ATE173929T1 - 7-thia-guanosin-derivate mit antiviraler, antitumoraler, antimetastatischer und immunstimulierender wirkung - Google Patents
7-thia-guanosin-derivate mit antiviraler, antitumoraler, antimetastatischer und immunstimulierender wirkungInfo
- Publication number
- ATE173929T1 ATE173929T1 AT94112331T AT94112331T ATE173929T1 AT E173929 T1 ATE173929 T1 AT E173929T1 AT 94112331 T AT94112331 T AT 94112331T AT 94112331 T AT94112331 T AT 94112331T AT E173929 T1 ATE173929 T1 AT E173929T1
- Authority
- AT
- Austria
- Prior art keywords
- antimetastatic
- tumoral
- thia
- immuno
- antiviral
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/24—Heterocyclic radicals containing oxygen or sulfur as ring hetero atom
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Genetics & Genomics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/136,020 US4880784A (en) | 1987-12-21 | 1987-12-21 | Antiviral methods utilizing ribofuranosylthiazolo[4,5-d]pyrimdine derivatives |
US07/236,366 US5041426A (en) | 1987-12-21 | 1988-08-25 | Immune system enhancing 3-β-d-ribofuranosylthiazolo[4,5-d]pyridimine nucleosides and nucleotides |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE173929T1 true ATE173929T1 (de) | 1998-12-15 |
Family
ID=26833912
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT94112331T ATE173929T1 (de) | 1987-12-21 | 1988-09-02 | 7-thia-guanosin-derivate mit antiviraler, antitumoraler, antimetastatischer und immunstimulierender wirkung |
AT88908566T ATE126060T1 (de) | 1987-12-21 | 1988-09-02 | Nucleoside und nucleotide mit antiviraler, antitumoraler, antimetastatischer sowie immunstimulierender wirkung. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT88908566T ATE126060T1 (de) | 1987-12-21 | 1988-09-02 | Nucleoside und nucleotide mit antiviraler, antitumoraler, antimetastatischer sowie immunstimulierender wirkung. |
Country Status (11)
Country | Link |
---|---|
US (1) | US5041426A (de) |
EP (2) | EP0348446B1 (de) |
JP (1) | JP2590248B2 (de) |
KR (1) | KR970002611B1 (de) |
AR (1) | AR246104A1 (de) |
AT (2) | ATE173929T1 (de) |
CA (1) | CA1319931C (de) |
DE (2) | DE3856279T2 (de) |
DK (1) | DK406389A (de) |
ES (1) | ES2010786A6 (de) |
WO (1) | WO1989005649A1 (de) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5166141A (en) * | 1983-11-01 | 1992-11-24 | Scripps Clinic And Research Foundation | Immunostimulating 7-deaza-7-oxa- and 7-deaza-7-oxo-analogs of 8-substituted-guanine-9-(1'-beta-D-aldoglycosidyl) derivatives and methods of treating test animals |
WO1989011487A1 (en) * | 1988-05-23 | 1989-11-30 | United States Of America, Represented By The Secre | Derivatives of cyclic amp as treatment for cancer |
KR100386140B1 (ko) * | 1996-10-16 | 2003-06-02 | 아이씨엔 파마슈티컬스, 인코포레이티드 | 푸린 l-누클레오시드, 이의 유사체 및 이들의 용도 |
US6509320B1 (en) * | 1996-10-16 | 2003-01-21 | Icn Pharmaceuticals, Inc. | Purine L-nucleosides, analogs and uses thereof |
EP1103559A1 (de) * | 1997-01-17 | 2001-05-30 | ICN Pharmaceuticals, Inc. | Autoimmun-Nukleoside |
US7638496B2 (en) | 2000-02-15 | 2009-12-29 | Valeant Pharmaceuticals North America | Nucleoside analogs with carboxamidine modified monocyclic base |
US6645990B2 (en) * | 2000-08-15 | 2003-11-11 | Amgen Inc. | Thiazolyl urea compounds and methods of uses |
KR100718371B1 (ko) * | 2001-11-27 | 2007-05-14 | 애나디스 파마슈티칼스, 인코포레이티드 | 3-β-D-리보푸라노실티아졸로[4,5-d]피리디민누클레오시드 및 이의 용도 |
US7321033B2 (en) * | 2001-11-27 | 2008-01-22 | Anadys Pharmaceuticals, Inc. | 3-B-D-ribofuranosylthiazolo [4,5-d] pyrimidine nucleosides and uses thereof |
ES2342069T4 (es) | 2003-09-05 | 2011-01-26 | Anadys Pharmaceuticals, Inc. | Ligandos de tlr7 para el tratamiento de la hepatitis c. |
CN1845745B (zh) * | 2003-09-05 | 2011-11-02 | 安那迪斯药品股份有限公司 | Tlr7配体及其前药在制备用于治疗丙型肝炎病毒感染的药物中的用途 |
GB0500020D0 (en) | 2005-01-04 | 2005-02-09 | Novartis Ag | Organic compounds |
US20080070852A1 (en) * | 2004-06-07 | 2008-03-20 | Averett Devron R | 3-Beta-D-Ribofuranosylthiazolo[ 4,5-D] Pyridimine Nucleosides and Uses Thereof |
CN101212968B (zh) * | 2004-12-17 | 2011-11-16 | 安那迪斯药品股份有限公司 | 3,5-二取代的和3,5,7-三取代的-3H-噁唑并以及3H-噻唑并[4,5-d]嘧啶-2-酮化合物及其前药 |
AR052995A1 (es) * | 2004-12-17 | 2007-04-18 | Anadys Pharmaceuticals Inc | Compuestos de 3h-oxazolo y 3h-tiazolo[4, 5 - d]pirimidin-2-ona3, 5-disustituidos y 3, 5, 7-trisustituidos con actividad inmunomoduladora, sus profarmacos, composiciones farmaceuticas que los contienen y su empleo en el tratamiento de enfermedades de origen viral |
AU2006318260B2 (en) * | 2005-11-21 | 2012-05-17 | Anadys Pharmaceuticals, Inc. | Process for the preparation of 5-amino-3H- thiazolo [4 , 5 -d] pyrimidin- 2 -one |
EP2007789B1 (de) | 2006-04-11 | 2015-05-20 | Novartis AG | Spirozyklische HCV/HIV-Hemmer und ihre Verwendung |
KR101461604B1 (ko) * | 2006-06-22 | 2014-11-18 | 애나디스 파마슈티칼스, 인코포레이티드 | 5-아미노-3-(3''-데옥시-β-D-리보퓨라노실)-티아졸로[4,5-d]파이리미딘-2,7-다이온의 프로드럭 |
WO2008011406A2 (en) | 2006-07-18 | 2008-01-24 | Anadys Pharmaceuticals, Inc. | Carbonate and carbamate prodrugs of thiazolo [4,5-d] pyrimidines |
KR100880298B1 (ko) | 2006-12-06 | 2009-01-28 | 애나디스 파마슈티칼스, 인코포레이티드 | 3-β-D-리보푸라노실티아졸로[4,5-d]피리미딘뉴클레오시드 및 이의 용도 |
WO2010077613A1 (en) | 2008-12-09 | 2010-07-08 | Gilead Sciences, Inc. | Modulators of toll-like receptors |
US8512690B2 (en) | 2009-04-10 | 2013-08-20 | Novartis Ag | Derivatised proline containing peptide compounds as protease inhibitors |
US20110182850A1 (en) | 2009-04-10 | 2011-07-28 | Trixi Brandl | Organic compounds and their uses |
PE20130151A1 (es) | 2010-03-31 | 2013-02-21 | Gilead Pharmasset Llc | Sintesis estereoselectiva de activos que contienen fosforo |
EP2624826B1 (de) | 2010-10-08 | 2018-07-18 | Novartis AG | Zusammensetzungen enthaltend vitamin e und sulfamide mit ns3 hemmender wirkung |
WO2012102366A1 (ja) * | 2011-01-28 | 2012-08-02 | 日本たばこ産業株式会社 | 新規ピペラジン化合物の製造方法 |
PT3166607T (pt) | 2014-07-11 | 2022-12-07 | Gilead Sciences Inc | Moduladores de receptores de tipo toll para o tratamento do vih |
KR20190125537A (ko) | 2014-09-16 | 2019-11-06 | 길리애드 사이언시즈, 인코포레이티드 | 톨-유사 수용체 조정제의 고체 형태 |
UA124184C2 (uk) | 2014-12-08 | 2021-08-04 | Ф. Хоффманн-Ля Рош Аг | 3-ЗАМІЩЕНІ 5-АМІНО-6H-ТІАЗОЛО[4,5-d]ПІРИМІДИН-2,7-ДІОНОВІ СПОЛУКИ ДЛЯ ЛІКУВАННЯ І ПРОФІЛАКТИКИ ВІРУСНИХ ІНФЕКЦІЙ |
