KR930019655A - 종양치료 조성물 및 치료방법 - Google Patents

종양치료 조성물 및 치료방법 Download PDF

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Publication number
KR930019655A
KR930019655A KR1019930003657A KR930003657A KR930019655A KR 930019655 A KR930019655 A KR 930019655A KR 1019930003657 A KR1019930003657 A KR 1019930003657A KR 930003657 A KR930003657 A KR 930003657A KR 930019655 A KR930019655 A KR 930019655A
Authority
KR
South Korea
Prior art keywords
carbonyl
amino
chlorophenyl
sulfonamide
halo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
KR1019930003657A
Other languages
English (en)
Korean (ko)
Inventor
모하마디 파리볼쯔
매리오트 스피스 마이클
Original Assignee
리오이 휘테커
일라이 릴리 앤드 캄파니
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 리오이 휘테커, 일라이 릴리 앤드 캄파니 filed Critical 리오이 휘테커
Publication of KR930019655A publication Critical patent/KR930019655A/ko
Withdrawn legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Indole Compounds (AREA)
KR1019930003657A 1992-03-13 1993-03-11 종양치료 조성물 및 치료방법 Withdrawn KR930019655A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/850,531 US5169860A (en) 1992-03-13 1992-03-13 Antitumor compositions and methods of treatment
US850,531 1992-03-13

Publications (1)

Publication Number Publication Date
KR930019655A true KR930019655A (ko) 1993-10-18

Family

ID=25308394

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019930003657A Withdrawn KR930019655A (ko) 1992-03-13 1993-03-11 종양치료 조성물 및 치료방법

Country Status (19)

Country Link
US (1) US5169860A (enExample)
EP (1) EP0560554A2 (enExample)
JP (1) JPH0649052A (enExample)
KR (1) KR930019655A (enExample)
CN (1) CN1076447A (enExample)
AU (2) AU662605B2 (enExample)
BR (1) BR9301137A (enExample)
CA (1) CA2091207A1 (enExample)
CZ (1) CZ36893A3 (enExample)
FI (1) FI931085A7 (enExample)
HU (1) HUT63830A (enExample)
IL (1) IL104981A0 (enExample)
MX (1) MX9301296A (enExample)
MY (1) MY111178A (enExample)
NO (1) NO930891L (enExample)
NZ (1) NZ247083A (enExample)
TW (1) TW215083B (enExample)
YU (1) YU16893A (enExample)
ZA (1) ZA931645B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101300702B1 (ko) * 2011-01-20 2013-08-26 대우조선해양 주식회사 탈가스 장치

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5254582A (en) * 1992-02-05 1993-10-19 Eli Lilly And Company Antitumor compositions and methods
US5270329A (en) * 1992-12-10 1993-12-14 Eli Lilly And Company Antitumor compositions and methods of treatment
CA2110524A1 (en) * 1992-12-10 1994-06-11 Gerald Burr Grindey Antitumor compositions and methods of treatment
ZA941500B (en) * 1993-03-10 1995-09-04 Lilly Co Eli Antitumor compositions and methods of treatment
US5529999A (en) * 1994-03-04 1996-06-25 Eli Lilly And Company Antitumor compositions and methods of treatment
US5629425A (en) * 1994-09-19 1997-05-13 Eli Lilly And Company Haloalkyl hemisolvates of 6-hydroxy-2-(4-hydroxyphenyl)-3-[4-piperidinoethoxy)-benzoyl]benzo[b]thiophene
CO4410191A1 (es) 1994-09-19 1997-01-09 Lilly Co Eli SINTESIS DE 3-[4-(2-AMINOETOXI)BENZOIL]-2-ARIL-6- HIDROXIBENZO [b] TIOFENOS
US5863936A (en) * 1995-04-18 1999-01-26 Geron Corporation Telomerase inhibitors
EP0888331A4 (en) * 1996-03-19 2001-05-23 Lilly Co Eli SYNTHESIS OF 3- [4- (2-AMINOETHOXY) BENZOYL] -2-ARYL-6-HYDROXY-BENZO [b] THIOPHENES
EP1021437B1 (en) * 1996-08-22 2001-11-14 Dong Wha Pharmaceutical Industrial Co. Ltd. Arylsulfonylimidazolone derivatives as an antitumor agent
EP0929540A4 (en) * 1996-10-04 2001-12-12 Lilly Co Eli ANTI-TUMOR COMPOSITIONS AND THERAPEUTIC METHODS
JP2000247949A (ja) * 1999-02-26 2000-09-12 Eisai Co Ltd スルホンアミド含有インドール化合物
ES2156550B1 (es) * 1999-04-19 2002-02-01 Univ Navarra Publica Derivados de benzo(b) tiofenosulfonamida-1,1-dioxido y su uso como agentes antineoplasicos.
JP4505876B2 (ja) * 1999-05-25 2010-07-21 東ソー株式会社 ４−ハロベンゾフラン誘導体及びその製造方法
TWI281916B (en) * 2001-10-25 2007-06-01 Lilly Co Eli Antitumor compounds and methods
US20050119318A1 (en) * 2003-10-31 2005-06-02 Hudyma Thomas W. Inhibitors of HCV replication
CN101965186A (zh) 2007-11-28 2011-02-02 塞阔伊亚药品公司 抑制细胞色素p450 2d6的化合物和方法
CN103450149B (zh) * 2012-06-01 2015-10-14 中国科学院上海有机化学研究所 苯基噻吩磺酰胺类化合物及其制备方法和用途
CN104564805B (zh) * 2013-10-29 2017-11-10 海尔集团公司 一种离心风机的扇叶结构、离心风机及嵌入式空调内机
PE20221627A1 (es) * 2015-02-16 2022-10-19 Univ Queensland Sulfonilureas y compuestos relacionados y uso de estos
WO2017184623A1 (en) 2016-04-18 2017-10-26 Ifm Therapeutics, Inc Compounds and compositions for treating conditions associated with nlrp activity
PT3661925T (pt) 2017-07-07 2022-01-31 Inflazome Ltd Novos compostos de sulfonamida-carboxamida
EP3658539B1 (en) 2017-07-24 2024-02-21 Novartis AG Compounds and compositions for treating conditions associated with nlrp activity
WO2019034693A1 (en) 2017-08-15 2019-02-21 Inflazome Limited SULFONYLURATES AND SULFONYLTHIOURES AS INHIBITORS OF NLRP3
WO2019034692A1 (en) 2017-08-15 2019-02-21 Inflazome Limited SULFONYLURATES AND SULFONYLTHIOURES AS INHIBITORS OF NLRP3
JP2020531453A (ja) 2017-08-15 2020-11-05 インフレイゾーム リミテッド Ｎｌｒｐ３阻害剤としてのスルホニルウレアおよびスルホニルチオウレア
JP2021502364A (ja) 2017-11-09 2021-01-28 インフレイゾーム リミテッド 新規なスルホンアミドカルボキサミド化合物
US12221434B2 (en) 2017-11-09 2025-02-11 Inflazome Limited Sulfonamide carboxamide compounds
WO2019166619A1 (en) 2018-03-02 2019-09-06 Inflazome Limited Novel compounds
US20230011652A1 (en) * 2018-10-24 2023-01-12 Novartis Ag Compounds and compositions for treating conditions associated with nlrp activity
CN109384764B (zh) * 2018-12-12 2021-09-03 中国科学院上海有机化学研究所 苯基噻吩磺酰胺类化合物、药物组合物、其制备方法和应用
WO2022022646A1 (zh) * 2020-07-29 2022-02-03 南京明德新药研发有限公司 含硒五元杂芳环化合物

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3083207A (en) * 1963-03-26 Indolinesulfonylureas
DE1144259B (de) * 1956-05-29 1963-02-28 Hoechst Ag Verfahren zur Herstellung von Sulfonylharnstoffen
US3097242A (en) * 1960-06-29 1963-07-09 Olin Mathieson Hydrindene sulfonylureas
US3102121A (en) * 1961-06-29 1963-08-27 Olin Mathieson Novel cumaransulfonylureas and 2,3-dihydrothionaphthenesulfonylureas
DE1240866B (de) * 1961-06-29 1967-05-24 Heyden Chem Fab Verfahren zur Herstellung von Indolin-6-sulfonylharnstoffen
BE634577A (enExample) * 1962-04-11
US3849110A (en) * 1963-01-07 1974-11-19 Lilly Co Eli Herbicidal method employing aryl-sulfonylureas or salts thereof
US3736122A (en) * 1969-04-10 1973-05-29 C Tung Method of controlling plant growth
AU1862083A (en) * 1982-09-02 1984-03-08 Duphar International Research B.V. Tumor growth inhibitors
CA1208561A (en) * 1984-01-19 1986-07-29 Marius S. Brouwer Pharmaceutical compositions containing benzoylurea compounds
US4845128A (en) * 1984-06-27 1989-07-04 Eli Lilly And Company N([(4-trifluoromethylphenyl)amino]carbonyl)benzene sulfonamides
GR862353B (en) * 1985-09-23 1987-01-19 Lilly Co Eli Anti-tumor method and compounds
CA1331464C (en) * 1987-05-12 1994-08-16 Eli Lilly And Company Anti-tumor method and compounds
NZ238911A (en) * 1990-07-17 1993-10-26 Lilly Co Eli Furyl, pyrrolyl and thienyl sulphonyl urea derivatives, pharmaceutical compositions and intermediates therefor

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101300702B1 (ko) * 2011-01-20 2013-08-26 대우조선해양 주식회사 탈가스 장치

Also Published As

Publication number Publication date
CZ36893A3 (en) 1994-04-13
HUT63830A (en) 1993-10-28
AU4028995A (en) 1996-02-15
YU16893A (sh) 1996-07-24
FI931085A0 (fi) 1993-03-11
CA2091207A1 (en) 1993-09-14
NZ247083A (en) 1995-09-26
US5169860A (en) 1992-12-08
TW215083B (enExample) 1993-10-21
MY111178A (en) 1999-09-30
NO930891L (no) 1993-09-14
FI931085L (fi) 1993-09-14
BR9301137A (pt) 1993-09-28
HU9300688D0 (en) 1993-05-28
JPH0649052A (ja) 1994-02-22
EP0560554A2 (en) 1993-09-15
NO930891D0 (no) 1993-03-11
CN1076447A (zh) 1993-09-22
MX9301296A (es) 1993-10-01
IL104981A0 (en) 1993-07-08
AU3519893A (en) 1993-09-16
FI931085A7 (fi) 1993-09-14
ZA931645B (en) 1994-09-08
EP0560554A3 (enExample) 1994-01-19
AU662605B2 (en) 1995-09-07

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Legal Events

Date Code Title Description
PA0109 Patent application

Patent event code: PA01091R01D

Comment text: Patent Application

Patent event date: 19930311

PG1501 Laying open of application
PC1203 Withdrawal of no request for examination
WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid