ATE149495T1 - 1,3-dioxolanderivate als cholesterolsenkende mittel - Google Patents

1,3-dioxolanderivate als cholesterolsenkende mittel

Info

Publication number
ATE149495T1
ATE149495T1 AT91121864T AT91121864T ATE149495T1 AT E149495 T1 ATE149495 T1 AT E149495T1 AT 91121864 T AT91121864 T AT 91121864T AT 91121864 T AT91121864 T AT 91121864T AT E149495 T1 ATE149495 T1 AT E149495T1
Authority
AT
Austria
Prior art keywords
lower alkyl
hydrogen
dioxoland
cholesterol
derivatives
Prior art date
Application number
AT91121864T
Other languages
English (en)
Inventor
Keith A M Walker
Pamela M Burton
David C Swinney
Original Assignee
Syntex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex Inc filed Critical Syntex Inc
Application granted granted Critical
Publication of ATE149495T1 publication Critical patent/ATE149495T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
AT91121864T 1990-12-20 1991-12-19 1,3-dioxolanderivate als cholesterolsenkende mittel ATE149495T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/633,599 US5158949A (en) 1990-12-20 1990-12-20 1,3-dioxolane derivatives as cholesterol-lowering agents

Publications (1)

Publication Number Publication Date
ATE149495T1 true ATE149495T1 (de) 1997-03-15

Family

ID=24540306

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91121864T ATE149495T1 (de) 1990-12-20 1991-12-19 1,3-dioxolanderivate als cholesterolsenkende mittel

Country Status (21)

Country Link
US (1) US5158949A (de)
EP (1) EP0492474B1 (de)
JP (1) JPH04308588A (de)
KR (1) KR920011484A (de)
AT (1) ATE149495T1 (de)
AU (1) AU650079B2 (de)
CA (1) CA2058068A1 (de)
DE (1) DE69124956T2 (de)
DK (1) DK0492474T3 (de)
FI (1) FI916018A (de)
GR (1) GR3022740T3 (de)
HU (2) HUT61998A (de)
IE (1) IE914442A1 (de)
IL (1) IL100430A (de)
IT (1) IT1250362B (de)
MX (1) MX9102703A (de)
NO (1) NO179006C (de)
NZ (1) NZ241068A (de)
PT (1) PT99859A (de)
TW (1) TW230208B (de)
ZA (1) ZA9110019B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5208331A (en) * 1992-06-18 1993-05-04 Syntex (U.S.A.) Inc. Process for preparing 1,3-dioxolane derivatives
US5274108A (en) * 1992-06-18 1993-12-28 Syntex (U.S.A.) Inc. Process for preparing 1,3-dioxolane derivatives
KR100331609B1 (ko) * 1995-04-21 2002-11-18 성 렬 류 신규한시스-튜불라졸유도체및그의제조방법
KR100704710B1 (ko) * 1999-10-29 2007-04-09 주식회사 중외제약 간 섬유화 억제작용을 나타내는 벤조[3,4-ｄ]1,3-디옥솔란 유도체
CA2727528A1 (en) * 2007-06-14 2008-12-18 Osta Biotechnologies Heme-oxygenase inhibitors and use of the same in the treatment of cancer and diseases of the central nervous system
WO2018060093A1 (en) * 2016-09-29 2018-04-05 Bayer Cropscience Aktiengesellschaft 1,5-substituted imidazole derivatives as fungicides for crop protection.
CA3104291A1 (en) 2018-06-21 2019-12-26 Yumanity Therapeutics, Inc. Compositions and methods for the treatment and prevention of neurological disorders

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4078071A (en) * 1976-03-08 1978-03-07 Syntex (U.S.A.) Inc. Derivatives of substituted N-alkyl imidazoles
US4144346A (en) * 1977-01-31 1979-03-13 Janssen Pharmaceutica N.V. Novel 1-(1,3-dioxolan-2-ylmethyl)-1H-imidazoles
US4321272A (en) * 1980-08-25 1982-03-23 Syntex (U.S.A.) Inc. Derivatives of substituted N-alkylimidazoles
DE3166517D1 (de) * 1980-11-24 1984-11-08 Janssen Pharmaceutica Nv Novel (2-aryl-4-phenylthioalkyl-1,3-dioxolan-2-yl-methyl)azole derivatives
US4490540A (en) * 1981-09-14 1984-12-25 Janssen Pharmaceutica N.V. (2-Aryl-4-phenylthioalkyl-1,3-dioxolan-2-ylmethyl)azole derivatives
US4359475A (en) * 1981-12-21 1982-11-16 Syntex (U.S.A.) Inc. Thioketal substituted N-alkyl imidazoles
US4375474A (en) * 1982-02-11 1983-03-01 Syntex (U.S.A.) Inc. Dioxalane containing imidazole compounds, compositions and use
DK305884A (da) * 1983-06-24 1984-12-25 Yamanouchi Pharma Co Ltd Phenoxyderivat, fremgangsmaade til fremstilling deraf og farmaceutisk praeparat indeholdende et saadant derivat
US4518607A (en) * 1983-07-18 1985-05-21 Syntex (U.S.A.) Inc. Male oral contraceptive N-alkylimidazole derivatives, compositions, and method of use therefor
US4940799A (en) * 1987-07-20 1990-07-10 Ciba-Geigy Corporation Preparation of the diastereomeric mixture 2R,4S-1-[2-(2,4-dichlorophenyl)-4-n-propyl-1,3-dioxolan-2-ylmethyl]-1H-1,2,4-triazole
AU614818B2 (en) * 1988-03-28 1991-09-12 Janssen Pharmaceutica N.V. 2-imidazolylmethyl-1,3-dioxolanyl methylthiophenyl carbamate derivatives and their use as antineoplastic agents

Also Published As

Publication number Publication date
DE69124956T2 (de) 1997-06-12
GR3022740T3 (en) 1997-06-30
NO915036L (no) 1992-06-22
PT99859A (pt) 1992-12-31
CA2058068A1 (en) 1992-06-21
NO179006B (no) 1996-04-09
IE914442A1 (en) 1992-07-01
HUT61998A (en) 1993-03-29
AU650079B2 (en) 1994-06-09
TW230208B (de) 1994-09-11
NZ241068A (en) 1996-12-20
HU210718A9 (en) 1995-06-28
IT1250362B (it) 1995-04-07
DE69124956D1 (de) 1997-04-10
FI916018A0 (fi) 1991-12-19
JPH04308588A (ja) 1992-10-30
ZA9110019B (en) 1993-06-21
DK0492474T3 (da) 1997-03-24
HU914024D0 (en) 1992-03-30
EP0492474A1 (de) 1992-07-01
EP0492474B1 (de) 1997-03-05
US5158949A (en) 1992-10-27
MX9102703A (es) 1992-06-01
NO179006C (no) 1996-07-17
NO915036D0 (no) 1991-12-19
ITTO910999A0 (it) 1991-12-19
ITTO910999A1 (it) 1992-06-21
IL100430A (en) 1997-03-18
KR920011484A (ko) 1992-07-24
IL100430A0 (en) 1992-09-06
AU8990591A (en) 1992-06-25
FI916018A (fi) 1992-06-21

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Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties