KR950032257A - 종양 간전이 억제제 - Google Patents

종양 간전이 억제제 Download PDF

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Publication number
KR950032257A
KR950032257A KR1019950006897A KR19950006897A KR950032257A KR 950032257 A KR950032257 A KR 950032257A KR 1019950006897 A KR1019950006897 A KR 1019950006897A KR 19950006897 A KR19950006897 A KR 19950006897A KR 950032257 A KR950032257 A KR 950032257A
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KR
South Korea
Prior art keywords
metastasis inhibitor
tumor
structural formula
group
liver
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KR1019950006897A
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English (en)
Inventor
데쓰야 도오게
도시히로 히라이
아끼히로 요시모도
겐이찌 요시다
Original Assignee
요시다 쇼오지
센쥬 세이야꾸 가부시기가이샤
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Application filed by 요시다 쇼오지, 센쥬 세이야꾸 가부시기가이샤 filed Critical 요시다 쇼오지
Publication of KR950032257A publication Critical patent/KR950032257A/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/665—Phosphorus compounds having oxygen as a ring hetero atom, e.g. fosfomycin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

(구성) 아래의 구조식으로 나타내어지는 인산 디에스테르 화합물 또는 그 약리학적으로 허용되는 염을 함유해서 되는 종양 간전이 억제제.
위의 구조식에서 R1및 R2는 동일하거나 상이하며 수소 원자 또는 메틸기를 나타낸다.
(효과) 본 발명의 제제는 과산화 지질의 간중에서의 농도 상승 및 간표면의 종양 결절수를 효과적으로 억제하므로 종양 간전이 억제제로서 기대할 수 있다.

Description

종양 간전이 억제제
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 개흥개복군 (LT군), 개복군(L군), 및 대조군(G군)에 있어서의 간표면 종양 결절수를 나타내는 그래프로서 종축은 간표면 종양 결절수(단위:개)를 나타낸다. 제2도는 개흉개복군(LT)군, 개복군(L군) 및 대조군(G군)에 있어서의 간중의 과산화 지질(LPO)의 변동량을 나타내는 그래프로서 종축은 간중의 과산화 지질의 양(단위:nmol/g)을 나타낸다. 제3도는 본 화합물 비투여군(C군)과 화합물 투여군(EPC-K투여군)에 있어서의 수술 침습(개흉개복)에 의한 24시간후의 간중의 과산화 지질(LPO)을 나타내는 그래프로서 종축은 간중의 과산화 지질의 양(단위:nmol/g)을 나타낸다. 제4도는 본 화합물 비투여군(C군)과 본 화합물 투여군(EPC-K투여군)에 있어서의 3주후의 간표면의 종양 결정수를 나타내는 그래프로서 종축은 간표면의 종양 결절수(단위:개)를 나타낸다.

Claims (1)

  1. 아래의 구조식으로 나타내어지는 인산 디에스테르 화합물 또는 그 약리학적으로 허용되는 염을 함유해서 되는 종양 간전이 억제제.
    위의 구조식에서 R1및 R2는 동일하거나 상이하며 수소 원자 또는 메틸기를 나타낸다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019950006897A 1994-03-29 1995-03-29 종양 간전이 억제제 KR950032257A (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP5867194 1994-03-29
JP94-58671 1994-03-29
JP94-240167 1994-10-04
JP24016794 1994-10-04

Publications (1)

Publication Number Publication Date
KR950032257A true KR950032257A (ko) 1995-12-20

Family

ID=26399697

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019950006897A KR950032257A (ko) 1994-03-29 1995-03-29 종양 간전이 억제제

Country Status (7)

Country Link
US (1) US5552389A (ko)
EP (1) EP0674904B1 (ko)
KR (1) KR950032257A (ko)
AT (1) ATE183394T1 (ko)
CA (1) CA2145229A1 (ko)
DE (1) DE69511448T2 (ko)
ES (1) ES2134409T3 (ko)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPR549901A0 (en) 2001-06-06 2001-07-12 Vital Health Sciences Pty Ltd Topical formulation containing tocopheryl phosphates
AU2002303210A1 (en) 2001-04-06 2002-10-21 Cytorex Biosciences, Inc. Pharmacologically active strong acid solutions
AU2002317053B2 (en) 2001-07-27 2004-08-05 Vital Health Sciences Pty Ltd Dermal therapy using phosphate derivatives of electron transfer agents
AU2002950713A0 (en) 2002-08-09 2002-09-12 Vital Health Sciences Pty Ltd Carrier
EP1720551B9 (en) 2004-03-03 2011-09-21 Vital Health Sciences Pty Ltd. Alkaloid formulations
KR20070108383A (ko) * 2005-03-03 2007-11-09 바이탈 헬스 사이언시즈 피티와이 리미티드 지질 저하성 화합물
AU2006220247B2 (en) * 2005-03-03 2011-08-25 Vital Health Sciences Pty Ltd Compounds having anti-cancer properties
WO2006092024A1 (en) * 2005-03-03 2006-09-08 Vital Health Sciences Pty Ltd Compounds having anti-cancer properties
EP1893159B1 (en) 2005-06-17 2015-09-30 Vital Health Sciences Pty Ltd. A carrier comprising one or more di- and/or monophosphate derivatives of electron transfer agents
EP2531047A4 (en) 2010-02-05 2014-03-19 Phosphagenics Ltd CARRIER WITH AN UNINUTRALIZED TOCOPHERYL PHOSPHATE
ES2829386T3 (es) 2010-03-30 2021-05-31 Phosphagenics Ltd Parche de administración transdérmica
WO2012122586A1 (en) 2011-03-15 2012-09-20 Phosphagenics Limited New composition
CN108601732A (zh) 2015-12-09 2018-09-28 磷肌酸有限公司 药物制剂
MX2019006845A (es) 2016-12-21 2019-10-15 Avecho Biotechnology Ltd Proceso.

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62145019A (ja) * 1985-12-19 1987-06-29 Senjiyu Seiyaku Kk 抗炎症剤
JPH02229169A (ja) * 1989-03-01 1990-09-11 Takeda Chem Ind Ltd ピラゾロン誘導体
JPH02229168A (ja) * 1989-03-01 1990-09-11 Takeda Chem Ind Ltd ピラゾロン誘導体

Also Published As

Publication number Publication date
ES2134409T3 (es) 1999-10-01
DE69511448D1 (de) 1999-09-23
US5552389A (en) 1996-09-03
CA2145229A1 (en) 1995-09-30
DE69511448T2 (de) 2000-04-27
ATE183394T1 (de) 1999-09-15
EP0674904A1 (en) 1995-10-04
EP0674904B1 (en) 1999-08-18

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