KR960700039A - β-시클로덱스트린 유도체 및 탄산 탈수효소 저해제로 이루어진 안과용 국소 투여 조성물(Topical Compositions for the Eye Comprising a β-cyclodextrin Derivative and a Carbonic Anhydrase Inhibitor) - Google Patents
β-시클로덱스트린 유도체 및 탄산 탈수효소 저해제로 이루어진 안과용 국소 투여 조성물(Topical Compositions for the Eye Comprising a β-cyclodextrin Derivative and a Carbonic Anhydrase Inhibitor)Info
- Publication number
- KR960700039A KR960700039A KR1019950702775A KR19950702775A KR960700039A KR 960700039 A KR960700039 A KR 960700039A KR 1019950702775 A KR1019950702775 A KR 1019950702775A KR 19950702775 A KR19950702775 A KR 19950702775A KR 960700039 A KR960700039 A KR 960700039A
- Authority
- KR
- South Korea
- Prior art keywords
- cyclodextrin
- carbonic anhydrase
- anhydrase inhibitor
- eye
- effective
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/40—Cyclodextrins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Ophthalmology & Optometry (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
유효량의 탄산 탈수효소 저해제 및 눈에 국소적으로 동시 투여될 때 탄산 탈수 효소 저해제의 생체이용가능성을 증가시키는데 효과적인 양의
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (27)
- 유효량의 탄산 탈수효소 저해제 및 눈에 국소적으로 동시 투여될때 탄산 탈수 효소 저해제의 생체이용가능성을 증가시키는데 효과적인 양의 비결정성-시클로덱스트린으로 이루어진 국소 투여를 위한 안과용 조성물을 함유하는 안과용 점안제 디스펜서.
- 유효량의 탄산 탈수효소 저해제 및 조성물 중의 탄산 탈수효소 저해제의 용해도를 비결정성-시클로덱스트린의 부재하의 그의 용해도에 비해 증가시키는데 효과적인 양의 비결정성-시클로덱스트린의 이루어진 국소 투여를 위한 안과용 조성물을 함유하는 안과용 점안제 디스펜서.
- 제1항에 있어서, 탄산 탈수효소 저해제가 헤테로시클릭 술폰아미드인 점안제 디스펜서.
- 제3항에 있어서, 헤테르시클릭 술폰아미드가 아세타졸아미드, 메타졸아미드 또는 에톡스졸아미드인 점안제 디스펜서.
- 제4항에 있어서, 아세타졸아미드 또는 메타졸아미드의 양이 눈에 국소 투여될때 안내압을 20%이상 감소시키는데 효과적인 점안제 디스펜서.
- 제5항에 있어서, 아세타졸아미드의 양이 약 0.1 내지 약 3.5w/V%인 점안제 디스펜서.
- 제1항에 있어서,-시클로덱스트린이 히드록시프로필--시클로덱스트린인 점안제 디스펜서.
- 제7항에 있어서, 히드록시프로필--시클로덱스트린의 양이 약 40-60w/v%인 점안제 디스펜서.
- 제1항에 있어서,-시클로덱스트린 유도체가 히드록시프로필--시클로덱스트린이고, 탄산 탈수효소 저해제가 아세타졸아미드 또는 메타졸아미드인 점안제 디스펜서.
- 제9항에 있어서, 히드록시프로필--시클로덱스트린의 양이 약 40-60w/v%인 점안제 디스펜서.
- 유효량의 탄산 탈수효소 저해제 및 눈에 국소적으로 동시 투여될때 탄산 탈수 효소 저해제의 생체이용가능성을 증가시키는데 효과적인 양의 비결정성-시클로덱스트린으로 이루어진 국소 투여를 위한 안과용 조성물을 눈에 국소 투여하는 것으로 이루어지는, 탄산 탈수효소 저해제 투여에 의한 안 질환의 치료 방법.
- 제11항에 있어서, 눈에서의 액 분비를 억제하거나 또는 안내압 이상을 치료하는 방법.
- 제11항에 있어서, 녹내장을 치료하는 방법.
- 제11항에 있어서, 탄산 탈수효소 저해제가 헤테로시클릭 술폰아미드인 방법.
- 제14항에 있어서, 헤테로시클릭 술폰아미드가 아세타졸아미드 또는 메타졸아미드인 방법.
- 제11항에 있어서,-시클로덱스트린이 히드록시프로필--시클로덱스트린인 방법.
- 제16항에 있어서, 히드록시프로필--시클로덱스트린의 양이 약 40-60w/v%인 방법.
- 제11항에 있어서,-시클로덱스트린이 히드록시프로필--시클로덱스트린이고 탄산 탈수효소 저해제가 아세타졸아미드 또는 메타졸아미드인 방법.
- 제18항에 있어서, 녹내장을 치료하는 방법.
- 유효량의 탄산 탈수효소 저해제 및 비결정성-시클로덱스트린 40-60w/v%로 이루어지며, 상기-시클로덱스트린의 양이 국소 투여시에 탄산 탈수효소 저해제의 생체이용가능성을 증가시키는데 효과적인 양인 국소 투여를 위한 안과용 조성물.
- 제20항에 있어서,-시클로덱스트린이 히드록시프로필--시클로덱스트린인 조성물.
- 제20항에 있어서, 탄산 탈수효소 저해제가 아세타졸아미드 또는 메타졸아미드인 조성물.
- 제21항에 있어서, 탄산 탈수효소 저해제가 아세타졸아미드 또는 메타졸아미드인 조성물.
- 제20항에 있어서, 비경구 투여에 유용하지 않은 조성물.
- 유효량이 안과적 활성제 및 눈에 국소 투여될 때 안과적 활성제의 생체이용가능성을 증가시키는데 효과적인 양의 비결정성-시클로덱스트린으로 이루어진 국소 투여를 위한 안과용 조성물을 눈에 국소 투여하는 것으로 이루어지는, 탄산 탈수효소 저해제 투여에 의한 안 질환의 치료 방법.
- 제25항에 있어서, 활성제가 스테로이드인 방법.
- 유효량의 탄산 탈수효소 저해제 및 눈에 국소적으로 동시 투여될때 탄산 탈수효소 저해제의 생체 이용가능성을 증가시키는데 효과적인 양의 비결정성-시클로덱스트린으로 이루어진 국소 투여를 위한 안과용 조성물을 함유하는 국소투여를 위한 안과용 어플리케이터.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US93593A | 1993-01-05 | 1993-01-05 | |
US08/000,935 | 1993-01-05 | ||
PCT/US1994/000339 WO1994015582A1 (en) | 1993-01-05 | 1994-01-05 | Topical compositions for the eye comprising a beta-cyclodextrin derivative and a carbonic anhydrase inhibitor |
Publications (1)
Publication Number | Publication Date |
---|---|
KR960700039A true KR960700039A (ko) | 1996-01-19 |
Family
ID=21693635
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019950702775A KR960700039A (ko) | 1993-01-05 | 1994-01-05 | β-시클로덱스트린 유도체 및 탄산 탈수효소 저해제로 이루어진 안과용 국소 투여 조성물(Topical Compositions for the Eye Comprising a β-cyclodextrin Derivative and a Carbonic Anhydrase Inhibitor) |
Country Status (8)
Country | Link |
---|---|
US (1) | US5494901A (ko) |
EP (1) | EP0678016A1 (ko) |
JP (1) | JPH08509205A (ko) |
KR (1) | KR960700039A (ko) |
AU (1) | AU6086194A (ko) |
BR (1) | BR9405698A (ko) |
CA (1) | CA2153268A1 (ko) |
WO (1) | WO1994015582A1 (ko) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5789435A (en) * | 1995-05-22 | 1998-08-04 | Advanced Research And Technology Institute | Method to increase retinal and optical nerve head blood flow velocity in order to preserve sight |
TW434023B (en) * | 1995-09-18 | 2001-05-16 | Novartis Ag | Preserved ophthalmic composition |
US6046223A (en) * | 1996-02-26 | 2000-04-04 | Advanced Research & Technology Institute | Treatment of macular edema |
CA2342797A1 (en) | 1998-09-02 | 2000-03-09 | Allergan Sales, Inc. | Preserved cyclodextrin-containing compositions |
EP1621199B8 (en) * | 2003-04-18 | 2011-01-19 | Advanced Medicine Research Institute | Remedies for diseases to be applied to eye |
US6933289B2 (en) | 2003-07-01 | 2005-08-23 | Allergan, Inc. | Inhibition of irritating side effects associated with use of a topical ophthalmic medication |
US20060141049A1 (en) * | 2003-11-12 | 2006-06-29 | Allergan, Inc. | Triamcinolone compositions for intravitreal administration to treat ocular conditions |
US20050101582A1 (en) | 2003-11-12 | 2005-05-12 | Allergan, Inc. | Compositions and methods for treating a posterior segment of an eye |
US20070224278A1 (en) * | 2003-11-12 | 2007-09-27 | Lyons Robert T | Low immunogenicity corticosteroid compositions |
CN100345594C (zh) * | 2004-01-19 | 2007-10-31 | 无锡杰西医药科技有限公司 | 乙酰唑胺滴眼液 |
AU2005209201B2 (en) | 2004-01-20 | 2010-06-03 | Allergan, Inc. | Compositions for localized therapy of the eye, comprising preferably triamcinolone acetonide and hyaluronic acid |
GB2413282B (en) * | 2004-04-23 | 2009-01-14 | Henderson Morley Plc | DNA Viral Infections |
US8147865B2 (en) | 2004-04-30 | 2012-04-03 | Allergan, Inc. | Steroid-containing sustained release intraocular implants and related methods |
US8119154B2 (en) | 2004-04-30 | 2012-02-21 | Allergan, Inc. | Sustained release intraocular implants and related methods |
JP2008505978A (ja) * | 2004-07-12 | 2008-02-28 | アラーガン、インコーポレイテッド | 眼病用組成物および眼病治療法 |
WO2006043965A1 (en) * | 2004-10-14 | 2006-04-27 | Allergan, Inc. | Therapeutic ophthalmic compositions containing retinal friendly excipients and related methods |
CA2609549A1 (en) * | 2005-05-25 | 2006-11-30 | Sirtris Pharmaceuticals, Inc. | Treatment of eye disorders with sirtuin modulators |
US8668676B2 (en) * | 2006-06-19 | 2014-03-11 | Allergan, Inc. | Apparatus and methods for implanting particulate ocular implants |
US9039761B2 (en) | 2006-08-04 | 2015-05-26 | Allergan, Inc. | Ocular implant delivery assemblies with distal caps |
ITRM20080182A1 (it) * | 2008-04-07 | 2009-10-08 | Medivis S R L | Preparato oftalmico a base di dorzolamide e latanoprost per il trattamento topico del glaucoma. |
US8545554B2 (en) * | 2009-01-16 | 2013-10-01 | Allergan, Inc. | Intraocular injector |
CN106822174B (zh) * | 2016-12-19 | 2019-10-11 | 上海大学 | 基于温敏环糊精的碳酸酐酶抑制剂及其制备方法 |
EP3505154B1 (en) * | 2017-12-26 | 2022-04-06 | Industrial Technology Research Institute | Composition for improving the solubility of poorly soluble substances, use thereof and complex formulation containing thereof |
Family Cites Families (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4438123A (en) * | 1980-03-04 | 1984-03-20 | Merck & Co., Inc. | Ophthalmic compositions of carbonic anhydrase inhibitors for topical application in the treatment of elevated intraocular pressure |
WO1982000096A1 (en) * | 1980-07-09 | 1982-01-21 | Maren T | Process for reducing intraocular pressure |
US4619939A (en) * | 1980-07-09 | 1986-10-28 | University Of Florida | Process for reducing intraocular pressure |
US4371673A (en) * | 1980-07-21 | 1983-02-01 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Water soluble forms of retinoids |
JPS58126810A (ja) * | 1981-12-24 | 1983-07-28 | Kaken Pharmaceut Co Ltd | 抗炎症眼科用液剤およびその製法 |
US4383992A (en) * | 1982-02-08 | 1983-05-17 | Lipari John M | Water-soluble steroid compounds |
