KR930007903A - 치환된 인돌의 제조방법 - Google Patents

치환된 인돌의 제조방법 Download PDF

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Publication number
KR930007903A
KR930007903A KR1019920019621A KR920019621A KR930007903A KR 930007903 A KR930007903 A KR 930007903A KR 1019920019621 A KR1019920019621 A KR 1019920019621A KR 920019621 A KR920019621 A KR 920019621A KR 930007903 A KR930007903 A KR 930007903A
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South Korea
Prior art keywords
compound
formula
vib
diazabicyclo
reacting
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KR1019920019621A
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English (en)
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게르스파허 마르크
잘만 알프레드
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베르너 발데그
시바-가이기 에이지
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Publication of KR930007903A publication Critical patent/KR930007903A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an alkyl or cycloalkyl radical attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/96—Esters of carbonic or haloformic acids

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Luminescent Compositions (AREA)
  • Electroluminescent Light Sources (AREA)
  • Optical Fibers, Optical Fiber Cores, And Optical Fiber Bundles (AREA)

Abstract

본 발명은 일반식(Ⅰ)의 화합물 및 이의 염을 제조하는 신규한 방법, 신규한 출발 물질 및 이의 용도에 관한 것이다.
상기식에서, R은 직쇄, C2-C4알크-1-엔-1-일이다.

Description

치환된 인돌의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (8)

  1. a)일반식(Ⅳ)의 화합물을 원-포트 공정으로, 즉, 중간체의 분리없이 환원시키고, 동시에 구조식(Ⅴ)의 화합물로 N-아실화시키고, b)이렇게 수득가능한 일반식(Ⅵa)의 화합물을 일반식(Ⅵb)의 화합물 또는 이의 염과 반응시켜 일반식(Ⅰ)의 화합물 또는 이의 염을 제조하는 방법.
    상기식에서, R은 직쇄, C2-C4알크-1-엔-1-일이고;
  2. 제1에 있어서, a1)일반식(Ⅱ)의 에스테르를 가수분해시키고, a2)이렇게 수득가능한 구조식(Ⅲ)의 카르복실산중 카복시그룹을 구조식(Ⅳd), (Ⅳe) 또는 (Ⅳf)의 화합물과 반응시켜 제1항에서 출발 물질로서 사용된 일반식(Ⅳ)의 화합물을 제조하는 방법.
    상기식에서, X1은 에테르화된 하이드록시이다.
  3. 제1항에 있어서, 1)구조식(Ⅲa)의 화합물중 카복시 그룹을 구조식(Ⅳd), (Ⅳe) 또는 (Ⅳe)의 화합물과 반응시켜 활성화시키고, 2)이렇게 수득가능한 일반식(Ⅲb)의 화합물을 할로겐화시키고, 3)이렇게 수득가능한 일반식(Ⅲc)의 화합물을 구조식(Ⅲd)의 화합물과 반응시켜 제1에서 출발 물질로서 사용된 일반식(Ⅳ)의 화합물을 제조하는 방법.
    상기 식에서,
    Hal은 할로겐이다.
  4. 제1항 내지 제3항중 어느 한 항에 있어서, 일반식(Ⅵb)의 화합물의 일반식(Ⅵa)의 화합물로의 N-아실화[공정 단계b)]를 1,8-디아자비사이클로[5,4,0]운데크-7-엔, 1,5-디아자비사이클로[4,3,0]논-5-엔, 알칼리금속 알콜레이트 및 수산화벤질 트리메틸암모늄 중에서 선택된 염기의 존재하에서 수행하는 방법.
  5. 제4항에 있어서, 일반식(Ⅵb)의 화합물을 일반식(Ⅵa)의 화합물로의 n-아실화[공정단계 b)]를 1,8-디아자비사이클로[5,4,0]운데크-7-엔의 존재하에 수행하는 방법.
  6. 제1항 내지 제5항중 어느 한 항에 있어서, R이 비닐인 일반식(Ⅰ)의 화합물 또는 이의 염을 제조하는 방법.
  7. 디사이클로펜틸 디카보네이트.
  8. 디사이클로펜틸 디카보네이트의 사이클로펜틸옥시카보닐 그룹을 도입하기 위한 아실화제로서의 용도.
    ※참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019920019621A 1991-10-25 1992-10-24 치환된 인돌의 제조방법 KR930007903A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH03136/91-0 1991-10-25
CH313691 1991-10-25

Publications (1)

Publication Number Publication Date
KR930007903A true KR930007903A (ko) 1993-05-20

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Application Number Title Priority Date Filing Date
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Country Status (19)

Country Link
US (2) US5359083A (ko)
EP (1) EP0539330B1 (ko)
JP (1) JPH05201975A (ko)
KR (1) KR930007903A (ko)
AT (1) ATE122656T1 (ko)
AU (1) AU661052B2 (ko)
CA (1) CA2081303A1 (ko)
DE (1) DE59202229D1 (ko)
DK (1) DK0539330T3 (ko)
ES (1) ES2072125T3 (ko)
FI (1) FI924769A (ko)
HU (1) HU213118B (ko)
IL (1) IL103527A (ko)
MX (1) MX9206128A (ko)
NO (1) NO178924C (ko)
NZ (1) NZ244870A (ko)
PH (1) PH30433A (ko)
TW (1) TW213899B (ko)
ZA (1) ZA928202B (ko)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3020612B2 (ja) * 1995-10-10 2000-03-15 ファイザー インク． ロイコトリエンアンタゴニストとしてのインドールカルバメート類
GB2382641A (en) * 2001-11-28 2003-06-04 Johnson Matthey Plc A refractory furnace block with a surface coated in a platinum alloy

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8607294D0 (en) * 1985-04-17 1986-04-30 Ici America Inc Heterocyclic amide derivatives
AU609704B2 (en) * 1985-10-17 1991-05-09 Ici Americas Inc. Indole and indazole ketosulphone leukotriene antagonists
GB8623429D0 (en) * 1985-10-17 1986-11-05 Ici America Inc Carboximide derivatives
MY103259A (en) * 1987-04-15 1993-05-29 Ici America Inc Aliphatic carboxamides
GB8906032D0 (en) * 1988-04-14 1989-04-26 Ici America Inc Hetera-aliphatic carboxamides
DE59103389D1 (de) * 1990-05-04 1994-12-08 Ciba Geigy Ag Substituierte Indole.
EP0539329A1 (de) * 1991-10-25 1993-04-28 Ciba-Geigy Ag Acetylen-Verbindungen, verwendbar als Leukotrien-Antagonisten

Also Published As

Publication number Publication date
FI924769A0 (fi) 1992-10-21
US5359083A (en) 1994-10-25
ZA928202B (en) 1993-04-28
HU9203344D0 (en) 1992-12-28
CA2081303A1 (en) 1993-04-26
TW213899B (ko) 1993-10-01
NO924113D0 (no) 1992-10-23
EP0539330A1 (de) 1993-04-28
HUT65541A (en) 1994-06-28
AU2723392A (en) 1993-04-29
FI924769A (fi) 1993-04-26
US5399714A (en) 1995-03-21
AU661052B2 (en) 1995-07-13
ES2072125T3 (es) 1995-07-01
IL103527A (en) 1998-06-15
JPH05201975A (ja) 1993-08-10
NO178924C (no) 1996-07-03
IL103527A0 (en) 1993-03-15
ATE122656T1 (de) 1995-06-15
NO178924B (no) 1996-03-25
EP0539330B1 (de) 1995-05-17
NZ244870A (en) 1995-01-27
DK0539330T3 (da) 1995-07-17
DE59202229D1 (de) 1995-06-22
NO924113L (no) 1993-04-26
MX9206128A (es) 1993-08-01
HU213118B (en) 1997-02-28
PH30433A (en) 1997-05-09

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