KR930017898A - 술포닐벤질 치환 피리돈 - Google Patents

술포닐벤질 치환 피리돈 Download PDF

Info

Publication number
KR930017898A
KR930017898A KR1019930002728A KR930002728A KR930017898A KR 930017898 A KR930017898 A KR 930017898A KR 1019930002728 A KR1019930002728 A KR 1019930002728A KR 930002728 A KR930002728 A KR 930002728A KR 930017898 A KR930017898 A KR 930017898A
Authority
KR
South Korea
Prior art keywords
carbon atoms
straight
branched chain
substituted
branched
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
KR1019930002728A
Other languages
English (en)
Korean (ko)
Inventor
한코 루돌프
휘브쉬 발테르
드레셀 위르겐
페이 페테르
크레머 토마스
에. 뮐러 울리히
뮐러-글리만 마티아스
보익 마르틴
카즈다 스타니스라프
히르트-디트리히 클라우디아
크노르 안드레아스
스타쉬 요하네스-페테르
볼파일 스테판
얄키노글루 외즈칸
Original Assignee
크누트 샤우에르테, 클라우스 데너
바이엘 악티엔게젤샤프트
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 크누트 샤우에르테, 클라우스 데너, 바이엘 악티엔게젤샤프트 filed Critical 크누트 샤우에르테, 클라우스 데너
Publication of KR930017898A publication Critical patent/KR930017898A/ko
Withdrawn legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Cephalosporin Compounds (AREA)
KR1019930002728A 1992-02-27 1993-02-26 술포닐벤질 치환 피리돈 Withdrawn KR930017898A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DEP4206045.1 1992-02-27
DE4206045A DE4206045A1 (de) 1992-02-27 1992-02-27 Sulfonylbenzyl substituierte pyridone

Publications (1)

Publication Number Publication Date
KR930017898A true KR930017898A (ko) 1993-09-20

Family

ID=6452730

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019930002728A Withdrawn KR930017898A (ko) 1992-02-27 1993-02-26 술포닐벤질 치환 피리돈

Country Status (18)

Country Link
US (1) US5254543A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EP (1) EP0557843A3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JPH0641081A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
KR (1) KR930017898A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CN (1) CN1078468A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (1) AU653288B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA2090267A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CZ (1) CZ15793A3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE4206045A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
HU (1) HUT64057A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IL (1) IL104843A0 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
MX (1) MX9300766A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
MY (1) MY129973A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NZ (1) NZ245999A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
PL (1) PL297870A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
SK (1) SK14593A3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
TW (1) TW230206B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ZA (1) ZA931370B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4215587A1 (de) * 1992-05-12 1993-11-18 Bayer Ag Sulfonylbenzyl-substituierte Benzo- und Pyridopyridone
JPH06306073A (ja) * 1992-12-10 1994-11-01 Japan Tobacco Inc ニコチン誘導体の光学分割法
WO2000058304A1 (fr) * 1999-03-26 2000-10-05 Shionogi & Co., Ltd. Derives sulfonamides heterocycliques
TW200303742A (en) * 2001-11-21 2003-09-16 Novartis Ag Organic compounds
US7482366B2 (en) 2001-12-21 2009-01-27 X-Ceptor Therapeutics, Inc. Modulators of LXR
EP1465869B1 (en) 2001-12-21 2013-05-15 Exelixis Patent Company LLC Modulators of lxr
DE60330126D1 (de) * 2002-02-14 2009-12-31 Pharmacia Corp Substituierte pyridinone als modulatoren für p38 map kinase
GB0316546D0 (en) 2003-07-15 2003-08-20 Novartis Ag Process for the manufacture of organic compounds
CN101277949A (zh) 2005-04-22 2008-10-01 阿兰托斯制药控股公司 二肽基肽酶-ⅳ抑制剂
GB0514686D0 (en) * 2005-07-18 2005-08-24 Novartis Ag Organic compounds
CN1985878B (zh) * 2005-12-20 2011-06-22 广州王老吉药业股份有限公司 一种治疗消化性溃疡的药物组合物及其制备方法
AR059898A1 (es) 2006-03-15 2008-05-07 Janssen Pharmaceutica Nv Derivados de 3-ciano-piridona 1,4-disustituida y su uso como moduladores alostericos de los receptores mglur2
TW200900065A (en) 2007-03-07 2009-01-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives
TW200845978A (en) * 2007-03-07 2008-12-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives
DE602008004794D1 (de) 2007-09-14 2011-03-10 Addex Pharmaceuticals Sa 1',3'-disubstituierte 4-phenyl-3,4,5,6-tetrahydro-2h,1'h-ä1,4'übipyridinyl-2'-one
MX2010002537A (es) * 2007-09-14 2010-08-10 Ortho Mcneil Janssen Pharm 4-fenil-1h-piridin-2-onas 1,3-disubstituidas.
CA2697399C (en) 2007-09-14 2016-01-19 Ortho-Mcneil-Janssen Pharmaceuticals, Inc. 1,3-disubstituted 4-(aryl-x-phenyl)-1h-pyridin-2-ones
US8785486B2 (en) * 2007-11-14 2014-07-22 Janssen Pharmaceuticals, Inc. Imidazo[1,2-A]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors
US8691849B2 (en) 2008-09-02 2014-04-08 Janssen Pharmaceuticals, Inc. 3-azabicyclo[3.1.0]hexyl derivatives as modulators of metabotropic glutamate receptors
JP5656848B2 (ja) 2008-10-16 2015-01-21 ジャンセン ファーマシューティカルズ, インコーポレイテッド. 代謝型グルタミン酸受容体モジュレーターとしてのインドールおよびベンゾモルホリンの誘導体
MX2011005242A (es) 2008-11-28 2011-09-06 Ortho Mcneil Janssen Pharm Derivados de indol y benzoxazina como moduladores de los receptores de glutamato metabotropicos.
JP2012513435A (ja) 2008-12-23 2012-06-14 エフ.ホフマン−ラ ロシュ アーゲー P2x7調節薬としてのジヒドロピリドンアミド
MX2011006843A (es) 2008-12-23 2011-08-04 Hoffmann La Roche Dihidropiridona-amidas como moduladores de p2x7.
US8153808B2 (en) 2008-12-23 2012-04-10 Roche Palo Alto Llc Dihydropyridone amides as P2X7 modulators
MX2011006245A (es) 2008-12-23 2011-07-13 Hoffmann La Roche Dihidropiridona-amidas como moduladores de p2x7.
SG172336A1 (en) 2008-12-23 2011-07-28 Hoffmann La Roche Dihydropyridone amides as p2x7 modulators
MY153912A (en) 2009-05-12 2015-04-15 Janssen Pharmaceuticals Inc 1, 2, 4,-triazolo[4,3-a[pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
MY153913A (en) 2009-05-12 2015-04-15 Janssen Pharmaceuticals Inc 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
PT2430022E (pt) 2009-05-12 2013-12-26 Janssen Pharmaceuticals Inc Derivados de 1,2,3-triazolo[4,3-a]piridina e a sua utilização para o tratamento ou prevenção de doenças neurológicas e psiquiátricas
WO2012062750A1 (en) 2010-11-08 2012-05-18 Janssen Pharmaceuticals, Inc. 1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS
EP2643320B1 (en) 2010-11-08 2015-03-04 Janssen Pharmaceuticals, Inc. 1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS
ES2552879T3 (es) 2010-11-08 2015-12-02 Janssen Pharmaceuticals, Inc. Derivados de 1,2,4-triazolo[4,3-a]piridina y su uso como moduladores alostéricos positivos de receptores mGluR2
JO3368B1 (ar) 2013-06-04 2019-03-13 Janssen Pharmaceutica Nv مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2
JO3367B1 (ar) 2013-09-06 2019-03-13 Janssen Pharmaceutica Nv مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2
HUE053734T2 (hu) 2014-01-21 2021-07-28 Janssen Pharmaceutica Nv 2-es altípusú metabotróp glutamáterg receptor pozitív allosztérikus modulátorait tartalmazó kombinációk és alkalmazásuk
KR20220038826A (ko) 2014-01-21 2022-03-29 얀센 파마슈티카 엔.브이. 대사 조절형 글루탐산 작동성 수용체 제2아형의 양성 알로스테릭 조절제 또는 오르토스테릭 작동제를 포함하는 조합 및 그 용도

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3406329A1 (de) * 1984-02-22 1985-08-22 Merck Patent Gmbh, 6100 Darmstadt Pyridone
US5138069A (en) * 1986-07-11 1992-08-11 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking imidazoles
EP0403158A3 (en) * 1989-06-14 1991-12-18 Smithkline Beecham Corporation Imidazolyl-alkenoic acids
ATE250587T1 (de) * 1989-06-14 2003-10-15 Smithkline Beecham Corp Imidazoalkensäure
JP2568315B2 (ja) * 1989-06-30 1997-01-08 イー・アイ・デュポン・ドゥ・ヌムール・アンド・カンパニー 縮合環アリール置換イミダゾール
AU640417B2 (en) * 1989-10-25 1993-08-26 Smithkline Beecham Corporation Substituted 5-((tetrazolyl)alkenyl)imidazoles
WO1991019697A1 (en) * 1990-06-19 1991-12-26 Meiji Seika Kabushiki Kaisha Pyridine derivative with angiotensin ii antagonism

Also Published As

Publication number Publication date
NZ245999A (en) 1995-10-26
JPH0641081A (ja) 1994-02-15
SK14593A3 (en) 1993-10-06
CZ15793A3 (en) 1993-12-15
DE4206045A1 (de) 1993-09-02
MX9300766A (es) 1993-08-01
MY129973A (en) 2007-05-31
PL297870A1 (en) 1993-10-04
IL104843A0 (en) 1993-06-10
US5254543A (en) 1993-10-19
HU9300545D0 (en) 1993-05-28
CA2090267A1 (en) 1993-08-28
EP0557843A3 (en) 1993-12-01
AU3377093A (en) 1993-09-02
EP0557843A2 (de) 1993-09-01
HUT64057A (en) 1993-11-29
TW230206B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1994-09-11
ZA931370B (en) 1993-03-23
AU653288B2 (en) 1994-09-22
CN1078468A (zh) 1993-11-17

Similar Documents

Publication Publication Date Title
KR930017898A (ko) 술포닐벤질 치환 피리돈
KR870001142A (ko) 페닐 에테르의 제법
RU2009113666A (ru) Способ получения биарилзамещенной 4-аминомасляной кислоты или ее производных и их применение в изготовлении ингибиторов нэп
KR840004739A (ko) 1,3-디옥산-5-일 알케논산의 제조방법
MX170515B (es) , "procedimiento para la preparacion de compuestos de cicloalcano benzo-fusionados y sus derivados
ES8600263A1 (es) Un compuesto.
KR930023362A (ko) 술포닐벤질 치환 벤조피리돈 및 피리도피리돈
KR860700254A (ko) 메틸렌-비스포스폰산 유도체의 제조방법
KR840003614A (ko) 항염 작용을 갖는 피롤아세트 아미드의 제조방법
KR890014486A (ko) N-시클로프로필아닐, 및 1-시클로프로필-퀴놀론카르복실산 및 그의 유도체의 제조에 있어서 n-시클로프로필아닐린의 용도
KR930023364A (ko) 비페닐메틸-치환 피리돈
KR960031442A (ko) 페닐시클로헥실카르복스아미드의 용도
KR830001188A (ko) 신규 화합물
KR840006206A (ko) 이소퀴놀린 유도체의 제조방법
BR8704825A (pt) Composicao a base de terras raras para estabilizar os combustiveis para motores diesel
ATE191915T1 (de) Herstellung von borester
ES453304A1 (es) Un procedimiento para la preparacion de nuevos derivados de aminoacidos.
KR840005449A (ko) 벤조티오 피라노 피리디논
KR850006934A (ko) 3-페닐-2-프로펜아민 유도체의 제법
KR940021532A (ko) 헤테로시클릭 치환된 페닐아세트산 유도체의 페닐글리산아미드
KR910009713A (ko) 3-플루오로술포닐록시세프-3-엠 치환방법
KR850007588A (ko) β-나프틸알킬아민의 제조방법
KR930702285A (ko) 옥시술포닐 카르바메이트
JPS6413083A (en) Streptonigrin derivative and medicinal composition
DE69306760T2 (de) Säureanhydride, ihre herstellung und ihre verwendung

Legal Events

Date Code Title Description
PA0109 Patent application

Patent event code: PA01091R01D

Comment text: Patent Application

Patent event date: 19930226

PG1501 Laying open of application
PC1203 Withdrawal of no request for examination
WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid