KR940001372B1 - 안정한 인터페론 복합체 - Google Patents

안정한 인터페론 복합체 Download PDF

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Publication number
KR940001372B1
KR940001372B1 KR1019880701321A KR880701321A KR940001372B1 KR 940001372 B1 KR940001372 B1 KR 940001372B1 KR 1019880701321 A KR1019880701321 A KR 1019880701321A KR 880701321 A KR880701321 A KR 880701321A KR 940001372 B1 KR940001372 B1 KR 940001372B1
Authority
KR
South Korea
Prior art keywords
interferon
zinc
protamine
complex
glycine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
KR1019880701321A
Other languages
English (en)
Korean (ko)
Other versions
KR890700359A (ko
Inventor
임 재커리
에이. 주폰 마이클
에이. 쳐드리 임티아츠
Original Assignee
쉐링 코포레이션
스테이너 브이. 칸스태드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 쉐링 코포레이션, 스테이너 브이. 칸스태드 filed Critical 쉐링 코포레이션
Publication of KR890700359A publication Critical patent/KR890700359A/ko
Application granted granted Critical
Publication of KR940001372B1 publication Critical patent/KR940001372B1/ko
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A61K38/212—IFN-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Inorganic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
KR1019880701321A 1987-02-24 1988-02-23 안정한 인터페론 복합체 Expired - Fee Related KR940001372B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US018243 1987-02-24
US07/018,243 US4853218A (en) 1987-02-24 1987-02-24 Zinc-protamine-alpha interferon complex
PCT/US1988/000410 WO1988006456A1 (en) 1987-02-24 1988-02-23 Stable interferon complexes

Publications (2)

Publication Number Publication Date
KR890700359A KR890700359A (ko) 1989-04-24
KR940001372B1 true KR940001372B1 (ko) 1994-02-21

Family

ID=21786960

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019880701321A Expired - Fee Related KR940001372B1 (ko) 1987-02-24 1988-02-23 안정한 인터페론 복합체

Country Status (23)

Country Link
US (1) US4853218A (enExample)
EP (2) EP0281299B1 (enExample)
JP (1) JPH0611712B2 (enExample)
KR (1) KR940001372B1 (enExample)
AT (1) ATE76580T1 (enExample)
AU (1) AU608584B2 (enExample)
CA (1) CA1316105C (enExample)
DE (1) DE3871407D1 (enExample)
DK (1) DK167048B1 (enExample)
ES (1) ES2032009T3 (enExample)
FI (1) FI93309C (enExample)
GR (1) GR3005358T3 (enExample)
HU (1) HU201881B (enExample)
IE (1) IE61340B1 (enExample)
IL (1) IL85523A (enExample)
MX (1) MX9203328A (enExample)
MY (1) MY103212A (enExample)
NO (1) NO173279C (enExample)
NZ (1) NZ223598A (enExample)
OA (1) OA09737A (enExample)
PT (1) PT86810B (enExample)
WO (1) WO1988006456A1 (enExample)
ZA (1) ZA881258B (enExample)

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US5028422A (en) * 1986-05-27 1991-07-02 Schering Corporation Treatment of basal cell carcinoma intralesionally with recombinant human alpha interferon
DK264787A (da) * 1986-05-27 1987-11-28 Schering Corp Anvendelse af humant alfa-interferon til fremstilling af et pharmaceutisk praeparat
ATE90205T1 (de) * 1987-09-08 1993-06-15 Takeda Chemical Industries Ltd Wasserunloesliche cytokine.
CA2084406A1 (en) * 1990-06-04 1991-12-05 Paul Reichert Method for preparing interferon alpha-2 crystals
US5912015A (en) 1992-03-12 1999-06-15 Alkermes Controlled Therapeutics, Inc. Modulated release from biocompatible polymers
US5711968A (en) * 1994-07-25 1998-01-27 Alkermes Controlled Therapeutics, Inc. Composition and method for the controlled release of metal cation-stabilized interferon
US6514533B1 (en) 1992-06-11 2003-02-04 Alkermas Controlled Therapeutics, Inc. Device for the sustained release of aggregation-stabilized, biologically active agent
EP1013270A3 (en) * 1992-12-02 2001-03-28 Alkermes Controlled Therapeutics, Inc. Controlled release growth hormone containing microspheres
US5441734A (en) * 1993-02-25 1995-08-15 Schering Corporation Metal-interferon-alpha crystals
US6087324A (en) * 1993-06-24 2000-07-11 Takeda Chemical Industries, Ltd. Sustained-release preparation
AU706180B2 (en) * 1994-07-25 1999-06-10 Alkermes Controlled Therapeutics, Inc. Controlled release of metal cation-stabilized interferon
US5904935A (en) * 1995-06-07 1999-05-18 Alza Corporation Peptide/protein suspending formulations
JP3837769B2 (ja) * 1995-06-12 2006-10-25 大塚製薬株式会社 抗ウイルス剤
WO1997007788A2 (en) * 1995-08-31 1997-03-06 Alkermes Controlled Therapeutics, Inc. Composition for sustained release of an agent
CN1146402C (zh) * 1996-12-20 2004-04-21 阿尔萨公司 凝胶组合物及方法
US6465425B1 (en) 2000-02-10 2002-10-15 Alkermes Controlled Therapeutics, Inc. Microencapsulation and sustained release of biologically active acid-stable or free sulfhydryl-containing proteins
US20030211974A1 (en) * 2000-03-21 2003-11-13 Brodbeck Kevin J. Gel composition and methods
CA2466632C (en) * 2001-11-14 2014-02-11 Alza Corporation Injectable depot compositions and uses thereof
US20070196415A1 (en) * 2002-11-14 2007-08-23 Guohua Chen Depot compositions with multiple drug release rate controls and uses thereof
AU2002359407B2 (en) * 2001-11-14 2008-02-28 Durect Corporation Catheter injectable depot compositions and uses thereof
CA2466642C (en) * 2001-11-14 2011-01-18 Guohua Chen Injectable depot composition
TWI353854B (en) 2002-06-25 2011-12-11 Alza Corp Short duration depot formulations
US20040001889A1 (en) * 2002-06-25 2004-01-01 Guohua Chen Short duration depot formulations
ES2319400T3 (es) * 2002-07-31 2009-05-07 Durect Corporation Composiciones deposito inyectables y empleo de las mismas.
ATE419831T1 (de) 2002-07-31 2009-01-15 Alza Corp Injizierbare multimodale polymere depotzusammensetzungen und ihre verwendungen
DE60325511D1 (de) * 2002-11-06 2009-02-05 Alza Corp Depot-formulierungen mit verzögerter freisetzung
WO2004060920A1 (en) * 2002-12-31 2004-07-22 Altus Pharmaceuticals Inc. Complexes of protein crystals and ionic polymers
JP4686361B2 (ja) * 2002-12-31 2011-05-25 アルタス ファーマシューティカルズ インコーポレイテッド ヒト成長ホルモンの結晶およびその調製方法
CN1822816A (zh) * 2003-05-30 2006-08-23 阿尔萨公司 可植入的弹性体储库组合物、其用途以及制备方法
US20070184084A1 (en) * 2003-05-30 2007-08-09 Guohua Chen Implantable elastomeric caprolactone depot compositions and uses thereof
US20050106214A1 (en) * 2003-11-14 2005-05-19 Guohua Chen Excipients in drug delivery vehicles
US20050281879A1 (en) * 2003-11-14 2005-12-22 Guohua Chen Excipients in drug delivery vehicles
US7812049B2 (en) * 2004-01-22 2010-10-12 Vicept Therapeutics, Inc. Method and therapeutic/cosmetic topical compositions for the treatment of rosacea and skin erythema using α1-adrenoceptor agonists
US20060142234A1 (en) * 2004-12-23 2006-06-29 Guohua Chen Injectable non-aqueous suspension
JP2009521486A (ja) * 2005-12-23 2009-06-04 アルタス ファーマシューティカルズ インコーポレイテッド ポリカチオン錯化タンパク質結晶を含む組成物およびこれを使用した治療法
US7753077B2 (en) 2007-04-19 2010-07-13 Husco International Inc. Hybrid hydraulic joystick for electrically operating valves
US7753078B2 (en) 2007-04-19 2010-07-13 Husco International Inc. Hybrid hydraulic joystick with an integral pressure sensor and an outlet port
JP4889782B2 (ja) * 2008-12-24 2012-03-07 株式会社マルハニチロ食品 プロタミン及び／またはその塩と酸性高分子化合物とを含む生理活性複合体及びその用途
NZ594248A (en) * 2009-01-28 2015-03-27 Smartcells Inc Conjugate based systems for controlled drug delivery
EA026964B1 (ru) * 2010-11-24 2017-06-30 Дьюрект Корпорейшн Биоразлагаемая композиция для доставки лекарственного средства (варианты)
WO2015088990A1 (en) 2013-12-09 2015-06-18 Durect Corporation Pharmaceutically active agent complexes, polymer complexes, and compositions and methods involving the same
BR112022013784A2 (pt) 2020-01-13 2022-10-11 Durect Corp Sistemas de distribuição de fármacos de liberação prolongada com impurezas reduzidas e métodos relacionados
KR20230145053A (ko) 2021-01-12 2023-10-17 듀렉트 코퍼레이션 지속 방출 약물 전달 시스템 및 관련 방법

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1282504A (fr) * 1954-06-03 1962-01-27 Novo Terapeutisk Labor As Procédé de production de suspensions stables d'insuline zinc-protamine
US3912807A (en) * 1974-04-18 1975-10-14 American Home Prod Treatment of diabetes using somatostatin and insulin
IN150740B (enExample) * 1978-11-24 1982-12-04 Hoffmann La Roche
PH21848A (en) * 1980-01-08 1988-03-17 Biogen Nv Dna sequences and recombinant dna molecules
ES506955A0 (es) * 1980-11-10 1983-02-01 Genentech Inc Un procedimiento para producir un polipeptido antiviral.
DE3262575D1 (en) * 1981-12-23 1985-04-18 Schering Corp Stabilised interferon formulations and their preparation
US4605555A (en) * 1984-09-20 1986-08-12 Sun Star Kabushiki Kaisha Composition and method for treating keratosic disorder of skin and mucosa

Also Published As

Publication number Publication date
AU608584B2 (en) 1991-04-11
FI893929L (fi) 1989-08-22
HUT51902A (en) 1990-06-28
JPH0611712B2 (ja) 1994-02-16
OA09737A (en) 1993-11-30
DE3871407D1 (de) 1992-07-02
FI93309C (fi) 1995-03-27
KR890700359A (ko) 1989-04-24
ZA881258B (en) 1988-08-23
NO173279C (no) 1993-11-24
NO884596D0 (no) 1988-10-14
PT86810A (pt) 1988-03-01
EP0375678A1 (en) 1990-07-04
AU1394688A (en) 1988-09-26
NZ223598A (en) 1989-12-21
DK167048B1 (da) 1993-08-23
DK582188D0 (da) 1988-10-19
HU201881B (en) 1991-01-28
GR3005358T3 (enExample) 1993-05-24
IL85523A0 (en) 1988-08-31
MX9203328A (es) 1992-07-01
NO884596L (no) 1988-10-14
DK582188A (da) 1988-10-19
EP0281299A1 (en) 1988-09-07
CA1316105C (en) 1993-04-13
FI93309B (fi) 1994-12-15
WO1988006456A1 (en) 1988-09-07
EP0281299B1 (en) 1992-05-27
IL85523A (en) 1992-11-15
IE61340B1 (en) 1994-11-02
MY103212A (en) 1993-05-29
NO173279B (no) 1993-08-16
IE880480L (en) 1988-08-24
ES2032009T3 (es) 1993-01-01
FI893929A0 (fi) 1989-08-22
US4853218A (en) 1989-08-01
ATE76580T1 (de) 1992-06-15
PT86810B (pt) 1992-05-29
JPH03500286A (ja) 1991-01-24

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