KR940003937A - 신규한 이소부틸-치환 메탄술포닐 퀴놀릴메톡시페닐-시클로알킬아세트아미드 - Google Patents
신규한 이소부틸-치환 메탄술포닐 퀴놀릴메톡시페닐-시클로알킬아세트아미드 Download PDFInfo
- Publication number
- KR940003937A KR940003937A KR1019930015521A KR930015521A KR940003937A KR 940003937 A KR940003937 A KR 940003937A KR 1019930015521 A KR1019930015521 A KR 1019930015521A KR 930015521 A KR930015521 A KR 930015521A KR 940003937 A KR940003937 A KR 940003937A
- Authority
- KR
- South Korea
- Prior art keywords
- enantiomers
- quinolylmethoxyphenyl
- isobutyl
- general formula
- cycloalkylacetamide
- Prior art date
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-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D215/14—Radicals substituted by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pulmonology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Quinoline Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
본 발명은 대응하는 라세미산 또는 거울상 이성질체 산을 메탄술폰아미드와 반응시키고, 생성되는 최종 라세미 화합물을 통상적인 방법으로 거울상 이성질체로 분리시킬 수 있는 방법으로 제조될 수 있는 신규한 이소부틸-치환 메탄술포닐-퀴놀릴메톡시페닐-시클로알킬아세트아미드에 관한 것이다. 이소부틸-치환 메탄술포닐-퀴놀릴메톡시페닐-시클로알킬아세트아미드는 리폭시게나아제 억제 작용이 있으므로 이에 연루된 질환의 치료용 의약의 활성 화합물로서 사용될 수 있다.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (10)
- 하기 일반식의 신규한 이소부틸-치환 메탄술포닐-퀴놀릴메톡시페닐-시클로알킬아세트아미드 및 그의 염.상기 식 중, R¹은 시클로헥실, 시클로펜틸 또는 시클로헵틸이며, R1이 시클로헥실인 경우 화합물은 라세메이트 및 거울상 이성질체이고 R¹이 시클로펜틸 또는 시클로헵틸인 경우 화합물은 거울상 이성질체이다.
- 하기 일반식의 화합물의 라세메이트, (+)-거울상 이성질체 및 (-)-거울상 이성질체 및 그의 염
- 하기 일반식의 화합물의 (+)-거울상 이성질체 및 (-)-거울상 이성질체 및 그의 염.
- 하기 일반식의 화합물의 (+)-거울상 이성질체 및 (-)-거울상 이성질체 및 그의 염.
- 치료적 용도의 제1항에 따른 신규한 이소부틸-치환 메탄술포닐-퀴놀릴메톡시 페닐-시클로알킬아세트아미드.
- 하기 일반식(Ⅱ)의 카르복실산을, 불활성 용매중의 염기 및 (또는) 촉매의 존재하에, 적절한 경우 예비 활성화 과정을 거럭 하기 일반식(Ⅲ)외 메탄술폰아미드와 반응시키고, 목적 물질이 거울상 이성질체인 경우, 직접 순수한 거울상 이성질체 산(Ⅱ)을 사용하거나 또는 라세메이트를 통상의 방법으로 분리하는 것을 특징으로 하는 제1항에 따른 신규한 이소부틸-치환 메탄술포닐-퀴놀릴메톡시페닐-시클로알킬아세트아미드의 제조 방법.H2N-SO2-CH3(Ⅲ)식 중, R1은 제1항에 정의한 바와 같다.
- 제6항에 있어서, 거울상 이성질체를 칼럼 크로마토그래피에 의해 분리하는 것을 특징으로 하는 방법.
- 제1항에 따른 이소부틸-치환 메탄술포닐-퀴놀릴메톡시페닐-시클로알킬아세트아미드 1종 이상을 함유하는 의약.
- 제1항에 따른 이소부틸-치환 메탄술포닐-퀴놀릴메톡시페닐-시클로알킬아세트아미드의 의약의 제조를 위한 용도.
- 제9항에 있어서, 리폭시게나아제-억제 의약의 제조를 위한 용도.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4226649A DE4226649A1 (de) | 1992-08-12 | 1992-08-12 | Neue isobutylsubstituierte Methansulfonyl-chinolylmethoxyphenyl-cycloalkylessigsäureaminole |
DEP420260649.1 | 1992-08-12 |
Publications (1)
Publication Number | Publication Date |
---|---|
KR940003937A true KR940003937A (ko) | 1994-03-14 |
Family
ID=6465373
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019930015521A KR940003937A (ko) | 1992-08-12 | 1993-08-11 | 신규한 이소부틸-치환 메탄술포닐 퀴놀릴메톡시페닐-시클로알킬아세트아미드 |
Country Status (19)
Country | Link |
---|---|
EP (1) | EP0582916A1 (ko) |
JP (1) | JPH06157462A (ko) |
KR (1) | KR940003937A (ko) |
CN (1) | CN1039998C (ko) |
AU (1) | AU669913B2 (ko) |
CA (1) | CA2103600A1 (ko) |
CZ (1) | CZ282341B6 (ko) |
DE (1) | DE4226649A1 (ko) |
FI (1) | FI933529A (ko) |
HU (1) | HUT70171A (ko) |
IL (1) | IL106623A0 (ko) |
MX (1) | MX9304608A (ko) |
MY (1) | MY108716A (ko) |
NO (1) | NO179948C (ko) |
NZ (1) | NZ248350A (ko) |
PL (1) | PL174102B1 (ko) |
RU (1) | RU2103261C1 (ko) |
SK (1) | SK86693A3 (ko) |
ZA (1) | ZA935828B (ko) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4443892A1 (de) * | 1994-12-09 | 1996-06-13 | Bayer Ag | 4-(Chinolin-2-yl-methoxy)-phenyl-essigsäurederivate |
DE4443891A1 (de) | 1994-12-09 | 1996-06-13 | Bayer Ag | Heterocyclisch substituierte Oxy-phenyl-(phenyl)glycinolamide |
US5931170A (en) * | 1998-10-08 | 1999-08-03 | Addway Engineering Limited | Dental flosser |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3814504A1 (de) * | 1988-04-29 | 1989-11-09 | Bayer Ag | (alpha)-substituierte 4-(chinolin-2-yl-methoxy)phenylessigsaeuren und -ester, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln |
DE3900261A1 (de) * | 1988-05-31 | 1989-12-07 | Bayer Ag | Substituierte 4-(chinolin-2-yl-methoxy) phenyl-essigsaeure-derivate |
DE3916663A1 (de) * | 1989-05-23 | 1990-11-29 | Bayer Ag | Substituierte (chinolin-2-yl-methoxy)phenyl-acyl-sulfonamide und -cyanamide, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln |
DE4105551A1 (de) * | 1991-02-22 | 1992-08-27 | Bayer Ag | 2-substituierte chinoline, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln |
DE4112533A1 (de) * | 1991-04-17 | 1992-10-22 | Bayer Ag | Verfahren zur herstellung von enantiomerenreinen substituierten (chinolin-2-yl-methoxy)phenyl-essigsaeuren |
-
1992
- 1992-08-12 DE DE4226649A patent/DE4226649A1/de not_active Withdrawn
-
1993
- 1993-07-28 AU AU44255/93A patent/AU669913B2/en not_active Ceased
- 1993-07-29 NO NO932731A patent/NO179948C/no unknown
- 1993-07-30 EP EP93112258A patent/EP0582916A1/de not_active Withdrawn
- 1993-07-30 MX MX9304608A patent/MX9304608A/es unknown
- 1993-08-06 JP JP5213583A patent/JPH06157462A/ja active Pending
- 1993-08-09 CA CA002103600A patent/CA2103600A1/en not_active Abandoned
- 1993-08-09 NZ NZ248350A patent/NZ248350A/en unknown
- 1993-08-09 IL IL106623A patent/IL106623A0/xx unknown
- 1993-08-10 PL PL93300025A patent/PL174102B1/pl unknown
- 1993-08-10 CZ CZ931636A patent/CZ282341B6/cs unknown
- 1993-08-10 FI FI933529A patent/FI933529A/fi not_active Application Discontinuation
- 1993-08-10 SK SK866-93A patent/SK86693A3/sk unknown
- 1993-08-11 ZA ZA935828A patent/ZA935828B/xx unknown
- 1993-08-11 KR KR1019930015521A patent/KR940003937A/ko not_active Application Discontinuation
- 1993-08-11 RU RU93049257A patent/RU2103261C1/ru active
- 1993-08-11 HU HU9302320A patent/HUT70171A/hu unknown
- 1993-08-11 MY MYPI93001599A patent/MY108716A/en unknown
- 1993-08-12 CN CN93116502A patent/CN1039998C/zh not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
AU669913B2 (en) | 1996-06-27 |
DE4226649A1 (de) | 1994-02-17 |
IL106623A0 (en) | 1993-12-08 |
NO179948C (no) | 1997-01-15 |
FI933529A0 (fi) | 1993-08-10 |
MX9304608A (es) | 1994-02-28 |
PL174102B1 (pl) | 1998-06-30 |
RU2103261C1 (ru) | 1998-01-27 |
CZ163693A3 (en) | 1994-03-16 |
CA2103600A1 (en) | 1994-02-13 |
NZ248350A (en) | 1994-12-22 |
MY108716A (en) | 1996-11-30 |
SK86693A3 (en) | 1994-09-07 |
FI933529A (fi) | 1994-02-13 |
NO932731D0 (no) | 1993-07-29 |
HU9302320D0 (en) | 1993-10-28 |
CN1087084A (zh) | 1994-05-25 |
NO179948B (no) | 1996-10-07 |
JPH06157462A (ja) | 1994-06-03 |
AU4425593A (en) | 1994-02-17 |
ZA935828B (en) | 1994-03-10 |
EP0582916A1 (de) | 1994-02-16 |
CN1039998C (zh) | 1998-09-30 |
CZ282341B6 (cs) | 1997-07-16 |
HUT70171A (en) | 1995-09-28 |
NO932731L (no) | 1994-02-14 |
PL300025A1 (en) | 1994-03-21 |
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