KR940013505A - 항 알레르기 점안제 - Google Patents

항 알레르기 점안제 Download PDF

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Publication number
KR940013505A
KR940013505A KR1019930026858A KR930026858A KR940013505A KR 940013505 A KR940013505 A KR 940013505A KR 1019930026858 A KR1019930026858 A KR 1019930026858A KR 930026858 A KR930026858 A KR 930026858A KR 940013505 A KR940013505 A KR 940013505A
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KR
South Korea
Prior art keywords
antiallergic eye
eye drop
antiallergic
eye drops
pharmaceutically acceptable
Prior art date
Application number
KR1019930026858A
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English (en)
Other versions
KR100275016B1 (ko
Inventor
시게또시 오꾸무라
히또시 다나까
다다유끼 사이또
Original Assignee
야마다 야스꾸니
로또세이야꾸 가부시끼가이샤
나가따 마사오
가네보 가부시끼가이샤
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Application filed by 야마다 야스꾸니, 로또세이야꾸 가부시끼가이샤, 나가따 마사오, 가네보 가부시끼가이샤 filed Critical 야마다 야스꾸니
Publication of KR940013505A publication Critical patent/KR940013505A/ko
Application granted granted Critical
Publication of KR100275016B1 publication Critical patent/KR100275016B1/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

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  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Ophthalmology & Optometry (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

[구성]식(I):
로 표시되는 화합물 또는 그의 약학상 허용되는 염을 함유하는 항 알레르기 점안제
[효과]본 발명은 점안제는 안자극성이 적고, 극히 안정성이 높은 약제이다. 그리고 강한 화학전달물질 유리 억제 작용과 항 히스타민 작용을 발휘하고 그 효과의 발현은 신속하므로, 알레르기성 결막염등의 알레르기성 안질환의 예방 및 치료에 유용하다.

Description

항 알레르기 점안제
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 본 발명의 점안제 및 항 알레르기제 A의 안(眼)자극성 시험의 결과를 나타내는 그림이다. 도면에서, *는 대조용 생리 식염수와 비교하여 유의차 [p<0.05, 만 휘트리(Mann-Whitney)의 U검정]가 보여진 것을 나타낸다.
제2도는 본 발명의 점안제의 안 자극성(눈의 깜빡거림회수)에 미치는 pH의 영향을 나타내는 그림이다. 여기서, *는 pH7의 점안제와 비교하여 유의차(p<0.05, t검정)가 있다는 것을 나타낸다.

Claims (4)

  1. 식(I):
    로 표시되는 화합물 또는 그의 약학상 허용되는 염을 함유하는 항 알레르기 점안제.
  2. 제1항에 있어서, 식(I)로 표시되는 화합물 또는 그의 약학상 허용되는 염의 함유량이 0.001%~1.0%인 항 알레르기 점안제.
  3. 제2항에 있어서, 액성이 pH4.0 이상 8.0 미만인 항 알레르기 점안제.
  4. 제2항에 있어서, 약학상 허용되는 등장화제, 완충화제, 안정화제, 방부제, 용해보조제 및/ 또는 pH 조절제를 추가로 함유하는 항 알레르기 점안제.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019930026858A 1992-12-09 1993-12-08 항 알레르기 점안제 KR100275016B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP92-329216 1992-12-09
JP32921692A JP3527256B2 (ja) 1992-12-09 1992-12-09 抗アレルギー点眼剤

Publications (2)

Publication Number Publication Date
KR940013505A true KR940013505A (ko) 1994-07-15
KR100275016B1 KR100275016B1 (ko) 2000-12-15

Family

ID=18218955

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019930026858A KR100275016B1 (ko) 1992-12-09 1993-12-08 항 알레르기 점안제

Country Status (14)

Country Link
US (1) US5441958A (ko)
EP (1) EP0673250B1 (ko)
JP (1) JP3527256B2 (ko)
KR (1) KR100275016B1 (ko)
AT (1) ATE185696T1 (ko)
AU (1) AU667613B2 (ko)
CA (1) CA2151385C (ko)
DE (1) DE69326840T2 (ko)
DK (1) DK0673250T3 (ko)
ES (1) ES2137352T3 (ko)
GR (1) GR3032264T3 (ko)
HK (1) HK1013964A1 (ko)
TW (1) TW257676B (ko)
WO (1) WO1994013299A1 (ko)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2731618B1 (fr) * 1995-03-14 1997-08-01 Esteve Labor Dr Composition ophtalmique topique comprenant un derive de 2-(4-(azolylbutyl)-piperazinyl-methyl)-benzimidazole, notamment pour le traitement de la conjonctivite allergique
JPH09124484A (ja) * 1995-10-27 1997-05-13 Schering Purau Kk 点眼剤
US20040097486A1 (en) * 1999-11-18 2004-05-20 Yanni John M. Use of an H1 antagonist and a safe steroid to treat eye conditions
DE60109742T2 (de) 2000-01-25 2005-08-18 Alcon Inc. Antiallergische ophthalmische zubereitungen, geeignet zur anwendung mit kontaktlinsen
US20050026924A1 (en) * 2000-07-14 2005-02-03 Allergan, Inc. Compositions containing alpha-2-adrenergic agonist components
JP2002249445A (ja) * 2000-12-19 2002-09-06 Ophtecs Corp 眼科用液剤組成物
PL369630A1 (en) * 2001-12-05 2005-05-02 Alcon, Inc. Use of a h1 antagonist and rimexolone as a safe steroid to treat rhinitis
US6635654B1 (en) 2003-01-09 2003-10-21 Allergan, Inc. Ophthalmic compositions containing loratadine
GB2503687B (en) 2012-07-04 2018-02-21 Dyson Technology Ltd An attachment for a hand held appliance
SG11201408811RA (en) 2012-07-04 2015-01-29 Dyson Technology Ltd Attachment for a hand held appliance
CA3088740A1 (en) 2018-01-18 2019-07-25 Faes Farma, S.A. Ophthalmic compositions comprising bilastine, a beta-cyclodextrin and at least one gelling agent

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5879983A (ja) * 1981-11-06 1983-05-13 Kanebo Ltd 新規なベンズイミダゾ−ル誘導体、その製造法およびその医薬組成物
JPH0383924A (ja) * 1989-08-28 1991-04-09 Kanebo Ltd 経皮投与用組成物
US5192780A (en) * 1989-12-18 1993-03-09 Alcon Laboratories, Inc. Methods using antiallergics and antihistamines

Also Published As

Publication number Publication date
EP0673250A1 (en) 1995-09-27
WO1994013299A1 (en) 1994-06-23
ATE185696T1 (de) 1999-11-15
JP3527256B2 (ja) 2004-05-17
AU5744294A (en) 1994-07-04
JPH06172179A (ja) 1994-06-21
CA2151385A1 (en) 1994-06-23
DE69326840T2 (de) 2000-04-20
TW257676B (ko) 1995-09-21
DE69326840D1 (de) 1999-11-25
CA2151385C (en) 1999-02-09
EP0673250B1 (en) 1999-10-20
DK0673250T3 (da) 1999-12-27
HK1013964A1 (en) 1999-09-17
KR100275016B1 (ko) 2000-12-15
ES2137352T3 (es) 1999-12-16
AU667613B2 (en) 1996-03-28
GR3032264T3 (en) 2000-04-27
US5441958A (en) 1995-08-15

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