 (en) | 1998-12-02 |
WO1989005649A1 (en) | 1989-06-29 |
EP0348446A1 (en) | 1990-01-03 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
SA6 | Expiration date (snapshot 920101) |
Free format text: 2008-09-03 |
|
PC1A | Transfer granted | ||
FD1A | Patent lapsed |
Effective date: 20080904 |