KR970000591B1 - 신균주 스트렙토마이세스 라벤도폴리아 DKRS 및 이를 이용한 아클라시노마이신 A, B, Y 및 아글리콘(Aglycone)의 제조방법 - Google Patents

신균주 스트렙토마이세스 라벤도폴리아 DKRS 및 이를 이용한 아클라시노마이신 A, B, Y 및 아글리콘(Aglycone)의 제조방법 Download PDF

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Publication number
KR970000591B1
KR970000591B1 KR1019930017589A KR930017589A KR970000591B1 KR 970000591 B1 KR970000591 B1 KR 970000591B1 KR 1019930017589 A KR1019930017589 A KR 1019930017589A KR 930017589 A KR930017589 A KR 930017589A KR 970000591 B1 KR970000591 B1 KR 970000591B1
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KR
South Korea
Prior art keywords
medium
aclacinomycin
dkrs
culture
kctc
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
KR1019930017589A
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English (en)
Korean (ko)
Other versions
KR950008679A (ko
Inventor
조원태
김완섭
김명국
박진규
김학열
이상기
돔라체바
파니치키나
사브로바
노비코바
발토체비치
Original Assignee
동국제약 주식회사
강재헌
권기범
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by 동국제약 주식회사, 강재헌, 권기범 filed Critical 동국제약 주식회사
Priority to KR1019930017589A priority Critical patent/KR970000591B1/ko
Priority to GB9400513A priority patent/GB2281563B/en
Priority to JP6002565A priority patent/JP2718002B2/ja
Priority to ITMI940035A priority patent/IT1273049B/it
Priority to ES09400079A priority patent/ES2078875B1/es
Priority to FR9400527A priority patent/FR2709497B1/fr
Priority to CA002113871A priority patent/CA2113871C/en
Priority to NL9400096A priority patent/NL9400096A/nl
Priority to DE4401546A priority patent/DE4401546C2/de
Priority to TW083100481A priority patent/TW258754B/zh
Priority to CH00304/94A priority patent/CH688151A5/fr
Priority to US08/192,165 priority patent/US5468637A/en
Priority to CN94105525A priority patent/CN1104682A/zh
Priority to CN 94105525 priority patent/CN1108694A/zh
Priority to US08/369,375 priority patent/US5484712A/en
Publication of KR950008679A publication Critical patent/KR950008679A/ko
Application granted granted Critical
Publication of KR970000591B1 publication Critical patent/KR970000591B1/ko
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P15/00—Preparation of compounds containing at least three condensed carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/56—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical directly bound to a condensed ring system having three or more carbocyclic rings, e.g. daunomycin, adriamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces
    • C12R2001/56—Streptomyces lavendulae
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/886—Streptomyces

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
KR1019930017589A 1993-09-03 1993-09-03 신균주 스트렙토마이세스 라벤도폴리아 DKRS 및 이를 이용한 아클라시노마이신 A, B, Y 및 아글리콘(Aglycone)의 제조방법 Expired - Fee Related KR970000591B1 (ko)

Priority Applications (15)

Application Number Priority Date Filing Date Title
KR1019930017589A KR970000591B1 (ko) 1993-09-03 1993-09-03 신균주 스트렙토마이세스 라벤도폴리아 DKRS 및 이를 이용한 아클라시노마이신 A, B, Y 및 아글리콘(Aglycone)의 제조방법
GB9400513A GB2281563B (en) 1993-09-03 1994-01-12 A strain of streptomyces lavendofoliae dkrs & a method for producing aclacinomycins a,b,y & aglycone by using the same
JP6002565A JP2718002B2 (ja) 1993-09-03 1994-01-14 新菌株ストレプトマイセス・ラベンドフォリアｄｋｒｓならびにこれを用いたアクラシノマイシンａ，ｂ，ｙおよびアグリコンの製造方法
ITMI940035A IT1273049B (it) 1993-09-03 1994-01-14 Ceppo di streptomyces lavendofoliae dkrs e metodo per la sua utilizzazione nella produzione delle aclacinomicine a,b,y e dell'aglicone
ES09400079A ES2078875B1 (es) 1993-09-03 1994-01-17 Procedimiento para la produccion de aclacinomicinas a,b, y, y sus agluconas mediante el cultivo de la cepa streptomyces lavendofoliae dkrs.
FR9400527A FR2709497B1 (fr) 1993-09-03 1994-01-19 Souche de Streptomyces lavendofoliae DKRS et procédé de production des aclacinomycines A, B, Y et d'aglycone en utilisant ceux-ci.
DE4401546A DE4401546C2 (de) 1993-09-03 1994-01-20 Streptomyces lavendofoliae DRKS Stamm, Verfahren zur Gewinnung der Aclacinomycine A, B, Y und von Aglycon durch Anwendung dieses Verfahrens
NL9400096A NL9400096A (nl) 1993-09-03 1994-01-20 Nieuwe Streptomyces-stam en werkwijze voor het bereiden van antitumormiddelen daarmee.
CA002113871A CA2113871C (en) 1993-09-03 1994-01-20 A strain of streptomyces lavendofoliae dkrs and a method for producing aclacinomycins a,b,y and aglycones using the same
TW083100481A TW258754B (enExample) 1993-09-03 1994-01-20
CH00304/94A CH688151A5 (fr) 1993-09-03 1994-02-02 Souche de streptomyces lavendofoliae DKRS et procédé de production des aclacinomycines A, B, Y et d'aglycone en utilisant ceux-ci.
US08/192,165 US5468637A (en) 1993-09-03 1994-02-04 S. lavendofoliae DKRS cell culture producing anti-tumor aclacinomycins A, B, Y and aglycones
CN94105525A CN1104682A (zh) 1993-09-03 1994-05-17 一种淡紫灰叶链霉菌dkrs菌株及用它制备阿克拉希霉素a，b，y和糖苷配基的方法
CN 94105525 CN1108694A (zh) 1993-09-03 1994-05-17 一种淡紫灰叶链霉菌dkrs菌株及用它制备阿克拉希霉素a，b，y和糖苷配基的方法
US08/369,375 US5484712A (en) 1993-09-03 1995-01-06 Method for producing aclacinomycins A, B, Y using Strepomyces lavendofoliae DKRS

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019930017589A KR970000591B1 (ko) 1993-09-03 1993-09-03 신균주 스트렙토마이세스 라벤도폴리아 DKRS 및 이를 이용한 아클라시노마이신 A, B, Y 및 아글리콘(Aglycone)의 제조방법

Publications (2)

Publication Number Publication Date
KR950008679A KR950008679A (ko) 1995-04-19
KR970000591B1 true KR970000591B1 (ko) 1997-01-14

Family

ID=19362801

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019930017589A Expired - Fee Related KR970000591B1 (ko) 1993-09-03 1993-09-03 신균주 스트렙토마이세스 라벤도폴리아 DKRS 및 이를 이용한 아클라시노마이신 A, B, Y 및 아글리콘(Aglycone)의 제조방법

Country Status (13)

Country Link
US (2) US5468637A (enExample)
JP (1) JP2718002B2 (enExample)
KR (1) KR970000591B1 (enExample)
CN (2) CN1104682A (enExample)
CA (1) CA2113871C (enExample)
CH (1) CH688151A5 (enExample)
DE (1) DE4401546C2 (enExample)
ES (1) ES2078875B1 (enExample)
FR (1) FR2709497B1 (enExample)
GB (1) GB2281563B (enExample)
IT (1) IT1273049B (enExample)
NL (1) NL9400096A (enExample)
TW (1) TW258754B (enExample)

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5134915B2 (enExample) * 1974-07-27 1976-09-29
US4071411A (en) * 1974-07-27 1978-01-31 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai Antitumor antibiotics aclacinomycins A and B [RD-9187A]
US4204038A (en) * 1976-04-07 1980-05-20 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai Process for preparing antibiotics MA 144-M1 and MA 144-M2
NL176004C (nl) * 1976-10-05 1985-02-01 Microbial Chem Res Found Werkwijze ter bereiding van geneesmiddelen met antitumorwerking op basis van anthracycline glycosiden en werkwijze ter bereiding van daartoe dienende anthracycline glycosiden.
US4209588A (en) * 1976-10-05 1980-06-24 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai Process for producing new antitumor anthracycline antibiotics
JPS5648893A (en) * 1979-09-07 1981-05-02 Sanraku Inc Preparation of anthracycline glycoside
DE3168154D1 (en) * 1980-10-27 1985-02-21 Hoffmann La Roche Process for anthracycline glycosides
ATE8264T1 (de) * 1980-10-27 1984-07-15 F. Hoffmann-La Roche & Co. Aktiengesellschaft Verfahren zur herstellung von aclacinomycinen und verwendete mikroorganismen.
US4405713A (en) * 1981-12-28 1983-09-20 Hoffmann-La Roche Inc. Process for the preparation of optically active anthracycline glycosides A and B
US4471052A (en) * 1982-01-18 1984-09-11 Adria Laboratories, Inc. Biosynthesis of simplified anthracyclines
SU1069433A1 (ru) * 1982-06-29 1984-11-23 Всесоюзный научно-исследовательский институт антибиотиков Штамм @ @ 12/3а-продуцент аклациномицинов @ и @

Also Published As

Publication number Publication date
JPH0775575A (ja) 1995-03-20
CA2113871C (en) 2000-01-18
NL9400096A (nl) 1995-04-03
GB2281563A (en) 1995-03-08
JP2718002B2 (ja) 1998-02-25
ITMI940035A0 (it) 1994-01-14
FR2709497B1 (fr) 1996-11-15
IT1273049B (it) 1997-07-01
ES2078875A1 (es) 1995-12-16
US5468637A (en) 1995-11-21
CA2113871A1 (en) 1995-03-04
US5484712A (en) 1996-01-16
CN1104682A (zh) 1995-07-05
ITMI940035A1 (it) 1995-07-14
ES2078875B1 (es) 1996-08-16
CN1108694A (zh) 1995-07-05
GB9400513D0 (en) 1994-03-09
GB2281563B (en) 1998-01-28
KR950008679A (ko) 1995-04-19
DE4401546A1 (de) 1995-03-30
FR2709497A1 (fr) 1995-03-10
CH688151A5 (fr) 1997-05-30
TW258754B (enExample) 1995-10-01
DE4401546C2 (de) 1997-09-25

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