KR927003561A - β-페닐이소세린의 유도체, 그의 제조 및 이용 - Google Patents

β-페닐이소세린의 유도체, 그의 제조 및 이용 Download PDF

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KR927003561A
KR927003561A KR1019920701998A KR920701998A KR927003561A KR 927003561 A KR927003561 A KR 927003561A KR 1019920701998 A KR1019920701998 A KR 1019920701998A KR 920701998 A KR920701998 A KR 920701998A KR 927003561 A KR927003561 A KR 927003561A
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South Korea
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product according
phenylisoserine
salt
product
derivatives
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KR1019920701998A
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KR100197481B1 (ko
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뒤쉐느 장-삐에르
뮬호제 미쉘
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필라드 자끄
로오느-푸우랜크 로레르 소시에테 아노님
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Publication of KR927003561A publication Critical patent/KR927003561A/ko
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Publication of KR100197481B1 publication Critical patent/KR100197481B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Liquid Developers In Electrophotography (AREA)
  • Indole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

내용 없음

Description

β-페닐이소세린의 유도체, 그의 제조 및 이용
[도면의 간단한 설명]
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (6)

  1. 임의로 염 또는 에스테르 형태로의 하기 구조식의 새로운 β-페닐이소세린 유도체:
  2. 바람직하게 알칼리 금속 염 또는 질소성 염기를 가진 염의 형태로, 벤질아민을(2R, 3R)-시스-β-페닐글리시딘 산과, 반응시키고 이때 작업은 물에서 수행하며, 얻어진 생성물을 분리시키고, 임의로 염 또는 에스테르로 전환시키는 것을 특징으로 하는 제1항에 따른 생성물의 제조방법.
  3. 제1항에 따른 생성물이 바람직하게 에스테르 형태로, 촉매적으로 수소화 하는것을 특징으로 하는, 바람직하게 에스테르 형태로 (2R,3S)-β-페닐이소세린을 제조하기 위한 제1항에 따른 생성물의 이용.
  4. 공지된 방법으로 하기 일반 구조식의 탁산 유도체를 제조하기 위해 제3항의 방법에 따라 얻어진 (2R, 3R)-β-페닐이소세린의 이용:
    여기서 R은 수소원자 또는 아세틸 라디칼을 나타내고 R1은 페닐 또는 t-부톡시 라디칼을 나타낸다.
  5. 제1항에 따른 생성물을 사용한 방법으로 얻어진 하기 일반 구조식의 생성물:
    여기서, R1은 수소원자 또는 아세틸 라디칼을 나타내고 R2는 페닐 또는 터트-부톡시 라디칼을 나타낸다.
  6. 그들이 불활성 이든 생리학적으로 활성이든, 하나 또는 많은 제약학적으로 허용가능한 생성물과 조합하여 제5항에 따른 생성물을 함유하는 것을 특징으로 하는 제약학적 조성물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019920701998A 1990-02-21 1991-02-20 베타-페닐이소세린 유도체, 그의 제조 및 이용 KR100197481B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
FR90/02099 1990-02-21
FR90/2099 1990-02-21
FR9002099A FR2658510B1 (fr) 1990-02-21 1990-02-21 Nouveau derive de la beta-phenylisoserine, sa preparation et son emploi.
PCT/FR1991/000132 WO1991013053A1 (fr) 1990-02-21 1991-02-20 DERIVE DE LA β-PHENYLISOSERINE, SA PREPARATION ET SON EMPLOI

Publications (2)

Publication Number Publication Date
KR927003561A true KR927003561A (ko) 1992-12-18
KR100197481B1 KR100197481B1 (ko) 1999-06-15

Family

ID=9393962

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019920701998A KR100197481B1 (ko) 1990-02-21 1991-02-20 베타-페닐이소세린 유도체, 그의 제조 및 이용

Country Status (23)

Country Link
US (1) US5359124A (ko)
EP (1) EP0515540B1 (ko)
JP (1) JP3057097B2 (ko)
KR (1) KR100197481B1 (ko)
AT (1) ATE108176T1 (ko)
AU (1) AU642717B2 (ko)
CA (1) CA2071983C (ko)
CZ (1) CZ279656B6 (ko)
DE (1) DE69102762T2 (ko)
DK (1) DK0515540T3 (ko)
ES (1) ES2056639T3 (ko)
FI (1) FI111247B (ko)
FR (1) FR2658510B1 (ko)
HU (1) HU209615B (ko)
IE (1) IE64397B1 (ko)
IL (1) IL97277A (ko)
NO (1) NO179865C (ko)
PT (1) PT96849B (ko)
RU (1) RU2074172C1 (ko)
SK (1) SK278304B6 (ko)
WO (1) WO1991013053A1 (ko)
YU (1) YU48671B (ko)
ZA (1) ZA911211B (ko)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5939561A (en) * 1992-03-10 1999-08-17 Rhone-Poulence Rorer S.A. Process for the preparation of β-phenylisoserine and β-lactam and their analogues
FR2688499B1 (fr) * 1992-03-10 1994-05-06 Rhone Poulenc Rorer Sa Procede de preparation de la beta-phenylisoserine et de ses analogues.
EP0639186B1 (en) * 1992-04-17 1999-06-23 Abbott Laboratories Taxol derivatives
IL107950A (en) 1992-12-15 2001-04-30 Upjohn Co b 7, b 8 - Matano - Taxols, their preparation and pharmaceutical preparations against malignant tumors containing them
ATE192147T1 (de) * 1993-06-11 2000-05-15 Upjohn Co Delta 6, 7-taxolen, antineoplastische verwendung und diese enthaltende pharmazeutische zusammenstellungen
IL127597A (en) * 1994-01-28 2003-07-31 Upjohn Co Iso-taxol analogs
US5580899A (en) 1995-01-09 1996-12-03 The Liposome Company, Inc. Hydrophobic taxane derivatives
US6107332A (en) 1995-09-12 2000-08-22 The Liposome Company, Inc. Hydrolysis-promoting hydrophobic taxane derivatives
US6051600A (en) * 1995-09-12 2000-04-18 Mayhew; Eric Liposomal hydrolysis-promoting hydrophobic taxane derivatives
EP2861256B1 (en) 2012-06-15 2019-10-23 The Brigham and Women's Hospital, Inc. Compositions for treating cancer and methods for making the same
AU2015241198A1 (en) 2014-04-03 2016-11-17 Invictus Oncology Pvt. Ltd. Supramolecular combinatorial therapeutics

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1108180A (en) * 1976-07-21 1981-09-01 Hamao Umezawa Analogs of bestatin
FR2629819B1 (fr) * 1988-04-06 1990-11-16 Rhone Poulenc Sante Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii
FR2629818B1 (fr) * 1988-04-06 1990-11-16 Centre Nat Rech Scient Procede de preparation du taxol
US5175315A (en) * 1989-05-31 1992-12-29 Florida State University Method for preparation of taxol using β-lactam
FR2662440B1 (fr) * 1990-05-22 1992-07-31 Rhone Poulenc Sante Procede de preparation stereoselective de derives de la phenylisoserine.
FR2662441B1 (fr) * 1990-05-22 1992-10-23 Rhone Poulenc Sante Procede de preparation enantioselective de derives de la phenylisoserine.

Also Published As

Publication number Publication date
KR100197481B1 (ko) 1999-06-15
IL97277A (en) 1995-12-08
PT96849B (pt) 1998-07-31
AU7345391A (en) 1991-09-18
FR2658510A1 (fr) 1991-08-23
JPH05504954A (ja) 1993-07-29
NO179865B (no) 1996-09-23
FI111247B (fi) 2003-06-30
EP0515540B1 (fr) 1994-07-06
NO923226L (no) 1992-08-18
CA2071983A1 (fr) 1991-08-22
ES2056639T3 (es) 1994-10-01
DE69102762D1 (de) 1994-08-11
ATE108176T1 (de) 1994-07-15
YU48671B (sh) 1999-06-15
FI923679A0 (fi) 1992-08-17
NO179865C (no) 1997-01-02
AU642717B2 (en) 1993-10-28
FI923679A (fi) 1992-08-17
SK278304B6 (en) 1996-09-04
WO1991013053A1 (fr) 1991-09-05
CZ279656B6 (cs) 1995-05-17
HU209615B (en) 1994-09-28
RU2074172C1 (ru) 1997-02-27
CS9100438A2 (en) 1991-09-15
DE69102762T2 (de) 1994-10-27
IE64397B1 (en) 1995-08-09
PT96849A (pt) 1991-10-31
CA2071983C (fr) 2003-03-18
ZA911211B (en) 1991-11-27
US5359124A (en) 1994-10-25
FR2658510B1 (fr) 1992-04-30
NO923226D0 (no) 1992-08-18
YU31191A (sh) 1993-11-16
IL97277A0 (en) 1992-05-25
JP3057097B2 (ja) 2000-06-26
IE910586A1 (en) 1991-08-28
HU9202667D0 (en) 1992-12-28
HUT61971A (en) 1993-03-29
DK0515540T3 (da) 1994-08-15
EP0515540A1 (fr) 1992-12-02

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