TW230208B - - Google Patents

Info

Publication number
TW230208B
TW230208B TW080109874A TW80109874A TW230208B TW 230208 B TW230208 B TW 230208B TW 080109874 A TW080109874 A TW 080109874A TW 80109874 A TW80109874 A TW 80109874A TW 230208 B TW230208 B TW 230208B
Authority
TW
Taiwan
Prior art keywords
lower alkyl
hydrogen
piperazino
alkoxy
oxygen
Prior art date
Application number
TW080109874A
Other languages
English (en)
Original Assignee
Syntex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex Inc filed Critical Syntex Inc
Application granted granted Critical
Publication of TW230208B publication Critical patent/TW230208B/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
TW080109874A 1990-12-20 1991-12-17 TW230208B (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/633,599 US5158949A (en) 1990-12-20 1990-12-20 1,3-dioxolane derivatives as cholesterol-lowering agents

Publications (1)

Publication Number Publication Date
TW230208B true TW230208B (zh) 1994-09-11

Family

ID=24540306

Family Applications (1)

Application Number Title Priority Date Filing Date
TW080109874A TW230208B (zh) 1990-12-20 1991-12-17

Country Status (21)

Country Link
US (1) US5158949A (zh)
EP (1) EP0492474B1 (zh)
JP (1) JPH04308588A (zh)
KR (1) KR920011484A (zh)
AT (1) ATE149495T1 (zh)
AU (1) AU650079B2 (zh)
CA (1) CA2058068A1 (zh)
DE (1) DE69124956T2 (zh)
DK (1) DK0492474T3 (zh)
FI (1) FI916018A (zh)
GR (1) GR3022740T3 (zh)
HU (2) HUT61998A (zh)
IE (1) IE914442A1 (zh)
IL (1) IL100430A (zh)
IT (1) IT1250362B (zh)
MX (1) MX9102703A (zh)
NO (1) NO179006C (zh)
NZ (1) NZ241068A (zh)
PT (1) PT99859A (zh)
TW (1) TW230208B (zh)
ZA (1) ZA9110019B (zh)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5208331A (en) * 1992-06-18 1993-05-04 Syntex (U.S.A.) Inc. Process for preparing 1,3-dioxolane derivatives
US5274108A (en) * 1992-06-18 1993-12-28 Syntex (U.S.A.) Inc. Process for preparing 1,3-dioxolane derivatives
KR100331609B1 (ko) * 1995-04-21 2002-11-18 성 렬 류 신규한시스-튜불라졸유도체및그의제조방법
KR100704710B1 (ko) * 1999-10-29 2007-04-09 주식회사 중외제약 간 섬유화 억제작용을 나타내는 벤조[3,4-ｄ]1,3-디옥솔란 유도체
CA2727528A1 (en) 2007-06-14 2008-12-18 Osta Biotechnologies Heme-oxygenase inhibitors and use of the same in the treatment of cancer and diseases of the central nervous system
BR112019006451A2 (pt) * 2016-09-29 2019-06-25 Bayer Ag derivados substituídos de 1,5 imidazóis como fungicidas para proteção de plantação.
WO2019246494A1 (en) 2018-06-21 2019-12-26 Yumanity Therapeutics, Inc. Compositions and methods for the treatment and prevention of neurological disorders

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4078071A (en) * 1976-03-08 1978-03-07 Syntex (U.S.A.) Inc. Derivatives of substituted N-alkyl imidazoles
US4144346A (en) * 1977-01-31 1979-03-13 Janssen Pharmaceutica N.V. Novel 1-(1,3-dioxolan-2-ylmethyl)-1H-imidazoles
US4321272A (en) * 1980-08-25 1982-03-23 Syntex (U.S.A.) Inc. Derivatives of substituted N-alkylimidazoles
DE3166517D1 (de) * 1980-11-24 1984-11-08 Janssen Pharmaceutica Nv Novel (2-aryl-4-phenylthioalkyl-1,3-dioxolan-2-yl-methyl)azole derivatives
US4490540A (en) * 1981-09-14 1984-12-25 Janssen Pharmaceutica N.V. (2-Aryl-4-phenylthioalkyl-1,3-dioxolan-2-ylmethyl)azole derivatives
US4359475A (en) * 1981-12-21 1982-11-16 Syntex (U.S.A.) Inc. Thioketal substituted N-alkyl imidazoles
US4375474A (en) * 1982-02-11 1983-03-01 Syntex (U.S.A.) Inc. Dioxalane containing imidazole compounds, compositions and use
DK305884A (da) * 1983-06-24 1984-12-25 Yamanouchi Pharma Co Ltd Phenoxyderivat, fremgangsmaade til fremstilling deraf og farmaceutisk praeparat indeholdende et saadant derivat
US4518607A (en) * 1983-07-18 1985-05-21 Syntex (U.S.A.) Inc. Male oral contraceptive N-alkylimidazole derivatives, compositions, and method of use therefor
US4940799A (en) * 1987-07-20 1990-07-10 Ciba-Geigy Corporation Preparation of the diastereomeric mixture 2R,4S-1-[2-(2,4-dichlorophenyl)-4-n-propyl-1,3-dioxolan-2-ylmethyl]-1H-1,2,4-triazole
AU614818B2 (en) * 1988-03-28 1991-09-12 Janssen Pharmaceutica N.V. 2-imidazolylmethyl-1,3-dioxolanyl methylthiophenyl carbamate derivatives and their use as antineoplastic agents

Also Published As

Publication number Publication date
DE69124956T2 (de) 1997-06-12
FI916018A (fi) 1992-06-21
FI916018A0 (fi) 1991-12-19
NZ241068A (en) 1996-12-20
ITTO910999A1 (it) 1992-06-21
EP0492474A1 (en) 1992-07-01
ATE149495T1 (de) 1997-03-15
CA2058068A1 (en) 1992-06-21
MX9102703A (es) 1992-06-01
AU650079B2 (en) 1994-06-09
DK0492474T3 (da) 1997-03-24
AU8990591A (en) 1992-06-25
ZA9110019B (en) 1993-06-21
NO915036D0 (no) 1991-12-19
KR920011484A (ko) 1992-07-24
NO915036L (no) 1992-06-22
HU914024D0 (en) 1992-03-30
PT99859A (pt) 1992-12-31
IE914442A1 (en) 1992-07-01
IT1250362B (it) 1995-04-07
EP0492474B1 (en) 1997-03-05
HUT61998A (en) 1993-03-29
NO179006C (no) 1996-07-17
NO179006B (no) 1996-04-09
DE69124956D1 (de) 1997-04-10
IL100430A0 (en) 1992-09-06
ITTO910999A0 (it) 1991-12-19
US5158949A (en) 1992-10-27
JPH04308588A (ja) 1992-10-30
IL100430A (en) 1997-03-18
GR3022740T3 (en) 1997-06-30
HU210718A9 (en) 1995-06-28

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