KR960013446B1 - 17위치에서 3,4 또는 6개의 결합을 갖는 스피로 고리를 함유한 신규 스테로이드, 그의 제조 방법 및 제조용 중간체, 의약품으로서 그의 용도 및 이것을 함유하는 제약 조성물 - Google Patents

17위치에서 3,4 또는 6개의 결합을 갖는 스피로 고리를 함유한 신규 스테로이드, 그의 제조 방법 및 제조용 중간체, 의약품으로서 그의 용도 및 이것을 함유하는 제약 조성물 Download PDF

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Publication number
KR960013446B1
KR960013446B1 KR1019880012057A KR880012057A KR960013446B1 KR 960013446 B1 KR960013446 B1 KR 960013446B1 KR 1019880012057 A KR1019880012057 A KR 1019880012057A KR 880012057 A KR880012057 A KR 880012057A KR 960013446 B1 KR960013446 B1 KR 960013446B1
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South Korea
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compound
group
formula
general formula
salt
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Expired - Fee Related
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KR1019880012057A
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English (en)
Korean (ko)
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KR890005143A (ko
Inventor
네델렉 뤼시앙
끌로스네 앙드레
필리베르 다니엘
모귈레스키 마르띤느
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루셀-위클라프
위베르 프리뗄
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Application granted granted Critical
Publication of KR960013446B1 publication Critical patent/KR960013446B1/ko
Anticipated expiration legal-status Critical
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
    • C07J41/0083—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/005—Ketals
    • C07J21/006—Ketals at position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Glass Compositions (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
KR1019880012057A 1987-09-18 1988-09-16 17위치에서 3,4 또는 6개의 결합을 갖는 스피로 고리를 함유한 신규 스테로이드, 그의 제조 방법 및 제조용 중간체, 의약품으로서 그의 용도 및 이것을 함유하는 제약 조성물 Expired - Fee Related KR960013446B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8712937 1987-09-18
FR8712937A FR2620707B1 (fr) 1987-09-18 1987-09-18 Nouveaux steroides comportant un cycle spirannique a 3, 4 ou 6 chainons en position 17, leur procede et des intermediaires de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant

Publications (2)

Publication Number Publication Date
KR890005143A KR890005143A (ko) 1989-05-13
KR960013446B1 true KR960013446B1 (ko) 1996-10-05

Family

ID=9355024

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019880012057A Expired - Fee Related KR960013446B1 (ko) 1987-09-18 1988-09-16 17위치에서 3,4 또는 6개의 결합을 갖는 스피로 고리를 함유한 신규 스테로이드, 그의 제조 방법 및 제조용 중간체, 의약품으로서 그의 용도 및 이것을 함유하는 제약 조성물

Country Status (18)

Country Link
US (1) US4921846A (https=)
EP (1) EP0308345B1 (https=)
JP (1) JP2794297B2 (https=)
KR (1) KR960013446B1 (https=)
CN (1) CN1031942C (https=)
AT (1) ATE88716T1 (https=)
CA (1) CA1340344C (https=)
DE (1) DE3880601T2 (https=)
DK (1) DK174268B1 (https=)
ES (1) ES2054844T3 (https=)
FR (1) FR2620707B1 (https=)
GR (1) GR3008221T3 (https=)
HU (1) HU199505B (https=)
IE (1) IE61751B1 (https=)
MX (1) MX174142B (https=)
PT (1) PT88536B (https=)
SU (1) SU1665877A3 (https=)
ZA (1) ZA886820B (https=)

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FR2665901B2 (fr) * 1989-02-24 1994-07-29 Roussel Uclaf Nouveaux 19-nor sterouides ayant en position 11beta une chaine carbonee comportant une fonction amide, leur preparation, leur application comme medicaments.
DE3921059A1 (de) * 1989-06-23 1991-01-10 Schering Ag 11(beta)-aryl-4-estrene, verfahren zu ihrer herstellung sowie deren verwendung als arzneimittel
ATE172469T1 (de) * 1989-08-04 1998-11-15 Schering Ag 11 beta-aryl-gona-4,9-dien-3-one
FR2651233B1 (fr) * 1989-08-23 1991-12-13 Roussel Uclaf Nouveaux acides omega-phenylamino alcanouiques substitues sur le noyau aromatique par un radical derive de 19-norsterouides, leur procede de preparation, leur application a titre de medicaments et les compositions les renfermant.
DE4008584A1 (de) * 1990-03-15 1991-09-26 Schering Ag Verfahren zur herstellung von zwischenprodukten fuer die antigestagensynthese (onapristonsynthese)
ES2112268T3 (es) * 1990-08-14 1998-04-01 Hoechst Marion Roussel Inc Nuevos 19-nor-esteroides que tienen en posicion 11beta una cadena carbonada que comprende una funcion amida, su preparacion, su aplicacion como medicamentos y composiciones farmaceuticas que los contienen.
US5407928A (en) * 1990-08-15 1995-04-18 Schering Aktiengesellschaft 11β-aryl-gona-4,9-dien-3-ones
CA2100514C (en) * 1992-07-29 2005-03-29 Johannes A. M. Hamersma 17-spiromethylene steroids
FR2757399B1 (fr) * 1996-12-23 1999-12-17 Hoechst Marion Roussel Inc Application de composes steroides substitues en 11 pour la fabrication de medicaments ayant une activite estrogene dissociee
US6020328A (en) * 1998-03-06 2000-02-01 Research Triangle Institute 20-keto-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties
AU4093799A (en) 1998-05-22 1999-12-13 Board Of Trustees Of The Leland Stanford Junior University Bifunctional molecules and therapies based thereon
CA2789262C (en) 2005-04-28 2016-10-04 Proteus Digital Health, Inc. Pharma-informatics system
EP1945240B1 (en) 2005-09-16 2016-12-28 Raptor Pharmaceutical Inc Compositions comprising receptor-associated protein (rap) variants specific for cr-containing proteins and uses thereof
EP1862468A1 (de) * 2006-06-02 2007-12-05 Bayer Schering Pharma Aktiengesellschaft Kristallines 11beta-(4-Acetylphenyl)-20,20,21,21,21-pentafluor-17-hydroxy-19-nor-17alpha-pregna-4,9-dien-3-on
TR201908314T4 (tr) 2009-02-20 2019-06-21 2 Bbb Medicines B V Glutatyon bazlı ilaç dağıtım sistemi.
KR101909711B1 (ko) 2009-05-06 2018-12-19 라보라토리 스킨 케어, 인크. 활성제-칼슘 포스페이트 입자 복합체를 포함하는 피부 전달 조성물 및 이들을 이용하는 방법
DE102009034367A1 (de) 2009-07-20 2011-01-27 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-benzyliden-Derivate, Verfahren zu deren Herstellung und deren Verwendung zur Behandlung von Krankheiten
DE102009034366A1 (de) 2009-07-20 2011-01-27 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-methylenoxyalkylenaryl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten
DE102009034368A1 (de) 2009-07-20 2011-01-27 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-acyloxyalkylenphenyl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten
DE102009034362A1 (de) 2009-07-20 2011-01-27 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-aryl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten
DE102009034525A1 (de) 2009-07-21 2011-01-27 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-aryl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten
DE102009034526A1 (de) 2009-07-21 2011-02-10 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-ethinylphenyl-Derivate, Verfahren zu deren Herstellung und deren Verwendung zur Behandlung von Krankheiten
DE102010007722A1 (de) 2010-02-10 2011-08-11 Bayer Schering Pharma Aktiengesellschaft, 13353 Progesteronrezeptorantagonisten
DE102010007719A1 (de) 2010-02-10 2011-08-11 Bayer Schering Pharma Aktiengesellschaft, 13353 Progesteronrezeptorantagonisten
WO2023000135A1 (en) * 2021-07-19 2023-01-26 Context Biopharma Inc. Processes of making onapristone and intermediates thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3364207A (en) * 1962-08-13 1968-01-16 Searle & Co Polyhydrospiro[estr/androst-4-ene-17, 2'-furan/pyran]-3-one and intermediates
US3422096A (en) * 1967-08-08 1969-01-14 Searle & Co Spiro(estrene/androstene-17,2'-oxetane)-3-one and intermediates
FR2377418A1 (fr) * 1977-01-13 1978-08-11 Roussel Uclaf Nouveaux derives steroides 4,9-dieniques 11b-substitues, leur procede de preparation et leur application comme medicaments
DE3026783C2 (de) * 1980-07-11 1982-07-29 Schering Ag, 1000 Berlin Und 4619 Bergkamen Verfahren zur Herstellung von 5β-Hydroxy-δ↑6↑-steroiden
FR2528434B1 (fr) * 1982-06-11 1985-07-19 Roussel Uclaf Nouveaux 19-nor steroides substitues en 11b et eventuellement en 2, leur procede de preparation et leur application comme medicament
FR2522328B1 (fr) * 1982-03-01 1986-02-14 Roussel Uclaf Nouveaux produits derives de la structure 3-ceto 4,9 19-nor steroides, leur procede de preparation et leur application comme medicaments
EP0116974B1 (de) * 1983-02-18 1986-10-29 Schering Aktiengesellschaft 11-Beta-Aryl-Estradiene, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Präparate
DE3347126A1 (de) * 1983-12-22 1985-07-11 Schering AG, 1000 Berlin und 4709 Bergkamen 11ss-aryl-estradiene, deren herstellung und diese enthaltende pharmazeutische praeparate
DE3410880A1 (de) * 1984-03-21 1985-10-03 Schering AG, Berlin und Bergkamen, 1000 Berlin 17-substituierte estradiene und estratriene
FR2596395B1 (fr) * 1986-03-26 1989-05-26 Roussel Uclaf Nouveaux steroides comportant un cycle spirannique en position 17, leur procede de preparation, leur application comme medicaments et les compositions les renfermant

Also Published As

Publication number Publication date
FR2620707B1 (fr) 1989-12-08
HU199505B (en) 1990-02-28
HUT48275A (en) 1989-05-29
PT88536A (pt) 1988-10-01
ZA886820B (en) 1989-11-29
EP0308345A1 (fr) 1989-03-22
IE61751B1 (en) 1994-11-30
DK509088D0 (da) 1988-09-13
US4921846A (en) 1990-05-01
JP2794297B2 (ja) 1998-09-03
CN1031942C (zh) 1996-06-05
KR890005143A (ko) 1989-05-13
EP0308345B1 (fr) 1993-04-28
MX13052A (es) 1993-09-01
SU1665877A3 (ru) 1991-07-23
GR3008221T3 (https=) 1993-09-30
DE3880601D1 (de) 1993-06-03
DK174268B1 (da) 2002-10-28
IE882813L (en) 1989-03-18
DK509088A (da) 1989-05-23
MX174142B (es) 1994-04-25
PT88536B (pt) 1992-11-30
CN1034207A (zh) 1989-07-26
ATE88716T1 (de) 1993-05-15
JPH01106899A (ja) 1989-04-24
FR2620707A1 (fr) 1989-03-24
ES2054844T3 (es) 1994-08-16
CA1340344C (fr) 1999-01-26
DE3880601T2 (de) 1993-10-07

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