KR920021555A - 비사이클릭 라파 마이신 - Google Patents

비사이클릭 라파 마이신 Download PDF

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Publication number
KR920021555A
KR920021555A KR1019920008966A KR920008966A KR920021555A KR 920021555 A KR920021555 A KR 920021555A KR 1019920008966 A KR1019920008966 A KR 1019920008966A KR 920008966 A KR920008966 A KR 920008966A KR 920021555 A KR920021555 A KR 920021555A
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KR
South Korea
Prior art keywords
pharmaceutically acceptable
acceptable salt
compound
rapamycin
bicyclic
Prior art date
Application number
KR1019920008966A
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English (en)
Inventor
카오 웬링
루이스 보겔 로버트
헨리 머서 존
Original Assignee
이곤 이. 버그
아메리칸 홈 프로덕츠 코포레이션
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by 이곤 이. 버그, 아메리칸 홈 프로덕츠 코포레이션 filed Critical 이곤 이. 버그
Publication of KR920021555A publication Critical patent/KR920021555A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Transplantation (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음

Description

비사이클릭 라파 마이신
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (6)

  1. 일반식(I)의 화합물 라파마이신의 비사이클릭 유도체 또는 약제학적으로 허용되는 이의 염.
    상기식에서, A는 -(CH2)n, -(CH2)n-(CH=CH)-(CH2)m-, -(CH2)n-(CH≡CH)-(CH2)m- 또는
    이고, n 및 m은 동일하거나 상이하며,각각 2 내지 10이다.
  2. 제1항에 있어서, A가 -(CH2)4-인 화합물 또는 약제학적으로 허용되는 이의 염.
  3. 제1항에 있어서, A가 -(CH2)5-인 화합물 또는 약제학적으로 허용되는 이의 염.
  4. 제1항에 있어서, A가 -(CH2)6-인 화합물 또는 약제학적으로 허용되는 이의 염.
  5. 일반식(1)의 라파마이신의 비사이클릭 유도체 또는 약제학적으로 허용되는 이의 염의 유효량을 투여함을 특징으로 하여, 포유동물의 조직이식 거부반응, 식편에 대한 숙주의 질환, 자가 면역질환 및 염증질환을 치료하는 방법.
    상기 식에서, A는 -(CH2)n, -(CH2)n-(CH=CH)-(CH2)m-, -(CH2)n-(CH≡CH)-(CH2)m- 또는
    이고, n 및 m은 동일하거나 상이하며,각각 2 내지 10이다.
  6. 제1항에 따른 화합물 또는 약제학적으로 허용되는 이의 염 및 약제학적으로 허용되는 담체를 포함함을 특징으로 하는 약제학적 조성물.
    ※ 참고사항:최초출원 내용에 의하여 공개하는 것임.
KR1019920008966A 1991-05-29 1992-05-27 비사이클릭 라파 마이신 KR920021555A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/706,811 US5120725A (en) 1991-05-29 1991-05-29 Bicyclic rapamycins
US07/706,811 1991-05-29

Publications (1)

Publication Number Publication Date
KR920021555A true KR920021555A (ko) 1992-12-18

Family

ID=24839145

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019920008966A KR920021555A (ko) 1991-05-29 1992-05-27 비사이클릭 라파 마이신

Country Status (9)

Country Link
US (1) US5120725A (ko)
JP (1) JPH05163280A (ko)
KR (1) KR920021555A (ko)
CA (1) CA2069469A1 (ko)
CZ (1) CZ157192A3 (ko)
FI (1) FI922431A (ko)
HU (1) HUT62900A (ko)
MX (1) MX9202545A (ko)
NO (1) NO922112L (ko)

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Also Published As

Publication number Publication date
HU9201781D0 (en) 1992-08-28
JPH05163280A (ja) 1993-06-29
CZ157192A3 (en) 1994-01-19
US5120725A (en) 1992-06-09
MX9202545A (es) 1992-11-01
NO922112L (no) 1992-11-30
HUT62900A (en) 1993-06-28
NO922112D0 (no) 1992-05-27
FI922431A (fi) 1992-11-30
CA2069469A1 (en) 1992-11-30
FI922431A0 (fi) 1992-05-27

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