HUP0302479A2 - NF-kappa B gátló gyógyszerkészítmény, amely hatóanyagként helyettesített benzoesavszármazékot tartalmaz - Google Patents
NF-kappa B gátló gyógyszerkészítmény, amely hatóanyagként helyettesített benzoesavszármazékot tartalmazInfo
- Publication number
- HUP0302479A2 HUP0302479A2 HU0302479A HUP0302479A HUP0302479A2 HU P0302479 A2 HUP0302479 A2 HU P0302479A2 HU 0302479 A HU0302479 A HU 0302479A HU P0302479 A HUP0302479 A HU P0302479A HU P0302479 A2 HUP0302479 A2 HU P0302479A2
- Authority
- HU
- Hungary
- Prior art keywords
- group
- substituted
- active ingredient
- benzoic acid
- acid derivative
- Prior art date
Links
- 239000004480 active ingredient Substances 0.000 title abstract 2
- 150000001558 benzoic acid derivatives Chemical class 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
- 125000002252 acyl group Chemical group 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 102000003945 NF-kappa B Human genes 0.000 abstract 1
- 108010057466 NF-kappa B Proteins 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000004446 heteroarylalkyl group Chemical group 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
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- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
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- C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
- C07C65/24—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups polycyclic
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- C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/58—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/64—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
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- C07C235/84—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
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- C07C255/42—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being further bound to other hetero atoms
- C07C255/44—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being further bound to other hetero atoms at least one of the singly-bound nitrogen atoms being acylated
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- C07C65/40—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups containing singly bound oxygen-containing groups
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- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
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- General Chemical & Material Sciences (AREA)
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Abstract
A találmány (I) általános képletű új, helyettesített benzoesav-származékra - a képletben R1 jelentése (II) általános képletű vagy(III) általános képletű csoport (amelyekben R3, R4 és R5 jelentéseegymástól függetlenül hidrogénatom, 1-6 szénatomos alkilcsoport vagy1-6 szénatomos alkoxicsoport, és R9 és R10 jelentése egymástólfüggetlenül hidrogénatom, 1-6 szénatomos alkilcsoport vagy 2-11szénatomos acilcsoport); R2 jelentése hidrogénatom, 1-6 szénatomosalkilcsoport, amely helyettesített lehet, 6-12 szénatomos arilcsoport,amely helyettesített lehet, 4-11 szénatomos heteroaril-csoport, amelyhelyettesített lehet, 7-14 szénatomos aralkilcsoport, amelyhelyettesített lehet, 5-13 szénatomos heteroarilalkil-csoport, amelyhelyettesített lehet, vagy 2-11 szénatomos acilcsoport; és X jelentésekarboxilcsoport, amely észterezett vagy amidált lehet, és a vegyületethatóanyagként tartalmazó NF-kB gátló készítményekre vonatkozik. Ó
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2001091003 | 2001-03-27 | ||
PCT/JP2002/003017 WO2002076918A1 (en) | 2001-03-27 | 2002-03-27 | NF-λB INHIBITOR CONTAINING SUBSTITUTED BENZOIC ACID DERIVATIVE AS ACTIVE INGREDIENT |
Publications (1)
Publication Number | Publication Date |
---|---|
HUP0302479A2 true HUP0302479A2 (hu) | 2003-11-28 |
Family
ID=18945705
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0302479A HUP0302479A2 (hu) | 2001-03-27 | 2002-03-27 | NF-kappa B gátló gyógyszerkészítmény, amely hatóanyagként helyettesített benzoesavszármazékot tartalmaz |
Country Status (9)
Country | Link |
---|---|
US (1) | US7064124B2 (hu) |
EP (1) | EP1314712A4 (hu) |
JP (1) | JPWO2002076918A1 (hu) |
KR (1) | KR20030005417A (hu) |
CN (1) | CN1460097A (hu) |
BR (1) | BR0204678A (hu) |
CA (1) | CA2410816A1 (hu) |
HU (1) | HUP0302479A2 (hu) |
WO (1) | WO2002076918A1 (hu) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002049632A1 (fr) | 2000-12-18 | 2002-06-27 | Institute Of Medicinal Molecular Design. Inc. | Inhibiteurs de production et de liberation de cytokines inflammatoires |
HUP0303760A2 (hu) | 2001-09-17 | 2004-03-01 | Daiichi Suntory Biomedical Research Co., Ltd. | AZ NF-kB faktort gátló szubsztituált benzoesavszármazékok és ezeket tartalmazó gyógyszerkészítmények |
EP1510207A4 (en) * | 2002-06-05 | 2008-12-31 | Inst Med Molecular Design Inc | THERAPEUTIC MEDICAMENT AGAINST DIABETES |
EP1512396A4 (en) * | 2002-06-05 | 2008-12-31 | Inst Med Molecular Design Inc | INHIBITORS OF AP-1 AND NFAT ACTIVATION |
EP1510210A4 (en) * | 2002-06-05 | 2009-01-07 | Inst Med Molecular Design Inc | IMMUNITY-CONTAINING PROTEIN KINASE HEMMER |
JP4660674B2 (ja) * | 2002-06-06 | 2011-03-30 | 株式会社医薬分子設計研究所 | 抗アレルギー薬 |
EA009051B1 (ru) * | 2002-06-06 | 2007-10-26 | Инститьют Оф Медисинал Молекьюлар Дизайн. Инк. | О-замещенные гидроксиарильные производные |
TW200307535A (en) * | 2002-06-10 | 2003-12-16 | Inst Med Molecular Design Inc | Therapeutic agent for cancer |
AU2003242098B2 (en) * | 2002-06-10 | 2008-11-20 | Institute Of Medicinal Molecular Design, Inc | Inhibitors against activation of NFkappaB |
AU2003242124A1 (en) * | 2002-06-11 | 2003-12-22 | Institute Of Medicinal Molecular Design, Inc. | Medicament for treatment of neurodegenerative diseases |
NZ537858A (en) * | 2002-07-15 | 2008-04-30 | Myriad Genetics Inc | Compounds, compositions, and methods employing same |
CN100417847C (zh) * | 2002-11-12 | 2008-09-10 | Nok株式会社 | 橡胶状弹性部件 |
JPWO2005007151A1 (ja) * | 2003-07-16 | 2006-08-31 | 株式会社医薬分子設計研究所 | 皮膚色素沈着の治療剤 |
AU2005277223C1 (en) * | 2004-08-20 | 2009-05-21 | The Regents Of The University Of Michigan | Small molecule inhibitors of anti-apoptotic Bcl-2 family members and the uses thereof |
US20080139457A1 (en) * | 2005-09-16 | 2008-06-12 | Virginia Commonwealth University | Therapeutic compositions comprising chorionic gonadotropins and HMG CoA reductase inhibitors |
JP2007182397A (ja) * | 2006-01-05 | 2007-07-19 | Keio Gijuku | NF−κB阻害剤 |
US7671058B2 (en) * | 2006-06-21 | 2010-03-02 | Institute Of Medicinal Molecular Design, Inc. | N-(3,4-disubstituted phenyl) salicylamide derivatives |
AR077033A1 (es) | 2009-06-11 | 2011-07-27 | Hoffmann La Roche | Compuestos inhibidores de las quinasas de janus y su uso en el tratamiento de enfermedades inmunologicas |
FR2954316B1 (fr) * | 2009-12-23 | 2014-01-03 | Galderma Res & Dev | Nouveaux derives phenoliques, et leur utilisation pharmaceutique ou cosmetique |
KR101434461B1 (ko) | 2011-10-21 | 2014-09-01 | 한국생명공학연구원 | 2-하이드록시아릴아마이드 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는 암 예방 또는 치료용 약학적 조성물 |
WO2013058613A2 (ko) * | 2011-10-21 | 2013-04-25 | 한국생명공학연구원 | 2-하이드록시아릴아마이드 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는 암 예방 또는 치료용 약학적 조성물 |
EP3362436B1 (en) * | 2015-09-14 | 2021-06-30 | Universiteit Antwerpen | Process for the catalytic directed cleavage of amide-containing compounds |
EP3428150B1 (en) * | 2016-03-11 | 2023-07-12 | Takeda Pharmaceutical Company Limited | Aromatic ring compound having a cholinergic muscarine m1 receptor positive allosteric modulator activity |
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JP2506337B2 (ja) * | 1986-06-06 | 1996-06-12 | サントリー株式会社 | フエニルメチルベンゾキノン誘導体 |
JP3016625B2 (ja) * | 1990-06-01 | 2000-03-06 | サントリー株式会社 | フェノキシ酢酸誘導体及びそれを含む虚血による器質性又は機能性障害治療剤 |
JPH07291859A (ja) * | 1994-04-28 | 1995-11-07 | Eisai Co Ltd | 転写因子活性阻害剤 |
ATE317691T1 (de) | 1998-03-20 | 2006-03-15 | Daiichi Asubio Pharma Co Ltd | Benzochinonderivate enthaltende hemmer von nf-kb |
JPH11266872A (ja) * | 1998-03-20 | 1999-10-05 | Suntory Ltd | NF−κBの活性化を抑制する物質のスクリーニング方法 |
-
2002
- 2002-03-27 HU HU0302479A patent/HUP0302479A2/hu unknown
- 2002-03-27 CN CN02800894A patent/CN1460097A/zh active Pending
- 2002-03-27 KR KR1020027016125A patent/KR20030005417A/ko not_active Application Discontinuation
- 2002-03-27 JP JP2002576181A patent/JPWO2002076918A1/ja not_active Withdrawn
- 2002-03-27 WO PCT/JP2002/003017 patent/WO2002076918A1/ja not_active Application Discontinuation
- 2002-03-27 CA CA002410816A patent/CA2410816A1/en not_active Abandoned
- 2002-03-27 EP EP02708696A patent/EP1314712A4/en not_active Withdrawn
- 2002-03-27 BR BR0204678-4A patent/BR0204678A/pt not_active IP Right Cessation
- 2002-03-27 US US10/296,810 patent/US7064124B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
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KR20030005417A (ko) | 2003-01-17 |
CA2410816A1 (en) | 2002-10-03 |
US7064124B2 (en) | 2006-06-20 |
BR0204678A (pt) | 2003-04-29 |
WO2002076918A8 (en) | 2002-10-31 |
CN1460097A (zh) | 2003-12-03 |
US20040122244A1 (en) | 2004-06-24 |
EP1314712A4 (en) | 2004-12-15 |
JPWO2002076918A1 (ja) | 2004-07-15 |
EP1314712A1 (en) | 2003-05-28 |
WO2002076918A1 (en) | 2002-10-03 |
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