EP3845227A1 (de) | 2015-03-16 | 2021-07-07 | F. Hoffmann-La Roche AG | Kombinierte behandlung mit einem tlr7-agonisten und einem hbv-capsid-anordnungsinhibitor |
CN107743491B (zh) | 2015-05-08 | 2020-08-21 | 豪夫迈·罗氏有限公司 | 用于治疗和预防病毒感染的新的氧硫杂环戊烷甲酸及其衍生物 |
EP3294746B1 (de) | 2015-05-12 | 2021-10-06 | F. Hoffmann-La Roche AG | Substituierte aminothiazolopyrimidindionderivate zur behandlung und prophylaxe von virusinfektionen |
JP6839104B2 (ja) | 2015-06-30 | 2021-03-03 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | ウイルス感染の治療及び予防のための新規な置換アミノチアゾロピリミジンジオン |
EP3568400A1 (de) | 2017-01-06 | 2019-11-20 | H. Hoffnabb-La Roche Ag | Verfahren zur herstellung von 3-substituiertem 5-amino-6h |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5166141A (en) * | 1983-11-01 | 1992-11-24 | Scripps Clinic And Research Foundation | Immunostimulating 7-deaza-7-oxa- and 7-deaza-7-oxo-analogs of 8-substituted-guanine-9-(1'-beta-D-aldoglycosidyl) derivatives and methods of treating test animals |
US4746651A (en) * | 1983-11-01 | 1988-05-24 | Scripps Clinic And Research Foundation | Antimicrobial chemotherapeutic potentiation using substituted nucleoside derivatives |
-
1988
- 1988-08-25 US US07/236,366 patent/US5041426A/en not_active Expired - Lifetime
- 1988-09-02 CA CA000576416A patent/CA1319931C/en not_active Expired - Lifetime
- 1988-09-02 EP EP88908566A patent/EP0348446B1/de not_active Expired - Lifetime
- 1988-09-02 DE DE3856279T patent/DE3856279T2/de not_active Expired - Lifetime
- 1988-09-02 EP EP94112331A patent/EP0636372B1/de not_active Expired - Lifetime
- 1988-09-02 AT AT94112331T patent/ATE173929T1/de not_active IP Right Cessation
- 1988-09-02 DE DE3854297T patent/DE3854297T2/de not_active Expired - Lifetime
- 1988-09-02 AR AR88311844A patent/AR246104A1/es active
- 1988-09-02 AT AT88908566T patent/ATE126060T1/de not_active IP Right Cessation
- 1988-09-02 WO PCT/US1988/002982 patent/WO1989005649A1/en active IP Right Grant
- 1988-09-02 JP JP63507805A patent/JP2590248B2/ja not_active Expired - Lifetime
- 1988-09-03 ES ES8802722A patent/ES2010786A6/es not_active Expired
-
1989
- 1989-08-18 DK DK406389A patent/DK406389A/da unknown
- 1989-08-21 KR KR89701557A patent/KR970002611B1/ko not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
KR970002611B1 (en) | 1997-03-06 |
DE3856279D1 (de) | 1999-01-14 |
DE3856279T2 (de) | 1999-05-20 |
KR900700106A (ko) | 1990-08-11 |
EP0348446A4 (en) | 1991-09-25 |
WO1989005649A1 (en) | 1989-06-29 |
EP0348446A1 (de) | 1990-01-03 |
DE3854297D1 (de) | 1995-09-14 |
EP0348446B1 (de) | 1995-08-09 |
AR246104A1 (es) | 1994-03-30 |
DK406389D0 (da) | 1989-08-18 |
JPH03504122A (ja) | 1991-09-12 |
EP0636372B1 (de) | 1998-12-02 |
ES2010786A6 (es) | 1989-12-01 |
JP2590248B2 (ja) | 1997-03-12 |
DK406389A (da) | 1989-10-04 |
US5041426A (en) | 1991-08-20 |
ATE126060T1 (de) | 1995-08-15 |
DE3854297T2 (de) | 1996-03-28 |
CA1319931C (en) | 1993-07-06 |
EP0636372A1 (de) | 1995-02-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification | ||
EEIH | Change in the person of patent owner | ||
EELA | Cancelled due to lapse of time |