DE3856279D1 - 7-Thia-Guanosin-Derivate mit antiviraler, antitumoraler, antimetastatischer und immunstimulierender Wirkung - Google Patents

7-Thia-Guanosin-Derivate mit antiviraler, antitumoraler, antimetastatischer und immunstimulierender Wirkung

Info

Publication number
DE3856279D1
DE3856279D1 DE3856279T DE3856279T DE3856279D1 DE 3856279 D1 DE3856279 D1 DE 3856279D1 DE 3856279 T DE3856279 T DE 3856279T DE 3856279 T DE3856279 T DE 3856279T DE 3856279 D1 DE3856279 D1 DE 3856279D1
Authority
DE
Germany
Prior art keywords
antimetastatic
antitumoral
thia
antiviral
guanosine derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE3856279T
Other languages
English (en)
Other versions
DE3856279T2 (de
Inventor
Roland Kenith Robins
Howard Brinkerhoff Cottam
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Anadys Pharmaceuticals Inc
Original Assignee
ICN Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/136,020 external-priority patent/US4880784A/en
Application filed by ICN Pharmaceuticals Inc filed Critical ICN Pharmaceuticals Inc
Publication of DE3856279D1 publication Critical patent/DE3856279D1/de
Application granted granted Critical
Publication of DE3856279T2 publication Critical patent/DE3856279T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/24—Heterocyclic radicals containing oxygen or sulfur as ring hetero atom

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)
DE3856279T 1987-12-21 1988-09-02 7-Thia-Guanosin-Derivate mit antiviraler, antitumoraler, antimetastatischer und immunstimulierender Wirkung Expired - Lifetime DE3856279T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/136,020 US4880784A (en) 1987-12-21 1987-12-21 Antiviral methods utilizing ribofuranosylthiazolo[4,5-d]pyrimdine derivatives
US07/236,366 US5041426A (en) 1987-12-21 1988-08-25 Immune system enhancing 3-β-d-ribofuranosylthiazolo[4,5-d]pyridimine nucleosides and nucleotides

Publications (2)

Publication Number Publication Date
DE3856279D1 true DE3856279D1 (de) 1999-01-14
DE3856279T2 DE3856279T2 (de) 1999-05-20

Family

ID=26833912

Family Applications (2)

Application Number Title Priority Date Filing Date
DE3854297T Expired - Lifetime DE3854297T2 (de) 1987-12-21 1988-09-02 Nucleoside und nucleotide mit antiviraler, antitumoraler, antimetastatischer sowie immunstimulierender wirkung.
DE3856279T Expired - Lifetime DE3856279T2 (de) 1987-12-21 1988-09-02 7-Thia-Guanosin-Derivate mit antiviraler, antitumoraler, antimetastatischer und immunstimulierender Wirkung

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE3854297T Expired - Lifetime DE3854297T2 (de) 1987-12-21 1988-09-02 Nucleoside und nucleotide mit antiviraler, antitumoraler, antimetastatischer sowie immunstimulierender wirkung.

Country Status (11)

Country Link
US (1) US5041426A (de)
EP (2) EP0636372B1 (de)
JP (1) JP2590248B2 (de)
KR (1) KR970002611B1 (de)
AR (1) AR246104A1 (de)
AT (2) ATE173929T1 (de)
CA (1) CA1319931C (de)
DE (2) DE3854297T2 (de)
DK (1) DK406389A (de)
ES (1) ES2010786A6 (de)
WO (1) WO1989005649A1 (de)

Families Citing this family (34)

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US5166141A (en) * 1983-11-01 1992-11-24 Scripps Clinic And Research Foundation Immunostimulating 7-deaza-7-oxa- and 7-deaza-7-oxo-analogs of 8-substituted-guanine-9-(1'-beta-D-aldoglycosidyl) derivatives and methods of treating test animals
WO1989011487A1 (en) * 1988-05-23 1989-11-30 United States Of America, Represented By The Secre Derivatives of cyclic amp as treatment for cancer
US6509320B1 (en) * 1996-10-16 2003-01-21 Icn Pharmaceuticals, Inc. Purine L-nucleosides, analogs and uses thereof
CN1233254A (zh) * 1996-10-16 1999-10-27 Icn药品公司 嘌呤l－核苷、其类似物及其用途
EP1103559A1 (de) * 1997-01-17 2001-05-30 ICN Pharmaceuticals, Inc. Autoimmun-Nukleoside
US7638496B2 (en) 2000-02-15 2009-12-29 Valeant Pharmaceuticals North America Nucleoside analogs with carboxamidine modified monocyclic base
US6645990B2 (en) * 2000-08-15 2003-11-11 Amgen Inc. Thiazolyl urea compounds and methods of uses
UA79764C2 (en) 2001-11-27 2007-07-25 Anadys Pharmaceuticals Inc 3-?-D-RIBOFURANOSYLTHIAZOLO[4,5-d]PYRIDIMINE NUCLEOSIDES AND USES THEREOF
US7321033B2 (en) * 2001-11-27 2008-01-22 Anadys Pharmaceuticals, Inc. 3-B-D-ribofuranosylthiazolo [4,5-d] pyrimidine nucleosides and uses thereof
OA13310A (en) 2003-09-05 2007-04-13 Anadys Pharmaceuticals Inc TLR7 ligands for the treatment of hepatitis C.
CN1845745B (zh) * 2003-09-05 2011-11-02 安那迪斯药品股份有限公司 Tlr7配体及其前药在制备用于治疗丙型肝炎病毒感染的药物中的用途
GB0500020D0 (en) 2005-01-04 2005-02-09 Novartis Ag Organic compounds
CA2566541C (en) * 2004-06-07 2012-10-09 Anadys Pharmaceuticals, Inc. 3-.beta.-d-ribofuranosylthiazolo[4,5-d]pyrimidine nucleosides and uses thereof
CN101212968B (zh) * 2004-12-17 2011-11-16 安那迪斯药品股份有限公司 3,5-二取代的和3,5,7-三取代的-3H-噁唑并以及3H-噻唑并[4,5-d]嘧啶-2-酮化合物及其前药
US7560544B2 (en) * 2004-12-17 2009-07-14 Anadys Pharmaceuticals, Inc. 3,5-Disubsitituted and 3,5,7-trisubstituted-3H-oxazolo and 3H-thiazolo[4,5-d]pyrimidin-2-one compounds and prodrugs thereof
JP5117391B2 (ja) * 2005-11-21 2013-01-16 アナディス ファーマシューティカルズ インク ５−アミノ−３Ｈ−チアゾロ［４，５−ｄ］ピリミジン−２−オンを調製するための新規な方法
NZ571826A (en) 2006-04-11 2012-01-12 Novartis Ag HCV/HIV inhibitors and their uses
EP2034834B1 (de) 2006-06-22 2011-01-26 Anadys Pharmaceuticals, Inc. Prodrugs von 5-amino-3-(3'-deoxy-beta-d-ribofuranosyl)-thiazol[4,5-d]pyrimidin-2,7-dion
DE602007012881D1 (en) * 2006-07-18 2011-04-14 Anadys Pharmaceuticals Inc Carbonat- und carbamat-prodrugs von thiazolo ä4,5-dü-pyrimidinen
KR100880298B1 (ko) 2006-12-06 2009-01-28 애나디스 파마슈티칼스, 인코포레이티드 ３-β-Ｄ-리보푸라노실티아졸로[４,５-ｄ]피리미딘뉴클레오시드 및 이의 용도
TW201639852A (zh) 2008-12-09 2016-11-16 吉李德科學股份有限公司 用於製備可用作類鐸受體調節劑之化合物的中間體化合物
US20110182850A1 (en) 2009-04-10 2011-07-28 Trixi Brandl Organic compounds and their uses
US8512690B2 (en) 2009-04-10 2013-08-20 Novartis Ag Derivatised proline containing peptide compounds as protease inhibitors
UY33311A (es) 2010-03-31 2011-10-31 Pharmasset Inc Fosforamidatos de nucleosidos
WO2012048235A1 (en) 2010-10-08 2012-04-12 Novartis Ag Vitamin e formulations of sulfamide ns3 inhibitors
WO2012102366A1 (ja) * 2011-01-28 2012-08-02 日本たばこ産業株式会社 新規ピペラジン化合物の製造方法
MX2017000026A (es) 2014-07-11 2017-05-01 Gilead Sciences Inc Moduladores de receptores tipo toll para el tratamiento de virus de inmunodeficiencia humana (vih).
SI3194401T1 (sl) 2014-09-16 2020-12-31 Gilead Sciences, Inc. Trdne oblike modulatorja toličnega receptorja
SI3230298T1 (sl) * 2014-12-08 2021-04-30 F. Hoffmann-La Roche Ag Spojine 3-substituiranega 5-amino-6H-tiazolo(4,5-d)pirimidin-2,7-diona za zdravljenje ali preprečevanje okužbe z virusom
KR102359212B1 (ko) 2015-03-16 2022-02-08 에프. 호프만-라 로슈 아게 Tlr7 작용제 및 hbv 캡시드 조립 억제제를 사용하는 병용 치료
EP3294745B1 (de) 2015-05-08 2020-01-01 H. Hoffnabb-La Roche Ag Neuartige oxathiolan-carbonsäuren und derivate zur behandlung und prophylaxe von virusinfektionen
CN107592864B (zh) 2015-05-12 2021-04-16 豪夫迈·罗氏有限公司 用于治疗和预防病毒感染的新的取代的氨基噻唑并嘧啶二酮
WO2017001307A1 (en) 2015-06-30 2017-01-05 F. Hoffmann-La Roche Ag Novel substituted aminothiazolopyrimidinedione for the treatment and prophylaxis of virus infection
AU2018205994B2 (en) 2017-01-06 2021-09-09 F. Hoffmann-La Roche Ag Process for the preparation of 3-substituted 5-amino-6H-thiazolo[4,5-d]pyrimidine-2,7-dione compounds

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5166141A (en) * 1983-11-01 1992-11-24 Scripps Clinic And Research Foundation Immunostimulating 7-deaza-7-oxa- and 7-deaza-7-oxo-analogs of 8-substituted-guanine-9-(1'-beta-D-aldoglycosidyl) derivatives and methods of treating test animals
US4746651A (en) * 1983-11-01 1988-05-24 Scripps Clinic And Research Foundation Antimicrobial chemotherapeutic potentiation using substituted nucleoside derivatives

Also Published As

Publication number Publication date
EP0348446B1 (de) 1995-08-09
US5041426A (en) 1991-08-20
KR900700106A (ko) 1990-08-11
JPH03504122A (ja) 1991-09-12
AR246104A1 (es) 1994-03-30
CA1319931C (en) 1993-07-06
ATE173929T1 (de) 1998-12-15
ES2010786A6 (es) 1989-12-01
EP0636372A1 (de) 1995-02-01
KR970002611B1 (en) 1997-03-06
DE3854297D1 (de) 1995-09-14
DK406389A (da) 1989-10-04
DE3854297T2 (de) 1996-03-28
EP0348446A1 (de) 1990-01-03
EP0348446A4 (en) 1991-09-25
ATE126060T1 (de) 1995-08-15
EP0636372B1 (de) 1998-12-02
DK406389D0 (da) 1989-08-18
JP2590248B2 (ja) 1997-03-12
WO1989005649A1 (en) 1989-06-29
DE3856279T2 (de) 1999-05-20

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: ANADYS PHARMACEUTICALS, INC. (N.D.GES.D. STAATES D