KR950032184A - 3-(2-아미노에틸)-4-[3-(트리플루오로메틸)벤조일]-3, 4-디히드로-2h-1, 4-벤즈옥사진 유도체, 그 제조방법 및 그 치료학적 적용 - Google Patents
3-(2-아미노에틸)-4-[3-(트리플루오로메틸)벤조일]-3, 4-디히드로-2h-1, 4-벤즈옥사진 유도체, 그 제조방법 및 그 치료학적 적용 Download PDFInfo
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- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
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- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
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- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
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Abstract
본 발명은 일반식(Ⅰ)에 해당하는 화합물을 제공한다.
상기식에서 R1은 수소원자, 플루오르원자, 염소원자, 메틸기, C1-C3알콕시기 또는 니트로기를 나타내며, R3는 수소원자 또는 C1-C3알킬기를 나타내며, R4는 2, 3-이히드로-1H-인덴-2-일, 2, 3-디히드로-1H-일 또는 1, 2, 3, 4-테트라히들고 나프탈렌-1-일기를 나타내거나 양자택일로 R3및 R4는 질소원자와 함께 1, 2, 3, 4-테트라히드로-9H-피리도[3,4-b]인돌-2-일기, 1, 2, 3, 4-테트라히드로-9H-피리도[4, 3-b]인돌-3-일기, 4, 5, 6, 7-테트라히드로티에노[2, 3-c]피리드-6-일기, 4, 5, 6, 7-테트라히드로티에노[3, 2-c]피리드-6-일기 또는 2, 3-디히드로-1H-이소인돌-2-일기를 형성한다.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (5)
- 염기의 형태 또는 산의 부가염 형태로 다음 일반식(I)에 해당하는 순수한 광학 이성질체 또는 광학 이성질체의 혼합물의 형태인 것을 특징으로 하는 화합물.상기식에서 R1은 수소원자, 플루오르원자, 염소원자, 메틸기, C1-C3알콕시기 또는 니트로기를 나타내며, R3는 단독으로 수소원자 또는 C1-C3알킬기를 나타내며, R4는 단독으로 2,3-디히드로-1H-인덴-2-일기, 2,3-디히드로-1H-인덴-1-일기 또는 1,2,3,4-테트라히드로 나프탈렌-1-일기를 나타내거나 또는 양자택일로, R3및 R4는 질소원자와 함께 1,2,3,4-테트라히드로-9H-피리도[3,4-b]인돌-2-일기, 1,2,3,4-테트라히드로-9H-피리도[4,3-b]인돌-3-일기, 4,5,6,7-테트라히드로티에노[2,3-c]피리드-6-일기, 4,5,6,7-테트라히드로티에노[3,2-c]피리드-6-일기 또는 2,3-디히드로-1H-이소인돌-2-일기를 함께 형성하며, 이들의 구조식은 각각 다음과 같다;
- 제1항에 있어서, R1은 플루오르원자, 염소원자, 메틸기 또는 메톡시기를 나타내며, R3는 수소원자 또는 C1-C3알킬기를 나타내며 R4는 2, 3-디히드로-1H-인덴-2-일기, 2, 3-디히드로-1H-인덴-1-일기 또는 1, 2, 3, 4-테트라히드로나프탈렌-1-일기를 나타내는 것을 특징으로 하는 화합물.
- R1의 특허청구의 번위 제1항에 정의된 바와 같은 일반식(Ⅱ)의 2-아미노페놀을 무수트리플루오로아세트산과 반응시켜서 일반식(Ⅳ)의 아미드를 얻고 이것을 에틸 4-브로모-2부텐오에이트와 반응시키고 이어서 그렇게 하여 얻어진 일반식(Ⅵ)의 에틸 3, 4-디히드로-2H-1, 4-벤즈옥사진-3-아세테이트 유도체의 에스테르 작용기를 환원제로 환원시켜서 일반식(Ⅶ)의 3, 4-디히드로-2H-1, 4-벤즈옥사진-3-에탄올 유도체를 얻고 이것을 3-(트리플루오로메틸)벤조일클로라이드와 반응시켜서 일반식(Ⅸ)의 알코올을 얻고 이것을 염화티오닐과 반응시켜서 일반식(Ⅹ)의 화합물을 얻고 최종적으로 이 화합물을 R3및 R4가 특허청의 범위 제1항에 규정된 바의 일반식 HNR3R4의 아민과 반응시키는 것을 특징으로 하는 특허청구의 범위 제1항에 따른 화합물의 제조방법.
- 특허청구의 범위 제1항에 따른 화합물로 구성되는 것을 특징으로 하는 약제.
- 특허청구의 범위 제1항에 따른 화합물을 부형제와 결합하여 함유하는 것을 특징으로 하는 약학적 조성물.※ 참고사항 : 최초출원내용에 의하여 공개하는 것임.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9401196A FR2715659B1 (fr) | 1994-02-03 | 1994-02-03 | Dérivés de 3-(2-aminoéthyl)-4-[3-(trifluorométhyl)benzoyl]-3,4-dihydro-2H-1,4-benzoxazine, leur préparation et leur application en thérapeutique. |
FR94.01196 | 1994-02-03 | ||
FR94.01197 | 1994-02-03 | ||
FR9401197A FR2715655B1 (fr) | 1994-02-03 | 1994-02-03 | Dérivés de 3-(2-aminoéthyl)-4-benzoyl-3,4-dihydro-2H-1,4-benzoxazine, leur préparation et leur application en thérapeutique. |
Publications (1)
Publication Number | Publication Date |
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KR950032184A true KR950032184A (ko) | 1995-12-20 |
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Application Number | Title | Priority Date | Filing Date |
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KR1019950001835A KR950032184A (ko) | 1994-02-03 | 1995-02-02 | 3-(2-아미노에틸)-4-[3-(트리플루오로메틸)벤조일]-3, 4-디히드로-2h-1, 4-벤즈옥사진 유도체, 그 제조방법 및 그 치료학적 적용 |
Country Status (19)
Country | Link |
---|---|
US (1) | US5550125A (ko) |
EP (1) | EP0666260B1 (ko) |
JP (1) | JPH07278123A (ko) |
KR (1) | KR950032184A (ko) |
CN (1) | CN1109880A (ko) |
AT (1) | ATE182887T1 (ko) |
AU (1) | AU687134B2 (ko) |
CA (1) | CA2141728A1 (ko) |
CZ (1) | CZ27095A3 (ko) |
DE (1) | DE69511127D1 (ko) |
FI (1) | FI950457A (ko) |
HU (1) | HUT71238A (ko) |
IL (1) | IL112528A (ko) |
NO (1) | NO304229B1 (ko) |
NZ (1) | NZ270444A (ko) |
PL (1) | PL307040A1 (ko) |
RU (1) | RU2136670C1 (ko) |
SK (1) | SK12895A3 (ko) |
ZA (1) | ZA95834B (ko) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2235368T3 (es) * | 1997-10-27 | 2005-07-01 | Sumitomo Pharmaceuticals Company, Limited | Derivados de amida para tratar alteraciones neurodegenerativas de la retina. |
JP3201998B2 (ja) * | 1998-12-16 | 2001-08-27 | サムソン ジェネラル ケミカルズ カンパニー リミテッド | (s)−ベンゾオキサジン誘導体の製造方法及び(r)−ベンゾオキサジン誘導体のラセミ化方法 |
KR100397491B1 (ko) * | 2000-12-05 | 2003-09-13 | 이수화학 주식회사 | 광학활성 (s)-벤즈옥사진 유도체 및 그의 제조방법 |
EP1856126A2 (en) * | 2005-02-17 | 2007-11-21 | Wyeth a Corporation of the State of Delaware | Cycloalkylfused indole, benzothiophene, benzofuran and indene derivatives |
CN101268075A (zh) * | 2005-07-28 | 2008-09-17 | 百时美施贵宝公司 | 作为5-羟色胺受体激动剂和拮抗剂的取代的四氢-1h吡啶并[4,3,b]吲哚 |
AP2013007153A0 (en) | 2011-03-18 | 2013-09-30 | Lupin Ltd | Benzo [B] [1,4] oxazin derivatives as calcium sensing receptor modulators |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
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DE1287584B (de) * | 1962-07-04 | 1969-01-23 | Thomae Gmbh Dr K | Verfahren zur Herstellung von 2, 3-Dihydro-1, 4-benzoxazinderivaten |
US4636563A (en) * | 1985-09-16 | 1987-01-13 | American Home Products Corporation | Antipsychotic γ-carbolines |
FR2619111B1 (fr) * | 1987-08-07 | 1991-01-11 | Synthelabo | Derives de (piperidinyl-4)methyl-2 tetrahydro-1,2,3,4 9h-pyrido (3,4-b) indole, leur preparation et leur application en therapeutique |
FR2702477B1 (fr) * | 1993-03-08 | 1995-04-28 | Synthelabo | Dérivés de benzoxazine, leur préparation et leur application en thérapeutique. |
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1995
- 1995-01-30 CN CN95101657A patent/CN1109880A/zh active Pending
- 1995-02-02 IL IL11252895A patent/IL112528A/xx not_active IP Right Cessation
- 1995-02-02 ZA ZA95834A patent/ZA95834B/xx unknown
- 1995-02-02 US US08/382,589 patent/US5550125A/en not_active Expired - Fee Related
- 1995-02-02 NO NO950378A patent/NO304229B1/no unknown
- 1995-02-02 DE DE69511127T patent/DE69511127D1/de not_active Expired - Lifetime
- 1995-02-02 SK SK128-95A patent/SK12895A3/sk unknown
- 1995-02-02 HU HU9500310A patent/HUT71238A/hu unknown
- 1995-02-02 EP EP95400215A patent/EP0666260B1/fr not_active Expired - Lifetime
- 1995-02-02 PL PL95307040A patent/PL307040A1/xx unknown
- 1995-02-02 AT AT95400215T patent/ATE182887T1/de not_active IP Right Cessation
- 1995-02-02 RU RU95101386A patent/RU2136670C1/ru active
- 1995-02-02 AU AU11545/95A patent/AU687134B2/en not_active Ceased
- 1995-02-02 JP JP7015892A patent/JPH07278123A/ja active Pending
- 1995-02-02 CA CA002141728A patent/CA2141728A1/en not_active Abandoned
- 1995-02-02 CZ CZ95270A patent/CZ27095A3/cs unknown
- 1995-02-02 NZ NZ270444A patent/NZ270444A/en unknown
- 1995-02-02 FI FI950457A patent/FI950457A/fi unknown
- 1995-02-02 KR KR1019950001835A patent/KR950032184A/ko not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CZ27095A3 (en) | 1995-09-13 |
ATE182887T1 (de) | 1999-08-15 |
NO304229B1 (no) | 1998-11-16 |
RU2136670C1 (ru) | 1999-09-10 |
CN1109880A (zh) | 1995-10-11 |
NZ270444A (en) | 1996-02-27 |
IL112528A (en) | 1999-04-11 |
RU95101386A (ru) | 1996-11-20 |
EP0666260B1 (fr) | 1999-08-04 |
IL112528A0 (en) | 1995-05-26 |
FI950457A (fi) | 1995-08-04 |
JPH07278123A (ja) | 1995-10-24 |
NO950378D0 (no) | 1995-02-02 |
AU687134B2 (en) | 1998-02-19 |
NO950378L (no) | 1995-08-04 |
SK12895A3 (en) | 1995-08-09 |
ZA95834B (en) | 1996-02-12 |
HUT71238A (en) | 1995-11-28 |
PL307040A1 (en) | 1995-08-07 |
US5550125A (en) | 1996-08-27 |
EP0666260A1 (fr) | 1995-08-09 |
HU9500310D0 (en) | 1995-03-28 |
CA2141728A1 (en) | 1995-08-04 |
DE69511127D1 (de) | 1999-09-09 |
AU1154595A (en) | 1995-08-10 |
FI950457A0 (fi) | 1995-02-02 |
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