KR940013533A - 허혈 및 재관류 손상을 최소화 및 억제하는 방법 - Google Patents
허혈 및 재관류 손상을 최소화 및 억제하는 방법 Download PDFInfo
- Publication number
- KR940013533A KR940013533A KR1019930029122A KR930029122A KR940013533A KR 940013533 A KR940013533 A KR 940013533A KR 1019930029122 A KR1019930029122 A KR 1019930029122A KR 930029122 A KR930029122 A KR 930029122A KR 940013533 A KR940013533 A KR 940013533A
- Authority
- KR
- South Korea
- Prior art keywords
- arginal
- prolyl
- compound
- reperfusion injury
- tiq
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/06—Tripeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
본 발명은 조직을 허혈 및 재관류에 적용할때 야기되는 손상을 최소화하고 억제하기 위한 방법에 관한 것이다. 이 방법은 허혈성 조직에 혈액 흐름을 재정립하는 것과 동시에 또는 재정립한 직후에 특정 유도된 트리펩티드 아르기날 화합물을 투여함을 포함한다. 이 방법은 심근 경색으로 진전되는 동시에 심장에 대한 손상을 최소화하고 억제하는데 특히 유용하다.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (6)
- 재관류 손상을 치료하는데 사용하기 위한 일반식 A-Pro-Arg-h의 화합물:일반식에서, A는 1 또는 2개의이고, A의 키랄 중심은 DL, 바람직하게는 D이고, Pro의 키랄 중심은 L, Arg의 키랄 중심은 L이고;Z는 C1내지 C4알킬이거나 또는 H이고;X는 NH2, NHZ, t-부틸옥시카보닐-NH, 아세틸-NH, 또는 트리플루오로아세틸-NH이고; R은 H, OH, 할로겐, C1내지 C4알콕시, CF3, C1내지 C4알킬, NO2, 또는 NH2이고; q는 CH2또는 CO이다.
- 제 1 항에 있어서, 재관류 손상이 심근 경색인 화합물.
- 제 1 항 또는 2항에 있어서, 산화제 스캐빈저와 함께 사용되는 화합물.
- 제 1 항 내지 3항중 어느 한 항에 있어서, 베타 차단제와 함께 사용되는 화합물.
- 제 1 항 내지 4항중 어느 한 항에 있어서, 아스피린과 함께 사용되는 화합물.
- 재관류 손상을 최소화시키고 억제하는데 사용하기 위한, D―3―Piq―L―프롤릴―L―아르기날, D―7―하이드록실―1,2,3,4―Tiq―3―카보닐옥시―L―프롤릴―L―아르기날, D―3―Tiq―L―프롤릴―L―아르기날, D―1,2,3,4―Tiq―1―카보닐―L―프롤릴―L―아르기날, N―메틸―D―페닐알라닐―L―프롤릴―L―아르기날 및 Na―t―부틸옥시카보닐―D―페닐알라닐―L―프롤릴―L―아르기날로 이루어진 그룹중에서 선택된 제 1 항에 청구된 화합물.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/996,347 US5455229A (en) | 1992-12-23 | 1992-12-23 | Method for minimizing and containing ischemic and reperfusion injury |
US7/996,347 | 1992-12-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
KR940013533A true KR940013533A (ko) | 1994-07-15 |
Family
ID=25542806
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019930029122A KR940013533A (ko) | 1992-12-23 | 1993-12-22 | 허혈 및 재관류 손상을 최소화 및 억제하는 방법 |
Country Status (15)
Country | Link |
---|---|
US (1) | US5455229A (ko) |
EP (1) | EP0606003A1 (ko) |
JP (1) | JPH06199682A (ko) |
KR (1) | KR940013533A (ko) |
CN (1) | CN1092780A (ko) |
AU (1) | AU673020B2 (ko) |
BR (1) | BR9305203A (ko) |
CA (1) | CA2111763A1 (ko) |
CZ (1) | CZ285005B6 (ko) |
HU (1) | HUT65789A (ko) |
IL (1) | IL108048A0 (ko) |
NO (1) | NO934741L (ko) |
NZ (1) | NZ250543A (ko) |
PH (1) | PH31301A (ko) |
ZA (1) | ZA939478B (ko) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2021172844A1 (ko) * | 2020-02-25 | 2021-09-02 | 주식회사 만도 | 인덕터 장치, 필터 장치 및 조향 제어 장치 |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2300049C (en) * | 1997-08-08 | 2009-03-10 | Duke University | Compositions, apparatus and methods for facilitating surgical procedures |
US6711436B1 (en) | 1997-08-08 | 2004-03-23 | Duke University | Compositions, apparatus and methods for facilitating surgical procedures |