SE8305864D0 (sv) * | 1983-10-25 | 1983-10-25 | L E Medical | Ogondroppar |
DE3346123A1 (de) * | 1983-12-21 | 1985-06-27 | Janssen Pharmaceutica, N.V., Beerse | Pharmazeutische praeparate von in wasser schwerloeslichen oder instabilen arzneistoffen und verfahren zu ihrer herstellung |
US4727064A (en) * | 1984-04-25 | 1988-02-23 | The United States Of America As Represented By The Department Of Health And Human Services | Pharmaceutical preparations containing cyclodextrin derivatives |
US4596795A (en) * | 1984-04-25 | 1986-06-24 | The United States Of America As Represented By The Secretary, Dept. Of Health & Human Services | Administration of sex hormones in the form of hydrophilic cyclodextrin derivatives |
GB8506792D0 (en) * | 1985-03-15 | 1985-04-17 | Janssen Pharmaceutica Nv | Derivatives of y-cyclodextrin |
US4728509A (en) * | 1985-08-19 | 1988-03-01 | Takeda Chemical Industries, Ltd. | Aqueous liquid preparation |
US4822819A (en) * | 1986-11-07 | 1989-04-18 | Alcon Laboratories, Inc. | Use of trimoprostil and derivatives in glaucoma therapy |
US4824866A (en) * | 1987-02-02 | 1989-04-25 | Riker Laboratories, Inc. | Anti-glaucoma use of trifluoromethanesulfonamide |
GB2203039B (en) * | 1987-03-02 | 1990-10-24 | American Cyanamid Co | Stable ophthalmic preparations containing acetazolamide |
JP2577049B2 (ja) * | 1987-06-04 | 1997-01-29 | 三共株式会社 | シクロスポリン製剤 |
US5002935A (en) * | 1987-12-30 | 1991-03-26 | University Of Florida | Improvements in redox systems for brain-targeted drug delivery |
ES2037385T3 (es) * | 1988-01-14 | 1993-06-16 | Akzo N.V. | Un procedimiento de manufactura de una preparacion farmaceutica para administracion local. |
EP0335545B2 (en) * | 1988-03-29 | 1998-09-23 | University Of Florida | Pharmaceutical formulations for parenteral use |
JPH0228112A (ja) * | 1988-04-21 | 1990-01-30 | Kaken Pharmaceut Co Ltd | 点眼用眼圧調整剤 |
US5011843A (en) * | 1988-05-31 | 1991-04-30 | Iolab Corporation | Treatment of glaucoma using phosphodiesterase inhibitors |
US4975428A (en) * | 1988-05-31 | 1990-12-04 | Iolab Corporation | Treatment of glaucoma using phosphodiesterase inhibitors |
CA2017156A1 (en) * | 1989-06-02 | 1990-12-02 | Sotoo Asakura | Preparation of fr115224 substance for parenteral administration |
CA2031469A1 (en) * | 1989-12-28 | 1991-06-29 | Larry A. Wheeler | Use of inclusion complexes of prostaglandins with cyclodextrins in the treatment of ocular hypertension |
GB9001987D0 (en) * | 1990-01-29 | 1990-03-28 | Janssen Pharmaceutica Nv | Improved cyclodextrin based erythropietin formulation |
TW200402B (ko) * | 1990-08-13 | 1993-02-21 | Senju Pharma Co | |
US5212162A (en) * | 1991-03-27 | 1993-05-18 | Alcon Laboratories, Inc. | Use of combinations gelling polysaccharides and finely divided drug carrier substrates in topical ophthalmic compositions |
US5324718A (en) * | 1992-07-14 | 1994-06-28 | Thorsteinn Loftsson | Cyclodextrin/drug complexation |
-
1993
- 1993-01-05 US US08/000,935 patent/US5494901A/en not_active Expired - Fee Related
-
1994
- 1994-01-05 WO PCT/US1994/000339 patent/WO1994015582A1/en not_active Application Discontinuation
- 1994-01-05 BR BR9405698A patent/BR9405698A/pt not_active Application Discontinuation
- 1994-01-05 KR KR1019950702775A patent/KR960700039A/ko not_active Application Discontinuation
- 1994-01-05 AU AU60861/94A patent/AU6086194A/en not_active Abandoned
- 1994-01-05 CA CA002153268A patent/CA2153268A1/en not_active Abandoned
- 1994-01-05 JP JP6516280A patent/JPH08509205A/ja active Pending
- 1994-01-05 EP EP94907186A patent/EP0678016A1/en not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
BR9405698A (pt) | 1995-11-21 |
US5494901A (en) | 1996-02-27 |
AU6086194A (en) | 1994-08-15 |
EP0678016A1 (en) | 1995-10-25 |
JPH08509205A (ja) | 1996-10-01 |
WO1994015582A1 (en) | 1994-07-21 |
CA2153268A1 (en) | 1994-07-21 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
KR960700039A (ko) | β-시클로덱스트린 유도체 및 탄산 탈수효소 저해제로 이루어진 안과용 국소 투여 조성물(Topical Compositions for the Eye Comprising a β-cyclodextrin Derivative and a Carbonic Anhydrase Inhibitor) | |
JP7432654B2 (ja) | 人工涙液、コンタクトレンズ及び薬剤担体組成物並びにその使用方法 | |
US5891913A (en) | Ophthalmic and aural compositions containing diclofenac potassium | |
ES2094688A1 (es) | Manoemulsion del tipo de aceite en agua, util como vehiculo oftalmico y procedimiento para su preparacion. | |
ATE109970T1 (de) | Cyclosporin-augenmittel. | |
JP2005521691A (ja) | シクロデキストリン化合物及び塩化セチルピリジニウムを含有する眼科用抗菌性薬物製剤 | |
ATE228125T1 (de) | Alpha-azacyclomethylchinolinderivate zur behandlung von harninkontinenz | |
JP2006501133A (ja) | 眼科学および鼻科学における適用のための薬学的組成物 | |
JP2000508646A (ja) | 眼における滞留時間の長い目薬組成物 | |
US20070166402A1 (en) | Compositions, methods and kits for removing debris from an ocular area | |
EP0280797A2 (en) | Medicaments for treatment of ocular inflammation | |
US5435998A (en) | Treatment of low-tension glaucoma by topical administration of calcium channel blocking agents | |
JP2005513106A (ja) | ヘパリンを保有する眼薬剤 | |
NL8005998A (nl) | Anti-acnemiddel. | |
JP5532609B2 (ja) | 眼科用組成物及び刺激緩和剤 | |
CA2487332C (en) | Quaternised ammonium cyclodextrin compounds for use as antimicrobial agents, preservatives and penetration enhancers | |
US5200180A (en) | Pharmaceutical composition for the treatment of the human eye | |
EP0308460B1 (en) | A composition for the topical treatment of glaucoma or ocular hypertension | |
JP4849288B2 (ja) | 点眼剤及び涙液膜の安定化剤 | |
KR970701044A (ko) | 콜린에스테라제 활성제 | |
KR940013505A (ko) | 항 알레르기 점안제 | |
JP2007070350A (ja) | 眼粘膜適用製剤 | |
DE69123580T2 (de) | Verwendung von antagonisten des plättchen-aktivierenden faktors bei pruritus | |
JP2006089460A (ja) | 眼科用粘稠化剤 | |
KR920019767A (ko) | 티아졸 유도체 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
WITN | Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid |