KR920019767A - 티아졸 유도체 - Google Patents
티아졸 유도체 Download PDFInfo
- Publication number
- KR920019767A KR920019767A KR1019920006892A KR920006892A KR920019767A KR 920019767 A KR920019767 A KR 920019767A KR 1019920006892 A KR1019920006892 A KR 1019920006892A KR 920006892 A KR920006892 A KR 920006892A KR 920019767 A KR920019767 A KR 920019767A
- Authority
- KR
- South Korea
- Prior art keywords
- group
- pharmaceutically acceptable
- acceptable salt
- hydrogen atom
- lower alkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/40—Unsubstituted amino or imino radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/48—Acylated amino or imino radicals by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof, e.g. carbonylguanidines
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (7)
- 하기 일반식(1)로 표시되는 티아졸 유도체 또는 그의 약제학적으로 허용되는 염.식중, A는 단일결합, 직쇄 또는 분지쇄 저급 알킬렌기 또는 직쇄 또는 분지쇄 저급 알케닐렌기이고, B는 단일 결합 또는 -CO-이며, R1은 카르복시기 또는 -CON(R7)OR8(식중, R7및 R8은 각각 독립적으로 수소원자 또는 저급알킬기이다)이고, R2는 저급알킬기이며, R3및 R4는 각각 독립적으로 수소원자, 저급알킬기 또는 저급알콕시 카르보닐기고, R5는 수소원자 또는 할로겐원자이며, R6는 수소원자, 할로겐원자, 저급알킬기, 히드록시기, 저급알콕시기, 티올기, 저급알킬티오기, 저급알킬술피닐기, 저급알킬술포닐기, 니트로기, 아미노기, 치환된 아미노기, 시아노기, 카르복시기 또는 아실기이다.
- 제1항에 있어서, R1이 카르복시기인 티아졸유도체 또는 그의 약제학적으로 허용되는 염.
- 제1항에 있어서, R1이 카르복시기이고, R3및 R4는 각각 독립적으로 수소원자 또는 저급알킬기이며, R6는 수소원자, 카르복시기 또는 할로겐원자인 티아졸 유도체 또는 그의 약제학적으로 허용되는 염.
- 제1항에 있어서, A가 단일결합이고 R1은 카르복시기이며, R3는 저급알킬기이고 R4는 수소원자이며, R6는 수소원자 또는 할로겐원자인 티아졸 유도체 또는 그의 약제학적으로 허용되는 염.
- 유효성분으로서 제1항에 정의된 하나 이상의 화합물 또는 그의 약제학적으로 허용되는 염의 약제학적 유효량, 및 하나 이상의 약제학적으로 허용되는 비활성 담체 또는 희석제를 함유하는, 자기 면역 질환 및 염증성 질환이 치료 및 예방을 위한 약제학적 조성물.
- 제1항에 정의된 하나 이상의 화합물 또는 그의 약제학적으로 허용되는 염의 약제학적 유효량을 사람에게 투여하는 것을 특징으로 하는, 자기 면역 질환 또는 염증성 질환의 치료 또는 예방방법.
- 제1항에 따르는 화합물 및 약제학적으로 허용되는 염의, 자기 면역 질환 또는 염증성 질환의 치료 및 예방약으로서의 용도.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP91-122078 | 1991-04-24 | ||
JP12207891 | 1991-04-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
KR920019767A true KR920019767A (ko) | 1992-11-19 |
Family
ID=14827113
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019920006892A KR920019767A (ko) | 1991-04-24 | 1992-04-23 | 티아졸 유도체 |
Country Status (6)
Country | Link |
---|---|
US (1) | US5258396A (ko) |
EP (1) | EP0511021A1 (ko) |
KR (1) | KR920019767A (ko) |
AU (1) | AU644281B2 (ko) |
CA (1) | CA2066506A1 (ko) |
MX (1) | MX9201931A (ko) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ITMI20010395A1 (it) | 2001-02-27 | 2002-08-27 | Dompe Spa | Omega-amminoalchilammidi di acidi r-2-aril-propionici come inibitori della chemiotassi di cellule polimorfonucleate e mononucleate |
PT1581474E (pt) | 2002-12-10 | 2008-12-09 | Dompe Spa | Arilcetonas quirais no tratamento de doenças inflamatórias dependentes de neutrófilos |
CN101918389A (zh) * | 2007-11-02 | 2010-12-15 | 梅特希尔基因公司 | 组蛋白脱乙酰酶抑制剂 |
US10377697B2 (en) * | 2015-12-10 | 2019-08-13 | Novartis Ag | Process and intermediates |
CN105924355B (zh) * | 2016-05-11 | 2018-08-17 | 浙江宏元药业有限公司 | 沙库比曲中间体及沙库比曲中间体和沙库比曲的制备方法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE795907A (fr) * | 1972-02-25 | 1973-06-18 | Luso Farmaco Inst | 2-amino-4-arylthiazoles 5-substitues et leur preparation |
US4006241A (en) * | 1972-06-23 | 1977-02-01 | Schering Aktiengesellschaft | Certain halothien-2-yl 5-nitrothiazol-2-yl ketones and fungicidal composition |
US4308391A (en) * | 1979-10-01 | 1981-12-29 | Monsanto Company | 2-Amino-4-substituted-thiazolecarboxylic acids and their derivatives |
US5000775A (en) * | 1985-12-31 | 1991-03-19 | Monsanto Company | 2-amino-4,5-disubstituted-oxazole/thiazole compounds as herbicide antidotes |
US4914112A (en) * | 1986-06-03 | 1990-04-03 | Sumitomo Pharmaceuticals Company, Limited | Aminoazole derivatives and their production and use |
DE3905119A1 (de) * | 1989-02-20 | 1990-08-23 | Bayer Ag | Substituierte acrylsaeureester |
TW205041B (ko) * | 1989-08-07 | 1993-05-01 | Fujisawa Pharmaceutical Co |
-
1992
- 1992-04-16 AU AU14963/92A patent/AU644281B2/en not_active Ceased
- 1992-04-21 CA CA002066506A patent/CA2066506A1/en not_active Abandoned
- 1992-04-21 US US07/871,800 patent/US5258396A/en not_active Expired - Fee Related
- 1992-04-23 KR KR1019920006892A patent/KR920019767A/ko not_active Application Discontinuation
- 1992-04-24 EP EP92303750A patent/EP0511021A1/en not_active Withdrawn
- 1992-04-24 MX MX9201931A patent/MX9201931A/es unknown
Also Published As
Publication number | Publication date |
---|---|
MX9201931A (es) | 1992-11-01 |
US5258396A (en) | 1993-11-02 |
AU1496392A (en) | 1992-10-29 |
CA2066506A1 (en) | 1992-10-25 |
AU644281B2 (en) | 1993-12-02 |
EP0511021A1 (en) | 1992-10-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
WITN | Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid |