KR930005005B1 - 5-(6-이미다조[1,2-a]피리딜)피리딘 유도체의 제조방법 - Google Patents

5-(6-이미다조[1,2-a]피리딜)피리딘 유도체의 제조방법 Download PDF

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Publication number
KR930005005B1
KR930005005B1 KR1019860002202A KR860002202A KR930005005B1 KR 930005005 B1 KR930005005 B1 KR 930005005B1 KR 1019860002202 A KR1019860002202 A KR 1019860002202A KR 860002202 A KR860002202 A KR 860002202A KR 930005005 B1 KR930005005 B1 KR 930005005B1
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KR
South Korea
Prior art keywords
hydrogen atom
group
alkyl group
general formula
lower alkyl
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Expired - Fee Related
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KR1019860002202A
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English (en)
Korean (ko)
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KR860007257A (ko
Inventor
모도스께 야마나까
가즈도시 미야께
신지 스다
히데또 오오하라
도시아끼 오가와
Original Assignee
에이자이 가부시기가이샤
나이또오 유우지
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Publication of KR860007257A publication Critical patent/KR860007257A/ko
Application granted granted Critical
Publication of KR930005005B1 publication Critical patent/KR930005005B1/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR1019860002202A 1985-03-26 1986-03-25 5-(6-이미다조[1,2-a]피리딜)피리딘 유도체의 제조방법 Expired - Fee Related KR930005005B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP60059450A JPS61218589A (ja) 1985-03-26 1985-03-26 ５―（６―イミダゾ〔１，２―ａ〕ピリジニル）ピリジン誘導体
JP6059450 1985-03-26
JP59450 1985-03-26

Publications (2)

Publication Number Publication Date
KR860007257A KR860007257A (ko) 1986-10-10
KR930005005B1 true KR930005005B1 (ko) 1993-06-11

Family

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Family Applications (1)

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KR1019860002202A Expired - Fee Related KR930005005B1 (ko) 1985-03-26 1986-03-25 5-(6-이미다조[1,2-a]피리딜)피리딘 유도체의 제조방법

Country Status (23)

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US (4) US4751227A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EP (1) EP0199127B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JPS61218589A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
KR (1) KR930005005B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CN (1) CN1020608C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AT (1) ATE48603T1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (1) AU589410B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
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DK (1) DK164788C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
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GR (1) GR860720B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
HU (1) HU198045B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IE (1) IE59294B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IL (1) IL78248A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
MX (1) MX163696B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NO (1) NO163490C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
PH (1) PH22999A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
PT (1) PT82270B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
SU (1) SU1468420A3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ZA (1) ZA862259B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

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US5002941A (en) * 1985-12-12 1991-03-26 Smithkline Beecham Corporation Pyrrolo(1,2-a)imidazole and imidazo(1,2-a)pyridine derivatives and their use as 5-lipoxygenase pathway inhibitors
WO1991000092A1 (en) * 1989-06-13 1991-01-10 Smithkline Beecham Corporation Inhibition of interleukin-1 and tumor necrosis factor production by monocytes and/or macrophages
GB9008818D0 (en) * 1990-04-19 1990-06-13 Ici Plc Amine derivatives
US5958926A (en) * 1996-11-01 1999-09-28 Nitromed, Inc. Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses
SE9903611D0 (sv) * 1999-10-06 1999-10-06 Astra Ab Novel compounds III
JP2005104838A (ja) * 2003-01-09 2005-04-21 Tanabe Seiyaku Co Ltd 縮合フラン化合物
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
DE102005019181A1 (de) * 2005-04-25 2006-10-26 Novartis Ag Peptid-Deformylase (PDF) Inhibitoren 1
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
CA2688161C (en) 2007-06-04 2020-10-20 Kunwar Shailubhai Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US20100120694A1 (en) 2008-06-04 2010-05-13 Synergy Pharmaceuticals, Inc. Agonists of Guanylate Cyclase Useful for the Treatment of Gastrointestinal Disorders, Inflammation, Cancer and Other Disorders
ES2624828T3 (es) 2008-07-16 2017-07-17 Synergy Pharmaceuticals Inc. Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros
RU2570426C2 (ru) * 2009-12-18 2015-12-10 Мицубиси Танабе Фарма Корпорейшн Новое антитромботическое средство
CN101830900B (zh) * 2010-05-27 2012-06-06 齐鲁制药(海南)有限公司 盐酸奥普力农晶型及其制备方法
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
CN108676076A (zh) 2011-03-01 2018-10-19 辛纳吉制药公司 制备鸟苷酸环化酶c激动剂的方法
CN102718747B (zh) * 2012-06-27 2014-06-11 武汉武药科技有限公司 盐酸奥普力农衍生物及其合成方法
CN102702197B (zh) * 2012-06-27 2014-12-03 武汉武药科技有限公司 盐酸奥普力农衍生物及其制备方法
AU2014218599C1 (en) 2013-02-25 2018-09-06 Bausch Health Ireland Limited Guanylate cyclase receptor agonists for use in colonic cleansing
WO2014151200A2 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
EP2970384A1 (en) 2013-03-15 2016-01-20 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
AU2014274812B2 (en) 2013-06-05 2018-09-27 Bausch Health Ireland Limited Ultra-pure agonists of guanylate cyclase C, method of making and using same
KR20160042039A (ko) 2013-08-09 2016-04-18 알데릭스, 인코포레이티드 인산염 수송을 억제하기 위한 화합물 및 방법
CN106349246B (zh) * 2016-08-29 2018-10-26 山东百诺医药股份有限公司 奥普力农及9-氮杂吲哚-5-硼酸的制备方法
CN108840866A (zh) * 2018-05-24 2018-11-20 河北宇辰医药科技有限公司 一种奥普力农类似物ⅰ的制备方法与用途
CN109575017A (zh) * 2018-11-01 2019-04-05 山东蒲济医药科技有限公司 一种盐酸奥普力农化合物的制备方法
EP3972599A1 (en) 2019-05-21 2022-03-30 Ardelyx, Inc. Combination for lowering serum phosphate in a patient
CN111499631B (zh) * 2020-06-02 2021-07-30 济南康桥医药科技有限公司 一种盐酸奥普力农关键中间体1-咪唑并[1,2-a]吡啶-6-基-2-丙酮的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4105767A (en) * 1977-03-28 1978-08-08 Merck & Co., Inc. Imidazo [1,2-a] pyridines substituted with a thienyl, thiazolyl, or thiadiazolyl group
ZA81219B (en) * 1980-01-23 1982-01-27 Schering Corp Imidazo (1,2-a) pyridines ,process for their preparation and pharmaceutical compositions containing them
DE3269604D1 (en) * 1981-06-26 1986-04-10 Schering Corp Novel imidazo(1,2-a)pyridines and pyrazines, processes for their preparation and pharmaceutical compositions containing them
DE3406329A1 (de) * 1984-02-22 1985-08-22 Merck Patent Gmbh, 6100 Darmstadt Pyridone

Also Published As

Publication number Publication date
DK164788C (da) 1992-12-28
KR860007257A (ko) 1986-10-10
AU589410B2 (en) 1989-10-12
US4791202A (en) 1988-12-13
ES557587A0 (es) 1988-02-16
ZA862259B (en) 1986-11-26
FI861262A0 (fi) 1986-03-25
FI86722C (fi) 1992-10-12
DK137786D0 (da) 1986-03-25
IL78248A (en) 1989-09-10
MX163696B (es) 1992-06-15
ES553370A0 (es) 1987-05-16
US4803276A (en) 1989-02-07
FI861262A7 (fi) 1986-09-27
ES8801655A1 (es) 1988-02-16
ES8706146A1 (es) 1987-05-16
ES557236A0 (es) 1987-10-01
DD263057A5 (de) 1988-12-21
ES8708230A1 (es) 1987-10-01
EP0199127B1 (en) 1989-12-13
US4791203A (en) 1988-12-13
IE860775L (en) 1986-09-26
US4751227A (en) 1988-06-14
DE3667466D1 (de) 1990-01-18
ES8708231A1 (es) 1987-10-01
IE59294B1 (en) 1994-02-09
DK164788B (da) 1992-08-17
ES8801654A1 (es) 1988-02-16
HUT41026A (en) 1987-03-30
PT82270A (en) 1986-04-01
NO163490B (no) 1990-02-26
PH22999A (en) 1989-02-24
CA1309718C (en) 1992-11-03
JPS61218589A (ja) 1986-09-29
JPH0558437B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1993-08-26
ES557235A0 (es) 1987-10-01
IL78248A0 (en) 1986-07-31
SU1468420A3 (ru) 1989-03-23
ATE48603T1 (de) 1989-12-15
NO163490C (no) 1990-06-06
DD283390A5 (de) 1990-10-10
CN1020608C (zh) 1993-05-12
ES557588A0 (es) 1988-02-16
EP0199127A1 (en) 1986-10-29
HU198045B (en) 1989-07-28
AU5507286A (en) 1986-10-02
PT82270B (pt) 1988-02-17
GR860720B (en) 1986-03-25
FI86722B (fi) 1992-06-30
DK137786A (da) 1986-09-27
NO861190L (no) 1986-09-29
CN86102812A (zh) 1986-11-26

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