DE3880561D1 - Actinoninderivate mit physiologischen aktivitaeten. - Google Patents

Actinoninderivate mit physiologischen aktivitaeten.

Info

Publication number
DE3880561D1
DE3880561D1 DE8888401437T DE3880561T DE3880561D1 DE 3880561 D1 DE3880561 D1 DE 3880561D1 DE 8888401437 T DE8888401437 T DE 8888401437T DE 3880561 T DE3880561 T DE 3880561T DE 3880561 D1 DE3880561 D1 DE 3880561D1
Authority
DE
Germany
Prior art keywords
actinone
derivatives
physiological activities
physiological
activities
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8888401437T
Other languages
English (en)
Other versions
DE3880561T2 (de
Inventor
Seiji Shibahara
Yukiko Takahashi
Yuji Matsuhashi
Mitsugu Hachisu
Shinichi Kondo
Tomio Takeuchi
Takaaki Aoyagi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Microbial Chemistry Research Foundation
Meiji Seika Kaisha Ltd
Original Assignee
Microbial Chemistry Research Foundation
Meiji Seika Kaisha Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microbial Chemistry Research Foundation, Meiji Seika Kaisha Ltd filed Critical Microbial Chemistry Research Foundation
Application granted granted Critical
Publication of DE3880561D1 publication Critical patent/DE3880561D1/de
Publication of DE3880561T2 publication Critical patent/DE3880561T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Psychiatry (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
DE88401437T 1987-06-11 1988-06-10 Actinoninderivate mit physiologischen Aktivitäten. Expired - Fee Related DE3880561T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP62144176A JPH0774194B2 (ja) 1987-06-11 1987-06-11 生理活性を有する新規なアクチノニン誘導体

Publications (2)

Publication Number Publication Date
DE3880561D1 true DE3880561D1 (de) 1993-06-03
DE3880561T2 DE3880561T2 (de) 1993-09-30

Family

ID=15355973

Family Applications (1)

Application Number Title Priority Date Filing Date
DE88401437T Expired - Fee Related DE3880561T2 (de) 1987-06-11 1988-06-10 Actinoninderivate mit physiologischen Aktivitäten.

Country Status (4)

Country Link
US (1) US4929633A (de)
EP (1) EP0296040B1 (de)
JP (1) JPH0774194B2 (de)
DE (1) DE3880561T2 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2691442B2 (ja) * 1989-02-20 1997-12-17 株式会社ヤクルト本社 新規なプロリン誘導体
US5049578A (en) * 1990-03-09 1991-09-17 E. R. Squibb & Sons, Inc. 1-aroyl or 1-acyl-2-2pyrrolidinyl-3,5-dihydroxy alkanoic and alkenoic acids, salts, esters and lactones
EP0468469A2 (de) * 1990-07-27 1992-01-29 Japan Tobacco Inc. Prolinderivate
US5506256A (en) * 1990-07-27 1996-04-09 Yoshitomi Pharmaceutical Industries, Ltd. Proline derivatives possessing prolyl endopeptidase-inhibitory activity
JPH05239021A (ja) * 1990-09-04 1993-09-17 Microbial Chem Res Found 新規なアクチノニン誘導体
US5298627A (en) * 1993-03-03 1994-03-29 Warner-Lambert Company Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis
DE10100053A1 (de) * 2001-01-02 2002-08-22 Keyneurotek Ag I G Verwendung von Enzyminhibitoren der Dipeptidylpeptidase IV sowie der Aminopeptidase N und pharmazeutischen Zubereitungen daraus zur Prävention und/oder Therapie Ischämie-bedingter akuter und chronischer neurodegenerativer Prozesse und Erkrankungen
US6660741B2 (en) * 2001-03-19 2003-12-09 Sloan-Kettering Institute For Cancer Research Asymmetric synthesis of (S,S,R)-(-)-actinonin and its analogs and uses therefor

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1028921A (en) * 1962-01-23 1966-05-11 Ranjeet Bhagwan Singh New antibiotic
JPS6115840A (ja) * 1984-07-03 1986-01-23 Microbial Chem Res Found 免疫賦活剤
JPS6137764A (ja) * 1984-07-31 1986-02-22 Suntory Ltd 抗プロリルエンドペプチダ−ゼ活性を有する新規生理活性化合物
JPH0623190B2 (ja) * 1985-04-16 1994-03-30 サントリー株式会社 インヒビタ−活性を有するｎ−アシルピロリジン誘導体及びその製法並びに用途

Also Published As

Publication number Publication date
JPS63310864A (ja) 1988-12-19
US4929633A (en) 1990-05-29
DE3880561T2 (de) 1993-09-30
JPH0774194B2 (ja) 1995-08-09
EP0296040A1 (de) 1988-12-21
EP0296040B1 (de) 1993-04-28

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee