ZA95834B - 3-(2-aminoethyl)-4-[3-(trifluoromethyl)benzoyl]-3, 4-dihydro-2H-1, 4-benzoxazine derivatives process for their preparation and their therapeutic application: - Google Patents

3-(2-aminoethyl)-4-[3-(trifluoromethyl)benzoyl]-3, 4-dihydro-2H-1, 4-benzoxazine derivatives process for their preparation and their therapeutic application:

Info

Publication number
ZA95834B
ZA95834B ZA95834A ZA95834A ZA95834B ZA 95834 B ZA95834 B ZA 95834B ZA 95834 A ZA95834 A ZA 95834A ZA 95834 A ZA95834 A ZA 95834A ZA 95834 B ZA95834 B ZA 95834B
Authority
ZA
South Africa
Prior art keywords
dihydro
aminoethyl
benzoyl
trifluoromethyl
preparation
Prior art date
Application number
ZA95834A
Other languages
English (en)
Inventor
Pascal George
Jonathan Frost
Patrick Pasau
Corinne Rousselle
Regine Bartsch
Paul Howard Williams
Jean-Claude Muller
Original Assignee
Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR9401197A external-priority patent/FR2715655B1/fr
Priority claimed from FR9401196A external-priority patent/FR2715659B1/fr
Application filed by Synthelabo filed Critical Synthelabo
Publication of ZA95834B publication Critical patent/ZA95834B/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D265/00Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/281,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/341,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C07D265/361,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
ZA95834A 1994-02-03 1995-02-02 3-(2-aminoethyl)-4-[3-(trifluoromethyl)benzoyl]-3, 4-dihydro-2H-1, 4-benzoxazine derivatives process for their preparation and their therapeutic application: ZA95834B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9401197A FR2715655B1 (fr) 1994-02-03 1994-02-03 Dérivés de 3-(2-aminoéthyl)-4-benzoyl-3,4-dihydro-2H-1,4-benzoxazine, leur préparation et leur application en thérapeutique.
FR9401196A FR2715659B1 (fr) 1994-02-03 1994-02-03 Dérivés de 3-(2-aminoéthyl)-4-[3-(trifluorométhyl)benzoyl]-3,4-dihydro-2H-1,4-benzoxazine, leur préparation et leur application en thérapeutique.

Publications (1)

Publication Number Publication Date
ZA95834B true ZA95834B (en) 1996-02-12

Family

ID=26230930

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA95834A ZA95834B (en) 1994-02-03 1995-02-02 3-(2-aminoethyl)-4-[3-(trifluoromethyl)benzoyl]-3, 4-dihydro-2H-1, 4-benzoxazine derivatives process for their preparation and their therapeutic application:

Country Status (19)

Country Link
US (1) US5550125A (xx)
EP (1) EP0666260B1 (xx)
JP (1) JPH07278123A (xx)
KR (1) KR950032184A (xx)
CN (1) CN1109880A (xx)
AT (1) ATE182887T1 (xx)
AU (1) AU687134B2 (xx)
CA (1) CA2141728A1 (xx)
CZ (1) CZ27095A3 (xx)
DE (1) DE69511127D1 (xx)
FI (1) FI950457A (xx)
HU (1) HUT71238A (xx)
IL (1) IL112528A (xx)
NO (1) NO304229B1 (xx)
NZ (1) NZ270444A (xx)
PL (1) PL307040A1 (xx)
RU (1) RU2136670C1 (xx)
SK (1) SK12895A3 (xx)
ZA (1) ZA95834B (xx)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69828197T2 (de) 1997-10-27 2005-12-08 Sumitomo Pharmaceuticals Co., Ltd. Amidderivate zur behandlung neurodegenerativer erkrankungen der netzhaut
JP3201998B2 (ja) * 1998-12-16 2001-08-27 サムソン ジェネラル ケミカルズ カンパニー リミテッド (s)−ベンゾオキサジン誘導体の製造方法及び(r)−ベンゾオキサジン誘導体のラセミ化方法
KR100397491B1 (ko) * 2000-12-05 2003-09-13 이수화학 주식회사 광학활성 (s)-벤즈옥사진 유도체 및 그의 제조방법
CA2597616A1 (en) * 2005-02-17 2006-08-24 Wyeth Cycloalkylfused indole, benzothiophene, benzofuran and indene derivatives
BRPI0614485A2 (pt) * 2005-07-28 2011-03-29 Bristol-Myers Squibb Company tetrahidro-1h-pirido [4, 3, b] indóis substituìdos como agonistas e antagonistas receptores de serotonina
JP6033835B2 (ja) 2011-03-18 2016-11-30 ルピン アトランティス ホールディングス エスエー カルシウム感知受容体モジュレーターとしてのベンゾ[b][1,4]オキサジン誘導体

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1287584B (de) * 1962-07-04 1969-01-23 Thomae Gmbh Dr K Verfahren zur Herstellung von 2, 3-Dihydro-1, 4-benzoxazinderivaten
US4636563A (en) * 1985-09-16 1987-01-13 American Home Products Corporation Antipsychotic γ-carbolines
FR2619111B1 (fr) * 1987-08-07 1991-01-11 Synthelabo Derives de (piperidinyl-4)methyl-2 tetrahydro-1,2,3,4 9h-pyrido (3,4-b) indole, leur preparation et leur application en therapeutique
FR2702477B1 (fr) * 1993-03-08 1995-04-28 Synthelabo Dérivés de benzoxazine, leur préparation et leur application en thérapeutique.

Also Published As

Publication number Publication date
NZ270444A (en) 1996-02-27
ATE182887T1 (de) 1999-08-15
IL112528A (en) 1999-04-11
FI950457A (fi) 1995-08-04
CA2141728A1 (en) 1995-08-04
RU95101386A (ru) 1996-11-20
AU1154595A (en) 1995-08-10
CN1109880A (zh) 1995-10-11
CZ27095A3 (en) 1995-09-13
NO304229B1 (no) 1998-11-16
SK12895A3 (en) 1995-08-09
NO950378D0 (no) 1995-02-02
AU687134B2 (en) 1998-02-19
FI950457A0 (fi) 1995-02-02
EP0666260A1 (fr) 1995-08-09
HUT71238A (en) 1995-11-28
KR950032184A (ko) 1995-12-20
US5550125A (en) 1996-08-27
PL307040A1 (en) 1995-08-07
DE69511127D1 (de) 1999-09-09
JPH07278123A (ja) 1995-10-24
HU9500310D0 (en) 1995-03-28
NO950378L (no) 1995-08-04
IL112528A0 (en) 1995-05-26
EP0666260B1 (fr) 1999-08-04
RU2136670C1 (ru) 1999-09-10

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