DE69931975T2 (de) * | 1998-08-07 | 2006-10-05 | Applied Research Systems Ars Holding N.V. | FSH Mimetika zur Behandlung von Infertilität |
US7632803B2 (en) * | 1999-10-01 | 2009-12-15 | Dmi Life Sciences, Inc. | Metal-binding compounds and uses therefor |
US7592304B2 (en) | 1999-10-01 | 2009-09-22 | Dmi Life Sciences, Inc. | Metal-binding compounds and uses therefor |
US20030130185A1 (en) * | 2000-09-29 | 2003-07-10 | David Bar-Or | Metal-binding compounds and uses therefor |
US20070112414A1 (en) * | 2005-09-08 | 2007-05-17 | Conor Medsystems, Inc. | System and method for local delivery of antithrombotics |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU192646B (en) * | 1984-12-21 | 1987-06-29 | Gyogyszerkutato Intezet | Process for preparing new n-alkyl-peptide aldehydes |
JPH0813834B2 (ja) * | 1990-08-01 | 1996-02-14 | 日東紡績株式会社 | トリペプチド誘導体及びそれを有効成分とする蛋白分解酵素阻害剤 |
IL99527A (en) * | 1990-09-28 | 1997-08-14 | Lilly Co Eli | Tripeptide antithrombotic agents |
-
1992
- 1992-12-23 US US07/996,347 patent/US5455229A/en not_active Expired - Fee Related
-
1993
- 1993-12-16 IL IL10804893A patent/IL108048A0/xx unknown
- 1993-12-17 ZA ZA939478A patent/ZA939478B/xx unknown
- 1993-12-17 CZ CZ932818A patent/CZ285005B6/cs not_active IP Right Cessation
- 1993-12-17 CA CA002111763A patent/CA2111763A1/en not_active Abandoned
- 1993-12-21 PH PH47502A patent/PH31301A/en unknown
- 1993-12-21 NZ NZ250543A patent/NZ250543A/en unknown
- 1993-12-21 HU HU9303704A patent/HUT65789A/hu unknown
- 1993-12-21 NO NO934741A patent/NO934741L/no unknown
- 1993-12-22 BR BR9305203A patent/BR9305203A/pt unknown
- 1993-12-22 KR KR1019930029122A patent/KR940013533A/ko not_active Application Discontinuation
- 1993-12-22 AU AU52648/93A patent/AU673020B2/en not_active Ceased
- 1993-12-22 EP EP93310445A patent/EP0606003A1/en not_active Withdrawn
- 1993-12-23 CN CN93112994A patent/CN1092780A/zh active Pending
- 1993-12-24 JP JP5328537A patent/JPH06199682A/ja not_active Withdrawn
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2021172844A1 (ko) * | 2020-02-25 | 2021-09-02 | 주식회사 만도 | 인덕터 장치, 필터 장치 및 조향 제어 장치 |
Also Published As
Publication number | Publication date |
---|---|
US5455229A (en) | 1995-10-03 |
IL108048A0 (en) | 1994-04-12 |
BR9305203A (pt) | 1994-08-16 |
CZ285005B6 (cs) | 1999-04-14 |
CN1092780A (zh) | 1994-09-28 |
NZ250543A (en) | 1997-06-24 |
JPH06199682A (ja) | 1994-07-19 |
AU673020B2 (en) | 1996-10-24 |
ZA939478B (en) | 1995-06-19 |
NO934741L (no) | 1994-06-24 |
AU5264893A (en) | 1994-07-07 |
EP0606003A1 (en) | 1994-07-13 |
HUT65789A (en) | 1994-07-28 |
HU9303704D0 (en) | 1994-04-28 |
CA2111763A1 (en) | 1994-06-24 |
CZ281893A3 (en) | 1994-07-13 |
NO934741D0 (no) | 1993-12-21 |
PH31301A (en) | 1998-07-06 |
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WITN | Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid |