KR920019778A - 피페리딘 유도체, 그의 제법 및 치료에의 이용 - Google Patents

피페리딘 유도체, 그의 제법 및 치료에의 이용 Download PDF

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Publication number
KR920019778A
KR920019778A KR1019920005518A KR920005518A KR920019778A KR 920019778 A KR920019778 A KR 920019778A KR 1019920005518 A KR1019920005518 A KR 1019920005518A KR 920005518 A KR920005518 A KR 920005518A KR 920019778 A KR920019778 A KR 920019778A
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KR
South Korea
Prior art keywords
compound
alkyl
group
general formula
hydrogen atom
Prior art date
Application number
KR1019920005518A
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English (en)
Inventor
지감 싸미르
드포스 제라르
퍼셀 토마스
슈마케 조안느
Original Assignee
에. 뚜레 레메뜨르
신떼라보 소시에떼 아노님
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 에. 뚜레 레메뜨르, 신떼라보 소시에떼 아노님 filed Critical 에. 뚜레 레메뜨르
Publication of KR920019778A publication Critical patent/KR920019778A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Peptides Or Proteins (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Developing Agents For Electrophotography (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

내용 없음

Description

피페리딘 유도체, 그의 제법 및 치로에의 이용
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (7)

  1. 일반식(I)에 따른 화합물 및 제약학적으로 허용되는 그의 산부가염.
    상기 식에서, R1은 수소원자 또는 직쇄 또는 분지쇄(C1-6)알킬기, 또는 시클로(C3-8)알킬기를 나타내고, X는 산소원자 또는 황원자 또는 R3이 수소원자인 일반식(N-R3)의 기, 직쇄 또는 분지쇄(C1-6)알킬기, 시클로(C3-6)알킬, 시클로(C3-6)알킬메틸, (C1-4)알콕시 (C1-4)알킬, 페닐, 피리딘-4-일, 피리딘-3-일-기를 나타내고, Z는 수소원자 도는 플루오르원자를 나타낸다.
  2. 제1항에 있어서, R1은 수소원자 또는 직쇄 또는 분지쇄(C1-6)알킬기를 나타내고, X이 R3이 직쇄 또는 분지쇄(C1-8)알킬기인 일반식 N-R3의 기를 나타내고 Z는 수소원자를 나타내는 것을 특징으로 하는 화합물.
  3. 2-〔4-(5-메틸-1H-이미다졸-4-일)피페리딘-1-일〕-1-(1-메틸에틸)-1H-벤즈이미다졸 및 제약학적으로 허용되는 그의 산부가염.
  4. 2-〔4-(1H-이미다졸-4-일)피페리딘-1-일〕-1-(1-메틸에틸)-1H-벤즈이미다졸 및 제약학적으로 허용되는 그의 산부가염.
  5. 일반식(Ⅸ)
    의 화합물을 얻고 이 화합물을 염화토실과 반응시켜 일반식(Ⅶ)
    의 화합물을 히드록실아민 하이드로클로라이드와 반응시켜 일반식(Ⅶ)
    의 화합물을 얻고, 여기세 무수에탄올중의 포타슘 에틸레이트 용액을 먼저 가하고 그런다음 진한 염산을 가하여 일반식(Ⅵ)
    의 화합물을 얻고, 이 화합물에 티오시안산칼륨을 가하여 일반식(Ⅴ)
    의 화합물을 얻고, 그런다음 질산을 가하여 일반식(Ⅳ)
    의 화합물을 얻고, 촉매수소화를 행하여 일반식(Ⅲ)
    의 화합물을 얻고 이 화합물을 일반식(Ⅱ)
    의 화합물과 반응시키는 것으로 이루어지는 것을 특징으로 하는 제1항에 따른 화합물의 제조방법.
    상기 식들에서, R1은 제1항에서 정의한 것과 같다.
  6. 제1항에 따른 화합물을 함유하는 것을 특징으로 하는 의약품.
  7. 제약학적으로 허용되는 부형제와 조합된 제1항에 따른 화합물을 함유하는 것을 특징으로하는 제약학적 조성물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019920005518A 1991-04-03 1992-04-02 피페리딘 유도체, 그의 제법 및 치료에의 이용 KR920019778A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9104009 1991-04-03
FR9104009A FR2674855B1 (fr) 1991-04-03 1991-04-03 Derives de piperidine, leur preparation et leur application en therapeutique.

Publications (1)

Publication Number Publication Date
KR920019778A true KR920019778A (ko) 1992-11-20

Family

ID=9411394

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019920005518A KR920019778A (ko) 1991-04-03 1992-04-02 피페리딘 유도체, 그의 제법 및 치료에의 이용

Country Status (19)

Country Link
US (1) US5280030A (ko)
EP (1) EP0507650B1 (ko)
JP (1) JPH0788378B2 (ko)
KR (1) KR920019778A (ko)
CN (1) CN1065459A (ko)
AT (1) ATE138375T1 (ko)
AU (1) AU646332B2 (ko)
CA (1) CA2064924A1 (ko)
CS (1) CS100192A3 (ko)
DE (1) DE69210875T2 (ko)
FI (1) FI921459A (ko)
FR (1) FR2674855B1 (ko)
HU (1) HUT62573A (ko)
IE (1) IE921048A1 (ko)
IL (1) IL101472A0 (ko)
MX (1) MX9201507A (ko)
NO (1) NO921281L (ko)
NZ (1) NZ242214A (ko)
PL (1) PL294088A1 (ko)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3361693A (en) * 1992-01-23 1993-09-01 Smithkline Beecham Plc Use of 5-HT4 receptor antagonists as medicaments for treating migraine
US5380858A (en) * 1992-04-01 1995-01-10 The University Of Toledo Process for the preparation of intermediates useful for the synthesis of histamine receptor antagonists
FR2696176B1 (fr) * 1992-09-28 1994-11-10 Synthelabo Dérivés de pipéridine, leur préparation et leur application en thérapeutique.
FR2710915B1 (fr) * 1993-10-04 1995-11-24 Synthelabo Dérivés de pipéridine, leur préparation et leur utilisation en thérapeutique.
US6096763A (en) * 1995-02-23 2000-08-01 Merck & Co., Inc. α1a adrenergic receptor antagonists
FR2731708B1 (fr) * 1995-03-13 1997-04-30 Synthelabo Derives de piperidine, leur procede de preparation et leur application en therapeutique
FR2731707B1 (fr) * 1995-03-13 1997-04-30 Synthelabo Derives de benzimidazole, leur preparation et leur application en therapeutique
FR2765221B1 (fr) * 1997-06-25 1999-07-30 Synthelabo Derives de 4-[(1h-imidazol-4-yl)piperidin-1-yl]anilide, leur preparation et leur application en therapeutique
FR2765580B1 (fr) * 1997-07-01 1999-08-06 Synthelabo Derives de (1h-imidazol-4-yl)piperidine, leur preparation et leur application en therapeutique
FR2772377B1 (fr) * 1997-12-12 2000-01-07 Synthelabo Derives de 1-(1-h-imidazol-2-yl)pyrrolidines et 1-(1-h-imidazol-2-ylpiperidines), leur preparation et leur application en therapeutique
GB9918425D0 (en) * 1999-08-04 1999-10-06 Novartis Ag Organic compounds
US6887870B1 (en) * 1999-10-12 2005-05-03 Bristol-Myers Squibb Company Heterocyclic sodium/proton exchange inhibitors and method
SK13752001A3 (sk) * 1999-12-27 2002-07-02 Japan Tobacco, Inc. Zlúčeniny s fúzovanými kruhmi a ich použitie ako liečiv
AU2002346216B2 (en) * 1999-12-27 2005-12-08 Japan Tobacco Inc. Fused cyclic compounds and medicinal use thereof
US6770666B2 (en) 1999-12-27 2004-08-03 Japan Tobacco Inc. Fused-ring compounds and use thereof as drugs
US7030150B2 (en) * 2001-05-11 2006-04-18 Trimeris, Inc. Benzimidazole compounds and antiviral uses thereof
AR035543A1 (es) * 2001-06-26 2004-06-16 Japan Tobacco Inc Agente terapeutico para la hepatitis c que comprende un compuesto de anillo condensado, compuesto de anillo condensado, composicion farmaceutica que lo comprende, compuestos de benzimidazol, tiazol y bifenilo utiles como intermediarios para producir dichos compuestos, uso del compuesto de anillo con
TW200517381A (en) * 2003-08-01 2005-06-01 Genelabs Tech Inc Bicyclic heteroaryl derivatives
RU2007130896A (ru) * 2005-01-14 2009-02-20 Дженелэбс Текнолоджиз, Инк. (Us) Индольные производные для лечения вирусных инфекций
CA2598516C (en) * 2005-02-25 2010-05-11 Pfizer Inc. Benzisoxazole derivatives
EP2579873A4 (en) * 2010-06-11 2013-11-27 Merck Sharp & Dohme NOVEL PROLYLCARBOXYPEPTIDASE HEMMER
CN108159048A (zh) * 2011-03-23 2018-06-15 拉夸里亚创药株式会社 作为促动力药的5-ht4受体激动剂
RU2015104103A (ru) * 2012-07-27 2016-09-20 Биал - Портела Энд К, С.А. Способ синтеза замещенных соединений мочевины

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4634704A (en) * 1983-10-06 1987-01-06 Janssen Pharmaceutica, N.V. Anti-allergic five membered heterocyclic ring containing N-(bicyclic heterocycyl)-4-piperidinamines
FR2579596B1 (fr) * 1985-03-26 1987-11-20 Inst Nat Sante Rech Med (imidazolyl-4) piperidines, leur preparation et leur application en therapeutique
DE3877406T2 (de) * 1987-04-28 1993-06-09 Fujisawa Astra Ltd Benzothiazolinon-derivate, ihre herstellung und pharmazeutische zusammensetzung.
FR2658823B1 (fr) * 1990-02-27 1992-04-30 Adir Nouveaux derives d'aminomethylpiperidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent .

Also Published As

Publication number Publication date
JPH05112563A (ja) 1993-05-07
IL101472A0 (en) 1992-12-30
CS100192A3 (en) 1992-10-14
CA2064924A1 (en) 1992-10-04
DE69210875D1 (de) 1996-06-27
FR2674855A1 (fr) 1992-10-09
NO921281L (no) 1992-10-05
EP0507650A1 (fr) 1992-10-07
ATE138375T1 (de) 1996-06-15
US5280030A (en) 1994-01-18
JPH0788378B2 (ja) 1995-09-27
AU1398992A (en) 1992-10-08
AU646332B2 (en) 1994-02-17
MX9201507A (es) 1992-10-01
IE921048A1 (en) 1992-10-07
NO921281D0 (no) 1992-04-02
CN1065459A (zh) 1992-10-21
HU9201116D0 (en) 1992-06-29
HUT62573A (en) 1993-05-28
EP0507650B1 (fr) 1996-05-22
NZ242214A (en) 1993-05-26
DE69210875T2 (de) 1996-12-05
FI921459A0 (fi) 1992-04-02
FR2674855B1 (fr) 1994-01-14
FI921459A (fi) 1992-10-04
PL294088A1 (ko) 1993-02-08

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