KR920011484A - 콜레스테롤-강하제로서의 1, 3- 디옥솔란 유도체 - Google Patents

콜레스테롤-강하제로서의 1, 3- 디옥솔란 유도체 Download PDF

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Publication number
KR920011484A
KR920011484A KR1019910023417A KR910023417A KR920011484A KR 920011484 A KR920011484 A KR 920011484A KR 1019910023417 A KR1019910023417 A KR 1019910023417A KR 910023417 A KR910023417 A KR 910023417A KR 920011484 A KR920011484 A KR 920011484A
Authority
KR
South Korea
Prior art keywords
hydrogen
compound
lower alkyl
methyl
cis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
KR1019910023417A
Other languages
English (en)
Korean (ko)
Inventor
에이. 엠. 워커 케이트
엠. 버튼 파멜라
씨. 스윈니 데이비드
Original Assignee
헤르비그 폰 모르제
신텍스 (유. 에스. 에이.) 인코포레이티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 헤르비그 폰 모르제, 신텍스 (유. 에스. 에이.) 인코포레이티드 filed Critical 헤르비그 폰 모르제
Publication of KR920011484A publication Critical patent/KR920011484A/ko
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
KR1019910023417A 1990-12-20 1991-12-19 콜레스테롤-강하제로서의 1, 3- 디옥솔란 유도체 Ceased KR920011484A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/633,599 1990-12-20
US07/633,599 US5158949A (en) 1990-12-20 1990-12-20 1,3-dioxolane derivatives as cholesterol-lowering agents

Publications (1)

Publication Number Publication Date
KR920011484A true KR920011484A (ko) 1992-07-24

Family

ID=24540306

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019910023417A Ceased KR920011484A (ko) 1990-12-20 1991-12-19 콜레스테롤-강하제로서의 1, 3- 디옥솔란 유도체

Country Status (21)

Country Link
US (1) US5158949A (enExample)
EP (1) EP0492474B1 (enExample)
JP (1) JPH04308588A (enExample)
KR (1) KR920011484A (enExample)
AT (1) ATE149495T1 (enExample)
AU (1) AU650079B2 (enExample)
CA (1) CA2058068A1 (enExample)
DE (1) DE69124956T2 (enExample)
DK (1) DK0492474T3 (enExample)
FI (1) FI916018A7 (enExample)
GR (1) GR3022740T3 (enExample)
HU (2) HUT61998A (enExample)
IE (1) IE914442A1 (enExample)
IL (1) IL100430A (enExample)
IT (1) IT1250362B (enExample)
MX (1) MX9102703A (enExample)
NO (1) NO179006C (enExample)
NZ (1) NZ241068A (enExample)
PT (1) PT99859A (enExample)
TW (1) TW230208B (enExample)
ZA (1) ZA9110019B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100704710B1 (ko) * 1999-10-29 2007-04-09 주식회사 중외제약 간 섬유화 억제작용을 나타내는 벤조[3,4-ｄ]1,3-디옥솔란 유도체

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5274108A (en) * 1992-06-18 1993-12-28 Syntex (U.S.A.) Inc. Process for preparing 1,3-dioxolane derivatives
US5208331A (en) * 1992-06-18 1993-05-04 Syntex (U.S.A.) Inc. Process for preparing 1,3-dioxolane derivatives
KR100331609B1 (ko) * 1995-04-21 2002-11-18 성 렬 류 신규한시스-튜불라졸유도체및그의제조방법
WO2008151437A1 (en) * 2007-06-14 2008-12-18 Osta Biotechnologies Heme-oxygenase inhibitors and use of the same in the treatment of cancer and diseases of the central nervous system
WO2018060093A1 (en) * 2016-09-29 2018-04-05 Bayer Cropscience Aktiengesellschaft 1,5-substituted imidazole derivatives as fungicides for crop protection.
EP3810777A4 (en) 2018-06-21 2022-03-30 Yumanity Therapeutics, Inc. COMPOSITIONS AND METHODS FOR THE TREATMENT AND PREVENTION OF NEUROLOGICAL DISORDERS

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4078071A (en) * 1976-03-08 1978-03-07 Syntex (U.S.A.) Inc. Derivatives of substituted N-alkyl imidazoles
US4144346A (en) * 1977-01-31 1979-03-13 Janssen Pharmaceutica N.V. Novel 1-(1,3-dioxolan-2-ylmethyl)-1H-imidazoles
US4321272A (en) * 1980-08-25 1982-03-23 Syntex (U.S.A.) Inc. Derivatives of substituted N-alkylimidazoles
DE3166517D1 (de) * 1980-11-24 1984-11-08 Janssen Pharmaceutica Nv Novel (2-aryl-4-phenylthioalkyl-1,3-dioxolan-2-yl-methyl)azole derivatives
US4490540A (en) * 1981-09-14 1984-12-25 Janssen Pharmaceutica N.V. (2-Aryl-4-phenylthioalkyl-1,3-dioxolan-2-ylmethyl)azole derivatives
US4359475A (en) * 1981-12-21 1982-11-16 Syntex (U.S.A.) Inc. Thioketal substituted N-alkyl imidazoles
US4375474A (en) * 1982-02-11 1983-03-01 Syntex (U.S.A.) Inc. Dioxalane containing imidazole compounds, compositions and use
ES533668A0 (es) * 1983-06-24 1985-10-01 Yamanouchi Pharma Co Ltd Un compuesto fenoxi
US4518607A (en) * 1983-07-18 1985-05-21 Syntex (U.S.A.) Inc. Male oral contraceptive N-alkylimidazole derivatives, compositions, and method of use therefor
US4940799A (en) * 1987-07-20 1990-07-10 Ciba-Geigy Corporation Preparation of the diastereomeric mixture 2R,4S-1-[2-(2,4-dichlorophenyl)-4-n-propyl-1,3-dioxolan-2-ylmethyl]-1H-1,2,4-triazole
AU614818B2 (en) * 1988-03-28 1991-09-12 Janssen Pharmaceutica N.V. 2-imidazolylmethyl-1,3-dioxolanyl methylthiophenyl carbamate derivatives and their use as antineoplastic agents

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100704710B1 (ko) * 1999-10-29 2007-04-09 주식회사 중외제약 간 섬유화 억제작용을 나타내는 벤조[3,4-ｄ]1,3-디옥솔란 유도체

Also Published As

Publication number Publication date
CA2058068A1 (en) 1992-06-21
EP0492474B1 (en) 1997-03-05
ZA9110019B (en) 1993-06-21
DK0492474T3 (da) 1997-03-24
IE914442A1 (en) 1992-07-01
JPH04308588A (ja) 1992-10-30
FI916018L (fi) 1992-06-21
HU914024D0 (en) 1992-03-30
FI916018A7 (fi) 1992-06-21
HU210718A9 (en) 1995-06-28
TW230208B (enExample) 1994-09-11
ATE149495T1 (de) 1997-03-15
ITTO910999A1 (it) 1993-06-19
NZ241068A (en) 1996-12-20
NO915036L (no) 1992-06-22
NO179006C (no) 1996-07-17
ITTO910999A0 (it) 1991-12-19
EP0492474A1 (en) 1992-07-01
US5158949A (en) 1992-10-27
IL100430A (en) 1997-03-18
MX9102703A (es) 1992-06-01
AU650079B2 (en) 1994-06-09
PT99859A (pt) 1992-12-31
DE69124956D1 (de) 1997-04-10
NO915036D0 (no) 1991-12-19
FI916018A0 (fi) 1991-12-19
IL100430A0 (en) 1992-09-06
IT1250362B (it) 1995-04-07
HUT61998A (en) 1993-03-29
GR3022740T3 (en) 1997-06-30
AU8990591A (en) 1992-06-25
DE69124956T2 (de) 1997-06-12
NO179006B (no) 1996-04-09

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Legal Events

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PA0109 Patent application

Patent event code: PA01091R01D

Comment text: Patent Application

Patent event date: 19911219

PG1501 Laying open of application
A201 Request for examination
PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 19960911

Comment text: Request for Examination of Application

Patent event code: PA02011R01I

Patent event date: 19911219

Comment text: Patent Application

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 19981030

Patent event code: PE09021S01D

E601 Decision to refuse application
PE0601 Decision on rejection of patent

Patent event date: 19981231

Comment text: Decision to Refuse Application

Patent event code: PE06012S01D

Patent event date: 19981030

Comment text: Notification of reason for refusal

Patent event code: PE06011S01I