KR940001372B1 - 안정한 인터페론 복합체 - Google Patents

안정한 인터페론 복합체 Download PDF

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Publication number
KR940001372B1
KR940001372B1 KR1019880701321A KR880701321A KR940001372B1 KR 940001372 B1 KR940001372 B1 KR 940001372B1 KR 1019880701321 A KR1019880701321 A KR 1019880701321A KR 880701321 A KR880701321 A KR 880701321A KR 940001372 B1 KR940001372 B1 KR 940001372B1
Authority
KR
South Korea
Prior art keywords
interferon
zinc
protamine
complex
glycine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
KR1019880701321A
Other languages
English (en)
Korean (ko)
Other versions
KR890700359A (ko
Inventor
임 재커리
에이. 주폰 마이클
에이. 쳐드리 임티아츠
Original Assignee
쉐링 코포레이션
스테이너 브이. 칸스태드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 쉐링 코포레이션, 스테이너 브이. 칸스태드 filed Critical 쉐링 코포레이션
Publication of KR890700359A publication Critical patent/KR890700359A/ko
Application granted granted Critical
Publication of KR940001372B1 publication Critical patent/KR940001372B1/ko
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A61K38/212—IFN-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Inorganic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
KR1019880701321A 1987-02-24 1988-02-23 안정한 인터페론 복합체 Expired - Fee Related KR940001372B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US07/018,243 US4853218A (en) 1987-02-24 1987-02-24 Zinc-protamine-alpha interferon complex
US018243 1987-02-24
PCT/US1988/000410 WO1988006456A1 (en) 1987-02-24 1988-02-23 Stable interferon complexes

Publications (2)

Publication Number Publication Date
KR890700359A KR890700359A (ko) 1989-04-24
KR940001372B1 true KR940001372B1 (ko) 1994-02-21

Family

ID=21786960

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019880701321A Expired - Fee Related KR940001372B1 (ko) 1987-02-24 1988-02-23 안정한 인터페론 복합체

Country Status (23)

Country Link
US (1) US4853218A (enExample)
EP (2) EP0281299B1 (enExample)
JP (1) JPH0611712B2 (enExample)
KR (1) KR940001372B1 (enExample)
AT (1) ATE76580T1 (enExample)
AU (1) AU608584B2 (enExample)
CA (1) CA1316105C (enExample)
DE (1) DE3871407D1 (enExample)
DK (1) DK167048B1 (enExample)
ES (1) ES2032009T3 (enExample)
FI (1) FI93309C (enExample)
GR (1) GR3005358T3 (enExample)
HU (1) HU201881B (enExample)
IE (1) IE61340B1 (enExample)
IL (1) IL85523A (enExample)
MX (1) MX9203328A (enExample)
MY (1) MY103212A (enExample)
NO (1) NO173279C (enExample)
NZ (1) NZ223598A (enExample)
OA (1) OA09737A (enExample)
PT (1) PT86810B (enExample)
WO (1) WO1988006456A1 (enExample)
ZA (1) ZA881258B (enExample)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5028422A (en) * 1986-05-27 1991-07-02 Schering Corporation Treatment of basal cell carcinoma intralesionally with recombinant human alpha interferon
CA1295243C (en) * 1986-05-27 1992-02-04 Daniel J. Tanner Treatment of basal cell carcinoma intralesionally with recombinant human alpha interferon
ATE90205T1 (de) * 1987-09-08 1993-06-15 Takeda Chemical Industries Ltd Wasserunloesliche cytokine.
MX9203319A (es) * 1990-06-04 1992-07-31 Schering Corp Metodo para la preparacion de cristales de alfa-2 interferona.
US5912015A (en) * 1992-03-12 1999-06-15 Alkermes Controlled Therapeutics, Inc. Modulated release from biocompatible polymers
US6514533B1 (en) 1992-06-11 2003-02-04 Alkermas Controlled Therapeutics, Inc. Device for the sustained release of aggregation-stabilized, biologically active agent
US5711968A (en) * 1994-07-25 1998-01-27 Alkermes Controlled Therapeutics, Inc. Composition and method for the controlled release of metal cation-stabilized interferon
JPH08503950A (ja) * 1992-12-02 1996-04-30 アルカーメス・コントロールド・セラピユーテイクス・インコーポレーテツド 徐放性成長ホルモン含有マイクロスフェア
US5441734A (en) * 1993-02-25 1995-08-15 Schering Corporation Metal-interferon-alpha crystals
US6087324A (en) 1993-06-24 2000-07-11 Takeda Chemical Industries, Ltd. Sustained-release preparation
AU706180B2 (en) * 1994-07-25 1999-06-10 Alkermes Controlled Therapeutics, Inc. Controlled release of metal cation-stabilized interferon
US5904935A (en) * 1995-06-07 1999-05-18 Alza Corporation Peptide/protein suspending formulations
JP3837769B2 (ja) * 1995-06-12 2006-10-25 大塚製薬株式会社 抗ウイルス剤
AU710347B2 (en) * 1995-08-31 1999-09-16 Alkermes Controlled Therapeutics, Inc. Composition for sustained release of an agent
ES2256898T3 (es) * 1996-12-20 2006-07-16 Alza Corporation Composicion de gel y procedimientos.
US6465425B1 (en) 2000-02-10 2002-10-15 Alkermes Controlled Therapeutics, Inc. Microencapsulation and sustained release of biologically active acid-stable or free sulfhydryl-containing proteins
US20030211974A1 (en) * 2000-03-21 2003-11-13 Brodbeck Kevin J. Gel composition and methods
US20070196415A1 (en) * 2002-11-14 2007-08-23 Guohua Chen Depot compositions with multiple drug release rate controls and uses thereof
WO2003041684A2 (en) * 2001-11-14 2003-05-22 Alza Corporation Injectable depot compositions and uses thereof
CN100446809C (zh) * 2001-11-14 2008-12-31 阿尔扎有限公司 可注射的长效组合物
MXPA04004665A (es) * 2001-11-14 2004-09-10 Alza Corp Composiciones de deposito inyectable y uso de los mismos.
US20040001889A1 (en) * 2002-06-25 2004-01-01 Guohua Chen Short duration depot formulations
TWI353854B (en) 2002-06-25 2011-12-11 Alza Corp Short duration depot formulations
CA2494342A1 (en) * 2002-07-31 2004-02-12 Alza Corporation Injectable depot compositions and uses thereof
US8501215B2 (en) 2002-07-31 2013-08-06 Guohua Chen Injectable multimodal polymer depot compositions and uses thereof
DE60325511D1 (de) * 2002-11-06 2009-02-05 Alza Corp Depot-formulierungen mit verzögerter freisetzung
DK1581251T3 (da) * 2002-12-31 2016-06-27 Althea Tech Inc Krystaller af humant væksthormon og fremgangsmåder til fremstilling deraf
NZ554885A (en) * 2002-12-31 2009-07-31 Altus Pharmaceuticals Inc Complexes of hgh crystals and protamine polymers
US20070184084A1 (en) * 2003-05-30 2007-08-09 Guohua Chen Implantable elastomeric caprolactone depot compositions and uses thereof
EP1643968A1 (en) * 2003-05-30 2006-04-12 ALZA Corporation Implantable elastomeric depot compositions, uses thereof and method of manufacturing
US20050106214A1 (en) * 2003-11-14 2005-05-19 Guohua Chen Excipients in drug delivery vehicles
US20050281879A1 (en) * 2003-11-14 2005-12-22 Guohua Chen Excipients in drug delivery vehicles
US7812049B2 (en) * 2004-01-22 2010-10-12 Vicept Therapeutics, Inc. Method and therapeutic/cosmetic topical compositions for the treatment of rosacea and skin erythema using α1-adrenoceptor agonists
US20060142234A1 (en) * 2004-12-23 2006-06-29 Guohua Chen Injectable non-aqueous suspension
JP2009521486A (ja) * 2005-12-23 2009-06-04 アルタス ファーマシューティカルズ インコーポレイテッド ポリカチオン錯化タンパク質結晶を含む組成物およびこれを使用した治療法
US7753078B2 (en) 2007-04-19 2010-07-13 Husco International Inc. Hybrid hydraulic joystick with an integral pressure sensor and an outlet port
US7753077B2 (en) 2007-04-19 2010-07-13 Husco International Inc. Hybrid hydraulic joystick for electrically operating valves
JP4889782B2 (ja) * 2008-12-24 2012-03-07 株式会社マルハニチロ食品 プロタミン及び／またはその塩と酸性高分子化合物とを含む生理活性複合体及びその用途
US9050370B2 (en) 2009-01-28 2015-06-09 Smartcells, Inc. Conjugate based systems for controlled drug delivery
CA2812102A1 (en) * 2010-11-24 2012-06-07 Durect Corporation Biodegradable drug delivery composition
EP3079668A1 (en) 2013-12-09 2016-10-19 Durect Corporation Pharmaceutically active agent complexes, polymer complexes, and compositions and methods involving the same
EP4090353A4 (en) 2020-01-13 2023-08-09 Durect Corporation DELAYED-RELEASE DRUG DELIVERY SYSTEMS WITH REDUCED IMPURITIES AND RELATED PROCEDURES
JP2024503402A (ja) 2021-01-12 2024-01-25 デュレクト コーポレーション 徐放性薬物送達システム及び関連の方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1282504A (fr) * 1954-06-03 1962-01-27 Novo Terapeutisk Labor As Procédé de production de suspensions stables d'insuline zinc-protamine
US3912807A (en) * 1974-04-18 1975-10-14 American Home Prod Treatment of diabetes using somatostatin and insulin
IN150740B (enExample) * 1978-11-24 1982-12-04 Hoffmann La Roche
EP0032134B2 (en) * 1980-01-08 1993-10-13 Biogen, Inc. Dna sequences, recombinant dna molecules and processes for producing human interferon-alpha like polypeptides
ES506955A0 (es) * 1980-11-10 1983-02-01 Genentech Inc Un procedimiento para producir un polipeptido antiviral.
EP0082481B2 (en) * 1981-12-23 1990-09-12 Schering Corporation Stabilised alpha-interferon formulations and their preparation
US4605555A (en) * 1984-09-20 1986-08-12 Sun Star Kabushiki Kaisha Composition and method for treating keratosic disorder of skin and mucosa

Also Published As

Publication number Publication date
IL85523A (en) 1992-11-15
MX9203328A (es) 1992-07-01
NO173279C (no) 1993-11-24
IL85523A0 (en) 1988-08-31
NZ223598A (en) 1989-12-21
ATE76580T1 (de) 1992-06-15
EP0375678A1 (en) 1990-07-04
NO884596L (no) 1988-10-14
DK167048B1 (da) 1993-08-23
OA09737A (en) 1993-11-30
US4853218A (en) 1989-08-01
DK582188A (da) 1988-10-19
FI93309B (fi) 1994-12-15
ZA881258B (en) 1988-08-23
AU608584B2 (en) 1991-04-11
IE61340B1 (en) 1994-11-02
EP0281299A1 (en) 1988-09-07
FI93309C (fi) 1995-03-27
FI893929L (fi) 1989-08-22
GR3005358T3 (enExample) 1993-05-24
WO1988006456A1 (en) 1988-09-07
PT86810B (pt) 1992-05-29
JPH03500286A (ja) 1991-01-24
JPH0611712B2 (ja) 1994-02-16
ES2032009T3 (es) 1993-01-01
KR890700359A (ko) 1989-04-24
HU201881B (en) 1991-01-28
FI893929A0 (fi) 1989-08-22
IE880480L (en) 1988-08-24
DK582188D0 (da) 1988-10-19
NO173279B (no) 1993-08-16
AU1394688A (en) 1988-09-26
DE3871407D1 (de) 1992-07-02
PT86810A (pt) 1988-03-01
HUT51902A (en) 1990-06-28
NO884596D0 (no) 1988-10-14
CA1316105C (en) 1993-04-13
EP0281299B1 (en) 1992-05-27
MY103212A (en) 1993-05-29

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